LOCUS       NM_001169128            3109 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus visual system homeobox 2 (Vsx2), mRNA.
ACCESSION   NM_001169128 XM_001058827 XM_001058888 XM_345704
VERSION     NM_001169128.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3109)
  AUTHORS   Rocha,S.F., Lopes,S.S., Gossler,A. and Henrique,D.
  TITLE     Dll1 and Dll4 function sequentially in the retina and pV2 domain of
            the spinal cord to regulate neurogenesis and create cell diversity
  JOURNAL   Dev Biol 328 (1), 54-65 (2009)
   PUBMED   19389377
REFERENCE   2  (bases 1 to 3109)
  AUTHORS   Morcillo,J., Martinez-Morales,J.R., Trousse,F., Fermin,Y.,
            Sowden,J.C. and Bovolenta,P.
  TITLE     Proper patterning of the optic fissure requires the sequential
            activity of BMP7 and SHH
  JOURNAL   Development 133 (16), 3179-3190 (2006)
   PUBMED   16854970
REFERENCE   3  (bases 1 to 3109)
  AUTHORS   Livne-Bar,I., Pacal,M., Cheung,M.C., Hankin,M., Trogadis,J.,
            Chen,D., Dorval,K.M. and Bremner,R.
  TITLE     Chx10 is required to block photoreceptor differentiation but is
            dispensable for progenitor proliferation in the postnatal retina
  JOURNAL   Proc Natl Acad Sci U S A 103 (13), 4988-4993 (2006)
   PUBMED   16547132
  REMARK    GeneRIF: Chx10 directly controls bipolar cell genesis by inhibiting
            rod differentiation independent of its temporally limited early
            effect on retinal progenitor cell proliferation
REFERENCE   4  (bases 1 to 3109)
  AUTHORS   Dorval,K.M., Bobechko,B.P., Fujieda,H., Chen,S., Zack,D.J. and
            Bremner,R.
  TITLE     CHX10 targets a subset of photoreceptor genes
  JOURNAL   J Biol Chem 281 (2), 744-751 (2006)
   PUBMED   16236706
  REMARK    GeneRIF: CHX10 may target specific motifs to inhibit rod
            photoreceptor gene expression in bipolar cells
REFERENCE   5  (bases 1 to 3109)
  AUTHORS   Dhomen,N.S., Balaggan,K.S., Pearson,R.A., Bainbridge,J.W.,
            Levine,E.M., Ali,R.R. and Sowden,J.C.
  TITLE     Absence of chx10 causes neural progenitors to persist in the adult
            retina
  JOURNAL   Invest Ophthalmol Vis Sci 47 (1), 386-396 (2006)
   PUBMED   16384989
REFERENCE   6  (bases 1 to 3109)
  AUTHORS   Knauer,S.K., Carra,G. and Stauber,R.H.
  TITLE     Nuclear export is evolutionarily conserved in CVC paired-like
            homeobox proteins and influences protein stability, transcriptional
            activation, and extracellular secretion
  JOURNAL   Mol Cell Biol 25 (7), 2573-2582 (2005)
   PUBMED   15767664
REFERENCE   7  (bases 1 to 3109)
  AUTHORS   Horsford,D.J., Nguyen,M.T., Sellar,G.C., Kothary,R., Arnheiter,H.
            and McInnes,R.R.
  TITLE     Chx10 repression of Mitf is required for the maintenance of
            mammalian neuroretinal identity
  JOURNAL   Development 132 (1), 177-187 (2005)
   PUBMED   15576400
REFERENCE   8  (bases 1 to 3109)
  AUTHORS   Ferda Percin,E., Ploder,L.A., Yu,J.J., Arici,K., Horsford,D.J.,
            Rutherford,A., Bapat,B., Cox,D.W., Duncan,A.M., Kalnins,V.I.,
            Kocak-Altintas,A., Sowden,J.C., Traboulsi,E., Sarfarazi,M. and
            McInnes,R.R.
  TITLE     Human microphthalmia associated with mutations in the retinal
            homeobox gene CHX10
  JOURNAL   Nat Genet 25 (4), 397-401 (2000)
   PUBMED   10932181
REFERENCE   9  (bases 1 to 3109)
  AUTHORS   Arber,S., Han,B., Mendelsohn,M., Smith,M., Jessell,T.M. and
            Sockanathan,S.
  TITLE     Requirement for the homeobox gene Hb9 in the consolidation of motor
            neuron identity
  JOURNAL   Neuron 23 (4), 659-674 (1999)
   PUBMED   10482234
REFERENCE   10 (bases 1 to 3109)
  AUTHORS   Burmeister,M., Novak,J., Liang,M.Y., Basu,S., Ploder,L.,
            Hawes,N.L., Vidgen,D., Hoover,F., Goldman,D., Kalnins,V.I.,
            Roderick,T.H., Taylor,B.A., Hankin,M.H. and McInnes,R.R.
  TITLE     Ocular retardation mouse caused by Chx10 homeobox null allele:
            impaired retinal progenitor proliferation and bipolar cell
            differentiation
  JOURNAL   Nat Genet 12 (4), 376-384 (1996)
   PUBMED   8630490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 10, 2014 this sequence version replaced NM_001169128.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN14984036,
                              SAMN17050755 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               JAXUCZ010000006.1  109948313-109948798
            487-571             JAXUCZ010000006.1  109950058-109950142
            572-695             JAXUCZ010000006.1  109954472-109954595
            696-876             JAXUCZ010000006.1  109967936-109968116
            877-3109            JAXUCZ010000006.1  109968868-109971100
FEATURES             Location/Qualifiers
     source          1..3109
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3109
                     /gene="Vsx2"
                     /gene_synonym="Chx10"
                     /note="visual system homeobox 2"
                     /db_xref="GeneID:171360"
                     /db_xref="RGD:621215"
     exon            1..486
                     /gene="Vsx2"
                     /gene_synonym="Chx10"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1202
                     /gene="Vsx2"
                     /gene_synonym="Chx10"
                     /note="ceh-10 homeo domain containing homolog"
                     /codon_start=1
                     /product="visual system homeobox 2"
                     /protein_id="NP_001162599.1"
                     /db_xref="GeneID:171360"
                     /db_xref="RGD:621215"
                     /translation="MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEP
                     PSSHPRAALDGLAPGHLLAARSVLSPAGVGSMGLLGPGGLPGFYAQPTFLEVLSDPQS
                     VHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQL
                     EELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAE
                     YGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEVERQV
                     LPKLDKMEQEERAPDAQAAISQEELRENSIAALRAKAQEHSTKVLGTVSGPDGLARNA
                     EKPEEEEAMDEDRPAEKLSPPQLEDMA"
     exon            487..571
                     /gene="Vsx2"
                     /gene_synonym="Chx10"
                     /inference="alignment:Splign:2.1.0"
     exon            572..695
                     /gene="Vsx2"
                     /gene_synonym="Chx10"
                     /inference="alignment:Splign:2.1.0"
     exon            696..876
                     /gene="Vsx2"
                     /gene_synonym="Chx10"
                     /inference="alignment:Splign:2.1.0"
     exon            877..3109
                     /gene="Vsx2"
                     /gene_synonym="Chx10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcattaga caccggaggg ggcacctggg accaacttca cgaagcgggg agcccggcgg
       61 ggggggcttg ggggagcaaa agacccgcgg cctcagcccc tccaaagaac cgggagatga
      121 cggggaaagc gggggaagcg ctgagcaagc ctaaatccga gacagtggcc aagagtacct
      181 cggggggtgc cccggccagg tgcacagggt tcggcatcca ggagatccta ggcttgaaca
      241 aggagcctcc cagctcccac ccgcgggctg ccctggacgg cctggccccc gggcatttgt
      301 tagctgcgcg ctctgttctc agccccgcag gagtgggcag catggggctg ctggggcccg
      361 gagggcttcc cggcttctac gcacagccca ccttcctgga agtgctgtcc gatccgcaga
      421 gcgtccactt gcagccacta ggcagagcgt cggggccgct ggacaccagc cagacggcca
      481 gctccgattc cgaagatgtt tcctccagtg accgaaaaat gtccaaatcg gctttaaacc
      541 agaccaagaa acgtaagaag cggcgacaca ggacaatctt tacttcctac cagctagagg
      601 agctggagaa ggcattcaat gaagcccact acccagatgt ctacgcccgg gagatgctgg
      661 ccatgaaaac ggagctacca gaagacagga tacaggtgtg gttccagaac cgcagagcca
      721 aatggaggaa gagggagaag tgctggggcc ggagcagcgt catggctgag tacggcctct
      781 atggagccat ggtgaggcac tccatccccc tgccagagtc catcctcaag tcggccaagg
      841 acggcatcat ggattcctgc gccccttggc tactggggat gcacaaaaag tcgctggagg
      901 cagcagccga gtccggaagg aagcccgagg tggaacgcca ggtcctgccc aaactcgaca
      961 agatggagca ggaggaaagg gccccggatg ctcaggcagc catctcccag gaagaactga
     1021 gggagaacag cattgcggcc ctccgagcca aagctcagga gcacagcacc aaggttctgg
     1081 ggactgtatc cgggcctgac ggcctagcca ggaatgctga gaagccagaa gaggaggaag
     1141 ccatggacga agacaggcca gcagagaagc tcagcccacc gcagctggag gacatggctt
     1201 aggttaaggg ctgcaggcct taagactgct cttctcgggt cctgtggtgt ggggagttct
     1261 ctctgaggca gggccatgtc tggcttctgc tgcacctccc cacacctcag gccctcgact
     1321 accccaccac tctaggcaca ggccagttct ggcgtagctt tggaccatgc tgagatatcc
     1381 tggacctact cctgatccag catcctcatc ctcagcccag ctcccctgcc tccaaagcct
     1441 tcttgctact ccaacatcga ggtcctgcca tttcatccct gagagactct tgtccaagcc
     1501 taacccttat tctctgctct ctaagcctcc ttctcagctc agccccactc gtgcactcca
     1561 gctcacagcc tggcagagct gtgattggat tgaggacatg cacaccagct ccggtgtcct
     1621 gagcacccca gtactgggca gacaggcctt tccctcgtca cctgttcctt ctcacagacc
     1681 tgcgtcctgc tgtgtgaatg cattgctcca cgtgtgaccg ctgcattctc tgccctacct
     1741 aaagactaac agggcaagtc tgtctgagtc cttctgcaaa cctgtctcat gctacgctgt
     1801 gggtcatcct caagcctttt ctgtacccag cctgccctat aggttcctcc tttgcagagg
     1861 tgggctcacc acattgccag tgtctaggcc ctgcaccctg agggtggggg cccttctcag
     1921 caatgctgtg tcttgctgtg ctgctggtga gccttcgccc agagcttttg caggccaggg
     1981 cctgtgttcc tgaagcgttt tgacctttct gcctatgatg ttgacttgct ggttaaagct
     2041 tcctttctct agagcttctt gtagcccagt ggttctcaag cttcctaatg ctgtgaccct
     2101 ttaataccgt tcctcatgct gtggtgacca ctcccacccc ctaacctcaa atttatttcc
     2161 ttgctacttc ataactgtaa ttttactact gttgtgaatc acaatgtaaa tatctgatat
     2221 gcagaatatc tgactatgtg actcccgcaa agggtcatga cccacaggtt gagaattgct
     2281 gttgtagcca attggttcac atgtgcctgc tttggagaaa accagtgcag ctcgaaagcc
     2341 acagacatgg cctcacgctg acctaggcag tcctaaaagg ctaatctatc taaatcagac
     2401 ctgcactgtc tacacacaca cacacacaca cacacacaca cacacacaca cacacacacg
     2461 atgaataaca agaaaggtac agggaaagct caaaggacga caaggcaggt agctaatgaa
     2521 aaacccagac taagctccag acactcctag ctccatgaca gttgtatgcc cagaaacatg
     2581 gagcatgtcc agagaaggag ccatgttgga ctgaaagact tctgcctgca aaggagtgga
     2641 gctgtccatc ctggtggccc atctgcagat gtcccttcca cctgacttta cacttgtact
     2701 gggggggcgg ggtacccggc cttatggaat cctctgcttc cagatcccca ggccaaccac
     2761 aagaatccct tcattctgtg aaactaggca ctccacccac cattttaggg gccgcctcac
     2821 aagagaggcg tgaggcagtg agtggtggtt ttaaatctgt tttgacagtt gagttcttct
     2881 ttcgttctgt tcatagaatt ctccacttcc cagttcttgt cttcttcggg ttgagatgtt
     2941 agaccgtagt tctgctgtgt aaatagtgta tataacgtga gaaggaagag actggatatc
     3001 gaggtgtttg aaacactgaa gtgtcagaac ttttaggtat ctgaagcata atttctgtgc
     3061 tgttttctgt aaagacacaa gcaagaataa aattcatgca aagactgct
//
