LOCUS       NM_001025114            2579 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus WASP family member 1 (Wasf1), mRNA.
ACCESSION   NM_001025114 XM_215432
VERSION     NM_001025114.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2579)
  AUTHORS   Ito,Y., Carss,K.J., Duarte,S.T., Hartley,T., Keren,B., Kurian,M.A.,
            Marey,I., Charles,P., Mendonca,C., Nava,C., Pfundt,R.,
            Sanchis-Juan,A., van Bokhoven,H., van Essen,A., van
            Ravenswaaij-Arts,C., Boycott,K.M., Kernohan,K.D., Dyack,S. and
            Raymond,F.L.
  CONSRTM   NIHR BioResource; Care4Rare Canada Consortium
  TITLE     De Novo Truncating Mutations in WASF1 Cause Intellectual Disability
            with Seizures
  JOURNAL   Am J Hum Genet 103 (1), 144-153 (2018)
   PUBMED   29961568
REFERENCE   2  (bases 1 to 2579)
  AUTHORS   Xu,C., Fu,X., Zhu,S. and Liu,J.J.
  TITLE     Retrolinkin recruits the WAVE1 protein complex to facilitate
            BDNF-induced TrkB endocytosis and dendrite outgrowth
  JOURNAL   Mol Biol Cell 27 (21), 3342-3356 (2016)
   PUBMED   27605705
REFERENCE   3  (bases 1 to 2579)
  AUTHORS   Burgers,P.P., van der Heyden,M.A., Kok,B., Heck,A.J. and
            Scholten,A.
  TITLE     A systematic evaluation of protein kinase A-A-kinase anchoring
            protein interaction motifs
  JOURNAL   Biochemistry 54 (1), 11-21 (2015)
   PUBMED   25097019
REFERENCE   4  (bases 1 to 2579)
  AUTHORS   Chen,Z., Borek,D., Padrick,S.B., Gomez,T.S., Metlagel,Z.,
            Ismail,A.M., Umetani,J., Billadeau,D.D., Otwinowski,Z. and
            Rosen,M.K.
  TITLE     Structure and control of the actin regulatory WAVE complex
  JOURNAL   Nature 468 (7323), 533-538 (2010)
   PUBMED   21107423
REFERENCE   5  (bases 1 to 2579)
  AUTHORS   Sanchez,A.M., Flamini,M.I., Fu,X.D., Mannella,P., Giretti,M.S.,
            Goglia,L., Genazzani,A.R. and Simoncini,T.
  TITLE     Rapid signaling of estrogen to WAVE1 and moesin controls neuronal
            spine formation via the actin cytoskeleton
  JOURNAL   Mol Endocrinol 23 (8), 1193-1202 (2009)
   PUBMED   19460862
  REMARK    GeneRIF: the control of actin polymerization and branching via
            moesin or WAVE1 is a key function of estrogen receptor alpha in
            neurons, which may be particularly relevant for the regulation of
            dendritic spines
REFERENCE   6  (bases 1 to 2579)
  AUTHORS   Kim,H.J., DiBernardo,A.B., Sloane,J.A., Rasband,M.N., Solomon,D.,
            Kosaras,B., Kwak,S.P. and Vartanian,T.K.
  TITLE     WAVE1 is required for oligodendrocyte morphogenesis and normal CNS
            myelination
  JOURNAL   J Neurosci 26 (21), 5849-5859 (2006)
   PUBMED   16723544
  REMARK    GeneRIF: Together, these data demonstrate a role for WAVE1 in
            oligodendrocyte morphogenesis and myelination.
REFERENCE   7  (bases 1 to 2579)
  AUTHORS   Song,K.S., Peterson,Y.K., Freidman,A., Blumer,J.B., Sato,M. and
            Lanier,S.M.
  TITLE     Identification and characterization of a G-protein regulatory motif
            in WAVE1
  JOURNAL   FEBS Lett 580 (8), 1993-1998 (2006)
   PUBMED   16530190
  REMARK    GeneRIF: The WAVE1 G-protein regulatory (GPR) peptide inhibited
            GTPgammaS binding to purified G-protein.A WAVE1-G-protein complex
            was also observed following transfection of COS7 cells with
            Gialpha3 and WAVE1.
REFERENCE   8  (bases 1 to 2579)
  AUTHORS   Pilpel,Y. and Segal,M.
  TITLE     Rapid WAVE dynamics in dendritic spines of cultured hippocampal
            neurons is mediated by actin polymerization
  JOURNAL   J Neurochem 95 (5), 1401-1410 (2005)
   PUBMED   16190876
REFERENCE   9  (bases 1 to 2579)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
REFERENCE   10 (bases 1 to 2579)
  AUTHORS   Danial,N.N., Gramm,C.F., Scorrano,L., Zhang,C.Y., Krauss,S.,
            Ranger,A.M., Datta,S.R., Greenberg,M.E., Licklider,L.J.,
            Lowell,B.B., Gygi,S.P. and Korsmeyer,S.J.
  TITLE     BAD and glucokinase reside in a mitochondrial complex that
            integrates glycolysis and apoptosis
  JOURNAL   Nature 424 (6951), 952-956 (2003)
   PUBMED   12931191
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091322.1.
            
            [WARNING] On Nov 15, 2024 this sequence was replaced by
            NM_001025114.2.
            
            On Jul 1, 2005 this sequence version replaced XM_215432.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091322.1, SRR8487227.119150.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132273
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..2579
                     /gene="Wasf1"
                     /note="WASP family member 1"
                     /db_xref="GeneID:294568"
                     /db_xref="RGD:1561954"
     exon            1..43
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
     exon            44..204
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1751
                     /gene="Wasf1"
                     /note="wiskott-Aldrich syndrome protein family member 1;
                     protein WAVE-1; WASP family protein member 1; WASP family
                     1; WAS protein family, member 1"
                     /codon_start=1
                     /product="actin-binding protein WASF1"
                     /protein_id="NP_001020285.1"
                     /db_xref="GeneID:294568"
                     /db_xref="RGD:1561954"
                     /translation="MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSL
                     SKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFR
                     SSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNVLTPYRDDGKEGLKFYTNPSYFFDL
                     WKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDA
                     DLLHKHIEVANGPASHFETRPQTYVDHMDGSYSLSALPFSQMSELLSRAEERVLVRPH
                     EPPPPPPMHAAGDARPTPTCVSSAAGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSA
                     LSTSSLRASMTSTPPPPVPPPPPPPAPALQAPAVPPPPAPLQIAPGVLHPAPPPIAPP
                     LVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVAALAH
                     PPSGLHPTPSPAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKG
                     IQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE"
     exon            205..339
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..493
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..611
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..784
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..964
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1593
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..2512
                     /gene="Wasf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcaggac agggggaagc gccgtcctct agcccacgga ccggtgagct ggcacagcgg
       61 ctgagctcaa gatgccgctg gtgaaaagaa acatcgaccc taggcacttg tgccacacag
      121 cactgcccag gggcattaag aacgagctgg aatgtgtgac caacatctcc ctggcaaata
      181 taattagaca actgagtagc ctaagtaaat atgctgaaga catatttgga gaattattca
      241 atgaagcaca tagtttttcc ttcagagtta actcattaca agagcgcgtg gaccgattgt
      301 ccgttagtgt cacacagctt gatcctaaag aagaagaact gtccttacaa gacataacga
      361 tgagaaaagc tttccggagc tctacaattc aggaccagca gcttttcgac cgcaagactt
      421 tgcctatccc gctgcaggaa acgtacgatg tgtgcgagca gcctccgcct ctcaatgtcc
      481 tcacacccta cagggacgat ggtaaggagg ggctgaagtt ttataccaac ccttcgtatt
      541 tctttgatct gtggaaagaa aagatgttgc aagatacaga ggataagagg aaggaaaaga
      601 gaaagcagaa gcagaaaaat ctagaccgtc ctcatgaacc agaaaaagtg ccaagagcac
      661 cacatgacag gcggcgagaa tggcagaagc tggcccaagg tccagagctg gctgaagatg
      721 atgccgatct cctccacaag cacatcgaag ttgctaacgg cccagcctct cattttgaga
      781 caaggccgca gacatacgtg gaccacatgg atggatctta ctcactctct gccttgccat
      841 tcagtcagat gagtgaactc ctaagcagag ctgaggagag ggtcttagtc agaccccatg
      901 aaccacctcc acctccacca atgcatgcag caggggatgc aagacccacc cccacctgtg
      961 tcagctctgc tgcgggtttg atagagaatc gtccccagtc cccagctgca ggcagaacac
     1021 ccgtgtttgt gagccccacg cccccacctc ctccaccacc tctcccgtct gccctgtcca
     1081 cctcctcact gagagcttcc atgacctcaa ctcctccccc accggtgcct cccccgcctc
     1141 ctcctccagc ccctgccttg caggccccag cagtgccccc gcctccagcc cctcttcaga
     1201 ttgcccctgg tgtccttcac ccagctcctc ctccaatcgc tcctcctcta gtacagccct
     1261 ctcccccggt agccagagcc gccccagtgt gtgagactgt acccgttcat ccactcccac
     1321 aaggtgaagt gcaggggctg cctccgcccc cgccgccgcc gcctctgcct cctccaggca
     1381 ttcggccatc atcacctgtc acggtcgcag ctcttgcgca tcctccctct gggctccacc
     1441 caactccatc tcctgcccct ggtccccatg ctccattaat gcctccgtcc ccaccttcac
     1501 aagtcctgcc tgcctctgag ccaaagcgcc atccttccac cctacccgtg atcagtgacg
     1561 cgaggagtgt gctgctggag gccatacgga aaggcattca gcttcgcaaa gtggaagagc
     1621 agcgtgaaca ggaagcaaag catgagcgga ttgaaaacga cgtggccacc atcctgtcac
     1681 gccgcatcgc tgtggagtac agcgactcgg aagacgactc ggagttcgat gaagtagact
     1741 ggctggagtg agagggccga gtcgccgtgg acgactcgga gttcgatgaa gtagactggc
     1801 ttgagtgaga gggccacgtc gctccgtgtt gcaaggctga atgcacatgt cctctgtggc
     1861 gcttgatctt tgaaaatgtt cggtcattct agtgttttgc ttcctattcc ccatgatgaa
     1921 taacccttct ccataatttt tgatttctat gagaagtatt agcatatatt tcaaactaaa
     1981 tatttcacag tggcttatct tcatcccccc caccccggaa aatataattt ggcccaataa
     2041 actactaagt attaagcatg gacagcagtt attagagtag cagattcagt ttttgataga
     2101 ccttaattgt gcactttgtg atgttttttt cttttaaatt tgaagaacac aaccgagaat
     2161 ggaatcttga aggcagctct gtccgtggtt gagccttatt ccgtttcttg atgttctcaa
     2221 tgaagacaca ctgcctcgat tacccgaacg cactcagaaa gaacatgtag cttgtagtgt
     2281 tggattctct taaaggagtg gttagttttt gttaccattt tattgttttt aaatacttgc
     2341 cttatttgaa cgtttagcag aacccttccc cacttatcta ttgtgtggta cagttttgct
     2401 tgcctataga agtttaaatt tttccatgtg agatactcag aataagcata cgtgtaactt
     2461 acataatgtg agaattacaa tctgatgtaa taaacggttc attttaaagg ctaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
