LOCUS       NM_001047847            1168 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus WD repeat domain 83 (Wdr83), mRNA.
ACCESSION   NM_001047847 XM_001065349 XM_213850
VERSION     NM_001047847.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1168)
  AUTHORS   Bondeva,T., Schindler,C., Schindler,K. and Wolf,G.
  TITLE     MORG1+/- mice are protected from histological renal damage and
            inflammation in a murine model of endotoxemia
  JOURNAL   BMC Nephrol 19 (1), 29 (2018)
   PUBMED   29402223
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1168)
  AUTHORS   Loeffler,I. and Wolf,G.
  TITLE     Morg1 heterozygous deficiency ameliorates hypoxia-induced acute
            renal injury
  JOURNAL   Am J Physiol Renal Physiol 308 (6), F511-F521 (2015)
   PUBMED   25550320
REFERENCE   3  (bases 1 to 1168)
  AUTHORS   Bondeva,T., Heinzig,J., Ruhe,C. and Wolf,G.
  TITLE     Advanced glycated end-products affect HIF-transcriptional activity
            in renal cells
  JOURNAL   Mol Endocrinol 27 (11), 1918-1933 (2013)
   PUBMED   24030251
REFERENCE   4  (bases 1 to 1168)
  AUTHORS   Hopfer,U., Hopfer,H., Jablonski,K., Stahl,R.A. and Wolf,G.
  TITLE     The novel WD-repeat protein Morg1 acts as a molecular scaffold for
            hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)
  JOURNAL   J Biol Chem 281 (13), 8645-8655 (2006)
   PUBMED   16407229
REFERENCE   5  (bases 1 to 1168)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY940050.1.
            
            On or before Sep 8, 2006 this sequence version replaced
            XM_213850.4, XM_001065349.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY940050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1168
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /note="WD repeat domain 83"
                     /db_xref="GeneID:288924"
                     /db_xref="RGD:1306947"
     exon            1..172
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1017
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /note="WD repeat protein Morg1; mitogen-activated protein
                     kinase organizer 1; MAPK organizer 1"
                     /codon_start=1
                     /product="WD repeat domain-containing protein 83"
                     /protein_id="NP_001041312.1"
                     /db_xref="GeneID:288924"
                     /db_xref="RGD:1306947"
                     /translation="MAFPEPKPRAPELPRKQLKTLDCGQGAVRAVRFNVDGNYCLTCG
                     SDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSHLCSGGGDKTVVLWDVATGQVV
                     RKFRGHAGKVNTVQFNEEATVILSGSIDSSVRCWDCRSRKPEPVQTLDEARDGISSVK
                     VSDHEILAGSVDGRVRRYDLRMGQVTSDYVGSPITCTCFSRDGQCTLISSLDSTLRLL
                     DKDTGELLGEYVGHKNQKYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGSLALALPVG
                     SNVVQSLAYHPADPCLLTAMGGSIQYWREETYEAEGGAG"
     exon            173..293
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
     exon            294..399
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
     exon            400..448
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
     exon            449..575
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
     exon            576..643
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
     exon            644..752
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
     exon            753..867
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1168
                     /gene="Wdr83"
                     /gene_synonym="Morg1; RGD1306947"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcttggaa ggaaggcggt ctctatacaa acagcagtaa agcgggaagc ggactaataa
       61 acttaaagta tggcttttcc tgagccaaag ccgcgggcac cggagctgcc gcggaaacaa
      121 ttgaagacac tggactgcgg acagggcgcg gtgcgagccg tgcgatttaa tgtggatggc
      181 aactactgcc tgacgtgcgg cagcgataaa accctaaagc tgtggaaccc gctgcgtggg
      241 acgctgctgc ggacgtacag tggccacggc tacgaagtgc tcgatgcggc cggctccttt
      301 gacaacagcc atctctgttc tggtggcggg gacaagacgg tggttctgtg ggatgtagca
      361 acagggcagg tcgtgcgcaa atttcggggc cacgctggaa aggtgaacac cgttcagttt
      421 aatgaagaag ccacagtcat cctctctggt tctatcgatt ccagtgtcag atgttgggac
      481 tgccgatcca ggaagcctga gccagtgcag acactagatg aagccaggga cggcatatcc
      541 agtgtaaagg tgtcagatca tgagatcttg gcaggctctg tggatggccg tgtaaggcgc
      601 tatgacctaa ggatgggaca agtcacctcg gactatgtgg gcagccccat cacctgcacc
      661 tgcttcagcc gggatgggca gtgcactctg atatccagcc tggactctac tctgaggctt
      721 ctagataaag acacagggga gctgctgggc gagtatgtgg gccataaaaa ccagaagtac
      781 aagctggact gctgcctgag tgagcgcgat acacacgtgg tcagctgctc tgaggacggc
      841 aaagtgttct tctgggacct ggtagagggt tccctagcac tggccctacc tgtgggttct
      901 aatgtggtac agtcactggc ttaccatccc gcagacccct gcctattgac tgccatggga
      961 ggcagcatcc agtactggcg agaagagacc tacgaggcag agggtggagc aggctgaact
     1021 tatggacctg acaccaagga cccagaccaa ttcagaaacc caacaaaaag gccatttatt
     1081 ctcaagatgc tgctgaccaa ggagagggcc cagggagggg ctggtatgca aataataaat
     1141 aaaggtgtgg cagaagcctc cgtcttta
//
