LOCUS       NM_001107525            1408 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus WD repeat domain 73 (Wdr73), mRNA.
ACCESSION   NM_001107525 XM_001066768 XM_218815
VERSION     NM_001107525.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1408)
  AUTHORS   Colin E, Huynh Cong E, Mollet G, Guichet A, Gribouval O, Arrondel
            C, Boyer O, Daniel L, Gubler MC, Ekinci Z, Tsimaratos M, Chabrol B,
            Boddaert N, Verloes A, Chevrollier A, Gueguen N, Desquiret-Dumas V,
            Ferre M, Procaccio V, Richard L, Funalot B, Moncla A, Bonneau D and
            Antignac C.
  TITLE     Loss-of-function mutations in WDR73 are responsible for
            microcephaly and steroid-resistant nephrotic syndrome:
            Galloway-Mowat syndrome
  JOURNAL   Am J Hum Genet 95 (6), 637-648 (2014)
   PUBMED   25466283
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158658.1.
            
            On Jan 27, 2008 this sequence version replaced NM_001107525.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158658.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1408
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..1408
                     /gene="Wdr73"
                     /note="WD repeat domain 73"
                     /db_xref="GeneID:308751"
                     /db_xref="RGD:1306429"
     exon            1..88
                     /gene="Wdr73"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1163
                     /gene="Wdr73"
                     /codon_start=1
                     /product="WD repeat-containing protein 73"
                     /protein_id="NP_001100995.1"
                     /db_xref="GeneID:308751"
                     /db_xref="RGD:1306429"
                     /translation="MELAEDWLVESLRLYQDFHAFDLSGATRVLEWVGEKGVFVAGYE
                     SLKKNEILHLILPLRLSVKENQGLYPERDFKVRHGGFSDRAVFDLKHVPDTRLLVTSG
                     LPGCYIQVWQIREDNDVIEAVSTIDVQDKEESLWPRVSIFCSAAPGILHGARLSGLRT
                     VDVESRKITYSSDTTDSESLSSLQVLDADTFAFCGTSGRLGLVDTRQKWAPLETVSPR
                     AGSSGERWCAEVRSKGQGPGPCIASLGSDGQLCLLDPRNLRDPVSSAQCPVFKSSPDP
                     ELLRVTWAPGLDNCLAISGFDGTVQIYDVTSWDGKKTQVEALFIHKGHIFLDGNEVES
                     APLVTTHTWHPSKPRTLLSAASDAALHVWDWVDLQAS"
     exon            89..156
                     /gene="Wdr73"
                     /inference="alignment:Splign:2.1.0"
     exon            157..245
                     /gene="Wdr73"
                     /inference="alignment:Splign:2.1.0"
     exon            246..334
                     /gene="Wdr73"
                     /inference="alignment:Splign:2.1.0"
     exon            335..399
                     /gene="Wdr73"
                     /inference="alignment:Splign:2.1.0"
     exon            400..564
                     /gene="Wdr73"
                     /inference="alignment:Splign:2.1.0"
     exon            565..930
                     /gene="Wdr73"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1382
                     /gene="Wdr73"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaagtct ggctggcgga agtgaagcga cggaagccac agttgctatg gagctcgcag
       61 aggactggct cgtggagtct ttgcgcttgt accaagactt ccatgcattt gacctctcag
      121 gagccactcg agttcttgaa tgggttggtg aaaaaggagt ctttgttgct ggttatgaaa
      181 gtttgaaaaa aaatgagatt cttcatttga ttctacctct aagactctct gtaaaggaaa
      241 accagggctt atacccagag agggacttca aagtacgcca cggaggattc tcagacagag
      301 ctgtctttga cctaaagcac gtgccagata ccaggttgct ggtgaccagt gggcttccag
      361 ggtgttacat acaagtgtgg caaattagag aagacaacga tgtcattgaa gctgtcagta
      421 ccattgatgt gcaggacaaa gaggagagtc tctggcctcg ggtctctatc ttctgctctg
      481 cggcgcctgg gatcctccat ggggcgcggc tcagcggcct gaggactgtg gatgtagaat
      541 cccggaagat cacatacagc tcagatacaa ccgacagtga gtccctgagc agccttcaag
      601 tcctagatgc agataccttt gctttctgtg gcacctcagg tcgcctgggg cttgtggaca
      661 cccgccagaa gtgggcgcca ttggagactg tcagcccccg cgctggctct agtggagaga
      721 gatggtgtgc agaagttagg agcaagggcc aaggccctgg gccctgcatt gccagccttg
      781 gctcagatgg gcagctctgt ctccttgacc cccggaatct ccgtgatcct gtgagctcag
      841 cccagtgccc agtgttcaag tccagccctg acccagagct gctgcgggtg acctgggctc
      901 caggcctgga caactgcttg gctatttcag gctttgatgg gacggtgcaa atctatgatg
      961 tcacatcatg ggatggaaag aaaacccagg tggaggctct tttcatccac aaaggccaca
     1021 tcttcctgga tgggaatgag gtcgagtctg ctcctctggt caccacccat acctggcacc
     1081 caagcaaacc cagaactttg ctgtcagcag caagcgatgc cgctctgcat gtgtgggact
     1141 gggttgacct ccaggcctcc tgacagcagc agcttctctc atctgacaag aggagctgcc
     1201 tgagaggctg atgaggactc tgagtgacca caggtctacc acagccattg gcttcaggca
     1261 agctagcctg gccttccgtt gttcttatct gtaaaatgaa ggtgtagtaa ctaccaccta
     1321 gtactgtggg gagcgtcaca agaaaattac ctgagaataa tggcataaat gtctggaagc
     1381 gaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
