LOCUS       NM_001109081            6597 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus WD repeat domain 26 (Wdr26), transcript variant
            1, mRNA.
ACCESSION   NM_001109081 XM_001062709 XM_039090993 XM_573529
VERSION     NM_001109081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6597)
  AUTHORS   Liu,Y., Zhao,Y., Li,K., Miao,S., Xu,Y. and Zhao,J.
  TITLE     WD-40 repeat protein 26 protects against oxidative stress-induced
            injury in astrocytes via Nrf2/HO-1 pathways
  JOURNAL   Mol Biol Rep 49 (2), 1045-1056 (2022)
   PUBMED   34981336
  REMARK    GeneRIF: WD-40 repeat protein 26 protects against oxidative
            stress-induced injury in astrocytes via Nrf2/HO-1 pathways.
REFERENCE   2  (bases 1 to 6597)
  AUTHORS   Lampert,F., Stafa,D., Goga,A., Soste,M.V., Gilberto,S., Olieric,N.,
            Picotti,P., Stoffel,M. and Peter,M.
  TITLE     The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell
            proliferation and targets the transcription factor Hbp1 for
            degradation
  JOURNAL   Elife 7, e35528 (2018)
   PUBMED   29911972
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6597)
  AUTHORS   Jiang,L., Wang,H., Chen,G., Feng,Y., Zou,J., Liu,M., Liu,K.,
            Wang,N., Zhang,H., Wang,K. and Xiao,X.
  TITLE     WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression
            levels in H9c2 cells
  JOURNAL   Free Radic Biol Med 117, 58-65 (2018)
   PUBMED   29253592
  REMARK    GeneRIF: Our research suggests that the protective effect of the
            WDR26 isoform, MIP2, on the cardiomyocytes against oxidative stress
            is partly associated with its interaction with VDAC1 and thus
            inhibiting its expression
REFERENCE   4  (bases 1 to 6597)
  AUTHORS   Feng,Y., Zhao,J., Hou,H., Zhang,H., Jiao,Y., Wang,J., Wang,Y. and
            Sun,Y.
  TITLE     WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia
            through Parkin translocation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 48 (12), 1075-1084 (2016)
   PUBMED   27797717
  REMARK    GeneRIF: After Parkin is translocated at mitochondria, WDR26 can
            increase mitochondrial protein ubiquitination in hypoxia of H9c2
            cells. WDR26 is a mediator of response to hypoxia, and WDR26 plays
            an important role in hypoxia-mediated autophagy and mitophagy
REFERENCE   5  (bases 1 to 6597)
  AUTHORS   Zhu,Y., Wang,Y., Xia,C., Li,D., Li,Y., Zeng,W., Yuan,W., Liu,H.,
            Zhu,C., Wu,X. and Liu,M.
  TITLE     WDR26: a novel Gbeta-like protein, suppresses MAPK signaling
            pathway
  JOURNAL   J Cell Biochem 93 (3), 579-587 (2004)
   PUBMED   15378603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            [WARNING] On Jan 22, 2025 this sequence was replaced by
            NM_001109081.3.
            
            On or before Feb 11, 2022 this sequence version replaced
            XM_039090993.1, NM_001109081.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.42319.1,
                                           SRR26643296.32459.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               JAXUCZ010000013.1  95502923-95503430   c
            509-608             JAXUCZ010000013.1  95501088-95501187   c
            609-713             JAXUCZ010000013.1  95500887-95500991   c
            714-850             JAXUCZ010000013.1  95495433-95495569   c
            851-948             JAXUCZ010000013.1  95492228-95492325   c
            949-1105            JAXUCZ010000013.1  95490914-95491070   c
            1106-1244           JAXUCZ010000013.1  95485303-95485441   c
            1245-1385           JAXUCZ010000013.1  95478523-95478663   c
            1386-1505           JAXUCZ010000013.1  95475543-95475662   c
            1506-1651           JAXUCZ010000013.1  95473561-95473706   c
            1652-1730           JAXUCZ010000013.1  95473049-95473127   c
            1731-1860           JAXUCZ010000013.1  95471982-95472111   c
            1861-2046           JAXUCZ010000013.1  95469907-95470092   c
            2047-6597           JAXUCZ010000013.1  95462020-95466570   c
FEATURES             Location/Qualifiers
     source          1..6597
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..6597
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /note="WD repeat domain 26"
                     /db_xref="GeneID:498301"
                     /db_xref="RGD:1565589"
     exon            1..508
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2072
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 26"
                     /codon_start=1
                     /product="WD repeat-containing protein 26 isoform 1"
                     /protein_id="NP_001102551.2"
                     /db_xref="GeneID:498301"
                     /db_xref="RGD:1565589"
                     /translation="MQANGAGGGGGGGGGGQGQTPELACLSAQNGESSPSATSAGDLA
                     HANGLLPAAPSAAGNNSNSLSVNNGVPGGAAAASATAAAAQATPELGSSLKKKKRLSQ
                     SDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLN
                     ELKPLVHSPHAIVVRGALEISQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQVLRC
                     ELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGAASRSKLLDKLQTYLPPSVML
                     PPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQFPCYTQQILTEH
                     CNEVWFCKFSNDGTKLATGSKDTTVIVWQVDADTHLLKLLKTLEGHAYGVSYIAWSPD
                     DSYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQF
                     YQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHP
                     IMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFI
                     ASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPA
                     PFIDHQNIEEECSSMDS"
     exon            509..608
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            609..713
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            714..850
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            851..948
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1105
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1244
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1385
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1505
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1651
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1730
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1860
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2046
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..6597
                     /gene="Wdr26"
                     /gene_synonym="RGD1565589"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcggccgg ccgagcaggc ctcccccccc cgccctcgcc ctcgccggcc gcctcctcct
       61 ccgtggtggt ggtggtggga ctgcctccgg ccgcccccgc cgccccgcag cggagcagcg
      121 gccacagcct ggtcagcggc ggcaccatgc aggccaacgg ggcgggagga ggcggcggcg
      181 ggggcggcgg gggccagggc cagaccccgg agctcgcctg cctgtcggcg cagaacgggg
      241 agtcatcccc ctcggcgacg tccgcggggg acctggccca cgccaacggg ctcctgcctg
      301 ccgccccctc cgccgctggc aacaatagca acagcctgag tgtcaataac ggggttcccg
      361 gcggggccgc cgcggcctcc gccaccgccg ccgccgccca ggccaccccg gagctgggca
      421 gcagcctcaa gaagaagaag cggctctcgc agtccgatga ggatgtcatt aggctcatag
      481 gacagcacct caatggccta gggctcaacc agactgttga tctcctcatg caagagtcag
      541 gatgtcgttt agagcatcct tctgctacca aattccgaaa tcatgtcatg gaaggagact
      601 gggataaggc agaaaatgac ctgaatgaac taaagccttt agtgcattct cctcatgcta
      661 ttgtggtaag aggcgcactt gaaatctctc aaacgttgtt gggaataatt gtgaggatga
      721 agtttctgct gctgcagcag aagtacctgg aatacctgga ggacggcaag gtcctggagg
      781 cacttcaagt tctacgctgc gaactgacgc cgttgaaata caacacagag cgcatccatg
      841 ttcttagtgg gtatctgatg tgtagccatg cagaagacct gcgggcaaaa gctgaatggg
      901 aaggaaaggg ggcagcttcg agatccaaac tgctggacaa gcttcagacc tatttaccac
      961 catcagtgat gcttccccca cggcgtttac agactctcct gcggcaggca gtggaactac
     1021 aaagggatcg gtgcctatat cacaatacca aacttgacaa caatctagat tctgtgtctc
     1081 tactcataga tcatgtttgt agtaggaggc agtttccctg ttacactcag cagatactga
     1141 cagagcattg taatgaagtg tggttctgta aattctccaa tgatggcact aaactcgcaa
     1201 caggctcaaa ggacaccaca gtgatcgtat ggcaagttga tgcggataca cacctgttaa
     1261 aactgcttaa aacgttagaa ggacatgcgt atggtgtctc ttacatagca tggagtccag
     1321 atgacagcta ccttgttgct tgtggtccag acgactgctc tgagctttgg ctttggaatg
     1381 tacaaacggg agaattaaga acaaaaatga gccaatctca tgaagatagt ctgaccagtg
     1441 tagcctggaa tccagatggg aaacgctttg tgacgggagg tcagcgcggc cagttctacc
     1501 agtgcgacct ggatggaaat cttctggact cctgggaggg agtgcgagtg caatgcctgt
     1561 ggtgcttgag tgacgggaag actgtgctgg cttctgacac acaccagaga atccggggct
     1621 acaacttcga ggacctgaca gatagaaaca tagtacaaga ggatcatcct attatgtcat
     1681 ttactatttc aaaaaacggc cgactagctt tgttaaatgt agcaactcag ggagttcatt
     1741 tatgggactt gcaagacaga gttttagtaa ggaaatatca aggtgttaca caagggtttt
     1801 atacaattca ttcgtgcttt ggaggccata atgaagactt catcgctagt ggcagtgaag
     1861 atcacaaggt ttacatctgg cacaaacgta gcgaactgcc cattgcggag ctcacagggc
     1921 acacgcgcac agtaaattgt gttagctgga acccacagat cccatccatg atggccagcg
     1981 cctcagacga tggcactgtt agaatatggg gaccagcgcc tttcatagac caccagaata
     2041 ttgaagagga atgcagtagc atggatagtt gatggcgaat ttggagcaga cgacttctgt
     2101 ttaacttaaa attagtcgta ttttaatggc ttgggatttg gtgcaaacaa acatgattga
     2161 tagctggaca gacatgctcg tcgtgaaaaa agaaccattt tgaagcccga ttggggccaa
     2221 acatttacac cttgcttcat agtaaccagt gatgaagcac gtctttagaa cgttgttgga
     2281 caccatgttg aattatcccc atcggttgtg aagaactgtg ctacattcag gcttacccat
     2341 tgaactcagt atatatattt tccctcctgc cttttgtctg gtgggatacc attcttgttg
     2401 ctcttctgtg taatgaagtt caaatgcttg tttggaaact ttatttaaca gtttagaagg
     2461 cttgatagga agagttcatt agtctgaaga gtatacattg gacaggaaag aatttccttt
     2521 tgtttctcca aatctttccg ccttatttag cttgagatct ttgcagcttg gttcatggat
     2581 tctagccttg cccgttgcgc agtatatact gatcagatga taaaccagtg aactatgtct
     2641 aaagcactct caatattaca tttgacaaaa agttttgtac ttttcacata gcttgttgcc
     2701 ccgtaaaagg gttaacagca caatttttta aaaataaatt aagaagtatt tataggatta
     2761 aagtgacttc atttgtatac atttgaaatc taaaccagct taaaaacagt gtcctctgtg
     2821 actgagatac gcagtgtaac cgatgctgtt ctgagtgcca cgtgagacat ggcatggtca
     2881 gaaagtgttc acaaggacat ggcacaggaa agccagaaag atactctgaa ggttccccct
     2941 ttttattttc ttcccgaagg aacatcagta cacaatactg aagaaattca agattcaaaa
     3001 aggaaaattt tataaataaa catgggagat cagcatcagt ctaggttttc aagacagctt
     3061 gtaccaagtt cttctgaact tgcaggaatc attttggtgt gatctagcaa aagtagacat
     3121 caggagatag acccacttcg gggattggta gtgtagttga attttgaatc gtagaggaat
     3181 tcagcaggct ccgaacatga aactggaatt aaagcctgaa tcgtttctcc taatggccct
     3241 taatgtccaa catatgtagg gacactcatt taagaagatt ccttctcagc ttctcagatg
     3301 ttgccataat gaacctcatt caaactggtg ctgtggacag tctttccctc tcctcccctt
     3361 tagttcacgg gaatgtttcc tttatggaag aaaagactac tcattttgaa aaccttctag
     3421 ctaacataag cccaactgat gttcatgatg cgctttaaac ctcataactg ttgggtctaa
     3481 cagtttccct cgaaatccat gttttccaat cggggataac cagggtgacc acagctattg
     3541 gaaagtggaa ttactcccaa tgtattctgg tgaacaaaaa aaagaaaatc ttgtacaact
     3601 tgcccttgag gccaagccaa gtccatagca tttgccatga tcacaccctt caggaccctg
     3661 agaagagcca ggcctgtact gaggagtctt cccactgtgg gggtcatagg aagggaaaag
     3721 ctaggaagtg ggagaagaaa acacatttgg ccttaagata gtgttcattc tcccaaagcc
     3781 acagtaagga gatgacagat catagtcagc agattattaa ttcgaatggg tatgtaagag
     3841 aatcctttaa gcatcatttt tcaaagacca ccactttaga aaatcaaaga aatcctgttt
     3901 tgatacttct tagttaaaat aatatgttac cgtttatctg gtacttcatt ttcttgacta
     3961 aaattacttt tcactttaag cttgaataaa aattttcatt cataactgta tataattaag
     4021 tggcaactcc tctttacctc agtgcagtta aaaccatctt ttgattgata taccctgaag
     4081 ccattaaccc acatacccca gtctctacag taacaatcac taacaacgtg tgggtgtaga
     4141 actccacagc tctttacaga tgtggttaca ttgtactatg tggcacatac atagtgttcc
     4201 ctgaggtttg tacccagcag ggcagttggc ccttatgttc tgctagcaca cccggctgca
     4261 cctagatctg agttttcaca gtgcttctga agtacattta aaacaccaaa ggtgagggac
     4321 atcagcagaa cataaccctg ttagagggga gttagagcta tgcagagctg ttcatagaag
     4381 ctaggtgagt ttgggttcca ggtctgtcat agctggcagc ttcctctaga gactgctact
     4441 tgaccgtgcc aatgtgctgt aagcgtctgt ttcgtacact tgccatgaat tgagtgtggt
     4501 agagaggtgg tgaagagacc tagggtttgt ggtggaagag cctggtggca ggagttaagt
     4561 gagggtctct gacaatgtgc taactctagg aaggcttgag agaatcctgt caggcctgcc
     4621 acaaggcgct agccaatgtc tgagctgaaa agtaccaaga ctttttgcac atagatcaaa
     4681 gtagtggaga attttgcctc caaaaatcag gttagtaggc tcaactccat gtgcttgaaa
     4741 tgcttttgtt gttaatgcat cgattaaggg ctagagtaag aatgaaatta aatgtctctt
     4801 tcctctaaat aactggttct tagtggtaaa gtgttggatt cggggatcac tgaggttggt
     4861 ttgtgggtgg tgatggaaag aatcggagag ggagtgagtt aggggagatt tgggttttga
     4921 ttctaactag tattcatgcc agctgtatgg cgctgctctt cctggccaga taaatgttct
     4981 ggtaacccag gtaagtggtc ataacaggac attttatttg caaatgtccc cataaattga
     5041 ctcattttat tgggtgggag aacaaaaaat ggaattctct gaattataag taattaaatt
     5101 aacctgctag ggaaaccgaa acagtaattc tgcaagatta gtcaattagg agtgcactgc
     5161 ctcaactggc gttctgtggc attaatagaa aattctttcc ccacccctcc ccgtcttgaa
     5221 attttctttt ttaggatgtt ggttcctgca aacaagaact gacccctgcc tcccagtggg
     5281 tgcatgtctt gcacacctct catcgcttac tttacagcag aaggatggga ggaaagaaga
     5341 taaattgtct taagatccgt tgttcccatt tctaaaaaca catttttact tagtaatttt
     5401 actttaatgt ctcatttaga cttcaccaac tctccctttg tgttgctggc caaagcatta
     5461 ccaccatttc caaaaccata cctgatttca cataaactgc taacttaaaa gaggtgaatt
     5521 tgcagttaca cttagacact ttctaaaaac agggtgagac caacctgaac tttgcagtgt
     5581 tgagttactg tcatagcagc tgccctagag ttgcaaaaac ccatccctat ctacttaatc
     5641 cagattgcct ggatttaatg aagttaatcg tataaaagtg tgtgtgtgtg tgtgtgtgtg
     5701 tgtgtgtgtg tgtgtgtgtg tgtgtgtgta agtgtgtaag aaagaacgat tcataaaata
     5761 tactaggaac aatttttagg ttgtcatttt tactgaacgt cttgtgcaca tgtaaagtac
     5821 tctcaagttt aaggcttggt taatacttgt ctatttttat aagaatgaaa ttgtgtccca
     5881 tctttaactt agacatttac attatcagga tcaacatgct agaattaaat caacatttat
     5941 aggctcgatg gtaatgttat tggcccctag agagggtggg gggagagaaa gaggggagag
     6001 agagcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta
     6061 gggagataga tcacaaaggc atgtatatgc ttataaacca agctgtagag atcatgtaaa
     6121 gaacctgggt gctgctccag agatctctga gctgtggaaa gtgctaaggc attgtggtgt
     6181 gtgtagctaa cagagctgtt ggtatggagt taaccatgga ctgataagat gttgccagag
     6241 gattgtgttc ttaaactttg gggtttgctt tttaactgcc tctcagatta tatttagtag
     6301 tttaaatttc tttgttttat tatttcatta aagtataaaa acttcaggtc ttatatttat
     6361 tttcacttgt tctactaatt atttacaaga caccttttgg ttgacattta ttttataaat
     6421 gtgtggtata ttaaatgtct ttaatttttt tgttttactg aaattacagt aactttgatt
     6481 tgctttcctg ggattttgaa atttcgtttg aattccacct tttccatgtc agtgcccagc
     6541 acttgcccag tctttgtatt ccctctgtcg attcaataaa cagaatgagt aatgaag
//
