LOCUS       NM_001006988            4164 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus WD repeat domain 6 (Wdr6), mRNA.
ACCESSION   NM_001006988 XM_217283
VERSION     NM_001006988.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 4164)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   3  (bases 1 to 4164)
  AUTHORS   Chiba,T., Inoue,D., Mizuno,A., Komatsu,T., Fujita,S., Kubota,H.,
            Luisa Tagliaro,M., Park,S., Trindade,L.S., Hayashida,T.,
            Hayashi,H., Yamaza,H., Higami,Y. and Shimokawa,I.
  TITLE     Identification and characterization of an insulin receptor
            substrate 4-interacting protein in rat brain: implications for
            longevity
  JOURNAL   Neurobiol Aging 30 (3), 474-482 (2009)
   PUBMED   17720279
REFERENCE   4  (bases 1 to 4164)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   5  (bases 1 to 4164)
  AUTHORS   Xie,X., Wang,Z. and Chen,Y.
  TITLE     Association of LKB1 with a WD-repeat protein WDR6 is implicated in
            cell growth arrest and p27(Kip1) induction
  JOURNAL   Mol Cell Biochem 301 (1-2), 115-122 (2007)
   PUBMED   17216128
REFERENCE   6  (bases 1 to 4164)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Dec 18, 2009 this sequence version replaced
            XM_217283.2, NM_001006988.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4164
                     /gene="Wdr6"
                     /note="WD repeat domain 6"
                     /db_xref="GeneID:301007"
                     /db_xref="RGD:1307649"
     exon            1..245
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..3523
                     /gene="Wdr6"
                     /note="WD repeat-containing protein 6; WD repeat domain 6
                     protein"
                     /codon_start=1
                     /product="tRNA (34-2'-O)-methyltransferase regulator WDR6"
                     /protein_id="NP_001006989.2"
                     /db_xref="GeneID:301007"
                     /db_xref="RGD:1307649"
                     /translation="MDAFGDYVWPRATSELILLPVTGLECVGDRLLAGEGPDLLVYNL
                     DFGGHLRMVKRVQNLLGHYLIHGFRVQPEPKGDLDSEAMIAVFGSKGLRVVKISWGQS
                     HLRELWRSGLWNMSDWIWDARWLEGNVALALGHNSVVLYDPVIGCMLQDVPCTDRCTL
                     SSACLIGDTWKELTIVAGAVSNELLVWYPATALPDNKPVAPDRRVSGHVGVIFSMSYL
                     ESKGLLATASEDRSVRIWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGE
                     DCVCLVWSHEGEILQAFRGHQGRGIRAIAAHERQTWVITGGDDSGIRLWHLVGRGYPG
                     LGVSSLSFKSPSRPGALKAVTLAGSWRVLAVTDVGGLYLYDLEVKCWEQLLEDNRFQS
                     YCLLEAAPGPEGFGLCALANGEGLVKVVPINTPTAAVDQNLFQGKVHSLSWALRGYEE
                     LLLLASGPGGVVACLEISAAPTGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVC
                     GDRRGSVLLFPARPCLFKKPGVGPKAITAAEAPQAGSSSGGSESVVTGLGPVSSLHSL
                     HGKQGVTSVTCHGGYVYSTGRDGSYYQLFVHGGRLQPVLRQKACRGMNWIAGLRMAPD
                     GSMVVLGFHANEFVVWSPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFAYLKDGDVMLY
                     RALGGCIRPNVILREGLHGREITCVKRVGTVTLGPEFEVPNLEHPDSLEPGSEGPGLI
                     DIVITGSEDTTVCVLALPTTTGAAHALTAVCNHISSVRALAVWGVGTPGGPQDSHPGL
                     TAQVVSAGGRAEMHCFSLMITPDASTPSRLACHIMHLSSHRLDEYWDRQRNRHRMIKV
                     DPETRYMSLAICELDSDRPGLGPGPLVAAACSDGAVRLFLLQDSGRILHLLAETFHHK
                     RCVLKVHSFTHEAPNQRRRLILCSAATDGSIAFWDLTTAMDRGSTTLEPPAHPGLPYQ
                     MGTPCLTVQAHSCGVNSLHTLPTPEGHHLVASGSEDGSLHVFTLAVKMPELEEADGEA
                     ELVPQLCVLDEYSVPCAHAAHVTGIKILSPKLMVSASIDQRLTFWRLGNGEPTFMNST
                     VYHVPDVADMDCWPVNPEFGHRCALAGQGLEVYNWYD"
     exon            246..2727
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2823
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2940
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3059
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..4164
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggacgtcc ccagccgagc gccagggctt tgctacctgt agctaaggct ccggagctct
       61 gcagcacggc tctccagatt gctggttctc gcgagaacgc agctctcttc ttgtccgagg
      121 cagctacagc agcttaagga acgtcatgga cgctttcggg gactatgtct ggccgcgggc
      181 gacctccgag ctcatactcc tcccggtcac gggtctggag tgcgttgggg acaggctgct
      241 ggcgggtgag gggcctgatt tactggtgta caacttggac tttggtgggc atctccggat
      301 ggtgaaacga gtccagaacc tgcttggtca ctatctcatc catgggttcc gagtgcaacc
      361 agagcccaaa ggagacctgg actctgaggc catgatagca gtgtttggga gcaagggcct
      421 cagagttgtg aaaataagct ggggtcaaag ccatctccga gagctctggc gctctggcct
      481 gtggaacatg tccgactgga tctgggatgc gcgctggctt gagggtaacg tagccctggc
      541 cttgggccac aactcagtgg tgctctatga tccagtgata gggtgcatgc tgcaggatgt
      601 cccctgcaca gacaggtgca ccctctcctc tgcctgcctg atcggcgaca cctggaagga
      661 actgaccata gtggcaggcg ccgtttccaa cgagctcctg gtgtggtatc cagcaactgc
      721 tttaccagac aacaaacctg tggcacctga ccggcgggtt agtggacacg tgggtgtcat
      781 ctttagcatg tcatacctgg aaagcaaggg cctgttggca actgcctcgg aggatcgaag
      841 cgttcgtatc tggaaagtgg gcgacctccg ggtgcctggg ggtcgggttc agaatattgg
      901 ccactgcttt gggcatagtg cccgtgtgtg gcaggtaaag ctcttagaga actatcttat
      961 cagtgccgga gaggactgtg tctgcttggt gtggagccac gaaggtgaga tccttcaggc
     1021 ctttcgcggc caccagggcc gagggatccg ggctatagct gcgcatgaga ggcaaacctg
     1081 ggtgatcact gggggagacg actcaggcat tcggctctgg cacctggtag gccgaggcta
     1141 cccaggcctg ggcgtctcat ctctgagctt caaatcccct agccggccag gtgccctcaa
     1201 ggctgtgact ctggctggtt cttggcgagt gctggcagtg actgatgtgg ggggcctgta
     1261 cctctatgac cttgaggtca aatgttggga gcagctgttg gaggacaatc gatttcagtc
     1321 ttactgcctg ctggaggcgg ctcccggccc tgagggcttt ggactctgtg ccttggccaa
     1381 tggggagggt cttgtcaagg tcgttcccat caacaccccc actgctgctg ttgaccagaa
     1441 cctgttccag gggaaggtgc acagcctgag ctgggccctt cgtgggtatg aagagcttct
     1501 gctgttggcc tcgggccctg gtggggtagt agcttgctta gagatctcgg ctgcacccac
     1561 tggcaaagct atctttgtca aggaacggtg ccggtatctg cttcccccaa gcaagcagag
     1621 atggcacacg tgtagtgcgt tcctaccccc gggtgacttc cttgtctgtg gggaccgccg
     1681 tggctctgtg ctgctatttc ctgccagacc atgtctgttc aaaaaacccg gggtgggacc
     1741 caaggctatc actgcagctg aggcgcccca agccggtagc agcagcggtg ggtctgagag
     1801 cgttgtgaca ggattaggcc cggtctcttc actgcattct ctgcatggga aacagggtgt
     1861 gacctcagtt acctgccacg gtggctacgt atacagcaca gggcgtgatg gctcctacta
     1921 ccagctcttt gttcatggtg gccgcctcca gccagtccta aggcagaaag cctgccgagg
     1981 catgaactgg atagctgggc ttcggatggc gcccgatgga agtatggtcg tcttgggttt
     2041 ccatgccaac gagtttgtag tgtggagccc gcggtcccat gagaagctgc acatcgtcaa
     2101 ctgcggggga gggcaccgct cctgggcctt ttctgatact gaggcagcca tggcctttgc
     2161 ctaccttaag gatggtgatg tcatgctcta ccgggctcta ggaggctgca tcaggccaaa
     2221 cgtgattctc cgggagggtc tgcatggccg ggaaatcaca tgtgtaaagc gtgtgggcac
     2281 tgttaccctg ggccctgaat ttgaggtacc caacttggag catcctgact ccctggagcc
     2341 tggcagtgag gggcctggtc tgattgacat cgtgataaca ggcagtgagg acactactgt
     2401 ctgtgtgcta gcacttccca ccaccacagg cgcagcccac gccctcactg ctgtctgtaa
     2461 ccatatctcc tccgtgcgag ccctggcagt gtggggtgtt ggcaccccag gtggcccaca
     2521 ggattctcac ccagggctca cagctcaggt agtgtctgca gggggtcgag ccgagatgca
     2581 ctgcttcagc ctcatgatca ctccggatgc cagcacccca agccgccttg cctgccacat
     2641 catgcacctt tcatcccacc ggctagatga gtactgggac cggcagcgca accggcaccg
     2701 gatgatcaag gtggaccctg agaccaggta catgtctctt gccatttgtg agcttgactc
     2761 cgataggcct ggccttggcc ccggccccct tgtggctgca gcctgtagtg acggggcagt
     2821 gaggcttttt ctcttgcagg actctgggcg aattctgcat ctccttgctg agactttcca
     2881 ccataagcgg tgtgtcctca aggtccattc gttcacacat gaggcaccca accagcgtcg
     2941 gaggctgatc ctgtgcagtg cagctacaga tggcagcata gccttctggg atctcaccac
     3001 ggcaatggac cgaggctcta ctaccctgga gcctccagca caccctgggc ttccctacca
     3061 gatgggcacc ccctgcctga ccgtccaggc ccatagctgt ggtgtcaaca gcctgcacac
     3121 tttgcctaca cctgagggcc atcatcttgt ggccagtggc agtgaggacg ggtccctgca
     3181 tgtcttcacg cttgctgtga agatgccaga gctggaagag gctgatgggg aggctgagtt
     3241 ggtgccccag ttatgtgtcc tagatgaata ttctgtcccc tgtgcacatg ctgcccatgt
     3301 gacgggcatc aagatcctaa gtcccaagct gatggtctca gcctccatag accaacggct
     3361 gaccttctgg cgtcttggaa atggtgagcc caccttcatg aatagcactg tgtaccacgt
     3421 gccagatgtg gctgacatgg actgctggcc tgtgaaccct gagtttggcc accgctgtgc
     3481 tcttgcgggt cagggactcg aggtttacaa ctggtatgac tgagttacca cagtagttgg
     3541 aggactgagc ctggggcttg accacagaca gcggagcagg gatcagctgt ctgtgtcatg
     3601 ctctatgtgc tctgaggagg tgaggcagta ccatgggttc ctgtagggtg ttgcataggt
     3661 ggaccaagaa tatgcctcac tcttcacaat aggatgaaac tgtatttatt ctgactttaa
     3721 gtgcccaaca tctgtgaggt ttctgtgagg tcttgttttt ttcccagttg atgcttttat
     3781 aaacattccc agctattggg cccttagatg tggctcagcg gagggaggcc cagcatggcc
     3841 aagcctgtgt ggaacacctc acgtactgcc ctcaaaagct gtaggcgagc aaacatctga
     3901 ccaaagaggt gtggccgagg ttcctgaaag aaaagcaacc aggcccatcc tcatttcccg
     3961 agcctgagcc cttgtccata tttcccacag accctccctt gctgtatgct cacccctaga
     4021 atgtgtacgc ggttatagta tgagctgaaa tccatgctga gctgcaccag gaacttgcac
     4081 acctagagac agaggttgaa tcgttgagct gttgtctttt ttcttgtgtc acaacccaga
     4141 ataaagaata gtgtgtgtag tgtc
//
