LOCUS       NP_001386701            1173 aa            linear   ROD 31-MAR-2024
DEFINITION  WASH complex subunit 4 [Rattus norvegicus].
ACCESSION   NP_001386701 XP_235003
VERSION     NP_001386701.1
DBSOURCE    REFSEQ: accession NM_001399772.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1173)
  AUTHORS   Tyrrell,B.J., Woodham,E.F., Spence,H.J., Strathdee,D., Insall,R.H.
            and Machesky,L.M.
  TITLE     Loss of strumpellin in the melanocytic lineage impairs the WASH
            Complex but does not affect coat colour
  JOURNAL   Pigment Cell Melanoma Res 29 (5), 559-571 (2016)
   PUBMED   27390154
REFERENCE   2  (residues 1 to 1173)
  AUTHORS   Gallon,M. and Cullen,P.J.
  TITLE     Retromer and sorting nexins in endosomal sorting
  JOURNAL   Biochem Soc Trans 43 (1), 33-47 (2015)
   PUBMED   25619244
  REMARK    Review article
REFERENCE   3  (residues 1 to 1173)
  AUTHORS   Ryder,P.V., Vistein,R., Gokhale,A., Seaman,M.N., Puthenveedu,M.A.
            and Faundez,V.
  TITLE     The WASH complex, an endosomal Arp2/3 activator, interacts with the
            Hermansky-Pudlak syndrome complex BLOC-1 and its cargo
            phosphatidylinositol-4-kinase type IIalpha
  JOURNAL   Mol Biol Cell 24 (14), 2269-2284 (2013)
   PUBMED   23676666
REFERENCE   4  (residues 1 to 1173)
  AUTHORS   Harbour,M.E., Breusegem,S.Y., Antrobus,R., Freeman,C., Reid,E. and
            Seaman,M.N.
  TITLE     The cargo-selective retromer complex is a recruiting hub for
            protein complexes that regulate endosomal tubule dynamics
  JOURNAL   J Cell Sci 123 (Pt 21), 3703-3717 (2010)
   PUBMED   20923837
REFERENCE   5  (residues 1 to 1173)
  AUTHORS   Derivery,E., Sousa,C., Gautier,J.J., Lombard,B., Loew,D. and
            Gautreau,A.
  TITLE     The Arp2/3 activator WASH controls the fission of endosomes through
            a large multiprotein complex
  JOURNAL   Dev Cell 17 (5), 712-723 (2009)
   PUBMED   19922875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 14, 2022 this sequence version replaced XP_235003.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.25157.1,
                                           SRR26643298.38458.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1173
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     Protein         1..1173
                     /product="WASH complex subunit 4"
                     /note="WASH complex subunit 7"
                     /calculated_mol_wt=136005
     Region          32..600
                     /region_name="WASH-4_N"
                     /note="WASH complex subunit 4, N-terminal; pfam14745"
                     /db_xref="CDD:434178"
     Region          605..949
                     /region_name="WASH-7_mid"
                     /note="WASH complex subunit 7; pfam14744"
                     /db_xref="CDD:434177"
     Region          966..1135
                     /region_name="WASH-7_C"
                     /note="WASH complex subunit 7, C-terminal; pfam14746"
                     /db_xref="CDD:464293"
     CDS             1..1173
                     /gene="Washc4"
                     /gene_synonym="RGD1309995"
                     /coded_by="NM_001399772.1:71..3592"
                     /db_xref="GeneID:314690"
                     /db_xref="RGD:1309995"
ORIGIN      
        1 mavdtlspdw dfdrvddgsq kihaevqlkn ygkfleeyts qlrriedald dlvgdvwdfn
       61 ldpialkllp yeqsslleli ktenkvlnkv itvyaalcce ikklkheaet kfyngllfyg
      121 egaadssmae gdcqiqmgrf vsflqelscf vtrcyevvms vihqlaalyi snktgpkiie
      181 ttgvhfqtmy ehlgelltvl ltldeiidnh vtlkdhwtmy krllksvhhn pskfgiqeer
      241 lkpfekfllk legqlldgmi fqacieqqfd slnggisvsk nstfaeefah sirsifanve
      301 aklgepseid qrdkyvgicg lfvlhfqifr tvdkkfyksl ldickkvpav tltaniiwfp
      361 dnflihkmpa aaklldrksl qaikihrdaf lqqkaqsltk dvqsyyvfvs swmmkmesml
      421 skeqrtdtfa edltntcnvf iqgflyaysi stiikttmnl ymsmqkpmtr tsvkalcrli
      481 ellkavehmf hrrsmvvads vshitqhlqh qalnsisvak krvisdkkys eqrldvlsal
      541 vlaentlngp stkqrrlvvs lalsvgtqmk tfkdeelfpl qvvmkkldli selrervqtq
      601 cdccflywhr avfpiylddv yenavdaarl hymfsalrdc vpammhsrhl eshellldcy
      661 dkeimdilne rlldklcket ekdlrlsvht hlklddrnpf kvgrkdlalf fslnpirffn
      721 rfidirayvt hyldktfynl ttvalhdwat ysemrnlatq ryglvmteah lpsqtleqgl
      781 dvleimrnih ifvsrylynl nnqifierts nnkhlntini rhiansirth gtgimnttvn
      841 ftyqflkkkf yifsqfmyde hiksrlikdi rffreikdqn dhkypfdrae kfnrgirklg
      901 itpegqsyld qfrqllsqig namgyirmir sgglhcssna irfvpdledi vsfeelvkee
      961 glaeetlraa rhldsvlsdh trnsaegtey fkmlvdvfap efrrpknihl rnfyiivppl
     1021 tlnfvehsis ckeklnkknk igaaftddgf amgvaytlkl ldqyqefdsl hwfqsvreky
     1081 ikeiravakq qsvqstsqde kllqtmnltq krlevylqef ellyfslssa riffradkta
     1141 aeenqekkek eeetkmsngd gsestvsadp vvk
//
