LOCUS       NM_001398592            3625 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus WAP, follistatin/kazal, immunoglobulin, kunitz
            and netrin domain containing 2 (Wfikkn2), mRNA.
ACCESSION   NM_001398592 XM_220855
VERSION     NM_001398592.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3625)
  AUTHORS   Lee,Y.S. and Lee,S.J.
  TITLE     Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2
  JOURNAL   Proc Natl Acad Sci U S A 110 (39), E3713-E3722 (2013)
   PUBMED   24019467
REFERENCE   2  (bases 1 to 3625)
  AUTHORS   Szlama,G., Kondas,K., Trexler,M. and Patthy,L.
  TITLE     WFIKKN1 and WFIKKN2 bind growth factors TGFbeta1, BMP2 and BMP4 but
            do not inhibit their signalling activity
  JOURNAL   FEBS J 277 (24), 5040-5050 (2010)
   PUBMED   21054789
REFERENCE   3  (bases 1 to 3625)
  AUTHORS   Hill,J.J., Qiu,Y., Hewick,R.M. and Wolfman,N.M.
  TITLE     Regulation of myostatin in vivo by growth and differentiation
            factor-associated serum protein-1: a novel protein with protease
            inhibitor and follistatin domains
  JOURNAL   Mol Endocrinol 17 (6), 1144-1154 (2003)
   PUBMED   12595574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 20, 2021 this sequence version replaced XM_220855.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220270.1, SRR26643292.42719.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               JAXUCZ010000010.1  79688102-79688553   c
            453-3625            JAXUCZ010000010.1  79682459-79685631   c
FEATURES             Location/Qualifiers
     source          1..3625
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3625
                     /gene="Wfikkn2"
                     /gene_synonym="RGD1305361"
                     /note="WAP, follistatin/kazal, immunoglobulin, kunitz and
                     netrin domain containing 2"
                     /db_xref="GeneID:287631"
                     /db_xref="RGD:1305361"
     exon            1..452
                     /gene="Wfikkn2"
                     /gene_synonym="RGD1305361"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1973
                     /gene="Wfikkn2"
                     /gene_synonym="RGD1305361"
                     /note="WAP, Kazal, immunoglobulin, Kunitz and NTR
                     domain-containing protein 2"
                     /codon_start=1
                     /product="WAP, Kazal, immunoglobulin, Kunitz and NTR
                     domain-containing protein 2 precursor"
                     /protein_id="NP_001385521.1"
                     /db_xref="GeneID:287631"
                     /db_xref="RGD:1305361"
                     /translation="MWAPGHHRFWFHWGLLLLLLLGAPLRGLALPHIRYSHAGICPND
                     MNPNLWVDAQSTCKRECETDQECETYEKCCPNVCGTKSCVAARYMDVKGKKGPVGMPK
                     EATCDHFMCLQQGSECDIWDGQPVCKCKDRCEKEPSFTCASDGLTYYNRCYMDAEACS
                     KGVTLSVVTCRYHFTWPNTSPPPPETTVHPTTASPETLGLDMAAPALLNHPVHQSVTV
                     GETVSFLCDVVGRPRPELTWEKQLEDRENVVMRPNHVRGNVVVTNIAQLVIYNAQPQD
                     AGIYTCTARNVAGVLRADFPLSVVRGGQARATSESSLNGTAFPATECLKPPDSEDCGE
                     EQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLACMSGPLATCSLPALQGPCKA
                     YVPRWAYNSQTGLCQSFVYGGCEGNGNNFESREACEESCPFPRGNQNCRACKPRQKLV
                     TSFCRSDFVILGRVSELTEEPDSGRALVTVDEVLKDEKMGLKFLGREPLEVTLLHVDW
                     TCPCPNVTVGETPLIIMGEVEGGMAMLKPDSFVGASSTRRVRKLREVMYKKTCDVLKD
                     FLGLQ"
     exon            453..3625
                     /gene="Wfikkn2"
                     /gene_synonym="RGD1305361"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctctccct gcgcaccagg ggtggggggg aacagagttt ccttccaaag acctttcttt
       61 tatctgaagc ctcacagccc agcaggctgc acttggcgga gccagtcaca gcagccgaaa
      121 gccagcaagc agcctcagcg aggagacttg ctggggtgag gagggcaggt gttgccagcc
      181 ctggagaaga agggcctggt ggccctcagc ccttggtgtc atcacagggg aaccctctgg
      241 ctactgcaga cagcaccatg tgggccccag ggcatcatcg gttctggttc cactgggggc
      301 tgcttttgct gctgctcctc ggggctcccc ttcgaggcct agcgctgcca cacatccgat
      361 actcccatgc aggcatctgc cccaacgaca tgaaccccaa cctctgggtg gatgcccaga
      421 gcacctgcaa gcgagagtgt gaaacagacc aggaatgtga gacctatgag aagtgctgcc
      481 ccaatgtgtg tgggaccaag agctgcgtag cagcccgcta catggatgtg aaagggaaga
      541 agggccctgt gggcatgccc aaggaggcca cgtgtgacca tttcatgtgt ctgcagcagg
      601 gctccgagtg tgacatctgg gacggccagc ctgtgtgtaa gtgtaaagac cgctgtgaga
      661 aggagcccag cttcacctgt gcctctgacg gccttaccta ctacaaccgt tgttacatgg
      721 acgccgaggc ctgctccaag ggcgtcacac tgtctgtggt cacctgccgc tatcacttca
      781 cctggcccaa caccagccct cctccgcccg agaccactgt acaccctacc accgcctctc
      841 cagagactct cgggctggac atggccgccc cggccctgct caaccacccc gtccatcagt
      901 cagtcactgt gggtgagact gtgagtttcc tctgtgacgt agtaggcagg cctaggccag
      961 agctcacttg ggagaaacag ctggaggatc gagagaatgt ggtcatgaga cccaaccacg
     1021 tgcgtggtaa tgtggtggtc accaacatcg cccagctggt catctacaat gcgcagcccc
     1081 aggatgcagg tatatacacc tgtacagctc ggaatgtcgc tggggtcctg agggctgact
     1141 tcccattgtc agtggtcagg ggaggtcagg ccagggccac ctcagagagc agtcttaacg
     1201 gcacagcctt cccggcaaca gagtgcctga agcccccaga cagtgaggac tgtggagagg
     1261 aacagacacg ctggcacttc gatgcccagg ctaacaactg cctcacgttc acctttggcc
     1321 actgccaccg caatctcaac cacttcgaga cctatgaggc ctgcatgctg gcttgtatga
     1381 gtgggccgtt ggccacatgc agcctgcccg ccctgcaggg accctgcaaa gcctacgtgc
     1441 cacgctgggc ctacaacagc cagacgggtc tatgccagtc cttcgtctat ggcggctgtg
     1501 aaggcaatgg aaacaacttt gaaagccgtg aggcctgcga ggagtcttgt cccttcccaa
     1561 ggggcaacca gaattgccga gcctgcaagc cacgacaaaa actcgttacc agcttctgtc
     1621 ggagtgactt tgtcatcctg ggcagggtct ctgagctgac cgaagagcct gactcaggcc
     1681 gtgccctggt gaccgtggat gaggtcctaa aagatgagaa gatgggtctc aagtttctgg
     1741 gccgggaacc gctggaagtc actctgcttc atgtggactg gacctgtcct tgccccaatg
     1801 tgacagtggg agagacaccg ctcatcatca tgggggaagt ggaggggggt atggccatgc
     1861 tgaaacctga tagctttgtg ggtgcatcaa gcactcggcg ggtcaggaag ctccgtgagg
     1921 tcatgtacaa gaaaacctgc gatgtcctca aggacttcct gggcttgcaa tgaagctagc
     1981 cttgctaccc tgtccctcct ccgcccaccc gctctgctct cagctagcca tccagacaag
     2041 tcaggttaga cagccttgac tagggaagaa acgtcagcta acacgtggga agaaagccac
     2101 caatgtctta aagccactga agttttagcg ccacccatat gctctctctc cctctccatg
     2161 ttctcccttt gaaaatggta gggagcacat gccccccttt agaggtctgt ggcccatctc
     2221 tccatactac cagccccttg accttggaca atttgcttaa cctctctgtg ccttagatta
     2281 ttgtatacaa aatgggaata gtggttgtac cccctgggct tagaagagag cagtcagcta
     2341 aaagaaaccc aggagcctca caggtgtttg gattcaataa aatgtctgtt tcttccctcc
     2401 accctagccc tacccccaga caaggttttt ctgtgtagct ctggctgtcc cggaatttac
     2461 tctgtagacc aggttggcca agaactaaga gatccacccg cctctgcctt ctgagtgctg
     2521 ggattaaaga tgtgcactac catgtctggc taaaaaggtc cgtttctttt tttttttttt
     2581 ttagctggga agggggttgg caaaagggaa gaaaggacac atgtaagttg ttttccatga
     2641 gtggttccct caggcagtct cattcccctt tgctgacccg tgcccctctg cccagtgtca
     2701 gcctggggtc aggaggagat accatctgca ttgttaaatg gtttagcttg tataggaggt
     2761 aatgtggggg gagaaaagag aggccaagga tcacttaaga caactgcccc actgcctcct
     2821 gcccccacca catcgctgta gtcagagacc acccacataa agggttgtga gcagtgggaa
     2881 gccagagcat tcaccctagg ctataactta tcctaatgaa ggctgcgggg accgctactt
     2941 ttgttggggt cggtttgtgt caccacacca ggggaatcca tgtttttttt cctgagctgc
     3001 atcggtttct tggtttactt ctgttcattt cagcccagtg gacccttcct gggtgccagg
     3061 tgctgggacc atagagagct gatacctctc tactgggcga gctggaaggc agtcccccac
     3121 gctcccccca ggagccagtg ggtgattgac agcggttagg catttccatc tgatgggtca
     3181 ggtgctttca tatgccatag acttccttgg agaagcccaa agatctgttt tggtagcaag
     3241 agaaataaag aagacaaagg caggagggac aggggacagc atcagagcgg aggtgggccc
     3301 agggagcatg aatattgctc gatgctgcca tctggtggtg catttgggca cctgcagggg
     3361 tcgggaggaa agctctatct gggtggggcc tgggaggggc ctcttggaga tggcagctct
     3421 gagatcactt gtttgttctg gtcccagcca cacaggcact ggaaagagga tttggagccc
     3481 ctctgtcatc actgcatctg ccctgtttcc tccccagccc ttcactctgc ccgcattccc
     3541 ccaatggaag cactgtggga cgtcctaatg tcttcctcaa atatacagag gacaagacta
     3601 aataaaaatt catagtgtca actgc
//
