LOCUS       NM_133581               1046 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus WAP four-disulfide core domain 1 (Wfdc1), mRNA.
ACCESSION   NM_133581
VERSION     NM_133581.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1046)
  AUTHORS   Ressler,S.J., Dang,T.D., Wu,S.M., Tse,D.Y., Gilbert,B.E.,
            Vyakarnam,A., Yang,F., Schauer,I.G., Barron,D.A. and Rowley,D.R.
  TITLE     WFDC1 is a key modulator of inflammatory and wound repair responses
  JOURNAL   Am J Pathol 184 (11), 2951-2964 (2014)
   PUBMED   25219356
REFERENCE   2  (bases 1 to 1046)
  AUTHORS   Hung,H.
  TITLE     Suppression of ps20 expression in the rat uterus by tamoxifen and
            estrogens
  JOURNAL   Endocrinology 146 (5), 2388-2396 (2005)
   PUBMED   15677758
  REMARK    GeneRIF: data indicate that ps20 protein uterine expression is
            negatively regulated by estrogens and tamoxifen and suggest that
            ps20 may function as a mediator of local growth
REFERENCE   3  (bases 1 to 1046)
  AUTHORS   Watson,J.E., Kamkar,S., James,K., Kowbel,D., Andaya,A., Paris,P.L.,
            Simko,J., Carroll,P., McAlhany,S., Rowley,D. and Collins,C.
  TITLE     Molecular analysis of WFDC1/ps20 gene in prostate cancer
  JOURNAL   Prostate 61 (2), 192-199 (2004)
   PUBMED   15305342
REFERENCE   4  (bases 1 to 1046)
  AUTHORS   McAlhany,S.J., Ayala,G.E., Frolov,A., Ressler,S.J., Wheeler,T.M.,
            Watson,J.E., Collins,C. and Rowley,D.R.
  TITLE     Decreased stromal expression and increased epithelial expression of
            WFDC1/ps20 in prostate cancer is associated with reduced
            recurrence-free survival
  JOURNAL   Prostate 61 (2), 182-191 (2004)
   PUBMED   15305341
REFERENCE   5  (bases 1 to 1046)
  AUTHORS   Larsen,M., Ressler,S.J., Lu,B., Gerdes,M.J., McBride,L., Dang,T.D.
            and Rowley,D.R.
  TITLE     Molecular cloning and expression of ps20 growth inhibitor. A novel
            WAP-type 'four-disulfide core' domain protein expressed in smooth
            muscle
  JOURNAL   J Biol Chem 273 (8), 4574-4584 (1998)
   PUBMED   9468514
REFERENCE   6  (bases 1 to 1046)
  AUTHORS   Rowley,D.R., Dang,T.D., Larsen,M., Gerdes,M.J., McBride,L. and
            Lu,B.
  TITLE     Purification of a novel protein (ps20) from urogenital sinus
            mesenchymal cells with growth inhibitory properties in vitro
  JOURNAL   J Biol Chem 270 (37), 22058-22065 (1995)
   PUBMED   7665628
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133581.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF037272.1, FQ216345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000019.1  64629048-64629215
            169-358             JAXUCZ010000019.1  64639379-64639568
            359-442             JAXUCZ010000019.1  64640283-64640366
            443-583             JAXUCZ010000019.1  64641195-64641335
            584-625             JAXUCZ010000019.1  64643945-64643986
            626-699             JAXUCZ010000019.1  64645939-64646012
            700-1046            JAXUCZ010000019.1  64647393-64647739
FEATURES             Location/Qualifiers
     source          1..1046
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1046
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /note="WAP four-disulfide core domain 1"
                     /db_xref="GeneID:171112"
                     /db_xref="RGD:68938"
     exon            1..168
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..684
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /note="WAP four-disulfide core domain protein 1; ps20
                     growth inhibitor; prostate stromal protein ps20; 20-kDa
                     prostate stromal protein"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 1
                     precursor"
                     /protein_id="NP_598265.1"
                     /db_xref="GeneID:171112"
                     /db_xref="RGD:68938"
                     /translation="MGSCDRKALWALSFLLLLLGSSSVQGTWEAMLPVRLAEKSQAEE
                     VAATGSRQPHADRCPPPPRTLPPGACQATRCQSDSECPRHRRCCYNGCAYACLEAVPP
                     PPVLDWLVQPKPRWLGGNGWLLDGPEEVLQAEACSTTEDGAEPLLCPSGYECHILQPG
                     DAAQGIPNHGRCVKQRRQAEGRVLRQKLHKEYPEGDSKYVAEPGKGQQRHFP"
     exon            169..358
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            359..442
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            443..583
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            584..625
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            626..699
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            700..1046
                     /gene="Wfdc1"
                     /gene_synonym="ps20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaggtca ctcgtgcaga aggaaagcct gccaccagcc tcgggatggg tagctgcgac
       61 aggaaagccc tctgggctct gagcttccta ctgctgctac tgggctccag ctctgttcag
      121 ggcacttggg aggcaatgtt gccggtcagg ctggctgaga agtcccaagc tgaagaggtt
      181 gcagcaacag gctcccggca gccccacgca gaccgctgcc caccaccgcc acggacgcta
      241 cccccgggtg cctgtcaggc cacacgctgc cagtctgact ctgagtgccc acgacacaga
      301 cgctgctgtt acaacggctg tgcctatgcc tgcctggagg cggtgccacc gccaccagtt
      361 ctagactggc tggtgcagcc caaaccacgg tggcttggtg gcaatggctg gctgctggat
      421 ggtccggagg aagtgttaca agcagaggcc tgcagcacca ctgaggatgg ggcagagcca
      481 ctcctctgtc cctcaggcta tgagtgccac atcctgcagc caggggatgc ggcccagggc
      541 atacccaacc atggacggtg tgttaagcaa cgtcgacaag cagaggggcg ggtcctgcga
      601 cagaagcttc acaaggagta cccagaaggt gactccaagt atgtggcaga gcctgggaag
      661 ggacaacaga ggcactttcc atgaagtgga gactggctgc ctttgtgggg cctttcctgt
      721 gctttccaca cactacccct tggaaacagc aaaagaattt gaccctagac gtcaaactcc
      781 attccacaga acgggactcc agagctcctg ggaaacggga cttcagactc ccaaccccag
      841 agtggcccag cctggtgcgg cggtaacttg gcggaagccc ctgaccacct ctgggtcccc
      901 gctcagcatc cttgtcacag gaacccgcag cttctaggtg acttttgcag attttgcctg
      961 cagaaggcat atattcatct ctttttttcc ccgaataaat ctgcccacca tgtagcagaa
     1021 ataagttcct ttatcaggct caagtc
//
