LOCUS       NM_001135895            3796 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus WD repeat domain 48 (Wdr48), mRNA.
ACCESSION   NM_001135895 XM_001077618 XM_343503
VERSION     NM_001135895.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Liang,F., Miller,A.S., Longerich,S., Tang,C., Maranon,D.,
            Williamson,E.A., Hromas,R., Wiese,C., Kupfer,G.M. and Sung,P.
  TITLE     DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in
            the Fanconi anemia DNA damage response
  JOURNAL   Nat Commun 10 (1), 2849 (2019)
   PUBMED   31253762
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Gangula,N.R. and Maddika,S.
  TITLE     WD repeat protein WDR48 in complex with deubiquitinase USP12
            suppresses Akt-dependent cell survival signaling by stabilizing PH
            domain leucine-rich repeat protein phosphatase 1 (PHLPP1)
  JOURNAL   J Biol Chem 288 (48), 34545-34554 (2013)
   PUBMED   24145035
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Park,E., Kim,J.M., Primack,B., Weinstock,D.M., Moreau,L.A.,
            Parmar,K. and D'Andrea,A.D.
  TITLE     Inactivation of Uaf1 causes defective homologous recombination and
            early embryonic lethality in mice
  JOURNAL   Mol Cell Biol 33 (22), 4360-4370 (2013)
   PUBMED   24001775
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Cohn,M.A., Kee,Y., Haas,W., Gygi,S.P. and D'Andrea,A.D.
  TITLE     UAF1 is a subunit of multiple deubiquitinating enzyme complexes
  JOURNAL   J Biol Chem 284 (8), 5343-5351 (2009)
   PUBMED   19075014
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Cohn,M.A., Kowal,P., Yang,K., Haas,W., Huang,T.T., Gygi,S.P. and
            D'Andrea,A.D.
  TITLE     A UAF1-containing multisubunit protein complex regulates the
            Fanconi anemia pathway
  JOURNAL   Mol Cell 28 (5), 786-797 (2007)
   PUBMED   18082604
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 11, 2009 this sequence version replaced NM_001135895.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1233554.1,
                                           SRR26360172.2368533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000008.1  128499721-128499787
            68-208              JAXUCZ010000008.1  128508446-128508586
            209-287             JAXUCZ010000008.1  128510385-128510463
            288-370             JAXUCZ010000008.1  128511311-128511393
            371-500             JAXUCZ010000008.1  128511477-128511606
            501-589             JAXUCZ010000008.1  128513241-128513329
            590-691             JAXUCZ010000008.1  128514180-128514281
            692-916             JAXUCZ010000008.1  128516227-128516451
            917-991             JAXUCZ010000008.1  128517774-128517848
            992-1094            JAXUCZ010000008.1  128519122-128519224
            1095-1192           JAXUCZ010000008.1  128520277-128520374
            1193-1300           JAXUCZ010000008.1  128522863-128522970
            1301-1397           JAXUCZ010000008.1  128523253-128523349
            1398-1493           JAXUCZ010000008.1  128524812-128524907
            1494-1599           JAXUCZ010000008.1  128525875-128525980
            1600-1687           JAXUCZ010000008.1  128526848-128526935
            1688-1764           JAXUCZ010000008.1  128528993-128529069
            1765-1954           JAXUCZ010000008.1  128530394-128530583
            1955-3796           JAXUCZ010000008.1  128531089-128532930
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3796
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /note="WD repeat domain 48"
                     /db_xref="GeneID:363164"
                     /db_xref="RGD:1309702"
     exon            1..67
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2050
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /codon_start=1
                     /product="WD repeat-containing protein 48"
                     /protein_id="NP_001129367.1"
                     /db_xref="GeneID:363164"
                     /db_xref="RGD:1309702"
                     /translation="MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNR
                     LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDVVLCCNGKTLISASSDTTVKVW
                     NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVT
                     TSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLL
                     HRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKI
                     YCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRA
                     SGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKA
                     CKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGF
                     SSPDGSDPKLNLGGLLLQALLEYWPRTHVTPMDEEENEVNHVSGEQESRVQKGNGYFQ
                     VPPHTPVIFGEAGGRTLFRLLCRDSGGETEAMLLNETVPQWVIDITVDKNMPKFNKIP
                     FYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPEQ
                     EKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST"
     exon            68..208
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            209..287
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            288..370
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            371..500
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            501..589
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            590..691
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            692..916
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            917..991
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1094
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1192
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1300
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1397
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1493
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1599
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1687
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1764
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1954
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..3796
                     /gene="Wdr48"
                     /gene_synonym="RGD1309702"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagtgtca acatgcaaga tggcggccca tcaccggcag aacacagccg ggcggagaaa
       61 agtgcaggtt tcctatgtaa ttcgagatga agtggagaag tacaatcgga acggagtcaa
      121 tgccctgcaa ctggacccag cactcaacag actcttcaca gcaggtcgag actccatcat
      181 aagaatatgg agtgtcaatc agcacaagca agatccatac atagcatcta tggagcacca
      241 cacagactgg gtgaacgatg ttgtactctg ttgcaatggg aaaacactaa tatctgcttc
      301 ttcagacaca acagtaaaag tctggaatgc acataaaggg ttctgcatgt ccaccctcag
      361 gacgcataag gactatgtca aggccttggc gtatgccaag gataaagagc tggtagcatc
      421 ggctgggctg gacagacaga tattcctttg ggatgtgaac actttgacag cactgactgc
      481 ctcaaacaac actgtcacaa cttcttcttt aagtgggaac aaagattcca tttatagcct
      541 ggccatgaac caactgggaa caatcattgt atctgggtcc actgagaagg ttctaagagt
      601 gtgggatcca agaacctgtg cgaaactcat gaagctgaaa ggacacacgg acaatgtgaa
      661 ggccctgctg ctgcacaggg acggcacaca gtgcctctct gggagttctg atgggacgat
      721 tcgcctgtgg tcccttggcc agcagagatg tatagcaaca taccgagtcc atgatgaggg
      781 cgtttgggcc ctacaggtca atgatgcctt cacacatgtc tattctgggg gacgggacag
      841 gaagatctac tgcacagacc taaggaaccc tgacattcgg gtgctgattt gtgaagaaaa
      901 agcaccagtt ctcaagatgg aacttgacag atcagcagat ccccctcctg caatctgggt
      961 tgcaacaaca aagtccacag taaataagtg gacactgaag ggaattcata atttccgagc
     1021 ctctggtgat tatgacaatg attgtacaaa ccccataacg cccctctgca cacagccgga
     1081 ccaagttatt aaagggggcg ctagtatcat ccagtgccac atcctaaatg ataagcgaca
     1141 tatattgacc aaagatacga ataacaatgt ggcctactgg gacgtgttga aggcatgcaa
     1201 agtggaagat ttgggcaaag tggacttcga agatgaaatt aagaaaagat ttaaaatggt
     1261 gtatgttcca aattggttct cagtagacct aaaaacaggg atgctgacca ttactctgga
     1321 tgaaagcgac tgcttcgctg cctgggtttc tgcgaaagat gctggcttca gcagtcccga
     1381 tgggtcagac ccaaaactga acttaggagg acttctacta caggccctcc tggagtactg
     1441 gcccagaaca catgtgactc ccatggacga ggaggagaat gaagtgaacc atgtgagtgg
     1501 ggaacaggag agccgagtcc agaaaggaaa tggctatttc caggtgcccc cccacacccc
     1561 cgtgatcttt ggagaagctg gaggtcgcac acttttcagg ctgctctgcc gggactccgg
     1621 gggcgagacc gaggcaatgc ttctcaatga gaccgtgcca caatgggtga tcgacatcac
     1681 tgtggataaa aatatgccca aattcaacaa aattcctttc tacctccaac ctcatgcatc
     1741 ttcaggagca aaaactttaa aaaaagacag actgtctgcc agtgacatgc tgcaggtccg
     1801 gaaggtgatg gaacacgtct acgagaagat tatcaacctg gataacgagt cccaaaccac
     1861 cagctcttct aataatgaaa aaccagagca ggagaaggag gaggacattg ctgtgttggc
     1921 agaggagaaa attgagcttc tgtgccagga ccaggttttg gaccccaata tggaccttcg
     1981 gacagtaaag cacttcatat ggaagagtgg tggggacctc accctccatt accgtcagaa
     2041 gtccacgtga agagtgggcc catgctcctg ggttctttac caaccacctt cctctgtggc
     2101 cccaagagta gtcctaggaa gcccaccacg tcctacggga acaagacctc caaccggcca
     2161 atggagatgt attatagaaa ccaggctcca cgcatagatt aaggtgtccc cagggactcg
     2221 agtgcaaaga cagaaaagcc ctggcactgt tctgggagat gcagagaatc tacaacaggc
     2281 agtgcagact tcgctgactc cttgtgaagg acccaccttt gtctcttagc acttgttaga
     2341 gaacatcagc ggggccacat ctgttcgccg tggttccgtt tcaaacccac aagttctgca
     2401 gctttgtcca agtacattcc actcatgcag tacctatgaa ggctttttcc aaatttgtca
     2461 ttacaaaaat taagttgttt tcaccatatg agagttattt ttaatggaaa tcactgttgg
     2521 acaatccaag agccagccta tttcctaaaa aatgaccacg ctgggctact tctgaaatac
     2581 cgcatctcag ccacactctt gtaggaagac cttccgcaac tccagggacc ttggacctcc
     2641 aggcagtaac agctggtgtg tgttgtgcag tgctgcccca tagtgccctg gctgtacgat
     2701 agcccaagat agcctaagcc gctgtggcca ctccttcctt ccgccagcac cgccttcctc
     2761 acaggcagag ccagcgagaa ccacagcttc ctgctctggg tgagcagcct gccgactgtc
     2821 aggacttaag accatgctga agtttgagtt tcattcaaat gctgaagttt tgtgttacta
     2881 gagtaaaaag atctcacagt gagctggttt gatatttata ttgtggtcca tgtttgtttt
     2941 tccagtttta tacacgggct tttgttacgc cttcgtccag gtctttccgc tgtctttcta
     3001 acagtcaaaa gctttcatag actcacttgg atcttgtaca gaatatttaa cttattgggg
     3061 ataaacactt caacttttgg caaaagatac tttggattct tcccttggtc atttacatcc
     3121 agacagatga aactttgagc acagcggaag cacacgtgcc ttgggagggc agcgtacacc
     3181 gtccagctgt ccgtgccttg tgtgtggtct gtccccacag gagcagggtg agggggcctg
     3241 gggaagggtt tttcctcgtc tctacatctt cacaggttct actggagaca gctgaagggc
     3301 ccagatccat cccttacaaa ccaaggcact aatccgtaca actacagagc agggcccctc
     3361 acaataactg tgggaacata catgccatgg cttccacacc ctccagtgag caaggacatc
     3421 ccaggggtta aaccgttctc cctccccaga gcagccagct tctttttttt acagaagttc
     3481 tttctatctg tgttggacaa cagtgcactt ttggtgcata ttttttagtg atagctgtaa
     3541 gcgaaaagcc aggggtgggt ggggtgtttg caggaggggc ctctgcacta agagtaggtt
     3601 ttgctggttg gctcaggcag tactgatcca caggcagttg tgcccctgtg gagagtttac
     3661 ccccagcatg gttgtacttc tttcccctct tgtcaaaaat cagtaataag tttccagaaa
     3721 attggacagt ctgcaatgcc aaaagggtca gaatctgtat ttcaagtcgt atagaataaa
     3781 gctttagtta caaaca
//
