LOCUS       NM_001398747            1759 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus WASP actin nucleation promoting factor (Was),
            mRNA.
ACCESSION   NM_001398747 XM_039099772
VERSION     NM_001398747.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   Li,S., Huang,J., Zhang,Y.L., Zhu,Y., An,Y.F., Du,J., Zhang,Z.L.,
            Xia,Y., Liu,L., Wang,L. and Luo,X.H.
  TITLE     Wiskott-Aldrich syndrome protein may be critical for CD8+ T cell
            function following MCMV infection
  JOURNAL   Cell Immunol 338, 43-50 (2019)
   PUBMED   30981413
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   Schrank,B.R., Aparicio,T., Li,Y., Chang,W., Chait,B.T.,
            Gundersen,G.G., Gottesman,M.E. and Gautier,J.
  TITLE     Nuclear ARP2/3 drives DNA break clustering for homology-directed
            repair
  JOURNAL   Nature 559 (7712), 61-66 (2018)
   PUBMED   29925947
REFERENCE   3  (bases 1 to 1759)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Lang,P.A., Shaabani,N., Borkens,S., Honke,N., Scheu,S., Booth,S.,
            Brenner,D., Meryk,A., Barthuber,C., Recher,M., Mak,T.W.,
            Ohashi,P.S., Haussinger,D., Griffiths,G.M., Thrasher,A.J., Bouma,G.
            and Lang,K.S.
  TITLE     Reduced type I interferon production by dendritic cells and
            weakened antiviral immunity in patients with Wiskott-Aldrich
            syndrome protein deficiency
  JOURNAL   J Allergy Clin Immunol 131 (3), 815-824 (2013)
   PUBMED   23141740
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Lafouresse,F., Cotta-de-Almeida,V., Malet-Engra,G., Galy,A.,
            Valitutti,S. and Dupre,L.
  TITLE     Wiskott-Aldrich syndrome protein controls antigen-presenting
            cell-driven CD4+ T-cell motility by regulating adhesion to
            intercellular adhesion molecule-1
  JOURNAL   Immunology 137 (2), 183-196 (2012)
   PUBMED   22804504
REFERENCE   6  (bases 1 to 1759)
  AUTHORS   Krawczyk,C., Bachmaier,K., Sasaki,T., Jones,R.G., Snapper,S.B.,
            Bouchard,D., Kozieradzki,I., Ohashi,P.S., Alt,F.W. and
            Penninger,J.M.
  TITLE     Cbl-b is a negative regulator of receptor clustering and raft
            aggregation in T cells
  JOURNAL   Immunity 13 (4), 463-473 (2000)
   PUBMED   11070165
REFERENCE   7  (bases 1 to 1759)
  AUTHORS   Kim,A.S., Kakalis,L.T., Abdul-Manan,N., Liu,G.A. and Rosen,M.K.
  TITLE     Autoinhibition and activation mechanisms of the Wiskott-Aldrich
            syndrome protein
  JOURNAL   Nature 404 (6774), 151-158 (2000)
   PUBMED   10724160
REFERENCE   8  (bases 1 to 1759)
  AUTHORS   Cory,G.O., MacCarthy-Morrogh,L., Banin,S., Gout,I., Brickell,P.M.,
            Levinsky,R.J., Kinnon,C. and Lovering,R.C.
  TITLE     Evidence that the Wiskott-Aldrich syndrome protein may be involved
            in lymphoid cell signaling pathways
  JOURNAL   J Immunol 157 (9), 3791-3795 (1996)
   PUBMED   8892607
REFERENCE   9  (bases 1 to 1759)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
REFERENCE   10 (bases 1 to 1759)
  AUTHORS   Derry,J.M., Ochs,H.D. and Francke,U.
  TITLE     Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
  JOURNAL   Cell 78 (4), 635-644 (1994)
   PUBMED   8069912
  REMARK    Erratum:[Cell. 1994 Dec 2;79(5):following 922. PMID: 8001129]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 22, 2021 this sequence version replaced XM_039099772.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158677.1, SRR26643290.55554.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               JAXUCZ010000021.1  17077057-17077250
            195-335             JAXUCZ010000021.1  17077560-17077700
            336-422             JAXUCZ010000021.1  17078229-17078315
            423-525             JAXUCZ010000021.1  17078404-17078506
            526-567             JAXUCZ010000021.1  17078639-17078680
            568-621             JAXUCZ010000021.1  17078774-17078827
            622-796             JAXUCZ010000021.1  17079732-17079906
            797-839             JAXUCZ010000021.1  17080746-17080788
            840-993             JAXUCZ010000021.1  17080990-17081143
            994-1403            JAXUCZ010000021.1  17081587-17081996
            1404-1518           JAXUCZ010000021.1  17082215-17082329
            1519-1759           JAXUCZ010000021.1  17085562-17085802
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1759
                     /gene="Was"
                     /gene_synonym="WASP"
                     /note="WASP actin nucleation promoting factor"
                     /db_xref="GeneID:317371"
                     /db_xref="RGD:1563567"
     exon            1..194
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1574
                     /gene="Was"
                     /gene_synonym="WASP"
                     /note="Wiskott-Aldrich syndrome homolog"
                     /codon_start=1
                     /product="actin nucleation-promoting factor WAS"
                     /protein_id="NP_001385676.1"
                     /db_xref="GeneID:317371"
                     /db_xref="RGD:1563567"
                     /translation="MSSGPVGGRSGGRGGPAVQQNIPSNLLQDHENQRLFELLGRKCW
                     TLATAVVQLYLALPPGAEHWTMEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELY
                     SQLVYLTPTPFFHTFAGDDCQVGLNFSDESEAQAFRALVQEKIQKRNQRQSGERRQLP
                     LTPAPTNEERRGGLPPVPPHPGGDHGGPSGGPLSLGLVTVDIQNPDITSSRYRGLPAP
                     GPGPTDKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGI
                     SEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPPPPPPCRGGGGSQPLRPPVGSN
                     KGRCGPLPPVPMGGAPPPPTPRVPPPPGRGGPPPPPPPATGRSGPPPPPLPGAGGPLA
                     PPPPPPPPPPPPVCPGSGPAPPPLPPTPVSGVGPAPGGGRGALLDQIRQGIQLNKTPG
                     AMENSVPQALPQQSEGLVGALMHVMQKRSKVIHSSDEGEDQTGEDEEDDEWDD"
     exon            195..335
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            336..422
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            423..525
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            526..567
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            568..621
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            622..796
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            797..839
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            840..993
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1403
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1518
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1759
                     /gene="Was"
                     /gene_synonym="WASP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttcttac cctgcaccca gagctttctt agctggagag gactaaggca gaaggcacca
       61 tcatgagtag tggccctgta ggaggcaggt ctgggggccg agggggacca gcagttcagc
      121 agaacattcc ttccaacctc ctccaggacc atgagaacca gagactcttc gagcttctcg
      181 gccgaaaatg ctggacactg gcaactgcag ttgttcagct gtacctggca ctgccccctg
      241 gagctgagca ctggaccatg gaacactgcg gggctgtgtg cttcgtgaag gataaccctc
      301 agaagtcgta cttcatccgc ctttatggcc tacaggctgg tcgactactc tgggaacagg
      361 agctatactc acagctggtt taccttactc ctaccccatt cttccacacc tttgctggag
      421 atgactgtca agtaggactg aacttttcgg atgagagtga agcccaggcc ttccgggcct
      481 tggtgcagga gaagatacaa aaaaggaatc agaggcaaag tggagaaaga cgccagctac
      541 cactgacacc agcaccaacc aatgaggaga gaagaggagg gctcccacct gtgcccccac
      601 atcccggtgg agatcatggg ggcccatcag gtggtccact atctctggga cttgtgacag
      661 ttgacattca gaatcctgac atcacaagtt cacgttaccg tgggctccct gcacctggcc
      721 ctggcccaac tgataagaaa cgctcaggaa aaaagaagat cagtaaagct gatattggtg
      781 caccaagtgg attcaaacac gtcagccacg tgggctggga tccacagaac ggatttgatg
      841 tgaacaacct cgacccggat ctgcgcagtt tgttctctag ggcagggatc agtgaggccc
      901 aactcactga cgcagagacc tccaagctca tctatgactt tattgaggac cagggtggtc
      961 tagaggcagt ccggcaggag atgaggcgcc aggagccacc accaccacca ccatgccgag
     1021 gaggaggagg aagccagccc ctaagacccc ctgttgggag taataagggt cgctgtggtc
     1081 cactgccccc tgtacctatg gggggtgctc cgcccccacc aacaccccga gtgcccccac
     1141 ctccgggccg agggggtcct ccaccaccac cccctccagc cactggaaga tctggaccac
     1201 cacctcctcc actccctgga gctgggggac cactagcgcc accgccacct ccaccaccac
     1261 caccaccacc tccagtctgc cctggaagtg ggccagcccc tcccccgctc cctcctactc
     1321 cagtgtctgg ggtggggcca gcacctggtg ggggccgggg cgcacttttg gatcaaatcc
     1381 ggcaaggaat tcagctgaac aagacccctg gagctatgga gaactcagta ccgcaagcac
     1441 tccctcagca gtcagaaggc ctagtgggtg ccctgatgca tgtcatgcag aagaggagta
     1501 aagtcatcca ctcctcagat gaaggggagg atcagaccgg tgaggatgaa gaggatgatg
     1561 aatgggacga ctgaactcat cttccttcct gcaggccagt tcctctcact ccacactcac
     1621 tctgccatcg agattcctct tcactgtcag cttccaaatt catctgtggt gaattcattc
     1681 aaccttatac ccactctaaa ctcaacaccg cgtcaacctt tacttcttcc cacgcaggga
     1741 ttaaacagga tgaaaatga
//
