LOCUS       NM_199410               2520 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus WD repeat domain 12 (Wdr12), transcript variant
            1, mRNA.
ACCESSION   NM_199410 XM_017596519 XM_343577
VERSION     NM_199410.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Moilanen,A.M., Rysa,J., Kaikkonen,L., Karvonen,T., Mustonen,E.,
            Serpi,R., Szabo,Z., Tenhunen,O., Bagyura,Z., Napankangas,J.,
            Ohukainen,P., Tavi,P., Kerkela,R., Leosdottir,M., Wahlstrand,B.,
            Hedner,T., Melander,O. and Ruskoaho,H.
  TITLE     WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in
            Failing Hearts and Causes Deterioration of Cardiac Function
  JOURNAL   PLoS One 10 (4), e0124907 (2015)
   PUBMED   25915632
  REMARK    GeneRIF: WDR12 triggers distinct deterioration of cardiac function
            in adult rat heart.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   Rohrmoser,M., Holzel,M., Grimm,T., Malamoussi,A., Harasim,T.,
            Orban,M., Pfisterer,I., Gruber-Eber,A., Kremmer,E. and Eick,D.
  TITLE     Interdependence of Pes1, Bop1, and WDR12 controls nucleolar
            localization and assembly of the PeBoW complex required for
            maturation of the 60S ribosomal subunit
  JOURNAL   Mol Cell Biol 27 (10), 3682-3694 (2007)
   PUBMED   17353269
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Grimm,T., Holzel,M., Rohrmoser,M., Harasim,T., Malamoussi,A.,
            Gruber-Eber,A., Kremmer,E. and Eick,D.
  TITLE     Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and
            cell proliferation via incorporation into the PeBoW-complex
  JOURNAL   Nucleic Acids Res 34 (10), 3030-3043 (2006)
   PUBMED   16738141
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Holzel,M., Rohrmoser,M., Schlee,M., Grimm,T., Harasim,T.,
            Malamoussi,A., Gruber-Eber,A., Kremmer,E., Hiddemann,W.,
            Bornkamm,G.W. and Eick,D.
  TITLE     Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is
            required for ribosome biogenesis and cell proliferation
  JOURNAL   J Cell Biol 170 (3), 367-378 (2005)
   PUBMED   16043514
REFERENCE   5  (bases 1 to 2520)
  AUTHORS   Nal,B., Mohr,E., Silva,M.I., Tagett,R., Navarro,C., Carroll,P.,
            Depetris,D., Verthuy,C., Jordan,B.R. and Ferrier,P.
  TITLE     Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a
            notchless-like amino-terminal domain
  JOURNAL   Genomics 79 (1), 77-86 (2002)
   PUBMED   11827460
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Mar 19, 2021 this sequence version replaced
            XM_017596519.2, NM_199410.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1991871.1,
                                           SRR26360186.667772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-606               JAXUCZ010000009.1  68996206-68996811   c
            607-828             JAXUCZ010000009.1  68995855-68996076   c
            829-923             JAXUCZ010000009.1  68993016-68993110   c
            924-1018            JAXUCZ010000009.1  68982618-68982712   c
            1019-1125           JAXUCZ010000009.1  68980931-68981037   c
            1126-1241           JAXUCZ010000009.1  68979663-68979778   c
            1242-1396           JAXUCZ010000009.1  68978776-68978930   c
            1397-1442           JAXUCZ010000009.1  68977501-68977546   c
            1443-1528           JAXUCZ010000009.1  68976555-68976640   c
            1529-1669           JAXUCZ010000009.1  68975280-68975420   c
            1670-1775           JAXUCZ010000009.1  68975066-68975171   c
            1776-1908           JAXUCZ010000009.1  68974809-68974941   c
            1909-1981           JAXUCZ010000009.1  68972264-68972336   c
            1982-2520           JAXUCZ010000009.1  68969547-68970085   c
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..2520
                     /gene="Wdr12"
                     /note="WD repeat domain 12"
                     /db_xref="GeneID:363237"
                     /db_xref="RGD:735072"
     exon            1..606
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            607..828
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     CDS             788..2059
                     /gene="Wdr12"
                     /note="WD repeat-containing protein 12"
                     /codon_start=1
                     /product="ribosome biogenesis protein WDR12"
                     /protein_id="NP_955442.1"
                     /db_xref="GeneID:363237"
                     /db_xref="RGD:735072"
                     /translation="MAQLQARFYTENKKYAVDDVPFSIPATSEVADLSNIINKLLETK
                     NELHKHVEFDFLIKGQFLRMPLVKHMELEDISSEEVVELEYVEKYTAPQPEQCMFHDD
                     WISSIKGAEEWILSGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLT
                     ASMDQTILLWEWNIERNKVKALHCCRGHAGSVDAIAVDSSGTKFCSGSWDKMLKIWST
                     VPTDEEDEIQEPTNRPRKKQKTEQLGLTRTPLVTLSGHTEAISSVLWSDADEVCSASW
                     DHTVRVWDVESGGLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLV
                     SLSLTSHTGWVTSVKWSPTHDQQLISGSLDNMVKLWDTRSCKAPLYDLAAHEDKVLSV
                     DWTDTGLLLSGGADNKLYSYRYSPTTSHVGA"
     exon            829..923
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1018
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1125
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1241
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1396
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1442
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1528
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1669
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1775
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1908
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1981
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2520
                     /gene="Wdr12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggttgg gagggagcgt ccggtctgtg ggcgcggaca gctctgccag acctctggct
       61 cctccaaccc tgccgccgca gtgagcccca caacgcgaga ggggagtccg ccgtagcaga
      121 agggagaaaa ttcaaaacga gactactcaa cctcgtcttg gctccgaggc cccgccgtgg
      181 agaccaccac aatgcgcagg cgcaactctc cgggaggcgc agcgcaggct catcagattg
      241 gacccgtctc ggccaccgtc gcccagttcc cttccgattc cttctccctt ctcgtgtttc
      301 cgctctgaag tctgaggtaa aaacacatgg tctcagctca atctggctgt tggaacgatt
      361 catagaaaac gaactggtgg agcctttgtc actcagatta aagaagcagg aagtgtaata
      421 tctgcccaga gaagggagtt ttaaaagcgg atgtaagaac ctaagagcga tgtggcaaag
      481 taaataaaac ctacaactcc cagtgttcag agggtctgaa acgcgcttcc tgctggggtt
      541 tgtagtatct gagcgctgag tctaaagggt ctgggtctaa cgacaccctc aaaaattagg
      601 ttcaaggtat ttgatgtgtg cgggctgggc accggtggaa atagaacctc gtggtatggt
      661 ctgtagaaac ccgaggaaga taactgaagc ctgtcttcta ctgcgctcga ggtgcagtct
      721 accttagagc tacttgatta tcggcgcata catttttgtg gagaagcctc gttgtatact
      781 ttctgccatg gcacaactcc aggcacgttt ctacacggag aacaagaaat atgcagtaga
      841 tgatgttcct ttctcaatcc ctgccacctc agaagttgct gaccttagta atattatcaa
      901 taaattgctg gagaccaaaa atgagctcca caaacatgtc gagtttgatt tcctcatcaa
      961 gggccagttt cttcgaatgc ccttggtcaa acacatggaa ctggaagaca tttcatcgga
     1021 agaggttgtg gaactagaat atgtggaaaa atacaccgca ccccagccag agcaatgcat
     1081 gttccacgat gactggatca gctcaattaa aggggcagaa gaatggatcc tgtctggttc
     1141 ttatgataag acttctcgaa tctggtcctt ggaaggaaag tcaataatga caattgtggg
     1201 acatacagat gttgtgaaag atgtggcttg ggtgaaaaaa gacagtctgt cttgcctact
     1261 cctgacggcc tcgatggacc agactattct cttatgggag tggaacatag agaggaacaa
     1321 agtgaaggct cttcactgct gcagagggca tgctgggagt gtggacgcca tagcagttga
     1381 tagctctgga actaaattct gcagtggctc ctgggataag atgctgaaga tctggtctac
     1441 agtccctaca gatgaggaag atgaaataca agaacccaca aatcgaccaa gaaagaagca
     1501 gaaaacagaa caattgggac tgacaagaac acccttggtg accctctctg gccacacaga
     1561 agcaatttcc tcagtactct ggtcagatgc tgacgaagtc tgcagtgcct cttgggatca
     1621 cacagtcaga gtgtgggatg ttgagtccgg aggtcttaag tcaactctga caggaaataa
     1681 ggtgttcaat tgtatttcct attctcccct ctgtaaacgt ttggcgtctg gaagcacaga
     1741 caggcacatt aggctgtggg atccccgaac taaagatggc tctttggtgt cgctgtccct
     1801 cacctcacat acaggctggg taacatcagt gaagtggtca cctacccatg atcagcagct
     1861 gatctcaggc tctttagata acatggtgaa gctatgggat acgagaagtt gtaaggctcc
     1921 tctctacgac ctagctgcac atgaagacaa agttctaagt gtggactgga cagacacagg
     1981 gctacttctg agtggaggag cagacaataa attgtattcc tacagatatt cccctaccac
     2041 ttcccatgtg ggggcttgaa aatgaatggc tgataagaga ctttcttgtt gcgttttgtt
     2101 ttaattctta gtgtctcact gttgtgttat aaactgtgaa tggaatggga aagagcgttt
     2161 ggaatgtagc tcagctggta gagtgcttgc ctgagattgc agagccctgt gctctctcca
     2221 gcactgtgca agagcagtgg gcatgtcggt gcattcctga aatcccaggc cctgaaaggt
     2281 tggaaacaga gtcagaagtt caaggccacc ctcagtgagg cagccagctt cagtcactcg
     2341 gctctgtctc aggaagaaag aaatctgtgg ataacctctg ataccattgt caatgcaggg
     2401 acaggaagca gccgtttaaa cttggataac agttcatcat tcataatagc tacattttac
     2461 tatgtttgtc ctccatgttt ataaagtaca ataaatgtgt ggcctgaatt ctccacccca
//
