LOCUS       NM_001401300            1222 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus WD repeat domain 74 (Wdr74), mRNA.
ACCESSION   NM_001401300 XM_006230999
VERSION     NM_001401300.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1222)
  AUTHORS   Hiraishi,N., Ishida,Y.I., Sudo,H. and Nagahama,M.
  TITLE     WDR74 participates in an early cleavage of the pre-rRNA processing
            pathway in cooperation with the nucleolar AAA-ATPase NVL2
  JOURNAL   Biochem Biophys Res Commun 495 (1), 116-123 (2018)
   PUBMED   29107693
REFERENCE   2  (bases 1 to 1222)
  AUTHORS   Lo,Y.H., Romes,E.M., Pillon,M.C., Sobhany,M. and Stanley,R.E.
  TITLE     Structural Analysis Reveals Features of Ribosome Assembly Factor
            Nsa1/WDR74 Important for Localization and Interaction with
            Rix7/NVL2
  JOURNAL   Structure 25 (5), 762-772 (2017)
   PUBMED   28416111
REFERENCE   3  (bases 1 to 1222)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1222)
  AUTHORS   Hiraishi,N., Ishida,Y. and Nagahama,M.
  TITLE     AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the
            nucleolar protein WDR74
  JOURNAL   Biochem Biophys Res Commun 467 (3), 534-540 (2015)
   PUBMED   26456651
REFERENCE   5  (bases 1 to 1222)
  AUTHORS   Maserati,M., Walentuk,M., Dai,X., Holston,O., Adams,D. and Mager,J.
  TITLE     Wdr74 is required for blastocyst formation in the mouse
  JOURNAL   PLoS One 6 (7), e22516 (2011)
   PUBMED   21799883
REFERENCE   6  (bases 1 to 1222)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 8, 2022 this sequence version replaced XM_006230999.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158834.1, SRR26643291.4069.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000001.1  215060969-215061052
            85-191              JAXUCZ010000001.1  215061134-215061240
            192-316             JAXUCZ010000001.1  215061323-215061447
            317-392             JAXUCZ010000001.1  215062809-215062884
            393-539             JAXUCZ010000001.1  215063004-215063150
            540-641             JAXUCZ010000001.1  215063291-215063392
            642-742             JAXUCZ010000001.1  215064366-215064466
            743-798             JAXUCZ010000001.1  215064547-215064602
            799-944             JAXUCZ010000001.1  215064873-215065018
            945-1001            JAXUCZ010000001.1  215065150-215065206
            1002-1222           JAXUCZ010000001.1  215065467-215065687
FEATURES             Location/Qualifiers
     source          1..1222
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1222
                     /gene="Wdr74"
                     /note="WD repeat domain 74"
                     /db_xref="GeneID:690229"
                     /db_xref="RGD:1582881"
     exon            1..84
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1178
                     /gene="Wdr74"
                     /codon_start=1
                     /product="WD repeat-containing protein 74"
                     /protein_id="NP_001388229.1"
                     /db_xref="GeneID:690229"
                     /db_xref="RGD:1582881"
                     /translation="MAATSARWNHVWVGTETGILKGVNLQRKLAANFTPSGQPRREEA
                     VNALCWGTGGETQILVGCADRTVRHFNAEEGTFQSQRYCPGGEGTFRGLAQADDGTLI
                     TCVDSGILRVWCENDKEASSDPLLELKVGPGVCRMRQDPTHTHVVATCGKENALKVWD
                     LQGSEEPVFRAKNVRNDWLDLRVPIWDQDIQFLPGSQKLVTCTGYHQVRIYDPASPQR
                     RPVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGL
                     QCHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQ
                     EPNLVPPEDTETDELWASLEAAAKRKLPDLDQKQGALQRRKKKKRPGSTSP"
     exon            85..191
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            192..316
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            317..392
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            393..539
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            540..641
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            642..742
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            743..798
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            799..944
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1001
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1222
                     /gene="Wdr74"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccatagg ctggtctgcg atggccgcta cctcggctcg ctggaaccat gtgtgggtcg
       61 gcactgagac tggaatcctg aaaggggtga accttcagcg gaaacttgcg gcaaatttta
      121 ctccgtccgg acagccacgg cgggaggagg cagtgaatgc tttgtgctgg ggcacaggcg
      181 gcgagaccca gattttggtg ggatgtgcgg acaggaccgt gaggcacttt aatgcggagg
      241 agggtacatt ccagagccag agatactgcc caggcgggga aggcacgttc cgaggtctcg
      301 cccaggccga tgatggcact cttatcacat gtgtggattc tgggatcctc agagtctggt
      361 gtgaaaatga caaggaggcg tcctctgacc cactcttgga actgaaggtg ggtcctgggg
      421 tgtgtaggat gcgccaagat cccacacaca cacatgtggt tgcaacatgt gggaaagaga
      481 atgctttgaa agtatgggac ctacaggggt ctgaggagcc tgtgttcagg gcgaagaatg
      541 tgcggaatga ttggcttgat ctgcgggttc cgatttggga ccaagatata cagttcctcc
      601 ctgggtcaca gaaacttgtc acatgtacag gataccacca ggtcagaatc tatgatccag
      661 cctcccccca gcgccggcca gtcctagagg ccacctatgg agaataccca ctgacagcca
      721 tgaccctgac tcctgagggc aattctgtca tcgtggggaa cactcatggg cagctggcag
      781 aaattgattt tcggcaaggg cgtctactgg gctgtctgaa ggggcttgca ggcagtgtac
      841 gtgggctgca gtgtcatcct tcgaagcccc tgttagcatc ttgtggctta gacagagtcc
      901 tgaggataca caggatccgc aatccacgag ggctagagca taaggtttat ctcaagtctc
      961 aactgaactg ccttctcctg tcaggccggg ataactggga ggatgagccc caagaacctc
     1021 aagagcccaa cctagtgccc ccagaagaca cagagacaga tgaactttgg gcgtctttgg
     1081 aggcagctgc caagcgaaag ctccctgatt tggaccagaa acaaggtgct ctccaaagaa
     1141 ggaagaaaaa gaagcgtcct ggatccacca gtccttgaag ccccttgctc actttgttaa
     1201 taaacagccc aacacatact ga
//
