LOCUS       XM_039094042            6962 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus von Willebrand factor A domain
            containing 8 (Vwa8), transcript variant X1, mRNA.
ACCESSION   XM_039094042
VERSION     XM_039094042.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051350.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_001427283.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..6962
                     /gene="Vwa8"
                     /note="von Willebrand factor A domain containing 8;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 30 ESTs, 4 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 121 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:290381"
                     /db_xref="RGD:1308772"
     CDS             164..5881
                     /gene="Vwa8"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 8 isoform X1"
                     /protein_id="XP_038949970.1"
                     /db_xref="GeneID:290381"
                     /db_xref="RGD:1308772"
                     /translation="MQSRLLLLGVPGGLGDVASRRVRLLLRQVLRGRPGGGQQRLEVR
                     LMHAGVTDSGETVNIGDVSYKLKTPKNPELVPQNYIAASPSQSVVQHLRWIMQKDLLG
                     QDVFLIGPPGPLRRSVAMQYLELTKQEVEYIALSRDTTETDLKQRREIRAGTAFYIDQ
                     CAVRAATEGRTLVLEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRDH
                     TKEELDAWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYFLPFQDQLKL
                     LYSVGANVSAEKISQLLSFATTLCSQESSTLGLPDFPLDSLPEAVQILDSFPMMPIEH
                     AIRWMYPYTVLLGHEGKMAVEGVLKRFELQGSGHSLLPKEIVRVERMTDSHISHAHVT
                     IRVSGKEVTIKVPAGTRAVNQPCAPDRFIQTVSHKQLLAEMMQSHMVKDICLIGGKGC
                     GKTVMAKNFAALLGYSIEPIMLYQDMTARDLLQQRYTLPNGDTAWRSSPLVSAAREGK
                     LVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYLCLKERLQLTDEQLQNR
                     SIFPIHPSFRIIALAEPPVVGSTTQQWLGPEFLTMFFFHHMKPLVKSEELQVIKEMVP
                     NVPQEALEKLLSVTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYPSENLHDAITK
                     ACLSRFLPSLAQSALEKNLADAAIEINADSSLEPELENYKCEVVAGSLKIGTVSAPVH
                     NAHEKMKVPDVLFYDNVQHMVVMEDMLKDFVLGEHLLLVGNQGVGKNKIVDRFLHLLN
                     RPREYIQLHRDTTVQSLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNVT
                     CILKTLVENGEMILADGRRIVADAASVDGRENAIVVHPDFRMVVLANRPGFPFLGNDF
                     FGTLGDIFSCHAIDNPKPHSELEMLKQYGPNVPVPVLEKLVAAFGELRNLADQGIINY
                     PYSTREVVNIVKHLEKFPTEGLSSVVRNVFDFDSYNNDMREILMNTLHKYGIPIGAKP
                     TNVQLAKEFPLPEKTFMGYWIIGQTGNGMQKVLCPAETHRIDIKGPVLVNIEKYPIEK
                     HESRFLNFTEECTSWRFPVDEVNLISDIAVSHENGEHTLYVATCNPISLYFMNMTGEN
                     GFFVDFFDIFPRMASGSWRPFVTVAPLGSPLRGQVVLHEEQSNVVLLLDTTGRAIHRL
                     VLPTEESTSKKSSWWNKEEGETYRMCKEFSHKNWVVFYRQTGNSLTVLDVLEGLTHTI
                     SLPINLRTVFLVAEDKWLLVENKTNQKCLLTKPAHIGAEDTGACQLYMLKEELPSTGF
                     GVTQETEFYVPHKVSSDQLSSENLTSAVGQKIASPNRILSDEKSHATIVVGFPDLMSP
                     CEVYSWKRSSSLGKPSVTNITMYTGKRTSVTPRHNNCVTLTHTNQVVRILPAGEVPLK
                     DIYPKDVTPPQTAGYIEVTDLQAKKLRYIPVPSAESLSPYTAWLSAISDTDALLAEWD
                     KSSVVTVDMGGCVRLWETGLERLQQSLMEWRNMIGQDSDKHMQITIERDSNEDVSEPK
                     HGKEDPDNMPHVGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHPVYQVSEVEKDAVPED
                     IKRAAREMAQRAFQQRLKEIQMSEYDAATYERFSRAVQRQVHALRVILDNLQAKGKER
                     QWLRHQATGELDDAKIIDGLAGEKAIYKRRGDLEPQLGSPQQKPKRLRLVVDVSGSMY
                     RFNGVDRRLERSMEAVCMVMEAFENYEEKFKYDIAGHSGDGYNIKLVPVNKIPKNNKQ
                     RLEILKTMHAHSQFCMSGDHTLEGTEHAIKDITTEEADEYFVIILSDANLSRYGINPA
                     RFAQILTSNPQVNAFAIFIGSLGDQAARLQRTLPAGRSFIAMDTKKIPQILQQIFTST
                     MLSSI"
ORIGIN      
        1 ggccgggccc acacggccga gcccagcgcg ccgggggaag gagtttccgg cggacccgcc
       61 tcccagccgc ttcctgtccc gcttgccgac cggctcctgc cccgtcccgg gacggcgctt
      121 ggccccgcag cccctggagg tcccactccg tgcctcctgc actatgcagt cccgcctcct
      181 cctccttgga gtcccgggcg gcctcggcga cgtggcctcg cggcgcgtgc ggctgcttct
      241 gcggcaggtg ctgcggggca ggccgggtgg gggccagcag cggctggagg tcagactgat
      301 gcacgctggg gtgactgact caggtgaaac tgttaatatt ggagatgtgt cttacaagct
      361 gaaaactccc aagaatccag aacttgtccc acagaactac attgcagctt ctccgtctca
      421 gtccgtagtc cagcacctga gatggataat gcagaaggac ctgctggggc aagatgtctt
      481 tctcataggg cctcccgggc ctctgcgacg ctcggttgct atgcagtact tggagctgac
      541 caaacaagag gtggaataca tcgccctgtc aagggacacc accgaaacag acctcaaaca
      601 acgccgggag atccgagctg gcacagcctt ttacattgac cagtgtgctg ttcgggctgc
      661 cacagaaggc aggacgctgg ttttagaagg cttggaaaaa gcagagagaa acgtgcttcc
      721 ggtactgaac aacttgctgg agaaccggga gatgcagctt gaagatggcc gcttcctgat
      781 gtctgctgag cgctacgaca agctcctccg agatcacact aaagaggagt tggatgcttg
      841 gaagattgtc cgagtcagcg aaaacttccg agtgattgcc ttgggcttgc cagtgcccag
      901 gtactctggg aatcctttag accctcctct ccgttctcga tttcaagcca gagatattta
      961 ttttctaccc tttcaggacc aattaaaact attatattca gttggagcca atgtttctgc
     1021 tgagaagatc tctcagctct tgtcctttgc tacaaccctc tgctcccaag aatcctctac
     1081 acttgggctt ccagactttc ccttagatag tttgccagag gcagttcaaa tcctggattc
     1141 ctttcccatg atgccaattg aacatgcaat ccggtggatg tatccttaca ctgttttact
     1201 aggacacgaa gggaagatgg cggtggaggg tgttctaaaa cgctttgagc tccaaggttc
     1261 tggacactcc ctgcttccta aagagatcgt aagagtggag aggatgactg acagccacat
     1321 ctcccatgcc cacgtgacaa tccgggtctc aggaaaagag gtgaccatta aggtgccagc
     1381 tgggactaga gcagtgaacc agccttgcgc tcctgaccgt ttcattcaga ctgtgagtca
     1441 caagcagtta ctggctgaga tgatgcagtc tcatatggtg aaggacatat gtttaattgg
     1501 agggaagggc tgtgggaaaa ctgtcatggc taagaacttt gctgctctcc taggatacag
     1561 catagaaccc atcatgctct accaggatat gacagctcgg gacctgctac agcagcggta
     1621 cacgctcccc aacggtgaca ctgcctggcg ctcctcaccc cttgtgagcg ctgctcggga
     1681 aggcaagctg gtcctgttgg atggcatcca ccgagtcaac gctggcacgc tggctgtatt
     1741 gcaaagacta atccatgacc gagagctcag cctgtatgat ggatctcggc tgctgaggga
     1801 agacaggtac ctgtgcctga aggagcggct acaactgacg gacgagcagc tacagaacag
     1861 atccattttt cctatccacc cctccttcag aatcattgca ttagcagagc ccccggttgt
     1921 tggaagcaca acacagcaat ggctgggacc agaattctta accatgttct ttttccatca
     1981 catgaagccg ctggtgaaga gtgaggagct ccaagtgata aaggagatgg ttccaaatgt
     2041 acctcaggaa gcgctggaga aattgctgtc agtcactcac aaactcaggg agacccagga
     2101 tcccacagca cagtccttgg ccgcctcgct ctccacccgt caactgttac ggatctctcg
     2161 ccggctctct cagtatccca gcgaaaatct ccatgatgct attaccaaag cctgtctttc
     2221 caggttctta ccaagcctcg ctcagtcagc cctggagaag aatctggcag atgctgcaat
     2281 agaaataaat gctgacagta gcctggaacc agaactggag aattacaagt gtgaagtagt
     2341 tgcagggtct ctgaagattg gcaccgtcag tgcaccagtg cacaatgccc atgagaagat
     2401 gaaagtgcct gacgttcttt tctatgacaa cgttcagcac atggtagtga tggaagacat
     2461 gcttaaagac tttgtcctcg gagagcactt gctactggtt ggtaaccagg gtgtaggaaa
     2521 gaacaagatc gtggaccgat tccttcacct gctcaacagg ccccgagaat atatccagct
     2581 gcacagggac accacagtgc agtctctgac tcttcagccc tcggttaaag atggactgat
     2641 tgtgtatgaa gactcacctc tggttaaagc agtaaagttg ggtcatattc tagtagtaga
     2701 tgaggcagac aaagccccaa caaatgtcac ctgtattttg aaaactctgg tagaaaacgg
     2761 agaaatgatt ctagcagatg ggagacgcat tgttgcagat gcagctagtg tggatgggag
     2821 agagaatgct atcgtggtcc atcctgactt taggatggtg gttctggcca acaggcctgg
     2881 cttccctttc ttgggcaatg acttctttgg cactttaggt gacattttta gctgtcatgc
     2941 cattgacaac cccaagcccc attcagagct tgagatgctc aaacagtatg gcccaaatgt
     3001 gcctgtgcct gtccttgaga agcttgtggc agcctttgga gagctgagga acttggctga
     3061 ccaagggatt atcaactatc cttattctac cagagaagtt gtcaacattg tcaaacactt
     3121 agagaaattc cctactgaag gcctctccag tgtggttcgg aatgtatttg actttgattc
     3181 ctacaacaac gacatgaggg agattttgat gaacactttg cacaaatatg ggatccccat
     3241 tggagcaaag cctaccaatg tgcagctggc aaaggagttt cccctaccag aaaagacatt
     3301 catgggctac tggataatcg gtcagacggg aaatggaatg caaaaggtct tgtgtccagc
     3361 agaaactcat cgcattgaca taaagggtcc agtacttgtg aacatagaaa agtacccaat
     3421 agagaaacat gaatccagat tcctgaactt tactgaggaa tgtacttctt ggcggtttcc
     3481 agtggatgaa gttaatttaa tctctgacat cgctgtatca catgaaaatg gagagcatac
     3541 actgtatgta gctacgtgca atcccatttc cttgtacttc atgaacatga ctggggaaaa
     3601 tggcttcttc gtggacttct tcgacatctt cccaaggatg gccagtggat cctggcggcc
     3661 gtttgtcaca gtagcaccat tgggaagtcc actcaggggt caggttgttc tgcatgagga
     3721 gcagagtaat gtcgtcctct tgctagacac cactggccgt gccatccacc gtctcgtcct
     3781 tcccacagaa gagtctacat ctaagaagtc ttcctggtgg aacaaggagg aaggtgaaac
     3841 ttatagaatg tgtaaagaat tttcacacaa aaactgggta gtattctaca gacaaacagg
     3901 gaatagcttg actgtcctgg atgtcttaga aggactaact cacaccatct cacttcccat
     3961 caacctcagg acagttttcc ttgtagcgga ggacaaatgg cttcttgtgg aaaacaaaac
     4021 aaatcagaag tgtctcctga ctaagcctgc acacattggt gctgaggaca ccggggcctg
     4081 ccagctgtat atgttgaaag aagagctgcc cagcacaggg tttggggtca cacaagaaac
     4141 agagttctac gtacctcata aagtttcaag cgatcagctg tcatctgaaa acctaacctc
     4201 agctgtgggc cagaagattg cctctcctaa ccgtattctc tcggatgaaa agagtcacgc
     4261 caccatagtt gttggcttcc cagacctcat gtcaccctgt gaagtttatt catggaagag
     4321 gtcgtcatct ttgggaaaac caagtgtcac taatataaca atgtatacgg ggaagcggac
     4381 aagtgttacc ccaaggcaca acaactgcgt gactctcaca cacacgaatc aggtggtgag
     4441 gattctgccc gcgggagaag tccctctgaa agacatctac ccaaaagatg tcactccccc
     4501 acagacagct ggctacatag aggttactga tcttcaagca aagaaactcc gatacatccc
     4561 tgtccccagt gcagagtctc tctcgccata taccgcatgg ttatccgcta tttcggacac
     4621 agatgctctg ctggctgagt gggacaagag cagcgtcgtg accgtggata tgggagggtg
     4681 cgtcagactc tgggaaacag gactcgaacg tctgcagcag tcgctcatgg aatggagaaa
     4741 catgattgga caagacagtg acaaacatat gcagataaca attgaaagag acagtaatga
     4801 agacgtgagt gagcccaaac acggcaagga ggacccagac aacatgcccc atgtgggcgg
     4861 caacacctgg gctggtggaa cagggggaag agacactgca ggtcttggtg gcaaaggagg
     4921 tccttatcgc ttggatgcag gccacccagt gtatcaagta tctgaggttg agaaagatgc
     4981 agttcctgag gatatcaaga gagctgcaag agagatggcc cagagagcat ttcagcagag
     5041 actaaaggag atccaaatga gtgagtacga tgccgcaacc tatgagcggt tttcacgtgc
     5101 tgtccagcga caggtgcatg ccctccgagt catcctggat aatctacagg ctaaaggcaa
     5161 agaaaggcag tggctaagac accaagctac cggagagcta gacgatgcca agatcattga
     5221 tgggctggct ggagaaaagg ccatctacaa acgtcgaggt gatctggaac cacagctggg
     5281 cagcccacaa cagaagccca agcgcctacg cctggtggta gatgtctctg gcagcatgta
     5341 ccgcttcaac ggggtggatc gccggctgga gcgctcgatg gaggcagtgt gcatggtcat
     5401 ggaggccttt gagaactatg aggagaaatt caagtacgac attgctggac actcgggaga
     5461 tggctacaat atcaagctcg ttccagttaa caagatccct aagaacaata agcagagact
     5521 agaaattctg aagacaatgc atgcccactc tcagttctgc atgagtgggg accacacact
     5581 cgaggggacg gaacatgcca tcaaggacat taccacagag gaagctgatg agtacttcgt
     5641 catcatattg agtgatgcga atctgtcccg atatggaata aacccagccc gctttgccca
     5701 gatcctcaca agcaatcctc aagtaaatgc ctttgccatt tttatcggct ctttggggga
     5761 tcaggcagcc aggcttcaga gaactctgcc tgctggccgg tccttcatcg ccatggacac
     5821 caagaagatc cctcagattt tacaacagat cttcacctcc accatgctct ccagtatcta
     5881 agaagcagcc tttaccgtcc ccagattgga ggcaatatga gcagacagaa ttctaaaaga
     5941 ccgcaaccca gctgacctgc gctgtggcgg gctgctgccg tccagccgcg agtgggcttg
     6001 tggatggaaa tgtattctgg atgggttgaa ggtctgcaga cgaaacaagt tgacctgcat
     6061 ttcttagaag gtcagcattg aaggatgcag gcgcagaact gcaagactcg gcctcgttct
     6121 aaccccagaa gatgcaaacc acccactttc gccttaatag gtcatctgct gcccgtagcc
     6181 atgcggagcc tttaacccca tagtttgaca ctgagtgggg acaagcctgc agaccccacc
     6241 caacacgctc ctgtctacaa ttatttccac tttctcccca gagtgtattg cccagcaaat
     6301 tacaatttta cagcatttaa ccttaacagg aaagtatttg gactgcagta cttcataagg
     6361 cattggcttc tctcaataat tccattctct tgtcagaaag gaaccaaacg atccttaggg
     6421 tgcttgctat gccactgact tctcttccct gctacctgag gtgaaggata aaggataaag
     6481 atgaagggcc tcagttccct gtgccaagcc ctttccgttc tccagagttc cacagtggcg
     6541 tggagtatac tgtccgacaa attacccaaa gttcaaagca ctgtgtttga ctgggtgctg
     6601 actggagact tgtttcgatt taactaaaga aaaggatact tttcagccaa attctctttc
     6661 ctttcaaagt ctttaaactc aaatactcca acagaactgt ctctcgaggc atccagtgaa
     6721 atgccactct ttacagctga ctgtgaagtc ggtgctgggg tgggatgtgc gtgcctactt
     6781 agtgtaagcg agagaactaa tctttggtga cgctacttac cctagccatg tacactgtca
     6841 ttgtacagta aattcatgtc atttagtcgt aggacagaaa atgctcccca tctcttctga
     6901 cacccatctc ctcctcatcc actgtcaaat aaaagcagtt gcttcccaat atggtgtcac
     6961 ca
//
