LOCUS       NM_001399297            4382 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus WD repeat domain 37 (Wdr37), transcript variant
            1, mRNA.
ACCESSION   NM_001399297 XM_039095765
VERSION     NM_001399297.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4382)
  AUTHORS   Reis,L.M., Sorokina,E.A., Thompson,S., Muheisen,S., Velinov,M.,
            Zamora,C., Aylsworth,A.S. and Semina,E.V.
  TITLE     De Novo Missense Variants in WDR37 Cause a Severe Multisystemic
            Syndrome
  JOURNAL   Am J Hum Genet 105 (2), 425-433 (2019)
   PUBMED   31327510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 6, 2022 this sequence version replaced XM_039095765.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1065650.1,
                                           SRR26360194.1219253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000017.1  66560817-66560994
            179-356             JAXUCZ010000017.1  66569599-66569776
            357-453             JAXUCZ010000017.1  66574247-66574343
            454-549             JAXUCZ010000017.1  66576284-66576379
            550-614             JAXUCZ010000017.1  66576654-66576718
            615-750             JAXUCZ010000017.1  66580517-66580652
            751-822             JAXUCZ010000017.1  66582282-66582353
            823-867             JAXUCZ010000017.1  66585202-66585246
            868-944             JAXUCZ010000017.1  66586956-66587032
            945-1185            JAXUCZ010000017.1  66592656-66592896
            1186-1327           JAXUCZ010000017.1  66594173-66594314
            1328-1462           JAXUCZ010000017.1  66609633-66609767
            1463-1577           JAXUCZ010000017.1  66610193-66610307
            1578-4382           JAXUCZ010000017.1  66611037-66613841
FEATURES             Location/Qualifiers
     source          1..4382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..4382
                     /gene="Wdr37"
                     /note="WD repeat domain 37"
                     /db_xref="GeneID:307075"
                     /db_xref="RGD:1306189"
     exon            1..178
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            179..356
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1709
                     /gene="Wdr37"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 37"
                     /codon_start=1
                     /product="WD repeat-containing protein 37 isoform 1"
                     /protein_id="NP_001386226.1"
                     /db_xref="GeneID:307075"
                     /db_xref="RGD:1306189"
                     /translation="MPTESGSCSTARQAKQKRKSHSLSIRRTNSSEQERTGLPREMLE
                     GQDSKLPSSVRSTLLELFGQIEREFENLYIENLELRREIDSLNERLAGEGQAIDGAEL
                     SKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAICQLVKEYIGHRDGIW
                     DVSVARTQPIVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTAS
                     GDQTAHIWRYVVQLPTPQPVADTSQQISGEDEIECSDKDEPDLDGDVSSDCPTVRVPL
                     TSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTH
                     PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTV
                     KVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRS
                     SRQGHRRMVCCSAWSEDHPICNLFTCGFDRQAIGWNINIPALLQEK"
     exon            357..453
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            454..549
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            550..614
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            615..750
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            751..822
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            823..867
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            868..944
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1185
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1327
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1462
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1577
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..4382
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagttaccg gaagtgcggg cgcgccagtt cgggtcgccg ggtcgtgtca gtgcggtagt
       61 cggccggttt tctttgctgc tctgggtctg tcctgggaac ctcgtcgggg gcggaatcta
      121 cgaattgagt acgacctagg ctggttccag gcggacgcga gtgctgctgc tgtgacagcg
      181 cattgcagga gtgaccagga cactgccttc tagaagtaat gcccacagaa agcggaagtt
      241 gttcaactgc tcgccaagca aaacaaaagc gcaaatctca tagcctttct atacgaagaa
      301 ctaacagctc agaacaagag aggactggac taccaagaga aatgttagaa ggacaagatt
      361 ctaaactacc gtcctcagta cgcagtacac ttttggaact gtttggtcag atagaaagag
      421 aatttgaaaa tctttacatc gaaaacttag aattgcgcag agaaattgat agtcttaatg
      481 aacgtttagc tggtgaagga caagcgattg atggggcaga attgagtaag ggccagctca
      541 aaacaaaagc cagtcacagt actagtcagc tttctcagaa gcttaagacc acctacaagg
      601 cttctaccag caagattgtc tccagcttta agactaccac atccagggcc atctgccagc
      661 ttgtgaagga gtatattggc cacagggacg gcatctggga cgtcagtgtt gcaaggacac
      721 agcctattgt tcttgggaca gcgtctgccg atcacacggc tttgttgtgg agcatagaga
      781 ctggcaaatg tcttgtcaaa tatgccggcc atgtgggctc agtaaattct ataaaattcc
      841 atccctcaga gcagttggcg cttactgctt ctggagatca gactgctcat atttggagat
      901 acgtggtaca gcttccgaca cctcagcctg ttgctgacac tagtcaacag atttctggtg
      961 aagatgaaat agagtgctct gataaagatg agcctgacct tgatggagac gtgtccagtg
     1021 actgccctac tgtccgcgtc ccactgacat ctctcaaaag ccatcagggc gtggttattg
     1081 ctgctgactg gctggttggt gggaaacaag tggtgacagc ctcatgggac agaaccgcca
     1141 acctgtatga tgtggagaca tctgaacttg ttcattctct gacagggcat gaccaggagt
     1201 taacacattg ttgcactcac cccacccagc ggctcgtggt gacctcctcc cgtgacacaa
     1261 ctttccgtct ctgggatttc agggaccctt ccatccactc tgtgaatgtt ttccaaggac
     1321 acacggacac tgtgacctct gctgtgttca ctgtgggaga caacgtcgtt tcaggcagtg
     1381 atgaccgcac agtaaaagtc tgggatttaa aaaatatgag atctccaatt gcaacaattc
     1441 gtacagactc tgccattaat aggatcaatg tatgtgttgg gcaaaaaatc atagctctcc
     1501 cccatgacaa ccggcaagtg cggttgtttg acatgtcagg cgtgcgactg gcacggctcc
     1561 cccggagcag ccgacagggt cacagacgaa tggtgtgctg ctcagcgtgg agtgaagacc
     1621 accccatatg caatctgttt acctgtgggt tcgataggca agctattggt tggaacatca
     1681 atattcctgc actgttacaa gaaaaataag tcactgatgt tccttagctc gaagtttgcc
     1741 atggactttt gattgatgca ggctcttctg catattaatc agccatttta gtgagcgttt
     1801 gaccctggga agggtgcctt gtatatgttc ttttcacatt gtgcccagct tgcatgaagt
     1861 gtacagagag atgtgtgatt ctgtttttat ttttgtcttg tgtatattgg catcctctgg
     1921 tcagtagaag tgaagctcac ctcccacgta gcatacacaa tgctttgagt tcttgatgct
     1981 gagggatgag cagtagggca ttacgttaca ttgtatgaat ccaatgtgaa ctgtgtatcc
     2041 gtgtctggag taactgcaca actgccttgt cctgggaaga ctgcagagct cattcgcata
     2101 ggctagcaag aggcaggaca gacggatttt gtacttggtt tatgtgaagt tgtagaatgc
     2161 gctgtcgtgt aattccattt caactcttga tttctgttcc agttctgtaa aagtaacctg
     2221 gatttgcaac gtttgtgcag aatttctttt gagaagaaaa tgtttctgct attttataga
     2281 aaattatttc aatctcttga ggtctcatac aagcaaattt taaaatacga ttattctaat
     2341 cactgatttt agacattaaa caaaattcaa agcactttaa tttatagctg tggttataaa
     2401 cagtttttag aagtttcaaa tgatttatcc attgaatgtg acttgacctt tatacaaagg
     2461 ccctgctacc tgaagacaaa atcttattta ttttctacat ctttagtttt catattttta
     2521 aatgggttca cttccttggt ggtgtttgag agccaagaat gcaaataaat gagcactacc
     2581 tcaaaataaa tattgggaaa cctttggagt ctcactgctg cctggataag cacttgcttt
     2641 aaagctggaa tactgacttc aaggtagaag gagaaagaca accataccgt atgtaccttg
     2701 acggtgaaag gctctctagg tagccggaag gtgatatcag atagttcaca ggtcttgagc
     2761 agcctggaga cctcttaaac cagtccttct actgcatgag tgagcctttg ttctcgcctt
     2821 ctagagatca ctgttcatct gatgttcgtg agtttgtgtt tcgtacagag ttacagtttt
     2881 gataaagaga catctcagtt actgcccctc gtatcttaat cctgtccata ctgccctttg
     2941 gagagtgacc gtctagggag aagaggagtg atgtatgctg ttatggttac ctcacctcct
     3001 gccctcccct agccctggtt ctctctcggg tggcacagga gggcagctga actactcagt
     3061 ggtaggaatc ggctgtaaga tgtgtaatgt gtaactttcc acgactggga acttggtcat
     3121 tggcatcttt gactcgggcg ccaaagttgc tgatcttagg aactttgtgt ctgactcatt
     3181 tagagagatt ctttgagtaa ttttgttttt tcaacttaaa aaaaaaaaaa aaagaggttg
     3241 tatttttaaa gtctgacctt ttctgatgac aagtctcacc acggcgtatt tgagagctga
     3301 gtcaggctgg tcactgtaga tgactagagt tttaagagcc agctctggct gtcttgaatg
     3361 tatttgcttg atggtggagt actgtatgat gatgttccta gtggcctact tcacagccac
     3421 tgcaggtttc tgtatcccct ccagtccact ctcttcagag ttgttaatgt cggtgacaag
     3481 ccacattctt ctgttcttgg catcttaatc tgaaggtcga ggtatagtta ggagcattga
     3541 gaatgtgcat gcaaatggga gcagcagagt caaacagaag acctacccga tagtcttgga
     3601 gctttagaaa tcgttcctgg tgaccatcga cttgtgtgca gtccagtgat cttcactgcc
     3661 agtggctgct tgttttcttt ggctaactgg agggaccagc ctctgaccca gaatcgaggc
     3721 tcctcactca ttccatgagg gcagaagacc ctaatggtgc tcgatgagag ctcaggagcg
     3781 ggatgtgact tctcttagct gctgttcgtc atctgttctc atcacactgc tgctgtgacc
     3841 acagtgctat ctttaagagt tcgtgactgg cacgggcgtg ggctcatgaa tgttgtaggc
     3901 tggtgtgcat gtggctaaca ataagtcaag ctgtcagcca caagtcctct tatcagaagt
     3961 agtgtttgga actattatgt gctggagtgt ccagaatttc acttaataat ggaggggaaa
     4021 tatgtggtta ctaaatgtgc attaatacaa aatttcccaa gagatttgtt gaacagaata
     4081 tcccagcccc caccgtaacc gatgcatact gatttctgta gagtggaaaa aactttgtac
     4141 atatttggga atctgaagac tatgtaaatc acttgttact taaatctgtg aaaaaaggtt
     4201 gtattttgtt ttgtggtttt ttttttttga gggaaaagtg catttataag tgttctgtgg
     4261 aatcagttat ccttactgta ttgatgtaac tgtttgtaaa cgttcagtgt cttcattgaa
     4321 atacgaagtt cattaaaacc tctgtgttcc ataattacta ttataaagac ttatgttgtt
     4381 ga
//
