LOCUS       NM_138975                793 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus WW domain binding protein 2 (Wbp2), mRNA.
ACCESSION   NM_138975
VERSION     NM_138975.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 793)
  AUTHORS   Buffa,L., Saeed,A.M. and Nawaz,Z.
  TITLE     Molecular mechanism of WW-domain binding protein-2 coactivation
            function in estrogen receptor signaling
  JOURNAL   IUBMB Life 65 (1), 76-84 (2013)
   PUBMED   23233354
REFERENCE   2  (bases 1 to 793)
  AUTHORS   Lim,S.K., Orhant-Prioux,M., Toy,W., Tan,K.Y. and Lim,Y.P.
  TITLE     Tyrosine phosphorylation of transcriptional coactivator WW-domain
            binding protein 2 regulates estrogen receptor alpha function in
            breast cancer via the Wnt pathway
  JOURNAL   FASEB J 25 (9), 3004-3018 (2011)
   PUBMED   21642474
REFERENCE   3  (bases 1 to 793)
  AUTHORS   Dhananjayan,S.C., Ramamoorthy,S., Khan,O.Y., Ismail,A., Sun,J.,
            Slingerland,J., O'Malley,B.W. and Nawaz,Z.
  TITLE     WW domain binding protein-2, an E6-associated protein interacting
            protein, acts as a coactivator of estrogen and progesterone
            receptors
  JOURNAL   Mol Endocrinol 20 (10), 2343-2354 (2006)
   PUBMED   16772533
REFERENCE   4  (bases 1 to 793)
  AUTHORS   Nitsch,R., Di Palma,T., Mascia,A. and Zannini,M.
  TITLE     WBP-2, a WW domain binding protein, interacts with the
            thyroid-specific transcription factor Pax8
  JOURNAL   Biochem J 377 (Pt 3), 553-560 (2004)
   PUBMED   14531730
REFERENCE   5  (bases 1 to 793)
  AUTHORS   Chen,H.I., Einbond,A., Kwak,S.J., Linn,H., Koepf,E., Peterson,S.,
            Kelly,J.W. and Sudol,M.
  TITLE     Characterization of the WW domain of human yes-associated protein
            and its polyproline-containing ligands
  JOURNAL   J Biol Chem 272 (27), 17070-17077 (1997)
   PUBMED   9202023
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF499026.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF499026.1, EV776174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..793
                     /gene="Wbp2"
                     /note="WW domain binding protein 2"
                     /db_xref="GeneID:192645"
                     /db_xref="RGD:620032"
     CDS             1..789
                     /gene="Wbp2"
                     /note="WBP-2"
                     /codon_start=1
                     /product="WW domain-binding protein 2"
                     /protein_id="NP_620431.1"
                     /db_xref="GeneID:192645"
                     /db_xref="RGD:620032"
                     /translation="MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKG
                     TKKGTVYLTPYRVIFLSKGKDAMRSFMMPFYLMKDCEVKQPVFGANFIKGTVKAEAGG
                     GWEGSASYKLTFTAGGAIEFGQQMLQVASQASRGEVPNGAYGYPYMPSGAYVFPPPVA
                     NGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVVSGPSAPPTP
                     AAEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ"
     exon            1..59
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            60..168
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            169..304
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..397
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            398..532
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..658
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..735
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..793
                     /gene="Wbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgctca acaagaatca ctcagagggc ggcggagtga tcgtcaacaa cactgagagc
       61 atcttaatgt cctatgatca tgtggaactt acattcaacg acatgaagaa tgtaccagag
      121 gccttcaaag ggaccaagaa aggcaccgtc tacctaactc cataccgggt catctttctg
      181 tccaagggca aggatgccat gcggtccttc atgatgccct tctacctgat gaaggactgt
      241 gaggtcaagc agccggtgtt tggtgccaac ttcattaagg ggacagtgaa agctgaagca
      301 ggaggtggtt gggaaggctc tgcctcctac aagctgacct tcacagcagg gggtgccatt
      361 gagtttgggc agcagatgct ccaggtggca tctcaagcct ccagaggtga agtccccaat
      421 ggagcctatg ggtaccctta catgcccagc ggggcctatg tctttccccc accagtcgcc
      481 aatggaatgt acccctgccc tcctggctac ccctatccac cgcccccacc cgagttctac
      541 cctgggcctc ctatgatgga cggggccatg ggatatgtac agcccccacc accaccctat
      601 cctgggccca tggagcctcc cgtcgtcagc ggccccagtg ccccccctac tcctgcagct
      661 gaggccaagg ctgcagaagc cgctgccagc gcctattaca acccgggcaa cccacacaat
      721 gtctacatgc ccacgagcca gccaccacca ccaccctact accctccaga agacaagaag
      781 acccagtaga ccc
//
