LOCUS       NM_001134360            6830 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus WD repeat domain 81 (Wdr81), mRNA.
ACCESSION   NM_001134360 XM_001080687 XM_220710
VERSION     NM_001134360.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6830)
  AUTHORS   Liu,X., Li,Y., Wang,X., Xing,R., Liu,K., Gan,Q., Tang,C., Gao,Z.,
            Jian,Y., Luo,S., Guo,W. and Yang,C.
  TITLE     The BEACH-containing protein WDR81 coordinates p62 and LC3C to
            promote aggrephagy
  JOURNAL   J Cell Biol 216 (5), 1301-1320 (2017)
   PUBMED   28404643
REFERENCE   2  (bases 1 to 6830)
  AUTHORS   Rapiteanu,R., Davis,L.J., Williamson,J.C., Timms,R.T., Paul
            Luzio,J. and Lehner,P.J.
  TITLE     A Genetic Screen Identifies a Critical Role for the WDR81-WDR91
            Complex in the Trafficking and Degradation of Tetherin
  JOURNAL   Traffic 17 (8), 940-958 (2016)
   PUBMED   27126989
REFERENCE   3  (bases 1 to 6830)
  AUTHORS   Liu,K., Jian,Y., Sun,X., Yang,C., Gao,Z., Zhang,Z., Liu,X., Li,Y.,
            Xu,J., Jing,Y., Mitani,S., He,S. and Yang,C.
  TITLE     Negative regulation of phosphatidylinositol 3-phosphate levels in
            early-to-late endosome conversion
  JOURNAL   J Cell Biol 212 (2), 181-198 (2016)
   PUBMED   26783301
  REMARK    Erratum:[J Cell Biol. 2016 Mar 14;212(6):739. doi:
            10.1083/jcb.20150608103012016c.. PMID: 26975852]
REFERENCE   4  (bases 1 to 6830)
  AUTHORS   Traka,M., Millen,K.J., Collins,D., Elbaz,B., Kidd,G.J., Gomez,C.M.
            and Popko,B.
  TITLE     WDR81 is necessary for purkinje and photoreceptor cell survival
  JOURNAL   J Neurosci 33 (16), 6834-6844 (2013)
   PUBMED   23595742
REFERENCE   5  (bases 1 to 6830)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   6  (bases 1 to 6830)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Aug 26, 2008 this sequence version replaced
            XM_001080687.1, XM_220710.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..6830
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /note="WD repeat domain 81"
                     /db_xref="GeneID:303312"
                     /db_xref="RGD:1311334"
     exon            1..3853
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..6012
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /codon_start=1
                     /product="WD repeat-containing protein 81"
                     /protein_id="NP_001127832.1"
                     /db_xref="GeneID:303312"
                     /db_xref="RGD:1311334"
                     /translation="MAQGSRRRKVVLTAGAEGCSSSSGPDMEELLRCAERDLNIDARQ
                     LALAPGGTHVVALVSTRWLASLRERRLGPCPRAEGLGEAEVRTLLQRSVQRLPQGWTR
                     VEVHGLRKRRLSYPLSRVLPFEEGSCSPETLTRFMQEVAAQNYRNLWRHAYHTYGQPY
                     SHSTAPSAIPALDSIRQALQRVYGCTFLPVGESMQCLSNVRDGPSRGSSACPSLLRAE
                     ALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRAMDACHRQGLA
                     CGALSLHHIAVDEKLCSELRLDLSAYEMPSEDENQEVSEEKDRTGVKSEKDGEGRPGC
                     PTCQKELRGLVLDWVHGRVSNFYYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPYGRF
                     RDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPLHVPHHISDVLSDITYYVYK
                     ARRTPRSVLCGHVRAQWEPHEYPATMERMQTWTPDECIPEFYTDPSIFCSIHPDMPDL
                     DVPAWCSSNQEFVTAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVD
                     AHTHLTSYGVVQLFDQPHPQRLAGAPALAPEPPLIPRLLVQPIQEATGQEDISGQLIN
                     GAGRHVVEVTPCESGWTRERPTAGEDDLEQATEALDSISIPGKAGDQPGSSSSQASPG
                     LLPFSAPSGSRPGRRSKATGLDSGEGDEGKIVLPEGFSPIQALEELEKVGNFLARGLG
                     SQLEEPEKPQAQPPVYLQSLFHRDMQVLGVLLAEMVFATRVRILQPDAPLWVRFEAVR
                     GLCTRHSKDIPVSLQPVLDTLLQLSGPKSPLVVKKGKLDPLFEYRPVSQGLPPPSPAQ
                     LLSPFSSVVPFPTYFPALHKFILLYQARRVEDEVQGRELVFALWQQLGAVLNEITPEG
                     LEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNTIKYLLKPLIGAYENPCRLHG
                     RFYLYTDCFVAQLVVRLGLQAFLIHLLPHVLQVLAGVEASQEEGKGLVGTTEDEENEL
                     PVPGPGSCAFGEEIQMGGQPAASSGLGLPDYRSGVSFHDQADLPDTEDFQAGLYVAES
                     PQPQEAEAVSLGQLSDKSSTSEASQGEERGGDDGGAPVDKNSVKSGDSSQDLKQSEGS
                     EEEEEEEEGCVVLEEEEQDEVTGTSELTLSDTILSMETVVAPGDGRDREEEEEPLPEQ
                     TEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSCD
                     DSPPLNAGNIYQKRPVLGDIVSGPVLSCLLHIAHLYGEPVLTYQYLPYISYLVAPGSN
                     SSPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVLLPVLSFLTSFVTG
                     FPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSHLHELRQQDLQ
                     LDLKGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVPFSCLLGDIIRK
                     IIPNHELVGELAGLYLESMSPSSLRNPASMEPVTPSAGPEWNPQSGSCLQDDGHSGTF
                     GSVLVGNRIQIPDSQPQSSGPLGSISGVGSGGLSSRNEDNALKRELPRSAHGLSGNWL
                     AYWQYEIGVSQQDAHFHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSKDRTVRLWP
                     LYNYGDGTSETAPRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTVD
                     PSDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRSL
                     AVSPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVIVSSSSDHS
                     LTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVANKIGVCSLLEPPSQATTKLS
                     SENFRGTLTSLALLPTKRHLLLGSDNGIIRLLA"
     exon            3854..3961
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     exon            3962..4152
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4343
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     exon            4344..4509
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     exon            4510..4675
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     exon            4676..5365
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     exon            5366..5511
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     exon            5512..5691
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
     exon            5692..6830
                     /gene="Wdr81"
                     /gene_synonym="RGD1311334"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctactgc gcccgggagc gcaggaccct gcggaggggt aagaacaccc ccaggtcttt
       61 tctcttttgt cgctggttcg cccagtcacc tgcactccac cccccgcttc tcgcccatct
      121 cagtcttccc ggcctggcac cccggaagcc actgcgagga gggccgtggc caggctcagc
      181 cttgcgctgc ccccaggcgg ccaggaccaa atggcccagg ggagcagaag gcggaaagtg
      241 gttcttacag caggggccga gggctgctcc tcctcctcag gacctgacat ggaggagctg
      301 ctccggtgcg cggagagaga tctgaacatc gatgcccggc agctggccct ggcgccgggg
      361 ggcacccacg tggtggccct agtgtccacg cgttggttag ctagtctccg ggagcgccgg
      421 ctgggaccct gtccccgggc tgagggcctg ggtgaagcgg aagtcaggac tctactgcaa
      481 cgttcggtac agaggctacc ccagggctgg acgcgagtgg aggtgcacgg gctgcggaaa
      541 cggagactgt cctacccgct gagcagagtc ttgccctttg aggaggggtc ctgtagccct
      601 gagactctca ctcgtttcat gcaggaggtg gctgcccaga attaccggaa cctgtggcgc
      661 catgcatatc acacttatgg gcagccctat agccacagca ctgccccctc agctatacct
      721 gccctagact ctatcagaca agctctacag agggtctatg gatgcacctt cctgccagtg
      781 ggtgaatcca tgcaatgtct atcaaatgtc agggatgggc cctctcgggg cagctctgcc
      841 tgccccagcc ttttgcgagc tgaggccctg ctggagtcac ccgagatgct ctatgtggta
      901 cacccttatg tgcagttctc cctgcatgat gtagttacct tcagccctgc caaactgacc
      961 aacagtcaag ccaaggtgct tttcattctc ttccgtgttc tgagggccat ggatgcctgt
     1021 caccgccagg gtctggcctg tggggccctg tctttgcacc acatcgctgt agacgagaag
     1081 ctttgcagcg agctccggct ggacctgagt gcttatgaga tgccttctga ggatgagaat
     1141 caggaggtct ctgaagagaa agacaggaca ggtgttaagt ctgaaaaaga cggggaaggg
     1201 agacctgggt gtcccacctg ccagaaagaa cttaggggcc ttgtgctaga ctgggtccat
     1261 ggccgcgtca gcaacttcta ctacctcatg cagctgaatc ggttggcagg tcgacggcag
     1321 ggggatccca actatcaccc agtgctgccc tgggtggtgg attttaccac gccttacggg
     1381 cgcttccgag accttcgtaa atccaagttc cgactcaaca agggagataa gcaattggac
     1441 ttcacctatg agatgacacg gcaggcattt gtagccggtg gtgcgggaag tggggagcca
     1501 cttcatgttc ctcaccacat ctccgatgtg ctctctgaca tcacatacta tgtatacaag
     1561 gcccgtcgca caccccgatc ggtgctctgt ggacatgtcc gggcacagtg ggagccccac
     1621 gagtatcctg ccaccatgga gcggatgcag acctggacac cagatgagtg catacccgaa
     1681 ttctacacgg atccctctat cttttgctcc atccaccctg acatgcctga cctggacgtg
     1741 ccagcctggt gcagttctaa ccaggaattt gtgactgccc atagagcact gctggagagc
     1801 tgggaggtgt cccaagacct gcatcattgg attgacctta cttttggcta caaactccag
     1861 ggcaaagaag ctgtgaagga gaagaatgtg tgtctgcacc tggtggatgc tcacacccat
     1921 ctgaccagct atggcgtggt acagctgttt gatcagccac acccccaacg cctggctggg
     1981 gctcctgccc tggcccctga acctccactc ataccccggc tgttggtcca gcctattcag
     2041 gaggccacgg gccaggagga catctcagga caacttatta atggtgcggg caggcatgtt
     2101 gtagaggtca ctccatgtga gagtggctgg actagagaga ggcccacggc aggggaagat
     2161 gacttagaac aggctacaga agctctggat tccatttcca tccctgggaa agcaggtgac
     2221 cagccaggct cttcctccag tcaggcctca cctggtctgt tgcctttttc tgcaccctca
     2281 ggctctcggc caggccgcag gagcaaagct accgggttgg actccgggga gggcgacgag
     2341 ggcaagattg ttcttccaga aggcttcagt cccatacagg ccttggaaga gctagagaaa
     2401 gtgggtaact tcctggccag aggcctaggg agccagttgg aggaacccga gaagcctcaa
     2461 gcccagccac ctgtgtacct gcagagtctc ttccatcgag acatgcaggt gctgggtgtc
     2521 ctgttggctg agatggtgtt tgccaccagg gtccggatac tgcagcccga tgcacctttg
     2581 tgggtacgct ttgaggctgt taggggcctc tgcacacgcc actccaagga catccccgtg
     2641 tctctgcagc ctgtgctgga cacactccta cagctgagtg gacccaaaag tcccttagtg
     2701 gtgaagaagg gcaagctaga cccactgttt gagtacaggc ctgtttccca aggattgccc
     2761 ccacccagcc cagctcagct cctcagtccc ttcagctctg tggtcccctt ccctacctac
     2821 ttcccagcgc tgcacaagtt cattctttta tatcaggccc ggcgtgtgga ggatgaggtc
     2881 cagggacggg agctggtgtt tgctctatgg cagcagctgg gtgccgtgtt aaacgaaatc
     2941 actcccgagg gcttggagat cctcctgcct tttgtgctgt cactcatgtc agaggagcac
     3001 acggctgtgt acacagcctg gtacctattt gaacctgttg ccaaggccct gggccccaaa
     3061 aataccatta agtacctcct gaagcctctc attggtgcct atgagaaccc ctgccgcctg
     3121 catggccgct tctacctgta cactgactgt tttgtagccc agttggtggt gcggttgggc
     3181 ttgcaggcct tccttatcca cctgctgccc cacgtcctac aggtactggc tggggtggag
     3241 gcctcccaag aggagggcaa aggcctggtt gggaccactg aggatgagga aaacgagctc
     3301 ccagtgcctg ggcctggctc ctgtgccttt ggggaggaga ttcaaatggg tggacagccg
     3361 gctgcttcct caggactggg gctcccagac tacaggtcag gcgtcagctt ccatgaccag
     3421 gctgacctgc cagacaccga ggacttccaa gctggactct atgtggccga gtctccacag
     3481 ccccaggagg ctgaggccgt gagcctgggc cagctgagcg acaagagcag cactagtgaa
     3541 gcctcacagg gcgaggagag gggtggggat gatgggggtg cccctgtgga caagaacagc
     3601 gtgaagtcag gggacagcag ccaggacttg aagcaaagtg aaggctctga ggaagaggag
     3661 gaggaggagg aaggctgtgt ggtgttggag gaggaggagc aggatgaagt cacaggaaca
     3721 tctgagctca ctctgtctga cacaatactg tccatggaga cggttgtggc tcccggcgat
     3781 gggagagaca gagaagagga agaggagccc ctgccagagc agacagaggg caaagagcag
     3841 aagatcctcc ttgatacagc ctgcaagatg gtccgctggc tgtccgccaa gcttggcccc
     3901 actgtagcct ctcgccacgt ggcccggaac ctgttgcgcc tgctgacatc ttgttatgtt
     3961 gggcccacta ggcagcagtt cacagtcagc tgtgatgaca gccccccact gaacgccggc
     4021 aacatctacc agaagaggcc agtactaggt gacatcgtgt ccgggcctgt gctcagctgt
     4081 cttctccata ttgcccacct atatggagaa cccgttctca cctaccagta cctgccctac
     4141 atcagctacc tggtagcccc ggggagcaac tcaagcccca gccgactgaa cagccgcaag
     4201 gaggccgggc tgctggctgc ggtgacactg actcagaaaa tcatcgtata cctctccgac
     4261 actaccctca tggacattct gccccgcatt agccacgagg tcttgctgcc tgtgctcagc
     4321 ttcctcacct cctttgttac agggttccca agcggggccc aggcccggac tgtcctgtgt
     4381 gtgaagacca ttagtctaat tgccctcatc tgcctgcgca tcggacagga gatggtccag
     4441 cagcacctca gtgagccggt ggccaccttc tttcaagtct tctctcatct gcatgagctt
     4501 cggcagcagg atctgcagct ggatctcaag ggctgtactg agggccaact gccagaggca
     4561 accttctctg atgggcagcg acggccagtg gaccccaccc tgctggagga gctgcagaag
     4621 gtgttcaccc tggaaatggc gtacacaatc tacgtacctt tctcctgcct gttgggtgac
     4681 atcatccgga aaattatccc caaccacgag ttggtcgggg agctggcagg gctatatctg
     4741 gagagcatga gcccgagctc tcttcgaaac ccagccagca tggaacccgt cacgcctagt
     4801 gctggccctg aatggaaccc tcagagtggg agctgtctcc aggatgatgg ccactcgggg
     4861 acctttggga gtgtcctggt tggaaatcgc atccagatcc ccgactctca gccccagagt
     4921 tccgggccac tgggctccat ctctggagtg ggtagtggag gcctcagcag caggaatgaa
     4981 gacaatgctc tgaagcggga gctgccccgg agtgcccacg gcctgagcgg gaactggcta
     5041 gcatactggc aatacgagat cggtgtgagc cagcaggatg cccacttcca cttccaccag
     5101 atccgcctgc agagctttcc aggccacacc ggggctgtca agtgtgtggc cgccctgagc
     5161 agtgaagact tctttctgag tggcagcaag gaccgtacgg tgcgtctttg gccactgtac
     5221 aactatgggg atgggaccag tgagacggct ccccgtctca tctacgccca gcaccgcaaa
     5281 agtgtcttct acgtgggcca gcttgaggcc ccgcagtatg tggtgagctg tgatggggca
     5341 gtgcacgtct gggacccctt cacagggaag acccttcgca cagtggatcc ttcagacagc
     5401 cgggtgcccc tgactgctgt agctgtcatg cctgcccccc acaccagcat caccatggcc
     5461 agctctgact ccaccctgcg ctttgtggat tgcaggaagc ctggcttgca gcatgagttc
     5521 cgactgggtg gagggctgaa ccctgggctt gttcgctcct tggctgtcag ccccagtggc
     5581 cggagtgttg tggctggctt ctcctctggc ttcatggtgc ttctagatac ccgcacgggc
     5641 ctggttctcc gaggctggcc ggcccatgaa ggggacattc tacagatcaa ggctgtagag
     5701 ggcagtgtga tagtcagctc ctcttccgac cattccttga ctgtttggaa ggagctggag
     5761 cagaagccca cgcaccacta caagtcagca tcggacccaa tccacacctt cgacctgtac
     5821 ggcagcgagg tggtcactgg cactgtggcc aacaagattg gtgtctgttc cctgcttgaa
     5881 ccaccctctc aggccaccac aaagctcagt tccgagaact tccgtggtac actcaccagt
     5941 ctggctttgc tgcccacgaa acgccacctc ctgctgggct ctgacaatgg catcatccgc
     6001 ctcctggcat aggtcctggc aggagttggc tgacggcagt gtgagatgac acctctcagg
     6061 tccaactcct catcctccat ctctcagcca gttctcagcg gagcccaggc tttgggtacc
     6121 cacatggcct gctgtctggg attgcacagc ttctcaatct ccaaagccgg ggaagtgact
     6181 tcattcgtga aactcgggag atgctgttcg taaccagcca gaagggggac aaggaaagca
     6241 ctgtgatccc cattgctccc cagctctgcc ttctggactc acatggggac agggaagctc
     6301 caggaaatga aaggagatgg gcgtttgctc agccagcttc ttctagccag gttctcctta
     6361 gctctgtctc ccaagggtag gaaaccgctc ctacctaagg ttctgatggg actgggagtc
     6421 cagcctcagg agggcttgcc atgacccaga agtctcaggg cttggtctgg ggttttatta
     6481 tccattcagc caggtcttcc cactgtggga ccagaaaaca ggggaaagga ggggacggcc
     6541 agggttattt gggcccagct ggtccaggaa tgaatccatg ccttgccttg gtacccctaa
     6601 ccacagcgtt tgtgccttca gccggggagg cagcccttgg gaccagcacc cctagggaga
     6661 ggaggcagca ggaatcatgt ttgcatctcg ggccctccca ggggatgggc agaccctggc
     6721 atctcttgag tccccatttg aagaagagaa gtctgagatg ccgctcttgc tgcctcctca
     6781 ctgtttgcaa tctgtgtaaa taaggtcaat aaattctttg gaagagccat
//
