LOCUS       NM_133537                440 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus WAP four-disulfide core domain 18 (Wfdc18), mRNA.
ACCESSION   NM_133537
VERSION     NM_133537.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 440)
  AUTHORS   Saad,Y., Garrett,M.R., Manickavasagam,E., Yerga-Woolwine,S.,
            Farms,P., Radecki,T. and Joe,B.
  TITLE     Fine-mapping and comprehensive transcript analysis reveals
            nonsynonymous variants within a novel 1.17 Mb blood pressure QTL
            region on rat chromosome 10
  JOURNAL   Genomics 89 (3), 343-353 (2007)
   PUBMED   17218081
REFERENCE   2  (bases 1 to 440)
  AUTHORS   Bribian,A., Barallobre,M.J., Soussi-Yanicostas,N. and de Castro,F.
  TITLE     Anosmin-1 modulates the FGF-2-dependent migration of
            oligodendrocyte precursors in the developing optic nerve
  JOURNAL   Mol Cell Neurosci 33 (1), 2-14 (2006)
   PUBMED   16876430
  REMARK    GeneRIF: Data suggest that the relative concentrations of Anosmin-1
            and FGF-2 modulate the migration of oligodendrocyte precursors
            during development through their interaction with FGFR1.
REFERENCE   3  (bases 1 to 440)
  AUTHORS   Dear,T.N. and Kefford,R.F.
  TITLE     The WDNM1 gene product is a novel member of the 'four-disulphide
            core' family of proteins
  JOURNAL   Biochem Biophys Res Commun 176 (1), 247-254 (1991)
   PUBMED   2018519
REFERENCE   4  (bases 1 to 440)
  AUTHORS   Dear,T.N., Ramshaw,I.A. and Kefford,R.F.
  TITLE     Differential expression of a novel gene, WDNM1, in nonmetastatic
            rat mammary adenocarcinoma cells
  JOURNAL   Cancer Res 48 (18), 5203-5209 (1988)
   PUBMED   3136918
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 24, 2010 this sequence version replaced NM_133537.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13309.1, CB730912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000010.1  69086319-69086406
            89-237              JAXUCZ010000010.1  69087024-69087172
            238-440             JAXUCZ010000010.1  69088271-69088473
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..440
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /note="WAP four-disulfide core domain 18"
                     /db_xref="GeneID:171059"
                     /db_xref="RGD:619957"
     exon            1..88
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..237
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /note="anosmin-1; Kallmann syndrome 1 sequence;
                     extracellular peptidase inhibitor; extracellular
                     proteinase inhibitor; WAP four-disulfide core domain
                     protein 18"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 18
                     precursor"
                     /protein_id="NP_598221.2"
                     /db_xref="GeneID:171059"
                     /db_xref="RGD:619957"
                     /translation="MKTASVLLLVALIAVGMNITYALFSPTKLEKPGKCPKNPPRSIG
                     TCVELCSGDQSCPNIQKCCSNGCGHVCKSPVF"
     exon            89..237
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..440
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaacatga agacagcctc agtcttgctt ctggtggctt tgatcgccgt gggaatgaac
       61 attacctatg ctctgttttc tcccacaaaa ttagaaaaac ctggaaagtg tcccaagaat
      121 cccccaagaa gtattggcac ttgtgttgaa ttatgctcag gagatcaatc gtgccccaac
      181 atacagaagt gctgttccaa tggctgtggt catgtttgca aatctcctgt cttttaagtt
      241 actaacagcg atgtggaata tggatttgat cttcataagc acgactgatg gccagcccca
      301 gaagatttct tctgaatccc tagagcccat gcttggctcc tcccttgtcc tagaattgca
      361 tccttggaaa aggaagatct atactgtgat gacagcttcc taatgtgttt gtgtccacaa
      421 ataaactctc cttagcattc
//
