LOCUS       NM_001127298            2586 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus WD repeat domain 91 (Wdr91), mRNA.
ACCESSION   NM_001127298 XM_001065006 XM_231599
VERSION     NM_001127298.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Liu,X., Li,Y., Wang,X., Xing,R., Liu,K., Gan,Q., Tang,C., Gao,Z.,
            Jian,Y., Luo,S., Guo,W. and Yang,C.
  TITLE     The BEACH-containing protein WDR81 coordinates p62 and LC3C to
            promote aggrephagy
  JOURNAL   J Cell Biol 216 (5), 1301-1320 (2017)
   PUBMED   28404643
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Rapiteanu,R., Davis,L.J., Williamson,J.C., Timms,R.T., Paul
            Luzio,J. and Lehner,P.J.
  TITLE     A Genetic Screen Identifies a Critical Role for the WDR81-WDR91
            Complex in the Trafficking and Degradation of Tetherin
  JOURNAL   Traffic 17 (8), 940-958 (2016)
   PUBMED   27126989
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   Liu,K., Jian,Y., Sun,X., Yang,C., Gao,Z., Zhang,Z., Liu,X., Li,Y.,
            Xu,J., Jing,Y., Mitani,S., He,S. and Yang,C.
  TITLE     Negative regulation of phosphatidylinositol 3-phosphate levels in
            early-to-late endosome conversion
  JOURNAL   J Cell Biol 212 (2), 181-198 (2016)
   PUBMED   26783301
  REMARK    Erratum:[J Cell Biol. 2016 Mar 14;212(6):739. doi:
            10.1083/jcb.20150608103012016c.. PMID: 26975852]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166785.1, EV771594.1 and AW919773.1.
            
            On Oct 15, 2009 this sequence version replaced NM_001127298.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166785.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1191              BC166785.1         1-1191
            1192-1192           EV771594.1         548-548
            1193-2578           BC166785.1         1193-2578
            2579-2586           AW919773.1         492-499
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2586
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /note="WD repeat domain 91"
                     /db_xref="GeneID:312225"
                     /db_xref="RGD:1306697"
     exon            1..139
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..2260
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /codon_start=1
                     /product="WD repeat-containing protein 91"
                     /protein_id="NP_001120770.2"
                     /db_xref="GeneID:312225"
                     /db_xref="RGD:1306697"
                     /translation="MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDK
                     IVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTINKLKTSLFRFYLVYTIQT
                     NRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIISLH
                     NFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEVHRLKKEEQQQEE
                     AAALVQHKLPPYVSSMDRLGDSELALVCSQRPASLSQSPRVGFLSSLLPQSKKSPSRL
                     SPAQGPPQAQSSAKKDTFSSQATKGKDPVPGAKDGKSLLSGPVPGEASWTHQRQRRLQ
                     DHGKERRELLSTSSSQTQCAEKKLEGSGPEAELCLDLHMGPVEALARVSTAGSEGDRP
                     EQPFIVLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISK
                     SPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDMPRILSLACSPNGA
                     SFVCSAAAPSLTSQPDSSAPDIGSKGMNQVPGKLLLWDTKTMKQQLQFSLDPEPIAIN
                     CTAFNHNGNLLVTGAADGVIRLFDMQQHGCAMSWKAHCGEVYSVEFSYDENAVNSIGE
                     DGKFIQWNIHKSGLKVSEYSLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYML
                     TCSATGGLIYKLGSEEKVLENCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLT
                     TLLAHKL"
     exon            140..319
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            320..527
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            528..610
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            611..741
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            742..907
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1066
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1260
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1411
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1506
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1675
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1784
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1897
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2095
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2583
                     /gene="Wdr91"
                     /gene_synonym="RGD1306697"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgcgcgc gcagcgatgg cggaggcggt ggagcgcaca gacgagctgg tccgggagta
       61 cctgctcttc cgtggcttca cgcacacact gcggcagctg gatgccgaga tcaaggcgga
      121 caaagagaag gggttccggg tggacaaaat tgtggaccag ttacaacagc tgatgcaggt
      181 atatgacttg gctgcccttc gggattattg gagctacctg gaacgcaggc tcttcagccg
      241 cctggaggac atatatcgac ccaccatcaa caaactgaaa accagcctgt tccgctttta
      301 tctagtctac acaatccaga caaaccgaaa tgacaaggca caggagttct ttgcaaagca
      361 ggctacggag ctccagaacc aggctgaatg gaaggattgg ttcgtcctgc ccttcttgcc
      421 gtccccggac accaacccta ccttcgctac ctacttctcc cgacagtggg ctgacacctt
      481 cattatttcc ctgcacaact tcctgagtgt cctcttccag tgcatgccgg tgcctgtgat
      541 cctgaacttt gatgcggagt gccagaggac caaccaggtc caggaagaaa atgaggttct
      601 gcgtcagaag ctctttgcac tgcaagccga ggtccatcgt ctgaagaagg aagaacagca
      661 gcaggaagaa gcagcagctt tggtccagca caagctgccc ccttatgtct ccagtatgga
      721 ccgccttggg gactcggagc tagcattggt gtgcagccag aggcctgcct ccctctccca
      781 gtctcctcga gtggggttcc tgtcctcact gctgcctcag agcaaaaaga gcccttcaag
      841 gttgtcacct gcccaaggcc cccctcaggc tcagagttca gccaagaaag ataccttcag
      901 cagtcaggct accaagggaa aggatccagt gcctggggcc aaggatggga agagccttct
      961 gagtgggcca gtccctgggg aagcaagctg gacacatcag cgacaacggc gtctgcagga
     1021 ccatggcaag gagaggaggg agctgctctc tacatcctcc tcccagacgc agtgtgcaga
     1081 gaagaagcta gaaggcagcg gcccagaggc tgagctctgc ctggacctcc acatggggcc
     1141 agtggaggct ctggctcggg tgtccacagc aggttccgag ggagaccgcc cggaacagcc
     1201 cttcatagtg ctgagccaag aagaatatgg ggagcaccat tcatccatca tgcactgcag
     1261 agtggactgc tctggtagga gagtggccag cttagacgta gatggggtca tcaaggtgtg
     1321 gtccttcaat cccatcatgc agaccaaggc gtcctccatc tctaagtcac cactgctctc
     1381 cctggagtgg gccaccaagc gagacaggct gctcctgctg ggcagtggtg tggggacggt
     1441 gcgtctttat gatacggaag ccaagaagaa cctctgtgaa atcaacatca acgatgacat
     1501 gcctagaatc ctgtctcttg cctgcagccc caatggggcc tctttcgtct gttcagccgc
     1561 agctccgagc cttacctccc agccagattc ctcagccccg gatatcggca gcaaaggcat
     1621 gaaccaggtt cctggcaagc tgctgctgtg ggatacgaaa accatgaagc agcagcttca
     1681 gttctcgctg gacccagagc ccattgccat caactgcaca gctttcaacc ataatgggaa
     1741 cctgctggtc acaggggcag ctgatggagt catccggctc tttgacatgc agcagcatgg
     1801 atgtgctatg agctggaagg cccactgtgg ggaggtctac tctgtggaat tcagctatga
     1861 tgagaatgcc gtgaacagca tcggcgagga cggcaagttc atccagtgga acatccacaa
     1921 gagtggtctc aaggtgtcgg agtacagcct cccttcagat gccactggcc cctttgtcct
     1981 gtctggctac agtggctaca agcaggtcca agttcccagg gggcggctgt ttgcttttga
     2041 ctcagagggc aattacatgc tgacgtgctc tgccacaggg ggcctcatct acaagctggg
     2101 cagtgaagag aaagttctag aaaactgtct gagcctgggt ggccaccgtg cccctgtggt
     2161 caccgtggac tggagcactg caatggactg tgggacgtgc ctcactgcct ccatggatgg
     2221 caagatcaag ctcactaccc tcctagcaca taagctctga tttccggcct ggagtgacac
     2281 actggaaaca gaattgtctc tggcagaaga gagatgagac gggggacaag acagggctct
     2341 ggttcaagcc agggctgcgg atcttcagga aagaccaccg agggggctcg gtcatccaaa
     2401 cgcagctcct ggagcaggag tctgtgcaga gtgcgctcca gagcacagga cagacgctga
     2461 ggaaggagcc acactggtgc accgtgctca gtccaagagg ctttgactgt attttgtaca
     2521 taattgctta cttttctctt tttaagggaa gaaaatcgga gcgtgataat gctcttactg
     2581 tcaaaa
//
