LOCUS       NM_012686               1895 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus visinin-like 1 (Vsnl1), mRNA.
ACCESSION   NM_012686
VERSION     NM_012686.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1895)
  AUTHORS   Trejter,M., Hochol,A., Tyczewska,M., Ziolkowska,A., Jopek,K.,
            Szyszka,M., Malendowicz,L.K. and Rucinski,M.
  TITLE     Visinin-like peptide 1 in adrenal gland of the rat. Gene expression
            and its hormonal control
  JOURNAL   Peptides 63, 22-29 (2015)
   PUBMED   25451331
  REMARK    GeneRIF: Expression of Vsnl1 in the rat adrenal gland or
            adrenocortical cells was acutely down regulated by ACTH, while
            chronic administration of corticotrophin or dexamethasone did not
            change Vsnl1 mRNA levels.
REFERENCE   2  (bases 1 to 1895)
  AUTHORS   Liu,M., Yang,H., Fang,D., Yang,J.J., Cai,J., Wan,Y., Chui,D.H.,
            Han,J.S. and Xing,G.G.
  TITLE     Upregulation of P2X3 receptors by neuronal calcium sensor protein
            VILIP-1 in dorsal root ganglions contributes to the bone cancer
            pain in rats
  JOURNAL   Pain 154 (9), 1551-1568 (2013)
   PUBMED   23707265
  REMARK    GeneRIF: This study demonistrated that Upregulation of P2X3
            receptors by neuronal calcium sensor protein VILIP-1 in dorsal root
            ganglions contributes to the bone cancer pain in rats.
REFERENCE   3  (bases 1 to 1895)
  AUTHORS   Braunewell,K.H., Dwary,A.D., Richter,F., Trappe,K., Zhao,C.,
            Giegling,I., Schonrath,K. and Rujescu,D.
  TITLE     Association of VSNL1 with schizophrenia, frontal cortical function,
            and biological significance for its gene product as a modulator of
            cAMP levels and neuronal morphology
  JOURNAL   Transl Psychiatry 1 (7), e22 (2011)
   PUBMED   22832524
  REMARK    GeneRIF: In dissociated rat hippocampal neurons, VILIP-1 small
            interfering RNA knockdown decreases cyclic AMP levels and reduces
            dendrite branching, compared with control-transfected cells. In
            contrast, VILIP-1 overexpression has the opposite effect.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1895)
  AUTHORS   Buttgereit,J., Qadri,F., Monti,J., Langenickel,T.H., Dietz,R.,
            Braunewell,K.H. and Bader,M.
  TITLE     Visinin-like protein 1 regulates natriuretic peptide receptor B in
            the heart
  JOURNAL   Regul Pept 161 (1-3), 51-57 (2010)
   PUBMED   20079378
  REMARK    GeneRIF: Results show that VILIP-1 regulates the cell surface
            localization of natriuretic peptide receptor B.
REFERENCE   5  (bases 1 to 1895)
  AUTHORS   Zhao,C., Anand,R. and Braunewell,K.H.
  TITLE     Nicotine-induced Ca2+-myristoyl switch of neuronal Ca2+ sensor
            VILIP-1 in hippocampal neurons: a possible crosstalk mechanism for
            nicotinic receptors
  JOURNAL   Cell Mol Neurobiol 29 (2), 273-286 (2009)
   PUBMED   18925431
  REMARK    GeneRIF: VILIP-1 might provide a novel functional crosstalk between
            alpha4- and alpha7-containing nAChRs.
REFERENCE   6  (bases 1 to 1895)
  AUTHORS   Spilker,C. and Braunewell,K.H.
  TITLE     Calcium-myristoyl switch, subcellular localization, and
            calcium-dependent translocation of the neuronal calcium sensor
            protein VILIP-3, and comparison with VILIP-1 in hippocampal neurons
  JOURNAL   Mol Cell Neurosci 24 (3), 766-778 (2003)
   PUBMED   14664824
  REMARK    GeneRIF: direct comparison of the localization and
            calcium-dependent translocation of visinin-like-proteins 1 and 3 in
            hippocampal neurons
REFERENCE   7  (bases 1 to 1895)
  AUTHORS   Spilker,C., Gundelfinger,E.D. and Braunewell,K.H.
  TITLE     Evidence for different functional properties of the neuronal
            calcium sensor proteins VILIP-1 and VILIP-3: from subcellular
            localization to cellular function
  JOURNAL   Biochim Biophys Acta 1600 (1-2), 118-127 (2002)
   PUBMED   12445467
  REMARK    GeneRIF: Evidence for different functional properties of NVP-1 and
            NVP-3: from subcellular localization to cellular function.
REFERENCE   8  (bases 1 to 1895)
  AUTHORS   Lin,L., Jeanclos,E.M., Treuil,M., Braunewell,K.H.,
            Gundelfinger,E.D. and Anand,R.
  TITLE     The calcium sensor protein visinin-like protein-1 modulates the
            surface expression and agonist sensitivity of the alpha 4beta 2
            nicotinic acetylcholine receptor
  JOURNAL   J Biol Chem 277 (44), 41872-41878 (2002)
   PUBMED   12202488
  REMARK    GeneRIF: novel role as AChR-associated protein that modulates the
            surface expression levels and functional properties of alpha4beta2
            AChRs in response to changes in calcium levels
REFERENCE   9  (bases 1 to 1895)
  AUTHORS   Corns,R.A., Hidaka,H. and Santer,R.M.
  TITLE     Neurocalcin-alpha immunoreactivity in the enteric nervous system of
            young and aged rats
  JOURNAL   Cell Calcium 31 (2), 53-58 (2002)
   PUBMED   11969245
  REMARK    GeneRIF: distribution of the calcium binding protein neurocalcin a
            examined in the enteric nervous system of young adult (3 months)
            and aged (24+ months) male rats.
REFERENCE   10 (bases 1 to 1895)
  AUTHORS   Kuno,T., Kajimoto,Y., Hashimoto,T., Mukai,H., Shirai,Y., Saheki,S.
            and Tanaka,C.
  TITLE     cDNA cloning of a neural visinin-like Ca(2+)-binding protein
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1219-1225 (1992)
   PUBMED   1375457
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092197.1.
            
            On Apr 11, 2005 this sequence version replaced NM_012686.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092197.1, D10666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q15"
     gene            1..1895
                     /gene="Vsnl1"
                     /gene_synonym="Nvp1; Ratnvp1"
                     /note="visinin-like 1"
                     /db_xref="GeneID:24877"
                     /db_xref="RGD:3966"
     exon            1..226
                     /gene="Vsnl1"
                     /gene_synonym="Nvp1; Ratnvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..393
                     /gene="Vsnl1"
                     /gene_synonym="Nvp1; Ratnvp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..807
                     /gene="Vsnl1"
                     /gene_synonym="Nvp1; Ratnvp1"
                     /note="neurocalcin alpha; neural visinin-like protein 1;
                     NVL-1; NVP-1; VILIP; 21 kDa CABP"
                     /codon_start=1
                     /product="visinin-like protein 1"
                     /protein_id="NP_036818.2"
                     /db_xref="GeneID:24877"
                     /db_xref="RGD:3966"
                     /translation="MGKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLN
                     LEEFQQLYVKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN
                     WVFNMYDLDGDGKITRVEMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDK
                     NKDDQITLDEFKEAAKSDPSIVLLLQCDIQK"
     exon            394..609
                     /gene="Vsnl1"
                     /gene_synonym="Nvp1; Ratnvp1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..1873
                     /gene="Vsnl1"
                     /gene_synonym="Nvp1; Ratnvp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaatctgc agcagagatt cacccgagcg tgttgcagcg gccactgggc ttgcaaggcg
       61 caatccaaga gggatttaag cagcccggag ctcccagaaa agaagcgaga gagaaccact
      121 cacagagacg gtttagccgt tagtctgaat taaatatata tatttttttg aaagaactgt
      181 ttagttttat cattttcctt aagtgacggt gcacagcgct ataactgcaa aatggggaaa
      241 cagaatagca aactggcccc agaagtcatg gaggacctgg tgaagagcac cgagttcaat
      301 gagcatgagc tcaagcagtg gtacaagggc ttcctcaagg actgtccgag cgggaggctg
      361 aatctcgaag agttccagca gctctatgtg aagttcttcc cctatggaga tgcctccaag
      421 ttcgctcagc acgccttccg caccttcgac aagaatggtg atggcaccat cgacttccga
      481 gagttcatct gtgctctgtc catcacctcc agaggcagct ttgagcagaa actgaactgg
      541 gttttcaaca tgtatgatct ggatggtgac ggcaagatca ccagggtgga gatgctggag
      601 attatcgagg ctatctacaa gatggtgggc actgtgatca tgatgaaaat gaatgaggat
      661 ggcctcacgc cagaacagcg agtggacaag attttcagca agatggataa gaacaaagat
      721 gaccagatta cattggatga attcaaagaa gctgcaaaaa gcgacccttc cattgtatta
      781 ctcctgcagt gcgacattca gaaatgagct gatgtcaatg ctatggactg cacagaagtc
      841 ttgatgttcc attcagtctg cagctacaca cacacacaca cacacacaca cacacacaca
      901 cacacactac acacacacac aattgcttgg actacctata aatggacttg cttcttgtgt
      961 ttgaaacact tgtgtgcatg agaatgtcat ttgctaatga attttaaaag catatattat
     1021 aaaaacccaa caaccggcca caatgtgata tgtgtaatat catttcatca aattacatct
     1081 tcctccaaag cctgggcaga agcgtgctgc aaagaattct atgatttctt gtacatgttt
     1141 tgctaatgct tgtgtctcct tgattatata atattagtag cactgagacc ccccacggta
     1201 atgtaactta ttatgggctg cgtcaccatt ctcctgtaaa atagtactgg acagacacag
     1261 gaggggccct tggcttcctg tctggcccac atacaataca cagcttgtat tatcagtgaa
     1321 tataaatgta ctacatttgc atgcctttgg gtttgcctta attcttacct catttgtaac
     1381 ctctcgatct ggaaagagct gttttggatg aatgcagtat acaacttaaa aatcctgcta
     1441 aactattcat taagtataac tatctatata tctatagaca caaaggtatt atatattgaa
     1501 cataaaaaca taataatggg aatgtattga tttgtttgac gtttcagagg cttccagaaa
     1561 ggtggcaata gatgtcccaa ataaatttct aatatttgat ttagtcccct aattattaat
     1621 ttaccatttt cagctcaatg ttcatagggg tcagctagtg atgacttact aaatctaccc
     1681 ttacacacat ctttggaatt tgcagaatga ctgaaggggg ggggggaagg aaagtcactt
     1741 tccaacttgt catccagccc ctcccccaaa gagggctaat taatatggca tgtaacattt
     1801 aaagaaaaca ggagatttgt tcattctgga aaacaatgct cattatgtga caataaactt
     1861 tatctcagtg tgaaaaaaaa aaaaaaaaaa aaaaa
//
