LOCUS       NM_001398793            1668 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus WD repeat domain 45 (Wdr45), transcript variant
            1, mRNA.
ACCESSION   NM_001398793 XM_039099635
VERSION     NM_001398793.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1668)
  AUTHORS   Bakula,D., Muller,A.J., Zuleger,T., Takacs,Z., Franz-Wachtel,M.,
            Thost,A.K., Brigger,D., Tschan,M.P., Frickey,T., Robenek,H.,
            Macek,B. and Proikas-Cezanne,T.
  TITLE     WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC
            signalling circuits in the control of autophagy
  JOURNAL   Nat Commun 8, 15637 (2017)
   PUBMED   28561066
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1668)
  AUTHORS   Saitsu,H., Nishimura,T., Muramatsu,K., Kodera,H., Kumada,S.,
            Sugai,K., Kasai-Yoshida,E., Sawaura,N., Nishida,H., Hoshino,A.,
            Ryujin,F., Yoshioka,S., Nishiyama,K., Kondo,Y., Tsurusaki,Y.,
            Nakashima,M., Miyake,N., Arakawa,H., Kato,M., Mizushima,N. and
            Matsumoto,N.
  TITLE     De novo mutations in the autophagy gene WDR45 cause static
            encephalopathy of childhood with neurodegeneration in adulthood
  JOURNAL   Nat Genet 45 (4), 445-449 (2013)
   PUBMED   23435086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 23, 2021 this sequence version replaced XM_039099635.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1278116.1,
                                           SRR26360190.454830.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000021.1  17453865-17454117   c
            254-325             JAXUCZ010000021.1  17452227-17452298   c
            326-400             JAXUCZ010000021.1  17452051-17452125   c
            401-505             JAXUCZ010000021.1  17451858-17451962   c
            506-611             JAXUCZ010000021.1  17450359-17450464   c
            612-706             JAXUCZ010000021.1  17450117-17450211   c
            707-786             JAXUCZ010000021.1  17449598-17449677   c
            787-995             JAXUCZ010000021.1  17449276-17449484   c
            996-1097            JAXUCZ010000021.1  17449091-17449192   c
            1098-1243           JAXUCZ010000021.1  17448868-17449013   c
            1244-1668           JAXUCZ010000021.1  17448207-17448631   c
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1668
                     /gene="Wdr45"
                     /note="WD repeat domain 45"
                     /db_xref="GeneID:302559"
                     /db_xref="RGD:1359718"
     exon            1..253
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            254..325
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1353
                     /gene="Wdr45"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat domain phosphoinositide-interacting protein 4;
                     WIPI-4; WD repeat-containing protein 45"
                     /codon_start=1
                     /product="WD repeat domain phosphoinositide-interacting
                     protein 4 isoform 1"
                     /protein_id="NP_001385722.1"
                     /db_xref="GeneID:302559"
                     /db_xref="RGD:1359718"
                     /translation="MTQQPLRGVTSLHFNQDQSCFCCAMETGVRIYNVEPLMEKGHLD
                     HEQVGSVGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKDKLVLEFTFT
                     KPVLAVRMRHDKIVIVLRNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLV
                     FPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDVACVSLNQPGTVVASASQKGTLIR
                     LFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSA
                     LARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHK
                     YVFTPDGNCNREAFDVYLDICDDDDF"
     exon            326..400
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            401..505
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            506..611
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            612..706
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            707..786
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            787..995
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1097
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1243
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1668
                     /gene="Wdr45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcaatgct tggcccgctt ccgttaaggg aggggcaggc cctctcccgg gttcccccag
       61 atagttctgc ctttgggcag tctcttgtgc ctccagtcct ctaatccgcc ctcatctcct
      121 tccggaactt ccctcggagg aatctactac ggctcgggat gctccacagg tcggccaagt
      181 gggtgaaaag agccgtggct ggattttctg cccagaatga gtcacttccg gtcacagact
      241 ccctcctccg gaagaaggtg atcctgaacc atgactcagc agccacttcg aggtgtgacc
      301 agcctccatt tcaaccaaga ccaaagctgc ttttgctgtg ccatggagac aggtgtacgg
      361 atctacaatg tggaaccact gatggagaaa gggcatcttg accacgagca ggtaggcagc
      421 gtgggccttg tagagatgct gcaccgatcc aacctgctgg ccctggtggg cggtggtagc
      481 agccccaagt tctccgagat ctcggtgctg atctgggacg atgcccgaga aggcaaggac
      541 tccaaggaca aactggtgct ggagttcacc ttcaccaagc cagtgctagc tgtgcgaatg
      601 cgccatgaca agattgtgat tgtgctgagg aaccgcatct atgtgtactc cttccctgac
      661 aaccctcgga agctgtttga gtttgacact cgggacaacc ccaaggggct gtgtgacctc
      721 tgcccaagcc tggagaagca gctgcttgtg tttcctggac acaagtgtgg aagtctgcaa
      781 cttgtggatc tggcaagcac aaagcctggt acttcatcag ctccattcac tatcaatgcc
      841 catcagagtg atgtggcctg tgtgtcccta aaccagccag gcactgtagt ggcctcagcc
      901 tcccagaagg gtacccttat tcgtcttttt gatacgcagt ccaaggaaaa gctggtagag
      961 cttcgaagag gcactgaccc tgccacccta tactgcatta acttcagcca tgactcctcc
     1021 ttcctctgtg cttccagtga caagggcact gtccatatct ttgctcttaa agacacccgc
     1081 cttaaccgcc gctctgcgtt ggcacgtgtg ggcaaagtgg gacctatgat tgggcaatac
     1141 gtggattctc agtggagcct ggccagcttt actgtgcctg ctgagtcagc ctgcatctgc
     1201 gcctttggtc gaaatacttc caaaaacgtc aattctgtaa tcgccatctg cgtagatggg
     1261 accttccaca aatatgtctt cactcctgat ggaaactgca acagagaggc ctttgacgtg
     1321 taccttgaca tctgtgatga cgatgacttt taagagtcct ggcagctata ctaggaacct
     1381 acagtagccg atggccgaac tgagtcttga gggtgttgaa ccagccagca agcataaaaa
     1441 tgagcctttc cactctccat tcaaacacag ctgtgtctaa ataaacagcc aacatccccc
     1501 caagcacttt tgtgactgcg tgctaaaggc caaggactga taccctgggc cacctagtct
     1561 ggaaaacacc agggacccaa agggattatc caaatccaag ctagggattt aaaaaaaatg
     1621 attacatagt ctctgtaatg tatatgaata aaaggccttt gaatggca
//
