LOCUS       NM_001013170            2874 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus tryptophanyl-tRNA synthetase 1 (Wars1), mRNA.
ACCESSION   NM_001013170 XM_234566
VERSION     NM_001013170.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2874)
  AUTHORS   Tsai,P.C., Soong,B.W., Mademan,I., Huang,Y.H., Liu,C.R.,
            Hsiao,C.T., Wu,H.T., Liu,T.T., Liu,Y.T., Tseng,Y.T., Lin,K.P.,
            Yang,U.C., Chung,K.W., Choi,B.O., Nicholson,G.A., Kennerson,M.L.,
            Chan,C.C., De Jonghe,P., Cheng,T.H., Liao,Y.C., Zuchner,S.,
            Baets,J. and Lee,Y.C.
  TITLE     A recurrent WARS mutation is a novel cause of autosomal dominant
            distal hereditary motor neuropathy
  JOURNAL   Brain 140 (5), 1252-1266 (2017)
   PUBMED   28369220
REFERENCE   2  (bases 1 to 2874)
  AUTHORS   Sajish,M., Zhou,Q., Kishi,S., Valdez,D.M. Jr., Kapoor,M., Guo,M.,
            Lee,S., Kim,S., Yang,X.L. and Schimmel,P.
  TITLE     Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-gamma
            and p53 signaling
  JOURNAL   Nat Chem Biol 8 (6), 547-554 (2012)
   PUBMED   22504299
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2874)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 2874)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 2874)
  AUTHORS   Wakasugi,K.
  TITLE     Species-specific differences in the regulation of the
            aminoacylation activity of mammalian tryptophanyl-tRNA synthetases
  JOURNAL   FEBS Lett 584 (1), 229-232 (2010)
   PUBMED   19941862
REFERENCE   6  (bases 1 to 2874)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   7  (bases 1 to 2874)
  AUTHORS   Wakasugi,K., Slike,B.M., Hood,J., Otani,A., Ewalt,K.L.,
            Friedlander,M., Cheresh,D.A. and Schimmel,P.
  TITLE     A human aminoacyl-tRNA synthetase as a regulator of angiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 99 (1), 173-177 (2002)
   PUBMED   11773626
REFERENCE   8  (bases 1 to 2874)
  AUTHORS   Otani,A., Slike,B.M., Dorrell,M.I., Hood,J., Kinder,K., Ewalt,K.L.,
            Cheresh,D., Schimmel,P. and Friedlander,M.
  TITLE     A fragment of human TrpRS as a potent antagonist of ocular
            angiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 99 (1), 178-183 (2002)
   PUBMED   11773625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY724504.1.
            
            On Apr 9, 2005 this sequence version replaced NM_001013170.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY724504.1, SRR8487226.86133.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984031 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2874              AY724504.1         1-2874
FEATURES             Location/Qualifiers
     source          1..2874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2874
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /note="tryptophanyl-tRNA synthetase 1"
                     /db_xref="GeneID:314442"
                     /db_xref="RGD:1308278"
     exon            1..55
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            56..228
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1545
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /EC_number="6.1.1.2"
                     /note="tryptophanyl-tRNA synthetase, cytoplasmic; trpRS"
                     /codon_start=1
                     /product="tryptophan--tRNA ligase, cytoplasmic"
                     /protein_id="NP_001013188.2"
                     /db_xref="GeneID:314442"
                     /db_xref="RGD:1308278"
                     /translation="MADMPSGESCTSPLELFNSIAAQGELVRSLKAGNAPKDEIESAV
                     KMLLSLKMNYKTAMGEEYKAGCPPGNSTAGSNGDPDATKASEDFVDPWTVRTSSAKGI
                     DYDKLIVQFGSSKIDKELINRIERATGQRPHRFLRRGIFFSHRDMNQILDAYENKKPF
                     YLYTGRGPSSEAMHLGHLVPFIFTKWLQDVFDVPLVIQMSDDEKYLWKDLTLEQAYSY
                     TVENAKDIIACGFDVNKTFIFSDLEYMGQSPGFYKNVVKIQKHVTFNQVKGIFGFTDS
                     DCIGKISFPAVQAAPSFSNSFPKIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGHP
                     KPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKSKVNKHAFSGGSDTVEEHR
                     QFGGNCEVDVSFMYLTFFLEDDDSLEQIRKDYTSGAMLTGELKKTLIDVLQPLIAEHQ
                     ARRKAVTEETVKEFMAPRQLSFHFQ"
     exon            229..442
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            443..551
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            552..671
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            672..854
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            855..955
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1068
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1242
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1383
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..2874
                     /gene="Wars1"
                     /gene_synonym="Wars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtaccggtg gctgaaccag cggtgctgac tggtggagcc gaacaggggc tgccgagtcc
       61 tgtctcaact gctgaacaca cttctcacac gccagctgca ggcctaggtc ctagaagatg
      121 gcagacatgc ccagtggcga gtcctgcacc tctccactgg agctcttcaa cagcatagct
      181 gctcaagggg agctcgtgag gtccctcaaa gctggaaatg caccaaaaga tgagattgag
      241 tctgcagtaa agatgttgtt gtcattaaaa atgaactata agactgccat gggggaggaa
      301 tacaaggctg gctgccctcc tgggaattca acagctggga gtaatggtga cccagatgcc
      361 acaaaagcca gcgaggattt tgtggatcca tggacggtgc ggacaagcag cgcaaaaggc
      421 atcgactacg acaaactcat tgttcagttt ggaagcagca aaattgacaa ggagctgata
      481 aaccgaatcg agcgagccac gggccaaagg ccacaccgct tcctgcgccg gggcatcttc
      541 ttctcccacc gagatatgaa tcaaattctg gatgcctatg aaaataagaa gccattttac
      601 ctgtacacag gcaggggccc ctcctccgaa gcaatgcatc tgggtcatct cgtcccattt
      661 attttcacaa agtggctgca ggatgtgttc gatgtgcctc tggtcatcca gatgtctgat
      721 gatgagaagt acctgtggaa ggacttgact ctggaacagg catacagcta caccgtggaa
      781 aatgccaagg acatcattgc ctgtggcttt gacgtcaaca aaacgttcat cttctctgat
      841 cttgagtata tggggcagag cccaggcttc tacaagaacg tggtgaagat tcagaagcat
      901 gtcaccttca accaagtgaa aggcatcttt ggcttcactg acagtgactg cattgggaag
      961 atcagttttc ctgctgttca ggctgcccca tcattcagca actctttccc gaagatcttc
     1021 cgagacagga cggatatcca gtgcctcatc ccatgtgcca ttgaccagga cccgtacttc
     1081 agaatgacaa gggatgtggc ccccagaatc ggccatccta agcctgccct gctgcactcg
     1141 accttcttcc ctgctttgca gggtgctcag accaagatga gcgccagtga ccccaactcc
     1201 tccatcttcc tcaccgacac ggccaagcag atcaagagca aggtcaacaa gcatgcattt
     1261 tctggaggaa gtgacaccgt ggaggaacac aggcagtttg ggggcaactg tgaagtagac
     1321 gtgtccttca tgtatctgac cttcttcctt gaagatgacg acagtctgga gcagatcaga
     1381 aaggattaca ctagcggagc catgctcact ggggagctca agaagacgct catagatgtc
     1441 cttcagcccc tgattgcaga gcaccaggcc cgacgcaagg cggtcaccga ggaaacagtg
     1501 aaggagttca tggcaccccg acagctgtcc tttcacttcc agtaatgcct cttttctgtg
     1561 acaaacctgt ccgtaatccc accctgtcaa atcaagtcac actccctata ggcttccgtc
     1621 acgtggtaat tcctggacct gggtctctat gcacttgtgc agcattctgg acgctgtttc
     1681 ttctgtgatg tctccgtctg ttttctgcta agggtgatca ggtgatgcta atgtcgtgtg
     1741 gtcagatgga agcccagccc agaatctctc ccacaaagag cccagatgtg ctgcctccct
     1801 ggcccacata ggactgtctg cctagcagcc tagggctcca aaacaaactc taaaatgtat
     1861 tccagtgtgt gtgttcagct ggtcttggtg gtacacactt tatagtctct gtactcagga
     1921 ggctaagaca caagatctga gccaccctgg gctactagca tgatcctgta gtaatctgtt
     1981 taattctggt tctgtggagt cagaatgtca ttattgtaaa actgaaaact gttgtgaaaa
     2041 actgacaagg agacatgtgg tgggaaatgc cactgctcca gccacaccac acacacacac
     2101 acacacacac cacacacact cacaccacac acacatacca catacacaca cacacacaca
     2161 cacacacaca cacacacaca cgtgtaatat ggacaggctt tgctttatac ctgactagga
     2221 agtcatcagc tttgtcctgg aggagtagct cagcagtaga gcactcgcct aacatgcatg
     2281 acaccctggg ttcagtctcc tgcaccacaa agctgggtgg ataattcagc tttatgcttt
     2341 aacactgatt atggagcagg ctgggtcact tctactaacc caaatcttgt gggagagact
     2401 tgaggctgaa gtaactaaac tccagatcac acgtgctgtc cactccagaa tcgtgcttgt
     2461 tacccttagt gtcctaactt tcccacagat ggcccagact ccaccttgtc aagcccagtg
     2521 gtggcttctc ccaaccacca gactctaagg acggtctgtt acctttgcag atgcttttgc
     2581 tttgacactt gactgaagtg gagggcaggc cagaagtgtg ctggccatgc ctcaggccgg
     2641 tggaccatag ctagacagac agaagaacag cagctgtcca ggccccagtg ctctccctct
     2701 ggggtggctg catgtatgag ccgccctcag agtcttggaa agcagaggcc atatctcagg
     2761 gaaagccctg gttgaagggt ctgtcctctc tgaaggcaca agggccgctc gctctgagtg
     2821 ttctgacctt gcaccatttt caggcaagaa ataataaact gttgtgctcc cgtc
//
