LOCUS       NM_001395597            3066 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus WD repeat domain 41 (Wdr41), transcript variant
            1, mRNA.
ACCESSION   NM_001395597 XM_039102529
VERSION     NM_001395597.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3066)
  AUTHORS   Yang,M., Liang,C., Swaminathan,K., Herrlinger,S., Lai,F.,
            Shiekhattar,R. and Chen,J.F.
  TITLE     A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual
            role in autophagy
  JOURNAL   Sci Adv 2 (9), e1601167 (2016)
   PUBMED   27617292
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3066)
  AUTHORS   Sellier,C., Campanari,M.L., Julie Corbier,C., Gaucherot,A.,
            Kolb-Cheynel,I., Oulad-Abdelghani,M., Ruffenach,F., Page,A.,
            Ciura,S., Kabashi,E. and Charlet-Berguerand,N.
  TITLE     Loss of C9ORF72 impairs autophagy and synergizes with polyQ
            Ataxin-2 to induce motor neuron dysfunction and cell death
  JOURNAL   EMBO J 35 (12), 1276-1297 (2016)
   PUBMED   27103069
REFERENCE   3  (bases 1 to 3066)
  AUTHORS   Sullivan,P.M., Zhou,X., Robins,A.M., Paushter,D.H., Kim,D.,
            Smolka,M.B. and Hu,F.
  TITLE     The ALS/FTLD associated protein C9orf72 associates with SMCR8 and
            WDR41 to regulate the autophagy-lysosome pathway
  JOURNAL   Acta Neuropathol Commun 4 (1), 51 (2016)
   PUBMED   27193190
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3066)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Aug 2, 2021 this sequence version replaced NM_001395597.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000002.1  27959255-27959471
            218-333             JAXUCZ010000002.1  27961453-27961568
            334-382             JAXUCZ010000002.1  27980915-27980963
            383-512             JAXUCZ010000002.1  27986436-27986565
            513-514             JAXUCZ010000002.1  27986566-27986567
            515-576             JAXUCZ010000002.1  27989237-27989298
            577-688             JAXUCZ010000002.1  27992616-27992727
            689-751             JAXUCZ010000002.1  27996700-27996762
            752-862             JAXUCZ010000002.1  27997193-27997303
            863-1047            JAXUCZ010000002.1  28000322-28000506
            1048-1169           JAXUCZ010000002.1  28002603-28002724
            1170-1258           JAXUCZ010000002.1  28003473-28003561
            1259-1392           JAXUCZ010000002.1  28004141-28004274
            1393-3065           JAXUCZ010000002.1  28006901-28008573
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3066
                     /gene="Wdr41"
                     /note="WD repeat domain 41"
                     /db_xref="GeneID:361879"
                     /db_xref="RGD:1306363"
     exon            1..217
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1549
                     /gene="Wdr41"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 41"
                     /codon_start=1
                     /product="WD repeat-containing protein 41 isoform 1"
                     /protein_id="NP_001382526.1"
                     /db_xref="GeneID:361879"
                     /db_xref="RGD:1306363"
                     /translation="MLRWLIGGGREPQGLAEKAALQTIGEDQGQNPYTELLVLKAHRD
                     IVRFLVQLDGYRFASAGDDGIIVVWNAQTGEKLLELRGHTQKITAVITFLPLDSCEAS
                     SQLLLTASADRTVGVWDCDTGRQIQRVTCFQSTVKCLAVLQRLDVWLSGGSDLGVWSR
                     KLDLLCKTSHLSDTGISALVEIPGNCVAAAVGRELIIFRLVTPTEELLEWDIIEVKRL
                     LDHQDNILSLANINDTSFVTGSHVGELIIWDALDWTVQACERTFWSPTPQLDAQQEIK
                     LCQKQNDIPVNHFACDEENVFAAVGRGLYVYNLQLKRVIACQKTAHDSNILHIDKLPN
                     RQLISCSEDGAVRMWEVREKQQLAAEPVPTGFFNMWGFGRVNKQANQPVKKQEENVTT
                     CSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILWKNGERESGLRSLKLFQKLE
                     ENGDLYPEST"
     exon            218..333
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            334..382
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            383..514
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            515..577
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            578..689
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            690..752
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            753..863
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1048
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1170
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1259
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1393
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..3066
                     /gene="Wdr41"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggggacg cggaacctcc gcctccgctg ccgccgcggc cttctgtgag ggctcccgaa
       61 ctagacttct gttttctcgc tgcctcgccc cagattcact cggccgcagc ctcagcgtct
      121 gcgccgcggc ggccctcgct ccgtgggctg cggacgcccc ggcccgatgc tgcgctggct
      181 gatcggagga ggccgcgagc cgcagggcct ggccgagaaa gctgctctgc agacaatagg
      241 agaggaccaa ggtcagaacc cctacactga actgctggta ctgaaggctc atcgcgacat
      301 tgtccgcttc ctggtgcagc tagacggcta caggtttgca tctgctggtg atgatggaat
      361 tatagttgtg tggaatgccc agacaggaga aaaacttctg gaactcagag gacatactca
      421 gaagataacg gctgtcatta cgttccttcc cctagactct tgtgaggcca gcagtcagct
      481 tctcttgaca gcctctgctg accggactgt cggtgtttgg gactgtgaca ccggccggca
      541 aatccagagg gtcacgtgct tccagtctac tgtcaagtgc ttggctgtcc ttcagaggct
      601 ggacgtctgg ctctcaggcg gaagtgacct gggtgtgtgg agccgaaaat tagacctgct
      661 gtgtaagacc agccaccttt ctgacacagg gatcagtgct ttggttgaaa tccctgggaa
      721 ctgtgtcgct gcagccgttg gcagagaatt gatcattttt aggcttgtaa cacccacaga
      781 agaactgctt gaatgggata ttatagaggt taaacgcctt ctcgatcacc aggacaatat
      841 cctgtcattg gctaacatca atgatacaag ttttgtcact ggctcccatg ttggggagct
      901 gatcatctgg gatgctctgg actggaccgt gcaggcctgt gaacgcacct tctggagccc
      961 gacgccacag ctggatgccc agcaggaaat aaagctctgc caaaagcaaa atgacattcc
     1021 tgtgaatcat ttcgcatgcg atgaagagaa cgtatttgca gcagttggaa gggggttata
     1081 cgtgtataac ctacagttga aacgtgtgat tgcctgccag aaaactgcac acgattccaa
     1141 catcctacac atcgacaaac ttccaaacag gcagttaatc tcgtgctcag aagatggcgc
     1201 tgtgcgcatg tgggaggtcc gggaaaagca gcagctggcg gccgagccgg tcccaacagg
     1261 gttttttaat atgtggggat ttggaagagt aaacaaacag gccaaccagc ctgttaaaaa
     1321 gcaggaagaa aacgtcacca cgtgttccct ggagctcatc ggagacctga tcggacactc
     1381 atcatcagtg gagatgtttc tctactttga ggatcacggg ctggtgacct gctctgcaga
     1441 ccacctcatt attttgtgga aaaatggaga gcgagaatct ggactacgca gcttgaagtt
     1501 atttcagaag ttagaagaaa acggtgactt atacccagaa tccacttgaa ggagccaggc
     1561 gggtgtgcac tcgagaaccc tgcacatcca gtacagggcg gccctctgga aaccaccacc
     1621 acttccgccc cttacatcag tactgtttgc ttgaccgtga agttctggct gtctggcggc
     1681 agcatgagtc cccccaagaa cacagcaggg catggccttg ctcctgagca agtgacgggt
     1741 gctctgttcc atctcggaaa gcagtagaca aaaaggataa atgtaaagtt gtcacacatc
     1801 atgtataagt tttattttgg gttcttttag agactgtcta agacctgccg tgagagatgt
     1861 atcctttctg ctctaaattc tcctgctcct cagtagctat cagtgtgaac tagaaccaaa
     1921 cttgaatatt agccagaaag caaaaaaaga attatattct ttaagtgcaa tgattctgtt
     1981 tggtaccaac taattttagt cattgaaaga atatttaatc gtgcccacta aaatccctga
     2041 gcccacaggc gccatctgaa catctctttc tcagtgtgaa ctggcctgac cccttattgg
     2101 cagaacggtt ttcaggtgtc cctgggttag gaaggaggca cagctttttt tcaggtcagg
     2161 aaccgtagct gaatttccct gtccgtctgc tttgccttaa atggctgaga gcagcctcac
     2221 cgttctgctc cctgagcatc cgctaagcct gggccatctt cctcgccctt ccagcctgat
     2281 ggctgtaccc tcacgtttgg cattgaaacg tgaaatgtac tccacacagt aagaacgggg
     2341 aggactatta ttcttgaact gctggtgaag gaatcttatt aaagacagtc aagatgagtg
     2401 taggcctacc gatttgtgcg tgtgcacaca cacgtgcgat gctccctaaa tggacactct
     2461 ataaactgtt gctttcacta gatccaactt tcacagctgt ctacagtcaa gtctcggtag
     2521 cattaaaatc atagggagat cagtggcaaa atgttaggaa tacggaaacc aaggcctggg
     2581 gtggtaagct ctctctccca tcccagttca tcatcactgc gcagccttaa aagcagaaac
     2641 cagaggagga gaatgagaag ggctgagagg acgacccggt gaccatgtta ggaaaacaga
     2701 gtgttctcag tccttgctgt tggcgtagtt cataatgaaa atagcttggc aggaagggat
     2761 aacattagag catgagacac cttagttagg agagcaggat gcacatgagg aaatcagcac
     2821 aagagtcagg ttcgtcacca tccatcccac catccagcca gccaggcaga caccctgagc
     2881 aagcagacgg cgccccagct tgcctgtcac ttcagctaat ttattctaga ctcacttaga
     2941 aagccttgac ttgtgctctg tagatggatt ttccctttta ccagcctttc ctctgcaaat
     3001 ttcatattcc gccattcgtt tgtaaagatg ttttcttaaa tgatataaga caaaggattc
     3061 agagtt
//
