LOCUS       NM_001024244            2657 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus V-set domain containing T cell activation
            inhibitor 1 (Vtcn1), mRNA.
ACCESSION   NM_001024244 XM_227553
VERSION     NM_001024244.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Chen,Y., Yang,C., Xie,Z., Zou,L., Ruan,Z., Zhang,X., Tang,Y.,
            Fei,L., Jia,Z. and Wu,Y.
  TITLE     Expression of the novel co-stimulatory molecule B7-H4 by renal
            tubular epithelial cells
  JOURNAL   Kidney Int 70 (12), 2092-2099 (2006)
   PUBMED   17051145
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Suh,W.K., Wang,S., Duncan,G.S., Miyazaki,Y., Cates,E., Walker,T.,
            Gajewska,B.U., Deenick,E., Dawicki,W., Okada,H., Wakeham,A.,
            Itie,A., Watts,T.H., Ohashi,P.S., Jordana,M., Yoshida,H. and
            Mak,T.W.
  TITLE     Generation and characterization of B7-H4/B7S1/B7x-deficient mice
  JOURNAL   Mol Cell Biol 26 (17), 6403-6411 (2006)
   PUBMED   16914726
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Nguyen,T., Liu,X.K., Zhang,Y. and Dong,C.
  TITLE     BTNL2, a butyrophilin-like molecule that functions to inhibit T
            cell activation
  JOURNAL   J Immunol 176 (12), 7354-7360 (2006)
   PUBMED   16751379
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Kryczek,I., Zou,L., Rodriguez,P., Zhu,G., Wei,S., Mottram,P.,
            Brumlik,M., Cheng,P., Curiel,T., Myers,L., Lackner,A., Alvarez,X.,
            Ochoa,A., Chen,L. and Zou,W.
  TITLE     B7-H4 expression identifies a novel suppressive macrophage
            population in human ovarian carcinoma
  JOURNAL   J Exp Med 203 (4), 871-881 (2006)
   PUBMED   16606666
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Salceda,S., Tang,T., Kmet,M., Munteanu,A., Ghosh,M., Macina,R.,
            Liu,W., Pilkington,G. and Papkoff,J.
  TITLE     The immunomodulatory protein B7-H4 is overexpressed in breast and
            ovarian cancers and promotes epithelial cell transformation
  JOURNAL   Exp Cell Res 306 (1), 128-141 (2005)
   PUBMED   15878339
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Sanchez-Lockhart,M., Marin,E., Graf,B., Abe,R., Harada,Y.,
            Sedwick,C.E. and Miller,J.
  TITLE     Cutting edge: CD28-mediated transcriptional and posttranscriptional
            regulation of IL-2 expression are controlled through different
            signaling pathways
  JOURNAL   J Immunol 173 (12), 7120-7124 (2004)
   PUBMED   15585831
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC095842.1.
            
            On May 27, 2005 this sequence version replaced XM_227553.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132303
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2657
                     /gene="Vtcn1"
                     /gene_synonym="RGD1311204"
                     /note="V-set domain containing T cell activation inhibitor
                     1"
                     /db_xref="GeneID:295322"
                     /db_xref="RGD:1311204"
     exon            1..126
                     /gene="Vtcn1"
                     /gene_synonym="RGD1311204"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..943
                     /gene="Vtcn1"
                     /gene_synonym="RGD1311204"
                     /note="immune costimulatory protein B7-H4"
                     /codon_start=1
                     /product="V-set domain-containing T-cell activation
                     inhibitor 1 precursor"
                     /protein_id="NP_001019415.1"
                     /db_xref="GeneID:295322"
                     /db_xref="RGD:1311204"
                     /translation="MASLGQIIFWSIINVIIILAGAIVLIIGFGISGKHFITVTTFTS
                     AGNIGEDGTLSCTFEPDIKLNGIVIQWLKEGIKGLVHEFKEGKDDLSQQHEMFRGRTA
                     VFADQVVVGNASLRLKNVQLTDAGTYTCYIHTSKGKGNANLEYKTGAFSMPEINVDYN
                     ASSESLRCEAPRWFPQPTVAWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVT
                     INNTYSCMIENDIAKATGDIKVTDSEVKRRSQLELLNSGPSPCVSSVSAAGWALLSLS
                     CCLMLR"
     exon            127..191
                     /gene="Vtcn1"
                     /gene_synonym="RGD1311204"
                     /inference="alignment:Splign:2.1.0"
     exon            192..539
                     /gene="Vtcn1"
                     /gene_synonym="RGD1311204"
                     /inference="alignment:Splign:2.1.0"
     exon            540..818
                     /gene="Vtcn1"
                     /gene_synonym="RGD1311204"
                     /inference="alignment:Splign:2.1.0"
     exon            819..988
                     /gene="Vtcn1"
                     /gene_synonym="RGD1311204"
                     /inference="alignment:Splign:2.1.0"
     exon            989..2619
                     /gene="Vtcn1"
                     /gene_synonym="RGD1311204"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggagggc agcggggcag cagcaggcag gcagcaccac tctccagaat ctagcctcac
       61 acacagcagg actgtgtgaa gaaactccct caccatggct tccttggggc agatcatctt
      121 ttggagtatt attaacgtca tcatcatcct ggctggagcc atcgtactca tcattggctt
      181 tggtatttca ggcaagcact tcatcacggt cacaaccttc acctcagctg gaaatattgg
      241 agaggacggg accctgagct gcacgtttga acctgacatc aaactcaacg gcatcgtcat
      301 ccagtggctg aaggaaggca tcaaaggttt ggtccatgag ttcaaagagg gcaaagacga
      361 cctctcacag cagcacgaga tgtttcgagg ccggacagca gtgtttgcag atcaagtggt
      421 ggttggcaat gcttccctga gactgaaaaa tgtgcagctc actgatgctg gcacctacac
      481 atgttatatc cacacctcaa aaggcaaagg gaatgctaac cttgagtata agactggagc
      541 cttcagtatg ccagagatta atgtggacta taatgccagt tcggagagtc tacgctgtga
      601 ggctcctcgg tggttccccc agcccacagt ggcctgggca tctcaagttg accaaggagc
      661 caacttctca gaagtctcca acactagctt cgagttgaac tctgagaatg tgaccatgaa
      721 ggtcgtatct gtgctctaca atgtcacaat caacaacaca tactcctgta tgatcgaaaa
      781 cgatattgcc aaagccacag gggacatcaa agtgacagat tcagaggtca aaaggcgtag
      841 tcagctggag ctgctgaact ctgggccttc tccgtgtgtt tcttctgtct ctgccgctgg
      901 ctgggcactc ctatctctct cctgttgcct gatgctaaga tgaggggcct tggccacaca
      961 aaagcatgca aagttactgg tacaacagaa tcccaggaat ctacagaaat attttccaca
     1021 agacatgacc tagttttata tttctagaag aaaatgaact catgtctgaa agtctggagt
     1081 gaacagacag gaacaagatg taaaaggaaa aacaaaagca acccccagac gccttcgata
     1141 ggaacaagac ggacctagaa aataattcaa ctggactaga gtgtagtaat cgtgccgtta
     1201 aaatgtgtgt cagggtgggt gttttcccat gtctcaggga cctctccttc cccaccagcc
     1261 cctgagtgag gatgggctgt tatgatgtca ctctgaaagt tcctgaatgg cttccactgc
     1321 catatcctcc ttctatattc agcacattaa accagagtgc acgccgagaa aagctgctaa
     1381 tcagccgcca cttctcaact tggatgtggc agcgtctgac tgacaggccc agtgattcac
     1441 ttttcattag gatgctttca aaagtgctgg ggcatctcct cccacctgac aaatgccaaa
     1501 cacataggga gggcgatcat aattttaggg ctaacaaaat agttgagtga tgctgatttt
     1561 tttccaaata gttcaagtca cttctccatt aggcaaacaa atgccctgtt atttctcaga
     1621 tgatgctgat ttgtgaattg gcccagggta aagtgctctc ctcatcctgc tacatggcct
     1681 tatgtcatca taaggtttga agtttccact ttctatcctg cacggagagc tgtaatctca
     1741 gcttctatcc ccatagcact gggagtaaac caggatgatg tcccccttct tgttccccat
     1801 gtgactgttg gcaatgtaga gactgattat cacaactaaa ggaagaggga caacagggtc
     1861 tctggtgtct agaggaaaga gctcagagat tatattcaac atgtcccact ggtgaagaat
     1921 ttatccaact tcaattgcca accacatcaa ggtctggaaa tcctgaattg ggataagaaa
     1981 gatccagaaa gtgagtgaac agcacatttg cttcctgatg gtgggcacct acttatgtct
     2041 ctggctactg ttcagagacc caggtctctg cattgtgcga catgcttcag tgaacccatg
     2101 tggggaattc tccatgggat tgtcttcagc tcactgtacc tctgaattcc tctccctaca
     2161 ttctgtgcca cacagcaagt ttggcttgaa cgctgcctga gtgccatttc aagttctctt
     2221 cctctggatt ttagatctca agaccatggg tgaaacatta gctaaggcaa caaaagcaaa
     2281 tcccccttga aatacgcaga gactcgtggg ctttgagggt tctgtttgtt ttcaggtgct
     2341 agagatcaaa cttggactct catatgctaa gtaagtgctc tgccgatgag ttacaccaca
     2401 cacagatctt ctaagagaaa atagggccat actctttgaa atgaagcctt gagggatgag
     2461 gcttggacgg caaagaacac ttttcaccag ctccctcctc acactcatat gtcaggcact
     2521 gcctccctgg acttcagacc accgtttctg tactacattt tgctacagaa ggcttgagac
     2581 cattcaagag aattattaaa tacacatccc ctgagctgca aaaaaaaaaa aaaaaaaaaa
     2641 aaaaaaaaaa aaaaaaa
//
