LOCUS       NM_001039034            3140 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus WD repeat domain 5 (Wdr5), mRNA.
ACCESSION   NM_001039034 XM_342397
VERSION     NM_001039034.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3140)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3140)
  AUTHORS   Shinsky,S.A. and Cosgrove,M.S.
  TITLE     Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the
            Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex
  JOURNAL   J Biol Chem 290 (43), 25819-25833 (2015)
   PUBMED   26324722
REFERENCE   3  (bases 1 to 3140)
  AUTHORS   Ravnskjaer,K., Hogan,M.F., Lackey,D., Tora,L., Dent,S.Y.,
            Olefsky,J. and Montminy,M.
  TITLE     Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated
            epigenetic effects
  JOURNAL   J Clin Invest 123 (10), 4318-4328 (2013)
   PUBMED   24051374
REFERENCE   4  (bases 1 to 3140)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   5  (bases 1 to 3140)
  AUTHORS   Shilatifard,A.
  TITLE     The COMPASS family of histone H3K4 methylases: mechanisms of
            regulation in development and disease pathogenesis
  JOURNAL   Annu Rev Biochem 81, 65-95 (2012)
   PUBMED   22663077
  REMARK    Review article
REFERENCE   6  (bases 1 to 3140)
  AUTHORS   Lee,J.H., Tate,C.M., You,J.S. and Skalnik,D.G.
  TITLE     Identification and characterization of the human Set1B histone
            H3-Lys4 methyltransferase complex
  JOURNAL   J Biol Chem 282 (18), 13419-13428 (2007)
   PUBMED   17355966
REFERENCE   7  (bases 1 to 3140)
  AUTHORS   Han,Z., Guo,L., Wang,H., Shen,Y., Deng,X.W. and Chai,J.
  TITLE     Structural basis for the specific recognition of methylated histone
            H3 lysine 4 by the WD-40 protein WDR5
  JOURNAL   Mol Cell 22 (1), 137-144 (2006)
   PUBMED   16600877
REFERENCE   8  (bases 1 to 3140)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   9  (bases 1 to 3140)
  AUTHORS   Brown,S.A., Ripperger,J., Kadener,S., Fleury-Olela,F., Vilbois,F.,
            Rosbash,M. and Schibler,U.
  TITLE     PERIOD1-associated proteins modulate the negative limb of the
            mammalian circadian oscillator
  JOURNAL   Science 308 (5722), 693-696 (2005)
   PUBMED   15860628
REFERENCE   10 (bases 1 to 3140)
  AUTHORS   Gori,F., Divieti,P. and Demay,M.B.
  TITLE     Cloning and characterization of a novel WD-40 repeat protein that
            dramatically accelerates osteoblastic differentiation
  JOURNAL   J Biol Chem 276 (49), 46515-46522 (2001)
   PUBMED   11551928
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100156.1.
            
            On Jan 12, 2006 this sequence version replaced XM_342397.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100156.1, SRR8487226.110483.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..3140
                     /gene="Wdr5"
                     /note="WD repeat domain 5"
                     /db_xref="GeneID:362093"
                     /db_xref="RGD:1305159"
     exon            1..281
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            282..445
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1369
                     /gene="Wdr5"
                     /note="WD repeat-containing protein 5-like"
                     /codon_start=1
                     /product="WD repeat-containing protein 5"
                     /protein_id="NP_001034123.1"
                     /db_xref="GeneID:362093"
                     /db_xref="RGD:1305159"
                     /translation="MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGH
                     TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL
                     VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT
                     GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS
                     FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS
                     GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
                     "
     exon            446..554
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            555..628
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            629..718
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            719..808
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            809..892
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            893..948
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            949..995
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1071
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1105
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1180
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1268
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..3030
                     /gene="Wdr5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaatctgca tttgattgga gggagactga tggctgctgc ccttccatga tcacgttccc
       61 tgtagtgtaa agctgcggtt gccagttaac tgcctccttt gtgggccgtg gaggccagct
      121 ccaaaccacc tgctgaggat cctgcttaac acacctccct cccagagctg tcctcttcaa
      181 gtcctgcttt ccggtgacct taaaacagaa cacctgagtg ctctctgtct tggactctac
      241 ccagtggaat tggaaattgg tttcctttga gacggtttca ggtcccatag agtacgggtt
      301 agctgacggc ttcttccatt gtgactccct cttcacggtg tcctgccctg tgggcttcag
      361 agccatggcc acggaggaga agaaaccaga gacagaggct gcaagagcac agcccactcc
      421 ttcctcatca gccacacaga gcaagcctac acctgttaag ccaaactatg ccctgaagtt
      481 caccctggct ggccacacaa aagctgtgtc ctctgtgaag ttcagcccca atggggagtg
      541 gctggcaagt tcctctgctg ataaactcat taaaatttgg ggagcatatg atggaaagtt
      601 tgagaaaact atatctggtc acaaactggg aatatctgat gtagcctggt catcagattc
      661 taacctcctt gtgtctgcct ctgatgataa aactttgaag atttgggacg tgagttccgg
      721 aaagtgtctg aagaccctaa agggccacag taactatgtc ttctgctgca acttcaaccc
      781 ccagtccaac ctcatcgtct cagggtcttt tgatgaaagt gtgaggatat gggatgtgaa
      841 gacagggaag tgcctcaaga ctttgcctgc ccattcggat ccagtctcag ccgttcattt
      901 caatcgtgat ggatccttga tcgtttccag tagctatgat ggcctctgcc gaatctggga
      961 cactgcctct ggccaatgtc tgaagacgct cattgatgac gacaatcctc cggtgtcctt
     1021 cgtgaagttc tctccaaatg gcaagtacat cctggctgca actttggaca acacactgaa
     1081 gctctgggac tacagcaaag ggaagtgcct gaagacatac accggccaca agaatgagaa
     1141 gtactgcata tttgccaact tctccgtgac aggtgggaag tggatcgtgt ctggctctga
     1201 agataacctg gtatatatct ggaatctgca gaccaaggag atcgtacaga agttgcaggg
     1261 tcatacagat gtcgtgatct ccacggcctg tcacccaaca gagaacatca ttgcctcagc
     1321 agcgttagag aatgacaaaa caatcaaact gtggaagagt gactgctaag ccctggctcc
     1381 atgggagact tcaggaagcc acccagattg gcaagaaaca catgtggggc agaggcgtgg
     1441 ggccaggttg ggttgacagg cttggtgcac ctcctctctg aagatgtcgg gccaggggcg
     1501 tgcatatata ccaccgagtc ttgatagcca ctgtgatatt tcttgccaat tctgtctctg
     1561 cctggggaag ttcctggtct gttctgtgtg ctcagaggca acaaattttt taatttttta
     1621 ttacaagagt gagtccaact cctcatgggt tgtttttctc tgtaattgtt gttttggtat
     1681 tgtattgccc agtgcacaca ctggaacagg acctacagcc ctactcccat tccctgcctc
     1741 cagccttggc ctgcttgttc aagttcccta cctgtaatag tacccagtgt gcttccatga
     1801 gtttctggaa acacagaaag gttgtaagtt gtatctgtgt caagtccctt tgtttttttg
     1861 gagttcatag gtcaacactg acctctcagt ggttgcagtg tccccttgtc tcactggtat
     1921 cactcagtaa agccacacac tgtaataaaa ggtgggtatg gactgggtgt ggccctgagt
     1981 tctgacagag ctcttcacat ctgggcttta gaacataccc cctccctgca ggagttggaa
     2041 aagtctctgg gaggtgggtt ctgctgggcc tcctcttccc agtggctgtg ttggcactaa
     2101 gtgtttcgag aggaagaacc tcagttgaga gagtggaagg aaggaagtct tggaaaggca
     2161 ccatgtagtg aggttctgga ccctctttat ctctgaatga ggctcagggt cacctgtgca
     2221 ggagggagaa gttcaatttg gtgcttgcct cagcagatac agcctcctgc cttggcctct
     2281 gaatccacca aacctctctt agcccttgct ccaaatggat cctcaggtga ccaggctaga
     2341 aagagataat ggccaagcta gaactgcaca gcattttcac aactgcttct ggccaaaccc
     2401 aggtggcctg acacgaagca gactgcagag ggtctgagtc cagatgggtg ggcaaggctg
     2461 ctgggcacag gcacaggcag aaaggagatt ctgggtttgc tctggttgtg gcagcttgcg
     2521 aggtcaatac tgatacgtat tgaagccagg ttgccctggt cagtagctgc tctactctgc
     2581 ctttgctgag acctgtcccc agctgtggtc ctcttggccc ttcctccgct ccatcgtggc
     2641 acaattaaga atccaaaggt gttggaaaag gacccccaca cacatacata ccagtacatt
     2701 gtctcttcct tgagggaggt gatgtgcaca tggactgtca cattgaagaa gccattgtaa
     2761 tagggtggct tgtcacactg acgtgggttc tgtggcccct ggcatctatg ggtagatgtg
     2821 cctgggttct ggtcaatgtt gtgggcaggt tgctggggtt tctggagggg tggtgaggtc
     2881 tttccagctg tggcccggtg tgcggcccct cctgagggag ggagcttgct tgccatgttg
     2941 agcgcagtat ccccaagtat agtttatttt ttctacagtt gaactctgtt gtagatttat
     3001 gtaaaaatac attctctttt taaaaataaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3061 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa
//
