LOCUS       NM_001107255            4215 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Rattus norvegicus WD repeat and HMG-box DNA binding protein 1
            (Wdhd1), transcript variant 3, mRNA.
ACCESSION   NM_001107255 XM_001062583 XM_223933
VERSION     NM_001107255.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4215)
  AUTHORS   Liu,B., Hu,Y., Qin,L., Peng,X.B. and Huang,Y.X.
  TITLE     MicroRNA-494-dependent WDHDI inhibition suppresses
            epithelial-mesenchymal transition, tumor growth and metastasis in
            cholangiocarcinoma
  JOURNAL   Dig Liver Dis 51 (3), 397-411 (2019)
   PUBMED   30314946
REFERENCE   2  (bases 1 to 4215)
  AUTHORS   Hsieh,C.L., Lin,C.L., Liu,H., Chang,Y.J., Shih,C.J., Zhong,C.Z.,
            Lee,S.C. and Tan,B.C.
  TITLE     WDHD1 modulates the post-transcriptional step of the centromeric
            silencing pathway
  JOURNAL   Nucleic Acids Res 39 (10), 4048-4062 (2011)
   PUBMED   21266480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474040.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223933.4, XM_001062583.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..4215
                     /gene="Wdhd1"
                     /note="WD repeat and HMG-box DNA binding protein 1"
                     /db_xref="GeneID:305827"
                     /db_xref="RGD:1310200"
     exon            1..301
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..3578
                     /gene="Wdhd1"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="WD repeat and HMG-box DNA-binding protein 1
                     isoform 3"
                     /protein_id="NP_001100725.1"
                     /db_xref="GeneID:305827"
                     /db_xref="RGD:1310200"
                     /translation="MPAIQKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRMWEDLD
                     DDDPKSVNVGEKAFSCALKNGKLVTAVSNNTVQVYTFPEGAPDGILTRFTTNANHVVF
                     NGDGTKIAAGSSDFLVKVVDVMDNSQQQTFRGHDAPVLSLSFDPKDVFLASASCDGTV
                     RVWNISDQTCAASWPVLRKSNDVVNSESICRLAWQPKTGKFLAVPVEKSVKLYRRETW
                     SNPFDLSDSSVTQTLNIVTWSPCGQYLAAGAINGLIVVWNVETKECMERVKHEKGYAI
                     CGLAWHPTYSRICYTDVEGNLGILENVCDLSGKLSSNKVPSGVEKDYSDLFDGDDTSS
                     AGDFLNDNAVEIPSFSKGIRNEEDDNDDLMLAADHVLGDDENSVDVTMLRNDLHREEG
                     EDRQASSLHSLPLVKSQRPLYDGPMPTPRQKPFQPSSTPLHLTHRFMAWNSVGIIRCY
                     NDDQDSAIDVEFHDTSIHHATHLSNAFNYTMGSLSHEAVLLACESADELASKLHCLHF
                     SSWDSSKEWIVDMPENEDIEAICLGLGWAAAATSALLLRLFTIGGVQKEVFCLPGPVV
                     SMAGHGEQLCIVYHRGTGFDGDQCLGVQLLELGRKKKQVLHGDPLPLTRKSYLTWLGF
                     SAEGTPCYVDSEGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCI
                     PCKGSRFPPTLPRPAVAILPFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAENGYD
                     YEESIKKQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVHLAIKYASRSRKL
                     ILAQKLSELAAEKAAELAEIQTEEREEDFRERLNAGYSHTTTEWSQPRVRSQVEEDAE
                     DREDTVSEGNPEPQNHGQNLIQSANSSDTPAMKSGAVFSSSQGRVNPFKVLVSSKEPA
                     VSVNATRSANILDNMNKLSRKSTSFNRVANNEKSPVIKPLIPKPRCKQASAASYFQKR
                     TSQAEKTEEVKENPKSSSSEAPAVCLQNSEVQRPKTGFQMWLEENRSHIMSDNPDISD
                     EADIIKEGMIRFRVLSAEERKEWTNKAKGGTASDGAEAKKRKRGVSEICETEKQEEAV
                     KENLELSKKQKALDLSTNQKLSAFAFKQE"
     exon            302..413
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..565
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..677
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..728
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..824
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..917
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1024
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1166
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1359
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1541
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1726
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1968
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2106
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2263
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2378
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2510
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2725
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2841
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2895
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..2939
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3110
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3238
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3377
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..4215
                     /gene="Wdhd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggctct gtgcggcgag acgctcgtgc acccgggctg ctcttagttc gcgtttccca
       61 atcctgcaga ggagaagctt gtcacctccc cgggcgtatg tgacataccc tccgccgcat
      121 cgtgctgtca ctcttccggt gagggaaacc ggactgcacg gctcgcagag gacgacctcc
      181 ctcctgaaaa tccagttctt agaaaacagc tcaggtaggg aaagatgccg gccatacaga
      241 agcccatgag gtacggacat acagaaggac acaccgaagt ctgctttgat gattctggaa
      301 gttttattgt gacttgtgga agtgatggtg atgtgaggat gtgggaagat ttggacgacg
      361 acgatcctaa gtccgttaat gttggagaaa aggcattttc atgtgctttg aagaatggga
      421 aattggtcac tgcagtttct aacaataccg tccaagtcta tacattccct gaaggagcac
      481 ccgatggtat attaacacgc ttcactacaa acgcaaacca tgtggtcttc aatggggacg
      541 gcactaaaat tgctgctggg tcaagtgatt ttctggtcaa agtcgtggat gtgatggata
      601 acagccagca gcaaacattt cgaggacacg acgcccctgt tttaagtctg tcttttgatc
      661 ctaaggatgt ctttctggca tcagctagtt gtgatggaac cgtcagagtg tggaatatat
      721 ctgatcagac ttgtgctgct agctggccgg tactgcgaaa gagcaatgat gtggtgaact
      781 cggagtccat ctgcagactc gcatggcagc ccaagaccgg gaagtttcta gcagttcctg
      841 ttgaaaaatc tgttaagctg tacagaagag aaacttggag taatccgttt gacctttcag
      901 acagttctgt cacccagaca ctcaatatcg tgacctggtc tccctgtggg cagtatttgg
      961 ctgcaggtgc tattaatggc ttaattgtag tttggaatgt ggaaaccaaa gagtgcatgg
     1021 aaagagtaaa acacgagaaa ggttatgcaa tctgcggcct ggcctggcat cctacctata
     1081 gtcggatatg ttacactgat gtggaaggaa acctgggaat cctggaaaat gtttgtgacc
     1141 tcagtgggaa gttgtcaagc aataaggtac ctagtggagt ggaaaaggat tacagcgatc
     1201 tctttgatgg agacgacacg agcagtgccg gcgattttct gaatgacaac gcggttgaga
     1261 tcccttcatt ttcaaagggg attagaaacg aggaggatga taatgatgac ctcatgctgg
     1321 cggcagatca tgtcttggga gatgatgaaa actcagttga tgttacaatg ctaagaaatg
     1381 atcttcatag agaggaaggg gaagatcgcc aggcaagcag tcttcacagt ctcccccttg
     1441 tgaaatccca aaggccgctt tatgacgggc ccatgccaac accgagacag aagccgttcc
     1501 agccaagttc tacacccttg catctcactc acagattcat ggcgtggaac tctgttggga
     1561 ttattcgctg ctataacgat gatcaagaca gtgccataga cgtggagttc catgacacct
     1621 ccatccatca tgcaacccat ctatccaatg ctttcaacta caccatgggc agtctttccc
     1681 acgaagctgt tctgttggct tgtgaaagtg ccgatgaatt agcaagcaag cttcactgct
     1741 tgcacttcag ttcttgggat tcaagcaaag agtggatagt agatatgcct gagaatgagg
     1801 atatcgaagc catatgtctc gggctgggct gggccgccgc tgctacctct gccctgctcc
     1861 tccgactgtt tactattgga ggcgttcaga aggaagtctt ctgccttcct ggacctgtgg
     1921 tgtccatggc gggacacgga gaacagcttt gcattgttta tcacagaggt acagggttcg
     1981 atggagatca gtgccttgga gttcaactgc tagagctggg gcggaagaaa aaacaggttt
     2041 tgcatggtga ccctcttcct cttacaagga aatcctacct tacatggctg gggttttctg
     2101 ctgaaggtac cccctgctac gtggactccg aaggctgtgt gcgaatgctt aacagaggac
     2161 ttgggaatac atggactcct gtatgtaaca tcagagagca ctgcaaagga aagtctgatc
     2221 actactgggt ggttggcatt catgagaacc cccagcagct aaggtgcatc ccttgtaaag
     2281 gttctcggtt tcctcccacc cttccacgac ctgctgtagc aatattacct tttaaacttc
     2341 cttattgtca gacttcaaca gagaaaggcc aaatggagga acaattttgg cattcggttc
     2401 tgtttcacaa ctaccttgat tacttggctg aaaatggtta tgattatgag gagagcatta
     2461 aaaaacaggc agtaaaagag cagcaggaac tcttaatgaa gatgcttgcg ctgtcttgta
     2521 aactggaacg agaattccgc tgtgtggaac ttgcagatct aatgactcaa aatgctgtgc
     2581 atttagccat taaatatgct tctcgctctc ggaaattaat attggctcaa aaacttagtg
     2641 aacttgccgc agaaaaggca gccgagttgg cagaaatcca gacagaagag agagaagagg
     2701 atttcagaga aagactgaat gctggttaca gccataccac tacagagtgg agtcagccac
     2761 gggtcagaag tcaagttgaa gaagatgctg aggacagaga agacaccgtt tcagaaggaa
     2821 atccagagcc acagaaccat gggcagaact taatccaaag tgcaaattcc tctgataccc
     2881 cagctatgaa atcaggtgca gttttctcta gcagccaagg acgggtaaac cccttcaagg
     2941 tactagtcag ttccaaagaa ccagccgtct cagtgaatgc aacacgctca gctaatattt
     3001 tagacaatat gaacaaatta tccaggaagt ccacttcttt taatcgagta gcaaataatg
     3061 aaaagtctcc agttataaag cctctcattc ccaagccaag gtgtaagcag gcgtctgcag
     3121 catcctattt ccagaaaaga acctcacagg ccgagaagac tgaagaagta aaagaaaatc
     3181 ctaaaagttc gtcatctgaa gctccagccg tgtgccttca aaactcagaa gtccaaaggc
     3241 cgaagaccgg gttccagatg tggctggagg aaaatagaag tcatattatg tccgacaacc
     3301 ctgacatttc agatgaagca gatataataa aagaggggat gatccgattt agagtactgt
     3361 ccgccgaaga aaggaaggaa tggactaaca aggccaaggg aggaactgcc agcgatggag
     3421 ctgaggcaaa gaagcgaaaa cgtggggtca gtgagatctg tgagacggag aagcaggaag
     3481 aggcagtgaa ggagaatctg gagctgtcta aaaagcaaaa ggcattagat ctttctacta
     3541 atcagaaatt gtcagctttt gcatttaagc aggaataaag gaagggagtg tggggaaata
     3601 atgaaacttc tgatggatcc tggacttcta gcctttaggg accgtatgtt atgtcctgtg
     3661 tgtttagaga cagctttgtt ttcttaaggc agtgtggggg cagggctgca gctcagtgct
     3721 agagggcttg cctagcactc actccatcct tactaccaca aaaaaccata ccaaaccgaa
     3781 cgaacaaaaa gtagtcattc tcctgtctca ggagcaccag gtaagagctg tctgggggtt
     3841 actctgcctt ccaggaacag aagtatcatt gcggttacta ccagggacac catcatgtcc
     3901 ctgtggaagc cattatgttt aaaaatcact aaatgcttta gtcttcagac ctctatacat
     3961 tatagtgcct tctagggctt tcttgccttc atttaggttc tgtagaagtg ccatggtcat
     4021 cggtttccca agtgagttgt cacagactac tcttgtcaac ttgacctcag gcccatggct
     4081 tttaatatgg ccccaaagtg taaatagtct gtaaatgaga tatgttattt tacgtgtttg
     4141 gagacatttt tcatgtgtta ctttatgttt gtatagcctg tgtctttgga ataaataaga
     4201 ctttctcatt tgcat
//
