LOCUS       NM_001303017            2598 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus WW domain binding protein 11 (Wbp11), transcript
            variant 2, mRNA.
ACCESSION   NM_001303017 XM_008763375 XM_008763449
VERSION     NM_001303017.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Ivatt,R.M., Sanchez-Martinez,A., Godena,V.K., Brown,S., Ziviani,E.
            and Whitworth,A.J.
  TITLE     Genome-wide RNAi screen identifies the Parkinson disease GWAS risk
            locus SREBF1 as a regulator of mitophagy
  JOURNAL   Proc Natl Acad Sci U S A 111 (23), 8494-8499 (2014)
   PUBMED   24912190
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Huang,X., Beullens,M., Zhang,J., Zhou,Y., Nicolaescu,E., Lesage,B.,
            Hu,Q., Wu,J., Bollen,M. and Shi,Y.
  TITLE     Structure and function of the two tandem WW domains of the pre-mRNA
            splicing factor FBP21 (formin-binding protein 21)
  JOURNAL   J Biol Chem 284 (37), 25375-25387 (2009)
   PUBMED   19592703
REFERENCE   4  (bases 1 to 2598)
  AUTHORS   Llorian,M., Beullens,M., Andres,I., Ortiz,J.M. and Bollen,M.
  TITLE     SIPP1, a novel pre-mRNA splicing factor and interactor of protein
            phosphatase-1
  JOURNAL   Biochem J 378 (Pt 1), 229-238 (2004)
   PUBMED   14640981
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1 and BC087082.1.
            
            On or before Apr 16, 2021 this sequence version replaced
            XM_008763449.2, XM_008763375.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1259166.1,
                                           SRR26360172.94168.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000004.1  171425560-171425634 c
            76-123              BC087082.1         1-48
            124-2598            BC087082.1         51-2525
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..2598
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /note="WW domain binding protein 11"
                     /db_xref="GeneID:297695"
                     /db_xref="RGD:1307911"
     exon            1..123
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..229
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..2091
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /note="splicing factor that interacts with PQBP-1 and PP1;
                     WW domain-binding protein 11-like 1"
                     /codon_start=1
                     /product="WW domain-binding protein 11"
                     /protein_id="NP_001289946.1"
                     /db_xref="GeneID:297695"
                     /db_xref="RGD:1307911"
                     /translation="MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAV
                     LKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPD
                     IYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPG
                     AQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVLQMYGRK
                     VGFALDLPPRRRDEDMLYSPELAQRGHDDDMSSTSEDDGYPEDMDQDKHDDSTEDSDT
                     DRSDAESDGDEFGHRDDSERDNTEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMM
                     LRMAGQEIPEEGREVEEFSEEEDDDDSEDSEAEKPSQKQHKEDSHADGSSAASSQQQA
                     PPQAVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGI
                     RGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMR
                     PPLVPPLGPAPPGLFPPAPLPNPGVLSAPPSLIQRPKADDASAATIEKKATATISAKP
                     QITNPKAEVTRFVPTALRVRRENKGATAVPQRRSEEDSAVPVAKAAPRSGPSVPVSVQ
                     TKDDVYEAFMKEMEGLL"
     exon            230..261
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            262..355
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..552
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..686
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..886
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1078
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1180
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1474
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1657
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2572
                     /gene="Wbp11"
                     /gene_synonym="wbp-11; Wbp11l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaggtttca agatggcggt gcctgtgtgg ttgaccgaga cccagaggtg aaggcccctt
       61 cggagaaagt actcgggaac ccctcgctag tcgctctcgc cgtcccggga gactctcagt
      121 cgtttttttt ttttaatgaa gaagtaaacc atataaactg tcaacatggg acgaagatca
      181 acatcctcca ccaagagtgg gaagtttatg aaccccacag accaagcccg aaaagaagcc
      241 cggaaaagag agttgaaaaa gaacaaaaaa cagcgcatga tggtccgagc tgcagttttg
      301 aagatgaaag accccaagca gattatccgg gacatggaga aattggatga aatggagttt
      361 aacccagtgc aacagccgca gttgaatgaa aaagtactga aagacaagcg taaaaagctg
      421 cgagaaacct ttgaacgaat tctgcggctc tatgagaaag aaaacccaga catctacaaa
      481 gagctgagga agctggaagt ggagtacgag cagaagaggg cgcagctgag ccagtacttt
      541 gatgccgtca agaacgccca gcatgtggaa gtagagagca tccctctgcc agatatgccg
      601 catgcccctt ccaacatcct gatccaggac attcctcttc ctggtgccca gccaccctct
      661 atcctgaaga aaacctcggc atatgggcct ccaactcgag cagtttctat ccttcctctc
      721 ctgggacacg gtgttccacg tttgccccct ggcagaaaac cgcctggccc tccacctggc
      781 ccacctcctc ctcaagttct gcagatgtat ggccgtaaag tgggctttgc tctcgatctt
      841 ccccctcgga ggcgagatga agacatgctg tacagtccgg aacttgctca gcggggccat
      901 gatgatgaca tgtccagcac cagtgaggac gacggctatc ctgaggacat ggatcaggat
      961 aagcacgatg acagtactga ggacagtgac actgacagat ccgatgcaga aagtgatggg
     1021 gatgagttcg gccaccgtga cgacagtgag cgtgacaaca ctgaggagaa gaagtcaggt
     1081 ctgagcgtcc ggtttgcaga tatgcctggg aaatctagga agaagaagaa gaacatgaag
     1141 gagctgactc ctcttcaagc catgatgctg cgaatggcag gtcaggaaat ccctgaggaa
     1201 ggacgggaag tggaggagtt ttcagaggag gaggacgacg acgactctga ggactctgag
     1261 gcagagaagc catcgcagaa gcagcataaa gaggattccc acgctgacgg ctcctcggcc
     1321 gcctcttcac agcagcaggc ccctccacag gccgttcctc cttctcagat acaagcacct
     1381 cccatgccag gaccgccacc tctcggacca ccgcctgccc cacccttacg gcctcctgga
     1441 ccacctacag gccttcctcc tgggccacct ccaggggctc ctccattcct gagaccacct
     1501 gggatgccag gaatccgagg gcctttacca cggcttttac ctccaggacc accaccaggc
     1561 cgacctcctg gccctccgcc aggcccacct ccaggtctcc cccctgggcc ccctcctcga
     1621 ggacccccac caaggctacc tcctcctgca cctccaggta tccctcctcc tcgtcctggc
     1681 atgatgcgcc ctccgttggt gcctcctctt ggacctgccc cgcctggcct tttcccgcca
     1741 gctcccttac ccaacccagg ggtgttgagt gccccaccca gcctcattca gcgaccgaag
     1801 gcggatgatg caagtgcagc caccatcgag aagaaggcca cagcgaccat cagtgccaag
     1861 ccccagatca ccaatcccaa ggcagaggtc acacggtttg tgcccactgc actgagggtg
     1921 cgccgcgaga ataagggggc tactgccgtt ccccaaagaa ggtcagagga ggactctgct
     1981 gtgcctgtgg ccaaagcagc ccccagatct gggccttcag ttcctgtgtc ggtacagact
     2041 aaggacgatg tctatgaagc gtttatgaaa gagatggaag ggctgctgtg acagattgtc
     2101 ctgccagtgc aggcttctcc tcagaggact ggtttgtgga acaagaggct ctcgttaaac
     2161 ttagagagaa gagcgaagtg cactgtcagg tgtaatagac caggctgtga agcactgctg
     2221 ctagccccat tccctgacac caccgtctcc tcccctcttc ccctctccat tttgggaatt
     2281 ctatcagcga ggtcttagtt acttgttttg actcatgtgc catgagcact agggtagaga
     2341 attctggagg aagaaagttt atttcatctt gacttttgtg tttgtgttat ttttaatatt
     2401 ttcctgtaaa tattttgtaa tattttcctt gtagtgaaat ggatcacaat atcatttcct
     2461 aattcaaagc aggatatgtg ggaagaaaat acacaattct ggggttaatg ttatttccca
     2521 caaactaaac tcttttgagt gtttcttgga gaaataaaat gttccatacc aaaaaaaaaa
     2581 aaaaaaaaaa aaaaaaaa
//
