LOCUS       NM_053889               8803 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus von Willebrand factor (Vwf), mRNA.
ACCESSION   NM_053889 XM_001066203 XM_342759
VERSION     NM_053889.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8803)
  AUTHORS   Zhou,H., Yang,Z., Mu,L. and Shi,Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8803)
  AUTHORS   Horioka,K., Tanaka,H., Isozaki,S., Okuda,K., Asari,M., Shiono,H.,
            Ogawa,K. and Shimizu,K.
  TITLE     Hypothermia-induced activation of the splenic platelet pool as a
            risk factor for thrombotic disease in a mouse model
  JOURNAL   J Thromb Haemost 17 (10), 1762-1771 (2019)
   PUBMED   31237986
REFERENCE   3  (bases 1 to 8803)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 8803)
  AUTHORS   Abdelmagid,N., Bereczky-Veress,B., Atanur,S., Musilova,A.,
            Zidek,V., Saba,L., Warnecke,A., Khademi,M., Studahl,M.,
            Aurelius,E., Hjalmarsson,A., Garcia-Diaz,A., Denis,C.V.,
            Bergstrom,T., Skoldenberg,B., Kockum,I., Aitman,T., Hubner,N.,
            Olsson,T., Pravenec,M. and Diez,M.
  TITLE     Von Willebrand Factor Gene Variants Associate with Herpes simplex
            Encephalitis
  JOURNAL   PLoS One 11 (5), e0155832 (2016)
   PUBMED   27224245
  REMARK    GeneRIF: Von Willebrand Factor Gene Variants Associate with Herpes
            simplex Encephalitis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8803)
  AUTHORS   Peyvandi,F., Scully,M., Kremer Hovinga,J.A., Cataland,S., Knobl,P.,
            Wu,H., Artoni,A., Westwood,J.P., Mansouri Taleghani,M., Jilma,B.,
            Callewaert,F., Ulrichts,H., Duby,C. and Tersago,D.
  CONSRTM   TITAN Investigators
  TITLE     Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura
  JOURNAL   N Engl J Med 374 (6), 511-522 (2016)
   PUBMED   26863353
REFERENCE   6  (bases 1 to 8803)
  AUTHORS   Rand,J.H., Patel,N.D., Schwartz,E., Zhou,S.L. and Potter,B.J.
  TITLE     150-kD von Willebrand factor binding protein extracted from human
            vascular subendothelium is type VI collagen
  JOURNAL   J Clin Invest 88 (1), 253-259 (1991)
   PUBMED   2056120
REFERENCE   7  (bases 1 to 8803)
  AUTHORS   Reidy,M.A., Chopek,M., Chao,S., McDonald,T. and Schwartz,S.M.
  TITLE     Injury induces increase of von Willebrand factor in rat endothelial
            cells
  JOURNAL   Am J Pathol 134 (4), 857-864 (1989)
   PUBMED   2650559
REFERENCE   8  (bases 1 to 8803)
  AUTHORS   Dorner,A.J., Bole,D.G. and Kaufman,R.J.
  TITLE     The relationship of N-linked glycosylation and heavy chain-binding
            protein association with the secretion of glycoproteins
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2665-2674 (1987)
   PUBMED   3121636
REFERENCE   9  (bases 1 to 8803)
  AUTHORS   Sporn,L.A., Marder,V.J. and Wagner,D.D.
  TITLE     Inducible secretion of large, biologically potent von Willebrand
            factor multimers
  JOURNAL   Cell 46 (2), 185-190 (1986)
   PUBMED   3087627
REFERENCE   10 (bases 1 to 8803)
  AUTHORS   Wagner,D.D., Mayadas,T. and Marder,V.J.
  TITLE     Initial glycosylation and acidic pH in the Golgi apparatus are
            required for multimerization of von Willebrand factor
  JOURNAL   J Cell Biol 102 (4), 1320-1324 (1986)
   PUBMED   3082891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BK007994.1.
            
            On or before Feb 10, 2013 this sequence version replaced
            XM_001066203.3, XM_342759.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK007994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8803              BK007994.1         1-8803
FEATURES             Location/Qualifiers
     source          1..8803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..8803
                     /gene="Vwf"
                     /note="von Willebrand factor"
                     /db_xref="GeneID:116669"
                     /db_xref="RGD:621759"
     exon            1..229
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..8668
                     /gene="Vwf"
                     /codon_start=1
                     /product="von Willebrand factor precursor"
                     /protein_id="NP_446341.1"
                     /db_xref="GeneID:116669"
                     /db_xref="RGD:621759"
                     /translation="MNPFGYEICLLVLALTWPGTLCTEDPRDRPSTARCSLFGDGFIN
                     TFDEAMYSFAGGCSYLLAGDCQKRSFSILGNFQDGKRVGLSVYLGEFFDIHLFANGTV
                     MQGDQSISMPYASKGLYVEHEAGYYKISSEAFGFAARIDGDGNFQVLMSDRHFNKTCG
                     LCGDFNIFAEDDFRTQEGTLTSDPYDFANSWALSSENQRCKRTSPPSTNCTSSSGDMQ
                     QAMWEQCQLLKTASVFARCHPLVDPEPFVALCEKTLCTCVTGPECACPALLEYARTCA
                     QEGMVLYGWADHSACRPACPAGMEYKECVSPCTRTCQSLPINEVCQQQCVDGCGCPEG
                     ELLDEDRCVQSSDCSCVHAGKRYPPGTSLPQDCNTCICRHSLWICSNEECPGECLVTG
                     QSHFKSFDNRHFTFSGICQYLLARDCQDHSFSIVIETMQCADDPDAVCTRSVSVRLSA
                     LHNSLMKLKHGGGVAIDGQDVQIPFLQGDLRIQHTVMASVRLSYGEDLQMEWDGRGRL
                     LVKLSPIYSGKTCGLCGNYNGNKGDDFLTPAGLVEPLVVDFGNAWKLQGDCPDLHRQH
                     SDPCSLNPRLTRFAEEACALLTSSKFETCHHAVSPLPYLQNCRYDVCSCADSQDCLCS
                     AVANYAAACARKGVHIGWREPDFCALSCPQGQVYLQCGNSCNMTCRSLSLPDEECSEV
                     CLEGCFCPPGLYQDERGDCVPKAQCPCYHDGELFQPADIFSDHHTMCYCEDGFMHCTT
                     SGASGSLLPNIVLSSPLSHRSKRSLSCRPPMVKLVCPADNPRAQGLECAKTCQNYDLE
                     CMSLGCVSGCLCPPGMVRHENRCVALERCPCFHQGEAYSPGDTVKIGCNTCVCRDRRW
                     NCTTHVCDATCSALGMAHYLTFDGLKYLFPGECQYVLVQDYCGGSSGTFRILVGNEGC
                     TYPSVKCKKRVTILVDGGEIELFNGEVNVKRPLKDESHFEMVESGQYVILLLGQGLSV
                     VWDHRLSISVVLKYTYQEHVCGLCGNFDGIQNNDFTSSSLQVEEDPIDFGNSWKVSPQ
                     CADTRKLSLDVSLAACHNNIMKQTMVDSSCRILTSDIFQGCNRLVDPEPYLDICIYDT
                     CSCESIGDCSCFCDTIAAYAHVCAQHGQVVAWRKPTLCPQSCEERNVRENSYECEWRY
                     NSCAPACPVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDAQDCPVCEVAGR
                     RLASGKKITLSPNDPQHCQNCHCDGVNLTCEACQEPGGLVVPPTDAPVSSTTPYVEDT
                     PEPPLHNFYCSKLLDLVFLLDGSYRLSEAEFEVLKAFVVGTMERLHISQKRIRVAVVE
                     YHDGSHAYLELRARKRPSELRRIASQIKYVGSQLASTSEVLKYTLFQIFGKIDRPEAS
                     RVILLLTASQEPQRMARYFTRYLQGFKKKKVILIPVGIGPHANLKQIRLIEKQAPENK
                     AFLLSGVDELEQRRDEIINYLCDLAPEAPAPTKPPQVAHITVSPGISGVSSPGPKRKS
                     LVLDVVFVLEASDEVGEANFNKSKEFLEEVIQRMDVSPAGTHIAVLQYSYTVNVEYTF
                     KEAQSKEDVLRHVREIRYQGGNRTNTGQALQYLSEHSFSPSQGDREQAPNLVYMVTGN
                     PASDEIRRLPGDIQVVPIGVGSRANLQELERISRPIAPIFIQDFETLPREAPDLVLRT
                     CCSKEGLQLPTLPPLPDCSQPLDVVLLLDGSSSLPASSFDEMKSFAKAFISKANIGPH
                     LTQVSVIQYGSINTIDVPWNVAQEKAYLQSLVDLMQQEGGPSQIGNALAFAVRYVTSQ
                     IHGARPGASKAVVMIIMDTSLDSVDTAVDAARSNRVAVFPIGVGDRYDEAQLRILAGP
                     GASSNVVKLQQVEDLLTMVTPGNSFFHRLCSGFSGVCVDEDGNEKRPGDVWTLPDQCH
                     TVTCLANGQTLLQSHRVNCDHGPRPSCSNSQSPVRVEETCGCRWTCPCVCTGSSTRHI
                     VTFDGQNFKLTGNCSYVIFQNKEQDLEVVLHNGACSPGAVQTCMKTIEVKHAGLSVEL
                     RSDMEMAVNGRPVLAPYVGGNMQVSIYGAIMYEVRFTHLGHTLTFTPQNNEFQLQLSP
                     KTFASKMYGLCGICDENGANDFTLRDGTVTTDWKRLIQEWTVQQPGSTCQSVPEEQCP
                     ISDSSHCQVLLSASFAECHKVIAPATFHTICQQDSCHQERVCEVIASYAHLCRTNGVC
                     VDWRTTDFCAMSCPPSLIYNHCERGCPRYCDGNTSFCGDHPSEGCFCPQHQVLLEGSC
                     VPEEACTQCVGDDGVRHQFLETWVPDHQPCQICMCLSGRKINCTAQPCPTARAPTCGP
                     CEVARLKQSADLCCPEYECVCDLVNCNLPPVPPCEGGLQPTLTNPGECRPTFTCACRK
                     EECKRVSPPSCPPHRTPTLRKTQCCDEYECTCSCVNSTLSCPLGYLASATTNDCGCTT
                     TTCLPDKVCVHRGTVYPVGQFWEEGCDTCTCTDMEDTVVGLRVAQCSQKPCEDSCQPG
                     FSYVLHEGECCGKCLPSACKVAGSPRGDSLSSWKSVGSQWAVPENPCLINECVRVEDA
                     VFVQQRNISCPQLAVPTCPTGFQLNCETSACCPSCHCEPVEACLLNGTIIGPGKSVMV
                     DLCTTCRCIVQRGAIFRFKLECRKTTCEACPVGYREEKSQSECCGRCLPTACTIQLRG
                     GRVMTLKQDETFQDGCDSHLCRVNERGEYIWEKRVTGCPPFDERKCLAEGGKIVKIPG
                     TCCDTCEEPDCKDITAKVQYIKVGDCKSEEEVDIHYCQGKCASKAVYSIDIEDLQEQC
                     SCCWPSSTERMRVPLLCTNGSVVHHEVINAMQCRCSPRNCGK"
     exon            230..284
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            285..449
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            450..552
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            553..761
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            762..886
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1103
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1226
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1338
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1385
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1522
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1661
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1762
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1958
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2174
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2415
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2510
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2671
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2775
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2914
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3049
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3196
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3337
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3451
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3608
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3767
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3903
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..5282
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            5283..5399
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5540
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            5541..5684
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            5685..5849
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            5850..5893
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            5894..6071
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            6072..6292
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            6293..6485
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            6486..6827
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            6828..7027
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7028..7130
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7131..7205
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7206..7310
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7311..7516
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7517..7666
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7667..7774
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7775..7955
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7956..7996
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            7997..8113
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            8114..8212
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            8213..8341
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            8342..8381
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            8382..8479
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
     exon            8480..8803
                     /gene="Vwf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacttgaagc tattgcagtg cagaggaatg ggcttggcct cagcttgggc ttgctctctc
       61 tggctgtgac gacttcaaag cccctggaca actcgccagc ccagagcctg agcagatcca
      121 tccagcattt gctcagggac atggcttagg agtgagcggt gtcaccactg agcagcggcc
      181 tgggttttgc aagggacctt ggagatacgg cccctgtttg tatggcaaga tgaatccttt
      241 cggatatgag atctgcctgt tagttctggc cctcacctgg ccagggaccc tctgcacaga
      301 agatcctcgt gacaggccgt cgacagcccg atgcagcctc tttggggatg gcttcatcaa
      361 cactttcgat gaagccatgt acagttttgc aggaggctgc agttatcttc tggctgggga
      421 ctgccagaaa cgttccttct caattctcgg gaacttccaa gatggcaaga gagtgggcct
      481 gtctgtgtat cttggggagt tttttgacat ccatttgttt gccaacggca ccgtgatgca
      541 gggggaccaa agcatctcca tgccctatgc ctccaaggga ctctatgtag agcatgaggc
      601 tgggtactac aaaatttcca gtgaggcctt cggctttgcg gccagaattg acggcgacgg
      661 caacttccaa gtcctgatgt cagacagaca cttcaacaag acctgtgggc tgtgtggtga
      721 cttcaacatc ttcgctgaag atgactttag gacgcaggag gggaccttga cctcagaccc
      781 ctacgacttt gccaactcct gggccctgag tagtgagaac cagcggtgta aacggacatc
      841 tcctcccagc actaactgca ccagctcctc tggggacatg cagcaggcca tgtgggagca
      901 gtgccagtta ctgaagacgg cgtcggtgtt tgcccgctgc caccctctgg tggatcccga
      961 gcccttcgtg gctctctgtg agaagacttt gtgtacatgc gtcacggggc cagagtgcgc
     1021 gtgtcctgct ctccttgagt atgcccgaac ctgtgcccag gaagggatgg tgctgtatgg
     1081 ctgggctgac cacagtgcct gtcgcccagc atgcccggct ggcatggagt ataaggagtg
     1141 tgtgtctcct tgcaccagaa cctgccagag cctgcctatc aatgaagtgt gtcagcagca
     1201 atgtgtagat ggctgtggct gccctgaggg agagctcctg gacgaagacc gctgtgtgca
     1261 gagctctgac tgttcttgtg tacacgccgg aaagcggtac ccacctggca cctccctccc
     1321 tcaagactgc aacacttgca tctgcagaca cagtctctgg atctgcagca atgaggaatg
     1381 cccaggggag tgtcttgtca caggccaatc ccacttcaag agcttcgaca acagacactt
     1441 caccttcagt ggcatctgcc agtacctgct ggcccgggac tgccaagacc actctttctc
     1501 cattgtcata gagaccatgc agtgcgctga tgaccctgat gctgtctgca cccgctcagt
     1561 cagtgtgcgg ctgtctgccc tgcacaacag cctcatgaag ctgaagcacg ggggaggggt
     1621 ggccatcgat ggtcaggatg tccagattcc cttcctgcaa ggtgacctcc gtatccagca
     1681 cacggtgatg gcttctgtac gcctcagcta tggggaggac ctgcagatgg aatgggatgg
     1741 ccgcgggcgg ctactggtta agctgtcccc aatctattct gggaagacct gtggtttgtg
     1801 tgggaattac aatggcaaca agggagacga cttcctcacg ccggccggcc tggtggagcc
     1861 tctggtggta gactttggaa acgcctggaa gcttcaaggg gattgtccgg acctgcacag
     1921 acaacacagc gacccctgca gcctgaaccc acgcttgacc aggtttgcgg aggaggcttg
     1981 tgcgctcctg acgtcctcca agttcgagac ctgccaccat gcggtcagcc ctctgcccta
     2041 cctgcagaac tgtcgttatg atgtttgctc ctgcgctgac agccaggatt gcctgtgtag
     2101 cgcagtagct aactacgctg ctgcgtgtgc ccgaaaaggc gtgcacatcg ggtggcggga
     2161 gccagacttc tgtgctctga gctgcccaca gggccaggtg tacctgcagt gtggcaattc
     2221 ctgcaacatg acctgccgct ccctctccct tccggatgaa gaatgcagtg aagtctgtct
     2281 tgaaggctgc ttctgccccc cagggctcta ccaggatgaa agaggggact gtgtgcccaa
     2341 ggcccagtgt ccctgttacc acgacggtga gctcttccag cctgcagaca tcttctcaga
     2401 ccaccacacc atgtgttact gtgaagatgg cttcatgcac tgtaccacga gtggtgcctc
     2461 ggggagcctg ttgcctaaca ttgtcctcag cagccccttg tctcaccgca gcaaaaggag
     2521 cctctcctgt cggccaccca tggtcaagtt ggtatgtcct gctgacaacc cacgggctca
     2581 agggctggag tgtgctaaga cgtgccagaa ctatgacctg gaatgcatga gtctgggctg
     2641 tgtgtcaggc tgcctctgtc ccccaggcat ggtccggcac gaaaacaggt gtgtggcctt
     2701 ggagcgctgt ccctgcttcc accagggtga ggcgtactcc ccaggagata cagtgaagat
     2761 cggctgcaac acctgtgtct gccgggaccg gaggtggaac tgtacaaccc acgtgtgtga
     2821 cgccacttgc tctgcccttg gtatggctca ctacctcacc ttcgatggtc tcaagtacct
     2881 gttccctggg gagtgtcagt acgttctggt gcaggattac tgtggcggta gctctgggac
     2941 ctttcggatc ctggtgggga atgagggttg cacttatccc tcggtgaaat gcaagaaacg
     3001 ggtgaccatc ctggtggatg gaggggagat tgaactgttc aatggagagg tgaatgttaa
     3061 gagacctctg aaagatgagt ctcactttga gatggtggag tcgggccagt acgtcatcct
     3121 gctgctgggt cagggccttt ctgtggtctg ggaccaccgc ctcagcatct ccgtggtcct
     3181 gaagtacaca taccaggaac acgtgtgtgg cctgtgtggg aacttcgatg gtatccagaa
     3241 caatgacttc accagcagca gccttcaggt ggaggaagac cccattgact ttgggaactc
     3301 ctggaaagtg agcccacagt gtgccgacac aagaaagctg tcactagacg tttcccttgc
     3361 cgcctgccac aacaatatca tgaaacagac aatggtggac tcatcttgca gaatccttac
     3421 cagtgacatc ttccagggct gcaacaggct ggtggacccc gagccatacc tggacatctg
     3481 catttatgac acttgctcct gtgagtccat cggggactgc tcctgtttct gtgacaccat
     3541 cgctgcctat gcccacgtgt gcgcccagca tggccaggtg gtagcctgga ggaaacccac
     3601 actgtgcccc cagagctgtg aagaaaggaa cgttcgggaa aacagctatg agtgtgagtg
     3661 gcgctataac agctgtgcac ccgcctgccc ggtcacatgc cagcaccctg agcctctggc
     3721 ttgtcctgta cagtgtgtgg agggctgcca tgcacactgc cctccaggga aaatcctgga
     3781 tgaacttctg cagacctgtg tggatgccca agactgccct gtgtgtgagg tggctggtcg
     3841 gcgcttggct tccgggaaga aaatcaccct gagtcccaat gaccctcagc actgtcagaa
     3901 ttgtcactgt gatggtgtga accttacctg tgaagcctgc caagagcccg gaggcctggt
     3961 ggtaccccca acagatgccc cagtcagctc caccacccca tatgttgagg acacccccga
     4021 accccccctg cacaacttct actgcagcaa gctgctggat ctcgtcttcc tcctggatgg
     4081 ctcctacagg ctgtctgagg ctgagtttga agtgctcaaa gcttttgtgg tgggtacgat
     4141 ggagaggcta cacatctctc agaagcgcat ccgcgtggca gtggtagagt accatgatgg
     4201 ctcccatgcc taccttgagc tcagggcccg gaagcgaccc tcagagcttc ggcgcatcgc
     4261 cagccagatt aagtatgtgg gcagccagtt ggcctctacc agtgaggttt tgaagtacac
     4321 actgttccag atctttggca aaattgaccg tcctgaagcc tcccgtgtca ttctgctcct
     4381 gaccgctagc caggagcccc aacggatggc taggtatttc acccgctatc tccaaggttt
     4441 caagaagaag aaggtcattc tgatccctgt gggcattggg ccgcacgcca acctcaaaca
     4501 gatccgcctc attgagaagc aggcccctga gaacaaggcc tttctgctta gtggggtgga
     4561 tgagctggag cagagaagag atgagataat taactacctc tgtgaccttg cccccgaggc
     4621 cccagcccct actaagcctc cacaggtagc acacatcact gtgagccctg gtatctctgg
     4681 ggtttcatca ccaggaccca aaaggaagtc tctggttctg gatgtggtgt ttgtcctgga
     4741 ggcgtcagac gaagttggtg aagccaactt caataagagc aaggagttcc tggaggaggt
     4801 tatccagcgc atggatgtga gcccggctgg gacgcacatc gcagttctgc agtactcata
     4861 cacagtaaac gtggagtaca ccttcaagga ggcccagtcc aaggaggatg tgctgcgaca
     4921 tgtgcgagag atccgctacc aggggggcaa caggacaaac actgggcagg ccctgcagta
     4981 cctttctgag cacagcttct ctcccagcca gggggaccgg gagcaggcac ctaacctggt
     5041 ctacatggtc acggggaacc ctgcctctga tgagatcagg aggttgcctg gagacatcca
     5101 ggtggtaccc attggggtgg gctccagggc caacctgcag gaactggaga ggatcagcag
     5161 acccatcgct cccatcttca tccaagactt tgagacactt ccccgagagg ctcccgacct
     5221 ggtcctgagg acgtgctgct ccaaggaggg gctgcagctg cccaccctcc cccctctccc
     5281 tgactgcagc caacccctgg atgtggtcct gctcctggat ggctcctcta gcttgcctgc
     5341 atcttccttt gatgagatga agagttttgc caaagctttc atctcaaagg ccaacattgg
     5401 gccccatctc actcaggtgt ccgtgataca atacggaagc atcaatacca tcgatgtacc
     5461 gtggaatgtg gcccaggaga aagcctatct acagagtttg gtggacctca tgcagcagga
     5521 gggcggcccc agccagattg ggaatgctct ggcctttgcc gtgcgctatg taacttcaca
     5581 gatccatgga gccaggcctg gagcctccaa agcagtggtc atgatcatca tggatacctc
     5641 cttggattcg gtggacacag cagtggatgc tgccagatcc aaccgggtgg cagtgttccc
     5701 cattggggtt ggggatcgat atgatgaagc ccagctgagg atcttggcag gccctggggc
     5761 cagctccaat gtggtaaagc tccagcaagt tgaagacctc ctcaccatgg tcaccccggg
     5821 aaactccttc ttccacagac tgtgttctgg gttttctgga gtttgtgtgg atgaggatgg
     5881 gaacgagaag aggcctggag acgtctggac cttgccagat cagtgccaca cagtgacttg
     5941 cttggcaaat ggtcagacct tgttgcagag tcatcgggtc aattgtgacc atggaccccg
     6001 gccttcatgt tccaacagcc agtctcccgt tcgggtggag gagacctgtg gctgccgctg
     6061 gacctgccct tgtgtgtgca cgggcagttc cactcggcac atcgtcacct tcgatggaca
     6121 gaatttcaag cttaccggca actgctccta cgtcatcttt caaaacaagg agcaggacct
     6181 ggaagtggtc ctccataatg gggcctgcag ccctggggcc gtgcaaacct gcatgaagac
     6241 catcgaggtt aagcatgctg gcctctctgt tgagctgcgc agtgacatgg agatggcagt
     6301 gaatgggaga cccgtccttg ccccgtacgt gggtggaaat atgcaagtca gcatctatgg
     6361 tgctatcatg tatgaagtca ggttcaccca tcttggtcac actctcacat ttactccaca
     6421 aaacaacgag ttccaactgc agcttagccc caagaccttt gcttcgaaga tgtatggtct
     6481 ctgtggaatc tgtgacgaaa atggggccaa tgacttcaca ttgcgagatg gcacggtcac
     6541 cacagactgg aagaggctta tccaggaatg gaccgtgcag cagccaggga gcacatgcca
     6601 gtctgttcct gaagagcagt gtcccatctc tgacagctcc cactgccagg tcctcctctc
     6661 agcatcgttt gctgaatgcc acaaggtcat cgctccagcc acattccata caatctgcca
     6721 gcaagacagt tgccaccagg agcgagtgtg tgaggtgatt gcttcttacg cccatctctg
     6781 tcggactaat ggagtctgtg ttgattggag gacaactgac ttctgtgcta tgtcatgccc
     6841 accatccctg atatataacc actgtgagcg tggctgccct cggtactgtg atggaaacac
     6901 tagcttctgt ggcgaccacc cctcagaagg ctgcttctgc ccccaacacc aagtcttgct
     6961 ggaaggcagc tgtgtccccg aagaggcctg cactcagtgt gttggggacg atggagtccg
     7021 acatcagttc ctagagacct gggtcccaga ccatcagccc tgtcagatct gtatgtgcct
     7081 cagtgggagg aagattaact gcactgcaca gccatgtccc acagcccggg ctcccacctg
     7141 tggcccttgt gaagtggctc gtctcaagca gagtgcagac ctgtgctgcc cagagtatga
     7201 gtgtgtgtgt gacctggtca actgcaactt gccaccagtg cctccgtgtg aaggaggact
     7261 ccagccaacc ctgaccaacc ctggagaatg cagacccacc tttacctgtg cctgcaggaa
     7321 agaagagtgc aaaagagtgt ccccaccctc ctgcccccct caccggacac ccacccttcg
     7381 gaagacccag tgctgtgatg agtatgaatg cacttgcagc tgtgtcaact ccacgctgag
     7441 ctgcccactt ggctacctgg cctcggccac caccaatgac tgtggctgca ccacaaccac
     7501 ctgtctccct gacaaggttt gtgtccaccg aggcaccgtc taccctgtgg gccagttctg
     7561 ggaggagggc tgtgacacat gcacctgcac cgacatggag gatactgttg tgggcctgcg
     7621 tgtggctcaa tgctctcaga agccctgtga agacagctgt cagccaggtt tttcttatgt
     7681 tctccacgaa ggggagtgct gtggaaagtg cctgccgtct gcttgcaagg tggctggctc
     7741 accgaggggt gattccctct cttcctggaa gagcgttggg tctcagtggg ctgttcctga
     7801 gaacccctgc ctcatcaatg agtgtgtccg agtggaggac gcagtgtttg tgcagcagag
     7861 gaacatctcc tgcccacagc tggctgtccc tacctgtccc acgggcttcc agctgaactg
     7921 tgagacctca gcatgctgtc ccagctgtca ctgtgagcct gtggaggcct gcctgctcaa
     7981 tggcaccatc attgggcccg ggaagagtgt gatggttgac ttatgcacga cctgccgttg
     8041 cattgttcag agaggagcca tcttcagatt caagctggag tgcagaaaga ccacctgtga
     8101 ggcctgccct gtgggctatc gggaggagaa gagtcagagc gaatgctgtg gccggtgcct
     8161 gcctacggct tgcactattc agctgagagg aggacgggtc atgaccctga agcaagatga
     8221 gacattccag gatggctgtg acagtcatct gtgcagggtc aacgagagag gggagtacat
     8281 ttgggagaag agggtcacgg gctgcccccc attcgatgaa cgcaagtgtc tggctgaagg
     8341 aggcaaaatc gtgaaaattc caggcacctg ctgtgacacg tgtgaggagc ccgattgcaa
     8401 agacatcaca gccaaggtgc agtatatcaa agtgggagat tgtaagtcgg aagaggaagt
     8461 ggacattcac tattgccagg gaaagtgcgc cagcaaagct gtgtactcca ttgacatcga
     8521 ggatcttcag gaacagtgct cctgctgctg gccctcaagt acagagcgca tgcgtgtgcc
     8581 cttgctctgc accaatggct cggttgtgca ccacgaggtc atcaatgcca tgcaatgcag
     8641 atgttctccc cgtaattgtg gcaagtgagg cctgtgcagc cacggcagac tcctactgct
     8701 acccatgctg tggcctgacc agccagagaa cctctctctc ccctgtgcat cctgcccttt
     8761 gtgccctcct gggcccacaa taaaggccaa gttctcctct taa
//
