LOCUS       NM_001399050            5277 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus V-set immunoregulatory receptor (Vsir),
            transcript variant 2, mRNA.
ACCESSION   NM_001399050 XM_006256426
VERSION     NM_001399050.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5277)
  AUTHORS   Yoon,K.W., Byun,S., Kwon,E., Hwang,S.Y., Chu,K., Hiraki,M.,
            Jo,S.H., Weins,A., Hakroush,S., Cebulla,A., Sykes,D.B., Greka,A.,
            Mundel,P., Fisher,D.E., Mandinova,A. and Lee,S.W.
  TITLE     Control of signaling-mediated clearance of apoptotic cells by the
            tumor suppressor p53
  JOURNAL   Science 349 (6247), 1261669 (2015)
   PUBMED   26228159
REFERENCE   2  (bases 1 to 5277)
  AUTHORS   Lines,J.L., Pantazi,E., Mak,J., Sempere,L.F., Wang,L.,
            O'Connell,S., Ceeraz,S., Suriawinata,A.A., Yan,S., Ernstoff,M.S.
            and Noelle,R.
  TITLE     VISTA is an immune checkpoint molecule for human T cells
  JOURNAL   Cancer Res 74 (7), 1924-1932 (2014)
   PUBMED   24691993
  REMARK    Erratum:[Cancer Res. 2014 Jun 1;74(11):3195]
REFERENCE   3  (bases 1 to 5277)
  AUTHORS   Parisi,S., Battista,M., Musto,A., Navarra,A., Tarantino,C. and
            Russo,T.
  TITLE     A regulatory loop involving Dies1 and miR-125a controls BMP4
            signaling in mouse embryonic stem cells
  JOURNAL   FASEB J 26 (10), 3957-3968 (2012)
   PUBMED   22751012
REFERENCE   4  (bases 1 to 5277)
  AUTHORS   Flies,D.B., Wang,S., Xu,H. and Chen,L.
  TITLE     Cutting edge: A monoclonal antibody specific for the programmed
            death-1 homolog prevents graft-versus-host disease in mouse models
  JOURNAL   J Immunol 187 (4), 1537-1541 (2011)
   PUBMED   21768399
REFERENCE   5  (bases 1 to 5277)
  AUTHORS   Wang,L., Rubinstein,R., Lines,J.L., Wasiuk,A., Ahonen,C., Guo,Y.,
            Lu,L.F., Gondek,D., Wang,Y., Fava,R.A., Fiser,A., Almo,S. and
            Noelle,R.J.
  TITLE     VISTA, a novel mouse Ig superfamily ligand that negatively
            regulates T cell responses
  JOURNAL   J Exp Med 208 (3), 577-592 (2011)
   PUBMED   21383057
REFERENCE   6  (bases 1 to 5277)
  AUTHORS   Sakr,M.A., Takino,T., Domoto,T., Nakano,H., Wong,R.W., Sasaki,M.,
            Nakanuma,Y. and Sato,H.
  TITLE     GI24 enhances tumor invasiveness by regulating cell surface
            membrane-type 1 matrix metalloproteinase
  JOURNAL   Cancer Sci 101 (11), 2368-2374 (2010)
   PUBMED   20666777
REFERENCE   7  (bases 1 to 5277)
  AUTHORS   Aloia,L., Parisi,S., Fusco,L., Pastore,L. and Russo,T.
  TITLE     Differentiation of embryonic stem cells 1 (Dies1) is a component of
            bone morphogenetic protein 4 (BMP4) signaling pathway required for
            proper differentiation of mouse embryonic stem cells
  JOURNAL   J Biol Chem 285 (10), 7776-7783 (2010)
   PUBMED   20042595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 30, 2021 this sequence version replaced XM_006256426.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.55663.1,
                                           SRR26360186.2299905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000020.1  28824515-28824711
            198-620             JAXUCZ010000020.1  28835506-28835928
            621-677             JAXUCZ010000020.1  28836425-28836481
            678-785             JAXUCZ010000020.1  28841473-28841580
            786-813             JAXUCZ010000020.1  28844793-28844820
            814-1010            JAXUCZ010000020.1  28845556-28845752
            1011-5277           JAXUCZ010000020.1  28845909-28850175
FEATURES             Location/Qualifiers
     source          1..5277
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..5277
                     /gene="Vsir"
                     /note="V-set immunoregulatory receptor"
                     /db_xref="GeneID:690899"
                     /db_xref="RGD:1590938"
     exon            1..197
                     /gene="Vsir"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1048
                     /gene="Vsir"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; platelet receptor Gi24; V-type immunoglobulin
                     domain-containing suppressor of T-cell activation"
                     /codon_start=1
                     /product="V-type immunoglobulin domain-containing
                     suppressor of T-cell activation isoform 2 precursor"
                     /protein_id="NP_001385979.1"
                     /db_xref="GeneID:690899"
                     /db_xref="RGD:1590938"
                     /translation="MGVPTVPEASSLRWGTLLLTIFLAASRGLVAAIKVTTPYSLYVC
                     PEGQNVTLTCRILDSVSKGHDANFLKTWFLSSRGEVQVCKEHRPIRNFISHHQHHRSH
                     PAVNASHDQPQKHGLEIAYDNHGNFSITLHNVTLSDSGLYCCLVIEVKHHHPERRLYG
                     YMELQVQTGKGSASTCTAYPPNEQDSDSITAAALATGACIVGILCLPLILLLVYKQRQ
                     AASHRRAQELVRMDSSNTQGIENPGYETTPPFQGMPEAKTRPPLSYVAQRQPSESGRH
                     LLSDPSTPLSPPGPGDVFFPSLDPVPDSPNSEAI"
     exon            198..620
                     /gene="Vsir"
                     /inference="alignment:Splign:2.1.0"
     exon            621..677
                     /gene="Vsir"
                     /inference="alignment:Splign:2.1.0"
     exon            678..785
                     /gene="Vsir"
                     /inference="alignment:Splign:2.1.0"
     exon            786..813
                     /gene="Vsir"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1010
                     /gene="Vsir"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..5277
                     /gene="Vsir"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcacttta gcaagcggtg tgtacagccg gctggctccc tgggctctcg gagccccgct
       61 tgctccacgc gcgccccagc agtctgtgtc tgctcttgcc cggctcgacg gcgacatggg
      121 tgtccccacg gtcccagagg ccagtagtct gcgctgggga accctgctcc tcactatttt
      181 tctggctgca tccagaggtc tggtagcagc catcaaggtc accactccat attctctgta
      241 tgtgtgtcca gaggggcaga atgtcaccct cacctgcagg attctggact ccgtatccaa
      301 agggcacgat gcaaacttct taaagacgtg gttccttagc tctcgaggcg aggttcaagt
      361 gtgcaaagaa cacaggccca tacgtaactt catatcacac catcaacacc acagaagtca
      421 cccggcagtc aatgccagcc atgaccagcc ccagaaacat gggctggaga tagcttatga
      481 caaccacggt aacttctcta tcaccctgca caatgtgacc ctaagcgaca gcggcctcta
      541 ctgctgtctg gtgatagaag tcaaacacca ccacccagaa cggcggctct acgggtacat
      601 ggagctgcag gtacagacag gcaaaggctc agcatctaca tgcacagcgt acccgcctaa
      661 tgagcaggac agtgacagca tcacggctgc ggccctggcc acgggcgcct gcattgtcgg
      721 aattctctgc cttcccctta tcctgttgct ggtctataag cagaggcagg cggcctctca
      781 ccgccgtgcc caggagctgg tgaggatgga cagcagcaac acccaaggaa tcgaaaaccc
      841 aggctatgag accactccac ccttccaggg gatgccggag gccaagacta ggcctccact
      901 gtcctatgtg gcccagcggc aaccttccga gtcgggacgg cacctgctgt ctgaccccag
      961 cacacctctg tcccctccag gccctgggga tgtcttcttc ccatccctgg atccagtccc
     1021 tgactcccct aactctgaag ccatctaaac cagctggggg accgtgcctg gtgcctgggt
     1081 cagggatgga tgtacttgat cgatgacagg cccttggaca gacctttagg cactgattcc
     1141 agttccttgc tcctgctctg agcctagact ctgctttacg agatgcacgg accctcctct
     1201 gtcactttga gatgttactt gggggcggga ggggcaggga gaagatgctg gattgcccat
     1261 agctgttctc aaggtcctgg gatgcggagt tctccctaga gtcttgatct cgccagccac
     1321 agatgtcaaa ctacctgaat tgtacgagca ccaacttggt aacagccttt cttcatggaa
     1381 accagcagcc cggatgggat gaggtaggca ccttgccacc ctcccaggtg agaggcacaa
     1441 ggtgtgagag actcctaccc actgtggggg tgtggcgtgt ctgcttgctt gcctgaggat
     1501 gctcctctgt tggcctggct ctaacccctg gattctggag tgtgcttccc accagcaacc
     1561 tgagggtctg tcagcagttt aagtgactct gggctctctt tgcctgtata gctgtccata
     1621 gggctcagtg gccagaagct ctaaaacagc aagtgcctgt taggttcagg agctcattag
     1681 tgtctcgagc aatgtgaggc ctggaccacc ggacacagag ggtgatgagg gcacgatggg
     1741 gacggtgagg ggagacaagc ctccttcctg tcctcaacat ccaatcactc ccactgctca
     1801 gtgtagagcg atggcaaagg tgacctctat aatgtcctaa tgatgctggg ctacttctaa
     1861 gtgtgaaaga gatgctatta aaaagaaata cgtgaacagc tatgagtgga ttggaggcac
     1921 tagctttaag gccccggggg tacaggacct ggtatgtggt tgggtttgca ctaagggcct
     1981 aggggtcact ctgcttctga tcactgttct tctgagtctc acttcagggt gacctccggg
     2041 cacacagaag agcttgtccc tggtctgatg ctactcttgg ctcccatctc cagggtctgg
     2101 catgacctgg gcacatagga gagtcttcat aaaggatttt aatgcatgaa gagaaagggt
     2161 agttcctttg aggtagagat agggcagctg atgtttgaga gtggagaggg ataaggctgg
     2221 gcaaatcacc ctcccatctc cagagggaca gtagccccaa cactgggaga gcagcagccc
     2281 aatttgtcta actgcagctt ccactggctg ggctgaactg ggcctgggta gaaaagctca
     2341 cacgctgggc ctgcagacag ggagaaaccc attcattccc cgaggacaga tgggtgggga
     2401 gaggagagca tttctggctg ggaataagct acctgctggg aacccaggca caatgtctga
     2461 taagatccaa gagcatagac tcctgtggga tgccagctag gcctggggcc tggggatctt
     2521 agaggctttt gtatcatcat cataggcgtg tcggggtggc caggacccct gttttatccc
     2581 agggccccct cttctgctcc atccgttgcc attgactcta cgcagttact gtagacagga
     2641 tttgttgctc ttttggcttt ggggattatg ggctggagaa gtaccagctg ttttgtggca
     2701 gggctatggg gccagtcaaa caatgagacc cagagaccag ctgtatgccg agtatcccct
     2761 ggggaccctg acctgtcccc agccctgagc ttcagacctc aacacccaga tgacttctaa
     2821 gaatttgact gtggggaccc ctgcatggct gcagctctgt ggaaaggaga ggaagccccc
     2881 agcagaacag ccaccaactt cctgcccagc ttcctcctgt cgggctctag tctcttcttc
     2941 tcgggaccct gcaagcaaag gcatgtcagc ttggtggttt cctgttttgg gtgaagtttt
     3001 gtgcggtctg ggctctgtag atccatgaac ttgggtgcta ccaccttgct gctgctgtgc
     3061 agacagcagc agggtcttgg gtggaaaatg gacgcgccct tgggtgctag ccctgggggc
     3121 aaaagatggg gtggtggtga gacacagcag ggaactgagg aggaagaaga ggaaggagcc
     3181 ctacagcctg aagggccata ttgggttcct ggtactagca gaagactaca gagggaagtc
     3241 tgtattttga ggaggtaatt catccttagg aaatcaatca gaaatttgga gagggtgatt
     3301 tatctatgtc tggagggtct ctacctatct ccgatgaagc tctccctggg actcggatgg
     3361 gtgggaccag taggaaaggt ttccgataca gcaggggctt cttgacaact ggtagctgtt
     3421 gttggaccaa gacggccctg caggagtact gtagtgtgcc ttggaccaac ttctcaaaag
     3481 agcagtcctg gggctaccct acttctgctt ggaagagacg gagagagagg ctgggaaggg
     3541 gctccttcga gaactgctcc ctggagaaag ggcttggagg aggcagctag gctaagggtg
     3601 ctgagggcgc tttgtctctc ctaacctgga cactgttagg aaaaggcttt cccgggtgtg
     3661 agctgcagcc ctgccccagc gctgaacctg ccatggtggg agctgaacta aaaatttctc
     3721 agggaactaa attaggcaaa agaggaactg ggggaggggg taccaagcag gatgggggat
     3781 ggggtgcaaa ggctcctgaa aacagaaagc ccagctgagt tccagtccca gaccacagag
     3841 gatatgggcc atctggcttg tgccctgcat gctcactgct ttgccctggc attttccttc
     3901 ctcacaatga atgtgagtcc tgggagggtg aggactaatg ccagcctggg gagctgatag
     3961 ttgacacagt ccttgggtaa ctgggttgaa ccaggacctc aggattccac tctggggatt
     4021 tagctttgtg tggatctttg aggatctcca tattggcatt attgccacag gataaatatt
     4081 tcactgggct tcactgttct gatctgttgg gtgtggcttc ctggaaaata cagtgagagg
     4141 aattctgata aggatacagc tgataaggaa gtgctgagat tgattaataa tgcctgcctt
     4201 ggacttggga agaggaagtg gccgaatgga tgccatatct taatcttgtt aaaatatgct
     4261 gcccagaaga tttccacatg tgtatgaagt atgcacgtgt atatgtttta ctgtgtgcct
     4321 atggaaacca gaaatcatca ctgggtgtct tcctcatttc ctttgcaatg tctttttttt
     4381 tttaaggatt tatttacttc atgaatgttt tgcccgaatg cacgcgtaag tgtcatgtgc
     4441 gtgccagttg gaaggactgg aactggagtc ataggtggtt atgagctacc atttgagtgc
     4501 cgggaatcaa acccaggtct tctgcaagag caacagatta aaagatagct cttagctgct
     4561 cgactttcca gccccaccat cgagcattct tagcgtttaa aatctcatgt gcatgttttt
     4621 gcttgtttgt tcgattttgc ctgcatgtct ctgagcgtcc ccacgtgagt gcctggcact
     4681 gtggaggcca tggggggggg ggcactgagt cacgtgggaa tggaggtata gattgttgtg
     4741 agttggcatg tggacggagt caacgtggat cctctgggag tcgagcaaga gctcccaact
     4801 gctgggctgt ctcgttagtg ttccacttta tttttggcag accctgcagt gaatctggag
     4861 ctcagcacta ggctgagcat cgagctctgg ggatctgcct gtctctgccc caccccaccc
     4921 ccaactgctg gggttatcga ctgcatccag cctgtggatg ctgagaatct gaacacagat
     4981 acgtgcgtgg tgagcactgt atcttccgag ccctgcccac ccctaaacaa gagtctttac
     5041 cgttcccatg taatgcagaa agaaatgatg gttctgaaag gctcatgctt tgtgactggt
     5101 ggaatgtatg ttgcctctcc tgcccctttc ccgtcaatga accaaagagc cttctcatcc
     5161 attgatctgc cattgccttc aacttgtaca cgccaggccg cggagagatg aacttgacct
     5221 cacaagtttg caattccagt tcactccaca ccaggaataa actcttattt atgctca
//
