LOCUS       NM_001012742            3305 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus WEE1 G2 checkpoint kinase (Wee1), mRNA.
ACCESSION   NM_001012742 XM_219264
VERSION     NM_001012742.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   Ilyas,S., Simanullang,R.H., Hutahaean,S., Rosidah,R. and
            Situmorang,P.C.
  TITLE     Correlation of Myc Expression with Wee1 Expression by Zanthoxylum
            acanthopodium in Cervical Carcinoma Histology
  JOURNAL   Pak J Biol Sci 25 (11), 1014-1020 (2022)
   PUBMED   36591933
  REMARK    GeneRIF: Correlation of Myc Expression with Wee1 Expression by
            Zanthoxylum acanthopodium in Cervical Carcinoma Histology.
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Prasad,S., Koch,B. and Chaube,S.K.
  TITLE     Maturation promoting factor destabilization facilitates
            postovulatory aging-mediated abortive spontaneous egg activation in
            rat
  JOURNAL   Dev Growth Differ 58 (3), 293-302 (2016)
   PUBMED   26991553
  REMARK    GeneRIF: Data suggest that the increase of Wee 1 tyrosine kinase
            but decrease of early mitotic inhibitor 2 level triggers maturation
            promoting factor (MPF) destabilization and thereby postovulatory
            aging-mediated abortive spontaneous egg activation in eggs.
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Hsu,W.C., Nenov,M.N., Shavkunov,A., Panova,N., Zhan,M. and
            Laezza,F.
  TITLE     Identifying a kinase network regulating FGF14:Nav1.6 complex
            assembly using split-luciferase complementation
  JOURNAL   PLoS One 10 (2), e0117246 (2015)
   PUBMED   25659151
  REMARK    GeneRIF: identified the PI3K/Akt pathway, the cell-cycle regulator
            Wee1 kinase, and protein kinase C (PKC) as prospective regulatory
            nodes of neuronal excitability through modulation of the
            FGF14:Nav1.6 complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Muller,M., Lutter,D. and Puschel,A.W.
  TITLE     Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and
            SadB-deficient neurons disrupts neuronal polarity
  JOURNAL   J Cell Sci 123 (Pt 2), 286-294 (2010)
   PUBMED   20026642
  REMARK    GeneRIF: The regulation of Wee1 by SadA and SadB kinases is
            essential for the differentiation of polarized neurons.
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   Polidarova,L., Sotak,M., Sladek,M., Pacha,J. and Sumova,A.
  TITLE     Temporal gradient in the clock gene and cell-cycle checkpoint
            kinase Wee1 expression along the gut
  JOURNAL   Chronobiol Int 26 (4), 607-620 (2009)
   PUBMED   19444744
  REMARK    GeneRIF: rhythmic profiles of the clock gene Wee1 expression within
            the epithelium from different parts of the rat gut exhibited a
            difference in phasing.
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Park,C.E., Kim,Y.H., Jeon,E.H., Cha,K.Y., Lee,S.H. and Lee,K.A.
  TITLE     Expression of wee1 and its related cell cycle components in mouse
            early stage follicles
  JOURNAL   Cells Tissues Organs 177 (4), 221-228 (2004)
   PUBMED   15459478
REFERENCE   7  (bases 1 to 3305)
  AUTHORS   Honda,R., Tanaka,H., Ohba,Y. and Yasuda,H.
  TITLE     Mouse p87wee1 kinase is regulated by M-phase specific
            phosphorylation
  JOURNAL   Chromosome Res 3 (5), 300-308 (1995)
   PUBMED   7551544
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC090346.1.
            
            On Apr 20, 2005 this sequence version replaced XM_219264.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..3305
                     /gene="Wee1"
                     /note="WEE1 G2 checkpoint kinase"
                     /db_xref="GeneID:308937"
                     /db_xref="RGD:1307895"
     exon            1..645
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2010
                     /gene="Wee1"
                     /EC_number="2.7.10.2"
                     /note="wee1 tyrosine kinase; wee1A kinase; wee 1 homolog"
                     /codon_start=1
                     /product="wee1-like protein kinase"
                     /protein_id="NP_001012760.1"
                     /db_xref="GeneID:308937"
                     /db_xref="RGD:1307895"
                     /translation="MSFLSRQQPPPTRRAAAACSLRQKLIFSPGSDCEEEEEEEEEGS
                     GHSTGEDSAFQEPDSPLPSARSPAEAEAERRRRSPGAEPSSPGELEEDLLLRGGGGGA
                     QAAGGGAEGDSWEEEGFGSSSPVKSPTTAYFLGSSFSPVRCGGPGDASPRGCGVPRAM
                     DDPCSPQPDYPSTPPHKTFRKLRLFDTPHTPKSLLSKARVIDSSSVKLRGSSLFMDTE
                     KSGKREFDTRQTPQVNINPFTPDPVMLHSSGQCRGRKRAYFNDSSEDMEASDYEFEDE
                     TRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLA
                     GSVDEQNALREVYAHAVLGQHPHVVRYFSAWAEDDHMLIQNEYCNGGSLADAVSENYR
                     VMSYFTEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAVSEEGDEDD
                     WISNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYSHLPKADIFALALTVVC
                     AAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQELTELLKVMIHPDPERRPSAMVLVKHS
                     VLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAAKVAAEERALLTDRMATRSTT
                     QSNRTSRLIGKKMNRSVSLTIY"
     exon            646..851
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..912
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1085
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1207
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1354
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1450
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1536
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1707
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1853
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..3276
                     /gene="Wee1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggacgccg ccggcctgtg ctcgccggtc ctctgctctc cggtgctccg ccgtgactgc
       61 agccgggaaa tgagcttcct gagccgacag cagccgccgc ccacccgccg cgccgcagcc
      121 gcctgcagtt tgcggcagaa gctcatcttc tcacccggca gcgattgtga ggaggaagag
      181 gaggaggagg aggaaggcag cggccacagt acgggggagg actcggcctt ccaggagcct
      241 gattcgccgc tgccctctgc acgcagccct gccgaggccg aggccgagcg ccgccgccgc
      301 tcgcccggcg cggagcccag cagcccggga gagctggagg aggacttgct gctgcggggc
      361 ggcggcgggg gcgcgcaagc ggcgggcgga ggagccgagg gcgactcttg ggaggaggag
      421 ggtttcggct cttcgtcgcc cgtcaagtca cctacgactg cctactttct gggcagctcg
      481 ttctcgccgg tgcgctgcgg cggccctggg gatgcctccc cgcggggctg cggggtcccg
      541 cgagccatgg acgacccctg ttctccgcag cccgactacc cgagcacccc tccgcacaag
      601 accttccgca agttgcgcct gttcgacacg ccgcacactc ccaagagttt gctttccaaa
      661 gctcgagtta ttgattccag ctctgttaaa ctccggggta gttctctatt catggacact
      721 gaaaaatcag gaaaaagaga attcgacaca cggcaaactc ctcaagtgaa tattaacccc
      781 tttactccgg atcctgtaat gcttcattcc tcaggacagt gtcgtgggag aaagagagca
      841 tattttaatg attcctctga agacatggaa gccagtgatt atgagtttga agatgaaaca
      901 agacctgcca aaagaattac aattactgaa agcaatatga agtcacgata tacaactgaa
      961 tttcatgagc tggagaaaat tggttctgga gaatttggtt ctgtgtttaa atgtgtgaag
     1021 aggctagatg gatgcattta tgccattaaa cgatcaaaaa agccattggc tggctctgtt
     1081 gatgaacaga atgctttgag agaagtgtat gctcatgctg tgcttggaca gcatccccat
     1141 gtggttcgtt atttctctgc ctgggcagaa gatgaccata tgcttataca gaatgaatac
     1201 tgtaatggtg ggagtttagc tgacgctgta agtgagaact acagagtcat gagctacttt
     1261 actgaagcag agctgaagga tctccttttg caagttggca ggggcttgag atacatacat
     1321 tcaatgtctt tggttcacat ggatataaaa cctagtaata tttttatatc tcgaacctca
     1381 atcccaaatg cagtctctga agaaggagat gaagatgact ggatatccaa caaagttatg
     1441 tttaaaatag gtgatcttgg gcatgtaaca agaatctcta gtccacaagt tgaagaaggt
     1501 gatagtcgtt ttctagcaaa tgaagtttta caagagaact atagccatct accgaaagca
     1561 gatatttttg ctcttgctct cacagtcgta tgtgctgctg gtgctgaacc ccttcccaga
     1621 aatggagacc agtggcatga aatccgacag ggtcgattac ctcggattcc acaagtgctt
     1681 tcccaggagt tgacagagtt gctaaaagtt atgattcatc ctgatccaga gagaagacct
     1741 tcagcaatgg tgctggtgaa gcattcagtg ttgctgtctg cctctagaaa gagcgcagag
     1801 cagttacgaa tagaattgaa tgctgaaaaa ttcaaaaatt ctcttttgca gaaagaactc
     1861 aagaaagccc aaatggcagc caaagttgca gctgaggaac gggcactcct cacagatcgg
     1921 atggccacta gatctaccac ccagagtaat agaacttctc gacttattgg aaagaaaatg
     1981 aaccgctctg tcagccttac tatatactga actgcttaca ttccccagcc cttccccctc
     2041 aaaggacaaa aaaaactgtg acaagaggaa gctaggttga aatcactgct agaatccact
     2101 ttgcaattac tttgccattg gtgtcagtag ttttcctaaa atgccttttg tgactttgtg
     2161 aattacagtt gagagctgta ttctgacttg gctctgtcag gcttttgtct catcttcccg
     2221 tctgtttcat gtaggatgtc agtcactgtt ggatgttcca ccaccctttg cggggtgagc
     2281 cactgtggtg gtgtgctgct tctcattcac tgttgccgtg tgatgaaagg tgtctttcct
     2341 tgttttgact gtggaaagga ctcgagggct ttactgcgat catcctctcc cttcaaaaag
     2401 ggaaatgctc agagactcag tactactcag cctccaatgt acctgtgtca atcttaacgt
     2461 ttcttttttt ctattgtgaa ttatacttgt atatccaact gggagcactt taggcatcat
     2521 gtgcaccatg ggatggtcat tctgtggaag ccttgccttg tgaatttgct gctattttag
     2581 tttcctcttg ctgtaaaact agcattaaac aatcattgtt gttaataggc tttctttcaa
     2641 aacaattatg tgaaatatgt agctgctctt catgaaaagc agctttgcct ccttttcttt
     2701 ggactttgaa gctagtgcat tgaaaaagtg cacctacccc ttccctgttc gaatgctgta
     2761 ttaatgtagt ataattatta ctggttttgt aaatttttct tataatgtcc tctgacttta
     2821 aaacatgttt ccttcctcct gtcaagtctt gtacttggtt gtatggttag cctattttta
     2881 aatgttttgc ccagtttctc ttcaatattt gtgtatataa actgatcttg gtaatactgt
     2941 acatagctgt ttaatatacc agaatgactt ctgactattc aagtttttca caaaatacat
     3001 tttacctgtg attagccatt tgactaacag tgtttggcta gtagatgttg ccctccaaaa
     3061 gtagggggaa atgtctcatt tgtttttcta ttaactttgg tctgaaacac atttgcactt
     3121 gtctgtttga cttgtgtctt attaacatta tctggcgtat taaaagtcat tctgtgctta
     3181 ccttaattgt ctaaatcttc acggtgcctg ttttctactt tgtatcccct cactgctcat
     3241 tacagaatgt ggataaatat atatgacttg ctgagaaaaa aaaaaaaaaa aaaaaaaaaa
     3301 aaaaa
//
