LOCUS       NM_019156               1628 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus vitronectin (Vtn), mRNA.
ACCESSION   NM_019156
VERSION     NM_019156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1628)
  AUTHORS   Brito VGB, Patrocinio MS, de Sousa MCL, Barreto AEA, Frasnelli SCT,
            Lara VS, Santos CF and Oliveira SHP.
  TITLE     Telmisartan Prevents Alveolar Bone Loss by Decreasing the
            Expression of Osteoclasts Markers in Hypertensive Rats With
            Periodontal Disease
  JOURNAL   Front Pharmacol 11, 579926 (2020)
   PUBMED   33364953
  REMARK    Erratum:[Front Pharmacol. 2021 Feb 19;11:635927. PMID: 33679393]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1628)
  AUTHORS   Zhang Q, Yu J, Guo T, Tian L, Quan J, Lin W, Niu XE and Liu J.
  TITLE     High glucose/ox-LDL induced hepatic sinusoidal capillarization via
            alphavbeta5/FAK/ERK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 513 (4), 1055-1062 (2019)
   PUBMED   31010681
  REMARK    GeneRIF: Integrin alphavbeta5 which induces LSECs dysfunction,
            promoting hepatic sinusoidal capillarization regulates VN
            expression via ERK/FAK pathway under high glucose/ox-LDL
REFERENCE   3  (bases 1 to 1628)
  AUTHORS   Tougan T, Edula JR, Takashima E, Morita M, Shinohara M, Shinohara
            A, Tsuboi T and Horii T.
  TITLE     Molecular Camouflage of Plasmodium falciparum Merozoites by Binding
            of Host Vitronectin to P47 Fragment of SERA5
  JOURNAL   Sci Rep 8 (1), 5052 (2018)
   PUBMED   29567995
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1628)
  AUTHORS   Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R,
            Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M,
            Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M,
            Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J,
            Kichler A, Otsu K and Mayr M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   5  (bases 1 to 1628)
  AUTHORS   Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X,
            Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins
            MT, Misra S, Stoughton J and Mayr M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   6  (bases 1 to 1628)
  AUTHORS   Otter M, Kuiper J, Rijken D and van Zonneveld AJ.
  TITLE     Hepatocellular localisation of biosynthesis of vitronectin.
            Characterisation of the primary structure of rat vitronectin
  JOURNAL   Biochem Mol Biol Int 37 (3), 563-572 (1995)
   PUBMED   8595397
REFERENCE   7  (bases 1 to 1628)
  AUTHORS   Casaroli Marano RP, Preissner KT and Vilaro S.
  TITLE     Fibronectin, laminin, vitronectin and their receptors at
            newly-formed capillaries in proliferative diabetic retinopathy
  JOURNAL   Exp Eye Res 60 (1), 5-17 (1995)
   PUBMED   7536680
REFERENCE   8  (bases 1 to 1628)
  AUTHORS   Hagege J, Peraldi MN, Rondeau E, Adida C, Delarue F, Medcalf R,
            Schleuning WD and Sraer JD.
  TITLE     Plasminogen activator inhibitor-1 deposition in the extracellular
            matrix of cultured human mesangial cells
  JOURNAL   Am J Pathol 141 (1), 117-128 (1992)
   PUBMED   1632457
REFERENCE   9  (bases 1 to 1628)
  AUTHORS   Ehrlich HJ, Gebbink RK, Keijer J, Linders M, Preissner KT and
            Pannekoek H.
  TITLE     Alteration of serpin specificity by a protein cofactor. Vitronectin
            endows plasminogen activator inhibitor 1 with thrombin inhibitory
            properties
  JOURNAL   J Biol Chem 265 (22), 13029-13035 (1990)
   PUBMED   1695900
REFERENCE   10 (bases 1 to 1628)
  AUTHORS   Baetscher,M., Pumplin,D.W. and Bloch,R.J.
  TITLE     Vitronectin at sites of cell-substrate contact in cultures of rat
            myotubes
  JOURNAL   J Cell Biol 103 (2), 369-378 (1986)
   PUBMED   2426279
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105821.1.
            
            On Dec 11, 2007 this sequence version replaced NM_019156.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105821.1, FQ209682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1628
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1628
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /note="vitronectin"
                     /db_xref="GeneID:29169"
                     /db_xref="RGD:3967"
     exon            1..143
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1516
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /codon_start=1
                     /product="vitronectin precursor"
                     /protein_id="NP_062029.2"
                     /db_xref="GeneID:29169"
                     /db_xref="RGD:3967"
                     /translation="MASLRPFFILALLALVSLADQESCKGRCTQGFMASKKCQCDELC
                     TYYQSCCVDYMEQCKPQVTRGDVFTMPEDEYWSYDYPEETKNSTSTGVQSENTSLHFN
                     LKPRAEETIKPTTPDPQEQSNTQEPEVGQQGVAPRPDTTDEGTSEFPEEELCSGKPFD
                     AFTDLKNGSLFAFRGEYCYELDETAVRPGYPKLIQDVWGIEGPIDAAFTRINCQGKTY
                     LFKGSQYWRFEDGVLDPDYPRNISEGFSGIPDNVDAALALPAHSYSGRERVYFFKGKQ
                     YWEYEFQQQPSQEECEGSSLSAVFEHFALLQRDSWENIFELLFWGRSSDGAKGPQFIS
                     RDWHGVPGKVDAAMAGRIYITGSTFRSVQAKKQKSGRRSRKRYRSRRGRGHSRSRSRS
                     MSSRRPSRSVWFSLLSSEESGLGTYNYDYDMNWRIPATCEPIQSVYFFSGDKYYRVNL
                     RTRRVDSVNPPYPRSIAQYWLGCPTSEK"
     exon            144..263
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            264..602
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            603..742
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            743..899
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1052
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1406
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1597
                     /gene="Vtn"
                     /gene_synonym="Aa1018; Vn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gattctttcc ccaggcaaga cagtgagact ccagaagctc cgagcccagt ttgccaaggc
       61 cctctgctag aggcctgcca tggcatctct gaggcccttt ttcatactag ccctgctggc
      121 attggtttct ctggctgacc aagagtcatg caagggccgc tgcactcagg gtttcatggc
      181 cagcaagaag tgtcaatgtg atgagctttg cacctactat cagagctgct gtgttgacta
      241 catggagcag tgcaagcccc aagtgacccg gggggatgtg tttaccatgc cagaagatga
      301 gtattggagc tatgactacc cggaggaaac caagaacagt accagcactg gcgtgcaatc
      361 cgagaacacc tctctacact tcaacctaaa gcctcgagcc gaagagacta taaagccaac
      421 aactcctgat cctcaggaac agtcaaacac ccaagaacct gaagtggggc aacagggagt
      481 ggccccaagg cctgacacca ctgatgaagg aacctctgag tttccagaag aagagctgtg
      541 tagtggaaag ccctttgatg ccttcacaga cctcaagaat ggttcccttt ttgccttccg
      601 aggtgagtat tgctatgagc tagatgaaac agcagtgagg cctgggtacc ccaaactcat
      661 ccaagatgtc tggggcatcg agggccccat cgacgctgcc ttcactcgca tcaactgtca
      721 ggggaagacc tacttgttca agggtagtca gtactggcgc tttgaggatg gtgtcctgga
      781 ccctgattat ccccgaaaca tctctgaagg cttcagtggc ataccagaca acgttgacgc
      841 agccttagcc cttcctgccc acagttacag tggccgggaa agggtctact tcttcaaggg
      901 aaaacagtac tgggagtatg aatttcagca gcagcccagc caggaggaat gtgaaggaag
      961 ttctctgtca gccgtgtttg agcactttgc cttgcttcag cgggacagct gggagaacat
     1021 ttttgaactc ctcttctggg gcagatcctc tgatggcgcc aaaggacccc aattcatcag
     1081 cagggattgg catggtgtac cagggaaagt ggacgctgct atggccggcc gcatctacat
     1141 cactggctcc acattccgct ctgtccaggc caaaaaacag aagtctgggc gtcgaagtcg
     1201 aaaacgctac cgttcacgcc gaggacgtgg ccatagccgc agccgcagtc gcagcatgag
     1261 ctctcgtcgc ccatcgcgtt cagtctggtt ctctttgctc tccagcgaag agagtgggct
     1321 aggaacctac aattacgatt atgatatgaa ctggcgcata cctgccacct gcgagcccat
     1381 tcagagcgtc tatttcttct ctggagacaa gtactaccga gttaacctta gaacacggcg
     1441 agtggactct gtgaatcctc cctacccacg ctccattgct cagtattggc tgggctgccc
     1501 aacctctgag aagtaggaat cagcacccac acagctgagc ttcagaaacc tcgtcctcca
     1561 gctttttcct cccagcccaa taaagtgttg gccccaaaaa aaaaaaaaaa aaaaaaaaaa
     1621 aaaaaaaa
//
