LOCUS       NM_001014135            2844 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus WD repeat domain 1 (Wdr1), mRNA.
ACCESSION   NM_001014135 XM_341228
VERSION     NM_001014135.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2844)
  AUTHORS   Lechuga,S., Baranwal,S. and Ivanov,A.I.
  TITLE     Actin-interacting protein 1 controls assembly and permeability of
            intestinal epithelial apical junctions
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (9), G745-G756 (2015)
   PUBMED   25792565
REFERENCE   2  (bases 1 to 2844)
  AUTHORS   Luxenburg,C., Heller,E., Pasolli,H.A., Chai,S., Nikolova,M.,
            Stokes,N. and Fuchs,E.
  TITLE     Wdr1-mediated cell shape dynamics and cortical tension are
            essential for epidermal planar cell polarity
  JOURNAL   Nat Cell Biol 17 (5), 592-604 (2015)
   PUBMED   25915128
REFERENCE   3  (bases 1 to 2844)
  AUTHORS   Yuan,B., Wan,P., Chu,D., Nie,J., Cao,Y., Luo,W., Lu,S., Chen,J. and
            Yang,Z.
  TITLE     A cardiomyocyte-specific Wdr1 knockout demonstrates essential
            functional roles for actin disassembly during myocardial growth and
            maintenance in mice
  JOURNAL   Am J Pathol 184 (7), 1967-1980 (2014)
   PUBMED   24840128
REFERENCE   4  (bases 1 to 2844)
  AUTHORS   Song,J.J., Adler,H.J., Lee,H.S., Jang,J.H., Park,M.H., Lee,J.H.,
            Chang,S.O. and Oh,S.H.
  TITLE     WDR1 expression in normal and noise-damaged Sprague-Dawley rat
            cochleae
  JOURNAL   J Comp Neurol 521 (7), 1470-1481 (2013)
   PUBMED   22821633
  REMARK    GeneRIF: elevated WDR1 expression after acoustic overstimulation in
            the current experiments may provide a mechanism for protection
            against noise exposure.
REFERENCE   5  (bases 1 to 2844)
  AUTHORS   Doukhanine,E., Gavino,C., Haines,J.D., Almazan,G. and Richard,S.
  TITLE     The QKI-6 RNA binding protein regulates actin-interacting protein-1
            mRNA stability during oligodendrocyte differentiation
  JOURNAL   Mol Biol Cell 21 (17), 3029-3040 (2010)
   PUBMED   20631256
REFERENCE   6  (bases 1 to 2844)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2844)
  AUTHORS   Kile,B.T., Panopoulos,A.D., Stirzaker,R.A., Hacking,D.F.,
            Tahtamouni,L.H., Willson,T.A., Mielke,L.A., Henley,K.J.,
            Zhang,J.G., Wicks,I.P., Stevenson,W.S., Nurden,P., Watowich,S.S.
            and Justice,M.J.
  TITLE     Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory
            disease and macrothrombocytopenia
  JOURNAL   Blood 110 (7), 2371-2380 (2007)
   PUBMED   17515402
REFERENCE   8  (bases 1 to 2844)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   9  (bases 1 to 2844)
  AUTHORS   Fujibuchi,T., Abe,Y., Takeuchi,T., Imai,Y., Kamei,Y., Murase,R.,
            Ueda,N., Shigemoto,K., Yamamoto,H. and Kito,K.
  TITLE     AIP1/WDR1 supports mitotic cell rounding
  JOURNAL   Biochem Biophys Res Commun 327 (1), 268-275 (2005)
   PUBMED   15629458
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085864.1.
            
            On Apr 20, 2005 this sequence version replaced XM_341228.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085864.1, AY986483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2844
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2844
                     /gene="Wdr1"
                     /note="WD repeat domain 1"
                     /db_xref="GeneID:360950"
                     /db_xref="RGD:1305789"
     exon            1..29
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1834
                     /gene="Wdr1"
                     /note="WD repeat protein 1"
                     /codon_start=1
                     /product="WD repeat-containing protein 1"
                     /protein_id="NP_001014157.1"
                     /db_xref="GeneID:360950"
                     /db_xref="RGD:1305789"
                     /translation="MPYEIKKVFASLPQVERGVSKILGGDPKGDNFLYTNGKCVILRN
                     IDNPAVADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHILKYEYQPFA
                     GKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDTGSSVGEITGHNKVINSVDIKQNRPY
                     RLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDG
                     KTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGS
                     NVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHKNGGK
                     SYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVDESGQLVSCSMDDTVRYTN
                     LTLRDYSGQGVVKLDVQPKCVAVGPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEV
                     VAVHPGGDTVAVGGSDGNVRVYSILGATLKDEGKLLEAKGPVTDLAYSHDGAFLAVCD
                     ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPET
                     KVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY"
     exon            30..151
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..242
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..390
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..571
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..649
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..730
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..964
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1052
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1209
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1297
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1408
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1582
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1727
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..2813
                     /gene="Wdr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagtaggcg aggatgccgt acgagatcaa gaaggtgttc gccagcctcc cccaggtgga
       61 gcggggtgtc tctaagatcc tcggcggaga ccccaagggc gataatttcc tctacaccaa
      121 tggcaagtgc gtcatcctga ggaacatcga caaccctgct gttgctgaca tctacacaga
      181 acacgcccat caggtggtag tagccaagta tgcacccagc ggattctaca ttgcttctgg
      241 agatatctct gggaagctaa ggatctggga taccacacag aaggagcaca ttctaaagta
      301 tgagtaccag cctttcgctg ggaagatcaa ggacatagcc tggaccgaag acagtaagag
      361 gatcgccgtg gtcggggaag gaagggagaa atttggagct gtcttcttat gggacactgg
      421 ctcttctgtg ggtgagatca caggacacaa caaagtcatt aacagcgtgg acatcaagca
      481 gaacaggccc taccgactag caacagggag tgacgataac tgtgctgcat tcttcgaggg
      541 ccccccattc aagttcaagt ttacaattgg tgaccacagc cgctttgtca actgtgtgcg
      601 attctctcct gatgggaaca gatttgccac agctagtgct gatggccaga ttttcattta
      661 tgatgggaag acaggagaaa aggtgtgtgc ccttggagga agcaaggctc atgatggagg
      721 aatttatgcc attagttgga gtcctgatag cacccatttg ctatctgcct ctggagacaa
      781 aacctctaag atttgggatg tcaatgtaaa ctctgtggtc agcacgtttc ccatgggctc
      841 caatgttctg gaccagcagc tgggctgcct ctggcagaag gaccacctcc ttagcatctc
      901 cctgtctgga tacatcaact acctggacaa aaataacccc agcaagcccc tccgggtcat
      961 caagggtcac agtaaatcca tccagtgtct gacagtgcac aaaaatggtg gcaaatccta
     1021 catctattct gggagccatg atggccatat taattactgg gattcagaga caggagagaa
     1081 tgactccttc tctggaaaag gccacacaaa tcaggtgtcc aggatgactg tggacgagtc
     1141 tgggcagttg gtcagctgca gcatggacga cacagtgcgg tatactaacc tcacactgag
     1201 ggactacagt ggacaaggcg ttgtgaaact ggatgttcag ccaaagtgtg tagctgttgg
     1261 ccctggggga tataccgtgg tcgtgtgcat tggacagatt gtccttctga aggaccagaa
     1321 gaaatgcttc agcatcgaca accctggcta cgagcctgaa gttgttgctg tgcaccctgg
     1381 tggggacaca gtagctgttg gtggctcgga tggcaatgtg cgtgtgtact ccatcctggg
     1441 tgccacacta aaggatgaag gcaaactcct agaggccaag gggccagtga cagacttggc
     1501 ctactctcat gacggtgcct tcctggctgt gtgtgatgcc agcaaggtgg tcacagtgtt
     1561 cagtgtagct gatggctatt cggagaataa tgttttttat ggacaccatg caaaaattgt
     1621 gtgcctggcc tggtcaccag ataatgaaca ctttgcctct ggcggcatgg acatgatggt
     1681 atatgtgtgg acactgagtg acccagagac caaagtcaag attcaagatg cccaccggct
     1741 gcaccacgtc agcagtctgg cctggctgga cgaacacaca ctggtcacca cctcccatga
     1801 cgcctctgtg aaggagtgga caatcaccta ctgaggacac cgctcacccc acggaccgaa
     1861 tcagggacta gagttaactg cctcggagca cccttctctt aactatttct gtaacgctcc
     1921 ccttcctgcc tgccctggga gtggggaggg cctgcgagta ccctcctctc ttcagggtgt
     1981 ccatgtctgt acgcgtcctt ctgagagctt tagacagtaa cagtttgcac acaagaaata
     2041 aagcgagcac taaaacagca gtggagcgag cctaagaact tacagcccac cagaccgtga
     2101 gcggggagca ttccagaggc agcagcctcc aagcacagcc caagcccctg cggctctgca
     2161 gcttaccagg gctgggtagg gagcaggcca cggctcccct ttctcatgca ggatgcagtg
     2221 cactggggag gagcagccgc tgtgcagagc tgtcagcatt ctgtgtagag caggtctgtt
     2281 cctctgtaag tcatgttaca cggctgcctc cctggagcta tccccgatcc cacggggaca
     2341 tgtgaacctt gatctcattg tcagattttg tgcttgattt ttaagaatgg aatcatgaga
     2401 attttttttt tttttaacgt atcttgactg ttgtctgtct tgttcctgac ctggcgcgct
     2461 gacagtgctt gtccagacaa gtagagccct ggttagccag actgaggtgt cctggtcatg
     2521 tgattaccac gcttcaatgt ttccctgtct cttcccaact ctggccccaa gagcaagatt
     2581 aaggacaaga tgatgttgct gtaatttgtc atgtttttac cttttttttc tttttcagtg
     2641 cagaaattaa agtaagtata aagcaccgtg attggcagtt tctttgcgtg tgtcggaatc
     2701 actggtaaat gttggctgag aacaatccct ccccttgcac ttgtgaaaac actttgaacg
     2761 ctttaagagt aattagactg agaaataatt aaatatcttt tctcttgatt gtgaaaaaaa
     2821 aaaaaaaaaa aaaaaaaaaa aaaa
//
