LOCUS       NM_053751                572 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus whey acidic protein (Wap), mRNA.
ACCESSION   NM_053751
VERSION     NM_053751.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 572)
  AUTHORS   Jura,J., Jura,J., Murzyn,K., Wegrzyn,P. and Zarebski,A.
  TITLE     Cloning and characterization of 5' upstream promoter region of rat
            WAP gene
  JOURNAL   Biochim Biophys Acta 1727 (1), 58-64 (2005)
   PUBMED   15652158
  REMARK    GeneRIF: there are two conserved regions highly similar to
            hypersensitive sites present in mouse and rabbit upstream region of
            WAP gene with binding sites for STAT5 transcription factor,
            essential for expression of WAP gene in mammary glands during
            lactation.
REFERENCE   2  (bases 1 to 572)
  AUTHORS   Campbell,S.M., Rosen,J.M., Hennighausen,L.G., Strech-Jurk,U. and
            Sippel,A.E.
  TITLE     Comparison of the whey acidic protein genes of the rat and mouse
  JOURNAL   Nucleic Acids Res 12 (22), 8685-8697 (1984)
   PUBMED   6095207
REFERENCE   3  (bases 1 to 572)
  AUTHORS   Dandekar,A.M., Robinson,E.A., Appella,E. and Qasba,P.K.
  TITLE     Complete sequence analysis of cDNA clones encoding rat whey
            phosphoprotein: homology to a protease inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 79 (13), 3987-3991 (1982)
   PUBMED   6955785
REFERENCE   4  (bases 1 to 572)
  AUTHORS   Hennighausen,L.G., Sippel,A.E., Hobbs,A.A. and Rosen,J.M.
  TITLE     Comparative sequence analysis of the mRNAs coding for mouse and rat
            whey protein
  JOURNAL   Nucleic Acids Res 10 (12), 3733-3744 (1982)
   PUBMED   6896749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Mar 27, 2023 this sequence version replaced NM_053751.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J00801.1, J00802.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760434,
                                           SAMN06680416 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000014.1  85719045-85719159   c
            116-250             JAXUCZ010000014.1  85718214-85718348   c
            251-412             JAXUCZ010000014.1  85717742-85717903   c
            413-572             JAXUCZ010000014.1  85717038-85717197   c
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..572
                     /gene="Wap"
                     /note="whey acidic protein"
                     /db_xref="GeneID:114596"
                     /db_xref="RGD:621851"
     exon            1..115
                     /gene="Wap"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..441
                     /gene="Wap"
                     /note="whey phosphoprotein"
                     /codon_start=1
                     /product="whey acidic protein precursor"
                     /protein_id="NP_446203.2"
                     /db_xref="GeneID:114596"
                     /db_xref="RGD:621851"
                     /translation="MRCFISLVLGLLALEVALARNLQEHVFNSVQSMCPDDSSSEDTE
                     CINCQTNEECAQNDMCCPSSCGRPCKTPVNIEVQKAGRCPWNPIQMIAAGPCPKDNPC
                     SIDSDCSGTMKCCNNGCIMSCMDPEPESPTVISFQ"
     exon            116..250
                     /gene="Wap"
                     /inference="alignment:Splign:2.1.0"
     exon            251..412
                     /gene="Wap"
                     /inference="alignment:Splign:2.1.0"
     exon            413..572
                     /gene="Wap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcacttgc ctgccgccgc cgacaccatg cgctgcttca tcagcctcgt tcttggcctg
       61 ctggccctgg aggtagccct tgctcggaac ctacaggaac atgtcttcaa ctcagttcag
      121 tccatgtgcc ctgatgacag ctccagtgag gacacagaat gtatcaactg tcaaaccaac
      181 gaggagtgtg cccagaatga catgtgttgt cccagttcct gtggtaggcc ctgcaaaact
      241 cctgtcaaca ttgaggttca aaaggctggc cgctgcccct ggaatccaat ccagatgatc
      301 gctgctggac catgcccaaa ggacaaccca tgctccatcg acagtgattg ttctggcacc
      361 atgaaatgct gcaacaatgg ctgtatcatg agttgtatgg acccagaacc agaatctcct
      421 acagtgatat cctttcagtg agaagcctgc cctgggatcc ctgcctgtca ggagtgacca
      481 gcccaagcct gtacagcaag aaccttcact cttggatcca gagagaacat aatgctttct
      541 aactgctgct aataaaaatc catttggctt ta
//
