LOCUS       NM_173109                711 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus WAP four-disulfide core domain 2 (Wfdc2), mRNA.
ACCESSION   NM_173109
VERSION     NM_173109.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 711)
  AUTHORS   Rowswell-Turner,R.B., Singh,R.K., Urh,A., Yano,N., Kim,K.K.,
            Khazan,N., Pandita,R., Sivagnanalingam,U., Hovanesian,V.,
            James,N.E., Ribeiro,J.R., Kadambi,S., Linehan,D.C. and Moore,R.G.
  TITLE     HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor
            Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1
            Expression
  JOURNAL   J Immunol 206 (10), 2478-2488 (2021)
   PUBMED   33903172
  REMARK    GeneRIF: HE4 Overexpression by Ovarian Cancer Promotes a
            Suppressive Tumor Immune Microenvironment and Enhanced Tumor and
            Macrophage PD-L1 Expression.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173109.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ515239.1, BQ203120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000003.1  173706475-173706589
            116-259             JAXUCZ010000003.1  173707083-173707226
            260-397             JAXUCZ010000003.1  173707795-173707932
            398-544             JAXUCZ010000003.1  173709506-173709652
            545-711             JAXUCZ010000003.1  173711987-173712153
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..711
                     /gene="Wfdc2"
                     /gene_synonym="re4"
                     /note="WAP four-disulfide core domain 2"
                     /db_xref="GeneID:286888"
                     /db_xref="RGD:628757"
     exon            1..115
                     /gene="Wfdc2"
                     /gene_synonym="re4"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..543
                     /gene="Wfdc2"
                     /gene_synonym="re4"
                     /note="WAP four-disulfide core domain protein 2;
                     epididymal secretory protein 4"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 2
                     precursor"
                     /protein_id="NP_775132.1"
                     /db_xref="GeneID:286888"
                     /db_xref="RGD:628757"
                     /translation="MPACRLCLLATGLLLGLLLFTPLSATGTRAEKPGVCPQLEPITD
                     CVKACILDNDCQDNYKCCQAGCGSVCSKPNGLSEGKLSRTATGTTTLSAGLARTSPLS
                     RGQVSTKPPVVTKEGGNGEKQGTCPSVDFPKLGLCEDQCQMDSQCSGNMKCCRNGCGK
                     MGCTTPKF"
     exon            116..259
                     /gene="Wfdc2"
                     /gene_synonym="re4"
                     /inference="alignment:Splign:2.1.0"
     exon            260..397
                     /gene="Wfdc2"
                     /gene_synonym="re4"
                     /inference="alignment:Splign:2.1.0"
     exon            398..544
                     /gene="Wfdc2"
                     /gene_synonym="re4"
                     /inference="alignment:Splign:2.1.0"
     exon            545..711
                     /gene="Wfdc2"
                     /gene_synonym="re4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccccccca ttcaggctgc aggttacacc tgcaccatgc ctgcttgtcg cctctgcttg
       61 ctggccacag gcctcctact cgggctgctg ctgttcaccc ccctctcagc cacaggcacc
      121 agagcagaga aacccggtgt gtgcccccag ctcgaaccaa ttactgactg tgtgaaggcg
      181 tgcatcttgg acaacgactg ccaggacaac tacaagtgct gccaggccgg ctgcggctct
      241 gtctgctcca agcctaatgg gctgagcgaa ggaaaactct ccaggaccgc gacgggtaca
      301 acgactctat cagccggcct tgcccgcaca tctcctctat cgagaggtca agtgtccacg
      361 aagccacccg ttgtgaccaa agaaggaggt aacggagaaa agcagggcac ctgccccagc
      421 gtggacttcc ccaagcttgg cctctgtgag gaccagtgcc agatggacag ccagtgttct
      481 ggcaacatga aatgctgccg aaatggctgt gggaagatgg gctgcaccac acccaaattc
      541 tgagcttcag ccaccagcag cctgaggaat ggagagaggt tgcttctgct ggaccatgca
      601 ttctggtgtc gttcctgtgg cctcctctct ctctggcctt tgcatttcgt cctggtccca
      661 caaaagcatc tcctttttct aaccaataaa gcgatcactt tcagcaatgg a
//
