LOCUS       NM_001099340            4194 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus WD repeat domain 35 (Wdr35), mRNA.
ACCESSION   NM_001099340 XM_578535
VERSION     NM_001099340.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4194)
  AUTHORS   Takahara,M., Katoh,Y., Nakamura,K., Hirano,T., Sugawa,M.,
            Tsurumi,Y. and Nakayama,K.
  TITLE     Ciliopathy-associated mutations of IFT122 impair ciliary protein
            trafficking but not ciliogenesis
  JOURNAL   Hum Mol Genet 27 (3), 516-528 (2018)
   PUBMED   29220510
REFERENCE   2  (bases 1 to 4194)
  AUTHORS   Hirano,T., Katoh,Y. and Nakayama,K.
  TITLE     Intraflagellar transport-A complex mediates ciliary entry and
            retrograde trafficking of ciliary G protein-coupled receptors
  JOURNAL   Mol Biol Cell 28 (3), 429-439 (2017)
   PUBMED   27932497
REFERENCE   3  (bases 1 to 4194)
  AUTHORS   Caparros-Martin,J.A., De Luca,A., Cartault,F., Aglan,M.,
            Temtamy,S., Otaify,G.A., Mehrez,M., Valencia,M., Vazquez,L.,
            Alessandri,J.L., Nevado,J., Rueda-Arenas,I., Heath,K.E.,
            Digilio,M.C., Dallapiccola,B., Goodship,J.A., Mill,P., Lapunzina,P.
            and Ruiz-Perez,V.L.
  TITLE     Specific variants in WDR35 cause a distinctive form of Ellis-van
            Creveld syndrome by disrupting the recruitment of the EvC complex
            and SMO into the cilium
  JOURNAL   Hum Mol Genet 24 (14), 4126-4137 (2015)
   PUBMED   25908617
REFERENCE   4  (bases 1 to 4194)
  AUTHORS   Fan,J.H., Feng,G.G., Huang,L., Tang,G.D., Jiang,H.X. and Xu,J.
  TITLE     Naofen promotes TNF-alpha-mediated apoptosis of hepatocytes by
            activating caspase-3 in lipopolysaccharide-treated rats
  JOURNAL   World J Gastroenterol 20 (17), 4963-4971 (2014)
   PUBMED   24803807
  REMARK    GeneRIF: TNF-alpha released from Kupffer cells treated with LPS may
            induce hepatic naofen expression, which then stimulates
            hepatocellular apoptosis through activation of caspase-3.
REFERENCE   5  (bases 1 to 4194)
  AUTHORS   Tsunekawa,K., Kondo,F., Okada,T., Feng,G.G., Huang,L., Ishikawa,N.
            and Okada,S.
  TITLE     Enhanced expression of WD repeat-containing protein 35 (WDR35)
            stimulated by domoic acid in rat hippocampus: involvement of
            reactive oxygen species generation and p38 mitogen-activated
            protein kinase activation
  JOURNAL   BMC Neurosci 14, 4 (2013)
   PUBMED   23289926
  REMARK    GeneRIF: The results of this study indicated that domoic acid
            activated AMPA/KA receptors and induced ROS production and p38 MAPK
            phosphorylation, resulting in an increase in the expression of
            WDR35 in vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4194)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 4194)
  AUTHORS   Sato,Y., Feng,G.G., Huang,L., Fan,J.H., Li,C., An,J., Tsunekawa,K.,
            Kurokawa,S., Fujiwara,Y., Komatsu,T., Kondo,F. and Ishikawa,N.
  TITLE     Enhanced expression of naofen in kidney of streptozotocin-induced
            diabetic rats: possible correlation to apoptosis of tubular
            epithelial cells
  JOURNAL   Clin Exp Nephrol 14 (3), 205-212 (2010)
   PUBMED   20224876
  REMARK    GeneRIF: naofen expression may be upregulated by hyperglycemia,
            with possible correlation to apoptosis of tubular epithelial cells
            and thereby to diabetic nephropathy.
            Erratum:[Clin Exp Nephrol. 2010 Jun;14(3):213]
REFERENCE   8  (bases 1 to 4194)
  AUTHORS   Feng,G.G., Li,C., Huang,L., Tsunekawa,K., Sato,Y., Fujiwara,Y.,
            Komatsu,T., Honda,T., Fan,J.H., Goto,H., Koide,T., Hasegawa,T. and
            Ishikawa,N.
  TITLE     Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor
            necrosis factor-induced apoptosis
  JOURNAL   Biochem Biophys Res Commun 394 (1), 153-157 (2010)
   PUBMED   20193664
  REMARK    GeneRIF: These results indicated that naofen may function as a
            novel modulator activating caspase-3, and promoting
            TNF-alpha-stimulated apoptosis.
REFERENCE   9  (bases 1 to 4194)
  AUTHORS   Feng,G.G., Yamada,M., Wongsawatkul,O., Li,C., Huang,L., An,J.,
            Komatsu,T., Fujiwara,Y. and Naohisa,I.
  TITLE     Role of naofen, a novel WD repeat-containing protein, in reducing
            nitric oxide-induced relaxation
  JOURNAL   Clin Exp Pharmacol Physiol 35 (12), 1447-1453 (2008)
   PUBMED   18671723
  REMARK    GeneRIF: Naofen N-terminal protein causes a significant decrease in
            acetylcholine-induced relaxation of aortic strips from normotensive
            rats.
REFERENCE   10 (bases 1 to 4194)
  AUTHORS   An,J., Tsunekawa,K., Feng,G.G., Li,C., Huang,L., Ito,Y.,
            Sugiyama,S., Kurokawa,T., Koide,T., Nonami,T. and Ishikawa,N.
  TITLE     Roles of naofen, a novel WD-repeat-2 protein, in the CCl4-treated
            livers--a possible relationship to cell proliferation
  JOURNAL   Eur J Pharmacol 587 (1-3), 285-290 (2008)
   PUBMED   18472094
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF613262.1.
            
            On Jul 1, 2007 this sequence version replaced XM_578535.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF613262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..4194
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /note="WD repeat domain 35"
                     /db_xref="GeneID:503018"
                     /db_xref="RGD:1564116"
     exon            1..128
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..3617
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /note="naofen"
                     /codon_start=1
                     /product="WD repeat-containing protein 35"
                     /protein_id="NP_001092810.1"
                     /db_xref="GeneID:503018"
                     /db_xref="RGD:1564116"
                     /translation="MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLE
                     TQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYK
                     GSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLC
                     HVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEG
                     YVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKV
                     VTQDKDVNIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPD
                     YKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNNEKYVKYVKSLISITTCGDFCILATKA
                     DENHPQFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEALYTWQYRVAKKLT
                     ALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIV
                     GRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVT
                     DSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYI
                     CNFEDLEIKSVLLDEILKNPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDN
                     PHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKRLGNLQSESMKQAEVIAYF
                     GRFEEAERMYLDMDRRDLAIGLRLKLGDWFRVLQLLKTGSGDADDSLLEQAHNAIGDY
                     FADRQKWMNAVQYYVKGRNQERLAECYYMLEDYEGLENLANSLPENHKLLPEIAQMFV
                     RVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLL
                     EKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHE
                     QMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLY
                     EGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSA
                     EQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKV
                     CKHYVLAQEISNYNFCPLCHSSVE"
     exon            129..246
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            247..318
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            319..411
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            412..540
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            541..674
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            675..840
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            841..986
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1112
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1298
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1359
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1504
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1574
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1628
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1738
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1949
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2030
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2167
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2371
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2518
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2651
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2762
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2927
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3068
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3225
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3466
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..4194
                     /gene="Wdr35"
                     /gene_synonym="RGD1564116"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgggagct tctccgagac accggtgctc gcaaatggag gtgtagaacg cgttatgtat
       61 agcgggcctt ggccgctgcc ggtcatcttc tccgagttcc cacgatgttc ttctacctga
      121 gcaagaaaat cgctgttccc aataatgtga agctgaaatg tatatcctgg aacaaggacc
      181 aagggttcat agcatgtggc ggtgaggacg gattactgaa agttttgaga ttagagacac
      241 agacagatga ctcaaaactg aggggtctag ccgctcctag taacctttcc atgaaccaga
      301 atcttgaagg ccatagcggt gctgttcaag ttgtaacatg gaatgaacag tatcagaagt
      361 tgactaccag tgatcaaaat gggcttatta ttgtctggat gctgtataaa ggttcttggt
      421 acgaggagat gatcaacaat cgcaataagt cggtggttcg aagcatgagc tggaacgctg
      481 atgggcagaa gatctgcatt gtgtacgaag acggagctgt gattgtcggc tcggtagacg
      541 ggaatcggat ttggggtaaa gacctgaagg gaattcagct gtgccatgtg acctggtctg
      601 cagatagtaa gatcctactt tttggaatgg caaatggaga aatacacatt tatgataatc
      661 aaggaaattt tataatgaaa atgaaactga actgcttggt gaacgtcacc ggagcgatca
      721 gtattgctgg gatccattgg taccatggca ccgaaggcta cgtggagccc gattgcccat
      781 gcctggcaat ttgttttgac aacgggagat gccaaataat gagacatgag aatgaccaaa
      841 acccggtgct gatcgacacg ggcatgtatg tggtcggcat ccagtggaac cacattggca
      901 gtgtgttagc tgtggcaggc tcccagaaag tagtcaccca ggacaaggac gtcaacatcg
      961 tgcagtttta cacaccgttt ggcgagcatc taggcaccct gaaagttcca ggaaagcaga
     1021 tgtgctctct gtcctgggaa ggaggcggac tgaagattgc tctagctgtt gactccttta
     1081 tatattttgc aaatatccga cctgattata agtggggcta ttgttccaac actgtggttt
     1141 atgcatacac cagacccgat cgtccagagt actgtgttgt tttctgggac acaaaaaaca
     1201 atgagaaata tgttaaatat gtgaagagtc tcatttctat caccacgtgt ggcgatttct
     1261 gcattttggc cacaaaagct gatgaaaatc accctcagtt tgtgcttgtt ctttgcaatt
     1321 ctattggcac acccttggac cctaaataca ttgatcttgt gccactgttt gttgcaatga
     1381 ccaagaccca tgtgatagca gcttcaaagg aagcgcttta tacctggcaa tatcgtgtgg
     1441 caaagaagct cacagcgttg gaaattaatc agatcacacg gtctcgaaaa gaaggaagag
     1501 aaagaattta tcatgttgac gatgttcctt ctggatctgt ggatggggtg tttgattata
     1561 gtaaagccat tcaaggtacg agggatccaa tttgtgccat aactgcatct gataagacat
     1621 tgattgtggg ccgtgaatct ggcgtcatcc agaggtacag ctttcccaat gttgctttga
     1681 ttcaaaagta ttctctggat tgccgagcct gccagttatc tctgaactgc aactccagtc
     1741 gccttgccat cattgacatc gcgggagtct tgacattctt tgacttggac actcgggtga
     1801 cagacagtac agggcagcaa gttgttggcg agttgctaaa actggagcgc aaagatgtct
     1861 gggatatgaa atgggccaag gacaatcccg atttgtttgc aatgatggag aagacaagaa
     1921 tgtatgtctt cagaaacttg gatcctgagg aacccattca gacctctggc tatatttgca
     1981 actttgagga tttggaaatt aaatctgtgc tcttggatga gatacttaag aacccagagc
     2041 accctagcaa ggattacata atgaattttg agatccggtc ccttcgagat agccgagcgt
     2101 tgatcgagaa agttggaatt gaagatgcgt ctcaattcat agaggacaat ccacatcctc
     2161 gactttggcg cctgttggct gaagctgccc tgcagaagct ggacttgtac accgcgcagc
     2221 aagcatttgt acgctgtaag gattatcaag gcatcaaatt tgtgaagcgc ctgggcaacc
     2281 tgcagagtga gtccatgaag caggctgaag ttattgccta ctttggcagg ttcgaagagg
     2341 ccgaaagaat gtatctagac atggacagaa gagaccttgc tattggtctg aggctgaaat
     2401 tgggggactg gttcagagta ctgcaactcc tgaaaactgg atctggtgac gcagacgaca
     2461 gtctcctgga acaagcccac aatgccattg gagactactt tgctgatcga cagaagtgga
     2521 tgaatgctgt acaatattat gtgaaaggca ggaaccagga gcgcctagcc gaatgctatt
     2581 atatgctaga agattacgag gggttagaga atcttgccaa ttcacttcca gaaaaccaca
     2641 agttacttcc agaaatagcc cagatgtttg tgagagttgg aatgtgtgag caagcagtca
     2701 gcgcgttcct gaagtgtaac cagccaaagg cagcggtgga cacctgcgta cacctgaatc
     2761 agtggaacaa ggctgttgaa ctggctaaaa gtcacagcat gaaggaaatc gggtctctgt
     2821 tagctcgcta cgcgtcacat ctgctggaga agaacaagac gctcgatgcc attgaactct
     2881 ataggaaagc cagctacttt ttcgatgccg ctaaactgat gtataagatt gcagatgaag
     2941 aggcgaagaa gaggacgaag cctttgcgtg tgaagaagct gtacgtgctg tcagccctgc
     3001 tcattgagca gtatcatgag cagatgaaaa acgcccagcg cgggaaagtt aaaggcaaga
     3061 actcagaggc cacttctgct ttggctggct tgctagaaga ggaggttctc tctacaacta
     3121 gtcggttcac tgataatgct tggagaggag cagaggccta ccatttcttt atactcgctc
     3181 agcggcagct ctacgaggga tacgtcgaca ccgcgctgaa gacagctctt cacctgagag
     3241 actatgaaga catcatcccc tcagttgaga tctactctct gttagctctc tgtgcttgtg
     3301 caagcagagc tttcgggacc tgttcaaaag cttttattaa actggagtct ttagagacgc
     3361 tcagtgctga acagaagcag caatatgaag acctggctct ggaaattttc accaaacaca
     3421 cgccaaaaga caacaggaag tctgagttga acagccttct tgaaggtggg gaaggcaaac
     3481 tgccaacatg tattgccact ggaagcccga tcattgagta ccagttctgg gtgtgcaaag
     3541 tgtgcaagca ctatgttctt gctcaggaaa tcagtaacta taacttttgc cctctgtgcc
     3601 acagttcggt agaataaagg aaagaagggt ctcaactgta aagtacacag agcatatatc
     3661 ctttctgcac ctgaatatac catagtgctt aatttcctta ggtttcctat gaaaatcagc
     3721 ttcatcatct gctagttgta tttttgtata aaatatatat cacgaaggaa taaaaataaa
     3781 aggggggctg gattgtgctc agtggtagag tgctttccaa gcatgcacaa cgtcctgggt
     3841 ccactgtcag tatcggaaac agatagttca tacatcacgg tgcaactatg aaataacttg
     3901 attattttca cataagtctt acagatgtga acttatattt tttgtagttc ctgtctgtcc
     3961 attttctatt tatataaatt atagtttgtg taagttacca cagaaatact ctcaaccaga
     4021 aatagttctc tcttgttaag gttagagaac tcacttagtt cttagagtac tacttagaga
     4081 accctgggga ggtagacggg agtggaggag ggtcggggtg ggggcagact tgaagcagag
     4141 agttcatata gcttgtattt cagggaggtg aagcaactag cgcatgacat gagc
//
