LOCUS       NM_001008771            2047 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus WD repeat domain 77 (Wdr77), mRNA.
ACCESSION   NM_001008771 XM_227562
VERSION     NM_001008771.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2047)
  AUTHORS   Takai,H., Masuda,K., Sato,T., Sakaguchi,Y., Suzuki,T., Suzuki,T.,
            Koyama-Nasu,R., Nasu-Nishimura,Y., Katou,Y., Ogawa,H.,
            Morishita,Y., Kozuka-Hata,H., Oyama,M., Todo,T., Ino,Y., Mukasa,A.,
            Saito,N., Toyoshima,C., Shirahige,K. and Akiyama,T.
  TITLE     5-Hydroxymethylcytosine plays a critical role in
            glioblastomagenesis by recruiting the CHTOP-methylosome complex
  JOURNAL   Cell Rep 9 (1), 48-60 (2014)
   PUBMED   25284789
REFERENCE   2  (bases 1 to 2047)
  AUTHORS   Guderian,G., Peter,C., Wiesner,J., Sickmann,A., Schulze-Osthoff,K.,
            Fischer,U. and Grimmler,M.
  TITLE     RioK1, a new interactor of protein arginine methyltransferase 5
            (PRMT5), competes with pICln for binding and modulates PRMT5
            complex composition and substrate specificity
  JOURNAL   J Biol Chem 286 (3), 1976-1986 (2011)
   PUBMED   21081503
REFERENCE   3  (bases 1 to 2047)
  AUTHORS   Vascotto,C., Fantini,D., Romanello,M., Cesaratto,L., Deganuto,M.,
            Leonardi,A., Radicella,J.P., Kelley,M.R., D'Ambrosio,C.,
            Scaloni,A., Quadrifoglio,F. and Tell,G.
  TITLE     APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in
            the rRNA quality control process
  JOURNAL   Mol Cell Biol 29 (7), 1834-1854 (2009)
   PUBMED   19188445
REFERENCE   4  (bases 1 to 2047)
  AUTHORS   Chari,A., Golas,M.M., Klingenhager,M., Neuenkirchen,N., Sander,B.,
            Englbrecht,C., Sickmann,A., Stark,H. and Fischer,U.
  TITLE     An assembly chaperone collaborates with the SMN complex to generate
            spliceosomal SnRNPs
  JOURNAL   Cell 135 (3), 497-509 (2008)
   PUBMED   18984161
REFERENCE   5  (bases 1 to 2047)
  AUTHORS   Peng,Y., Chen,F., Melamed,J., Chiriboga,L., Wei,J., Kong,X.,
            McLeod,M., Li,Y., Li,C.X., Feng,A., Garabedian,M.J., Wang,Z.,
            Roeder,R.G. and Lee,P.
  TITLE     Distinct nuclear and cytoplasmic functions of androgen receptor
            cofactor p44 and association with androgen-independent prostate
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 105 (13), 5236-5241 (2008)
   PUBMED   18356297
REFERENCE   6  (bases 1 to 2047)
  AUTHORS   Zhou,L., Wu,H., Lee,P. and Wang,Z.
  TITLE     Roles of the androgen receptor cofactor p44 in the growth of
            prostate epithelial cells
  JOURNAL   J Mol Endocrinol 37 (2), 283-300 (2006)
   PUBMED   17032745
REFERENCE   7  (bases 1 to 2047)
  AUTHORS   Hosohata,K., Li,P., Hosohata,Y., Qin,J., Roeder,R.G. and Wang,Z.
  TITLE     Purification and identification of a novel complex which is
            involved in androgen receptor-dependent transcription
  JOURNAL   Mol Cell Biol 23 (19), 7019-7029 (2003)
   PUBMED   12972618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB581439.1, BC097367.1 and CK842118.1.
            
            On Mar 30, 2010 this sequence version replaced NM_001008771.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213175.1, FQ226328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                CB581439.1         13-61
            50-1823             BC097367.1         1-1774
            1824-2047           CK842118.1         1-224               c
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2047
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /note="WD repeat domain 77"
                     /db_xref="GeneID:310769"
                     /db_xref="RGD:1310479"
     exon            1..211
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1125
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /note="methylosome protein 50; WD repeat-containing
                     protein 77; methylosome protein 50-like"
                     /codon_start=1
                     /product="methylosome protein WDR77"
                     /protein_id="NP_001008771.2"
                     /db_xref="GeneID:310769"
                     /db_xref="RGD:1310479"
                     /translation="MRKESPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGSLLL
                     GASSLSGRCWAGSLWFFKDPSAAPNEGFCSAGVQTEAGVADLTWVGDKGILVASDSGA
                     VELWELDENETLIVSKFCKYEHDDIVSTVTVLSSGTQAVSGSKDFCIKIWDLAQQMSL
                     NSYRAHAGQVTCVAASPHRETVFLSCSEDSRILLWDTRCPKPASQMGCNASGYLPTSL
                     AWHPQQSEIFVFGDENGSVSLVDTKNASCTLSSAVHSQCVTRLVFSPHSVPFLASLSE
                     DCSLAVLDSSFSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVIHHVVPLEPLPA
                     PGPDSVVE"
     exon            212..397
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     exon            398..539
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     exon            540..589
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     exon            590..660
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     exon            661..715
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     exon            716..787
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     exon            788..896
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     exon            897..965
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
     exon            966..2032
                     /gene="Wdr77"
                     /gene_synonym="Ac2-269; MEP-50; RGD1310479"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcggatg cgcagaggtg caccacgtgt ggtgttcctc cagcgcagtc aggatctcgt
       61 ctagtttggg tctaggttag atttggaatc gtggagatgc ggaaggaaag cccacctccg
      121 ctcgtgcccc cggcggcccg cgagtggaac ctgcccccca atgcgcccgc ctgcatggaa
      181 cggcagttgg aagctgcacg gtaccgctct gatggttccc ttctgctcgg ggcttccagt
      241 ctgagtggtc gctgctgggc aggatctctg tggtttttca aggatcctag tgcggccccc
      301 aacgaaggtt tctgctctgc tggcgtccag acggaggctg gagtagctga cctcacttgg
      361 gttggggaca aaggtatctt agtggcttct gattcaggtg ctgttgaatt gtgggagcta
      421 gatgagaacg agacacttat tgtcagcaag ttctgcaagt atgagcatga tgacattgtg
      481 tctactgtca ctgtcctgag ctccggcaca caggctgtca gtggtagcaa agacttctgc
      541 atcaaaattt gggacctggc tcagcagatg tcgctgaatt cataccgagc tcatgcggga
      601 caggtcacct gtgttgctgc ctctccccac agagaaactg tgtttctttc atgcagtgag
      661 gacagtagaa ttttgctctg ggatacccgc tgtcccaagc cggcatcaca gatgggctgc
      721 aatgcctctg gctacctccc tacctccctg gcttggcatc ctcagcagag tgaaatcttt
      781 gtctttggtg atgagaatgg atctgtctcc cttgtggaca ccaagaatgc aagctgcacc
      841 ctcagctcag ctgtgcactc gcagtgtgtc actagactgg tgttctctcc acacagtgtt
      901 cccttcctgg cctctctcag tgaagactgt tcacttgctg tgctggattc aagcttttct
      961 gaggtgttta gaagtcgagc ccacagagac tttgtgagag atgctacatg gtctccactc
     1021 aatcactccc ttcttaccac agttggctgg gaccatcagg tcatccacca tgttgtgccg
     1081 ttagagcctc tcccagcccc tggacctgac agtgttgtgg agtagaatgg attgcagaag
     1141 aaaagagcct tctgtctgca agtgtcgact cgcttgcccc tgccttccat ttgtgagaga
     1201 gagagcacag gagccttgta gagcatgatt actccctagt cccgtgcagt aactagtcag
     1261 attctcagcc tgagggaggc tgcatcccat agtgacttgg aggaaaaagc ttcctttata
     1321 aatggatgta tgtgtgagta cacgtgtgag tgcagtgtat agtttggagt ggagaaaatt
     1381 atccttcagc tttcccaaag caatgctctt tacccccgac aaaatgacca gaggatttta
     1441 tgcttcccat gtctgggggc tgactatgtt gttagggata tggagtgtgg gtatccctgg
     1501 atgcttggga atacttcaca ttactcagag gtgcgtaact tatttttata tagagtttaa
     1561 ttcactatat gggaattact tcccatatac aaaagtctag ccagactacc ttgagaagac
     1621 agaacagttt tgtacgaatg cctgttaaat ggaatcaaat ccactttctg ggtgaatcaa
     1681 tttggccctt ggagttcgcg ctcgctcacc ctgtgttcct tcttttgtgt tgtgtatgag
     1741 agatgagtgc tttcctgtcc tagatttcac agttttaggg atgatggagt acttaaatta
     1801 aaagtgtttc agtgaagcga gaagattgac atggattgtt acagagaaat ctgtcattgt
     1861 catttttccc acctaaaaat tccctgagga ctgatctggg tactttgctc tggagagctg
     1921 aagtctgagc gctgtatatt tggactccta agattgaaga tccggcatca gagaaactgt
     1981 caaaaatact ggaaggtgaa ataaagactt atcctttcat ctttcctcca aaaaaaaaaa
     2041 aaaaaaa
//
