LOCUS       NM_001005561            1734 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus VRK serine/threonine kinase 3 (Vrk3), mRNA.
ACCESSION   NM_001005561 XM_006229095 XM_341848
VERSION     NM_001005561.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Quiel,A., Jurgen,B., Greinacher,A., Lassen,S., Worl,R., Witt,S. and
            Schweder,T.
  TITLE     Sensitive detection of idiotypic platelet-reactive alloantibodies
            by an electrical protein chip
  JOURNAL   Biosens Bioelectron 36 (1), 207-211 (2012)
   PUBMED   22572157
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Kang,T.H. and Kim,K.T.
  TITLE     VRK3-mediated inactivation of ERK signaling in adult and embryonic
            rodent tissues
  JOURNAL   Biochim Biophys Acta 1783 (1), 49-58 (2008)
   PUBMED   18035061
  REMARK    GeneRIF: various other rodent adult tissues and embryos possess a
            common signaling mechanism which is involved in an indirect
            regulation of ERK activity by VRK3-mediated vaccinia H1-related
            (VHR) phosphatase activity
REFERENCE   4  (bases 1 to 1734)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Jun 26, 2015 this sequence version replaced
            XM_006229095.2, NM_001005561.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218807.1, BC081928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                JAXUCZ010000001.1  104379948-104379979
            33-94               JAXUCZ010000001.1  104382548-104382609
            95-234              JAXUCZ010000001.1  104386244-104386383
            235-384             JAXUCZ010000001.1  104389886-104390035
            385-579             JAXUCZ010000001.1  104391848-104392042
            580-644             JAXUCZ010000001.1  104393027-104393091
            645-711             JAXUCZ010000001.1  104394879-104394945
            712-796             JAXUCZ010000001.1  104396031-104396115
            797-902             JAXUCZ010000001.1  104396685-104396790
            903-995             JAXUCZ010000001.1  104398824-104398916
            996-1128            JAXUCZ010000001.1  104400040-104400172
            1129-1249           JAXUCZ010000001.1  104401131-104401251
            1250-1308           JAXUCZ010000001.1  104404725-104404783
            1309-1468           JAXUCZ010000001.1  104405522-104405681
            1469-1734           JAXUCZ010000001.1  104407013-104407278
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1734
                     /gene="Vrk3"
                     /note="VRK serine/threonine kinase 3"
                     /db_xref="GeneID:361565"
                     /db_xref="RGD:1549692"
     exon            1..32
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            33..94
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1457
                     /gene="Vrk3"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase VRK3; vaccinia
                     related kinase 3"
                     /codon_start=1
                     /product="inactive serine/threonine-protein kinase VRK3"
                     /protein_id="NP_001005561.2"
                     /db_xref="GeneID:361565"
                     /db_xref="RGD:1549692"
                     /translation="MDQALSPQSMISFCPLCGKSVKVSFKFCPYCGEALPVEEDGGTQ
                     TGITPLVSPFRGSKRDLNSSSETSPKKVKWSRTVTSLPLSLHSDYDSSGSDDTLSSPD
                     RATGTRSRSQTPKGSPLANRLSPRTLKRSRVTTSLQALPTGTELTDQNGKHWTLGTLQ
                     TRDDQGILYAAEPTSAISSESRTQKWRFSLKLDSKDGRLFNEQNFFQRAAKPLQVNKW
                     KKRCLTPLLAIPTCIGFGVHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERCMLQVAC
                     RLLDALEYLHEHEYVHGNLTTENVFVNPEDLSQVTLVGYGFTYRYCPGGKHVAYKEGS
                     RSLHDGDLEFISMDVHKGCGPSRRSDLQTLGYCMLKWLYGSLPWTNCLPNTEEITKQK
                     QKYQDNPEPLVGLCGRWNKTSETLREYLKVVMALDYEEKPPYATLRNNLEVLLQNMRV
                     SPYDPLDLQMVP"
     exon            95..234
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            235..384
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            385..579
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..644
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            645..711
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..796
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            797..902
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            903..995
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1128
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1249
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1308
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1468
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1734
                     /gene="Vrk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accccggaag tttccgctgg gcaactgaaa aggttgttgt caagatggag tgcctaaccc
       61 agtaatccat ggaccaggcc ctgagtccac aaagcatgat ctccttctgt ccactctgtg
      121 gcaaaagtgt caaagtatca ttcaagttct gcccttactg tggcgaggcc ctgcctgtag
      181 aggaggatgg aggcacccag actggcatta cgcctcttgt gtcacccttt cgaggctcca
      241 agagagacct gaactccagt tctgaaacct cccccaagaa agtgaaatgg tcacgcactg
      301 tcacttctct cccgctctcc ctccactctg actatgacag ttctggatct gatgacacct
      361 tgagttctcc tgacagagcc acaggcaccc ggagcagatc ccagacccct aaaggcagcc
      421 cacttgccaa caggctgagc cctcggacac tgaagcggag ccgggtgacc acctcactcc
      481 aggctctgcc cacagggaca gagctgacag accagaatgg gaagcactgg acactgggga
      541 ccctgcagac ccgggatgac caaggcattc tctatgcagc tgagcctact tctgccatct
      601 ccagtgaatc aaggacccag aagtggagat tctccctcaa actggactcc aaagacgggc
      661 gccttttcaa tgagcagaac ttctttcaga gagcagccaa gcctctgcaa gtgaacaagt
      721 ggaagaagcg gtgcttgacc ccgctcctgg ccatccccac ctgcatcggc tttggcgttc
      781 accaggacaa gtacaggttc ctagtgttcc ccagcctggg gaggagcctt cagtcagccc
      841 tggacgacaa cccgaagcat gtggtatccg agagatgtat gctgcaggtg gcctgcaggc
      901 tgctggatgc tctggagtat ctccatgaac acgagtatgt tcacgggaac ctgaccactg
      961 agaatgtctt tgtgaatcca gaggacctga gccaggtgac cctggtgggc tatggcttca
     1021 cctaccgata ctgcccaggt ggcaagcacg tggcctataa agaaggcagc aggagtctac
     1081 acgatgggga cctggagttc attagcatgg acgtgcacaa gggatgcggg ccctcccgcc
     1141 gcagcgatct ccagaccttg ggctactgta tgctcaagtg gctttatggg tccctgccat
     1201 ggacaaactg ccttcccaac actgaagaga taactaagca gaagcagaag tatcaggaca
     1261 accctgagcc cctggtggga ctgtgtggcc gctggaacaa gacctcagag accttgcggg
     1321 agtacctgaa ggtggtgatg gcccttgatt acgaggagaa gccgccctat gccacgctga
     1381 ggaacaatct agaagttctg ctgcagaata tgcgggtgtc accctatgac cccctggacc
     1441 tccagatggt gccttaggtg gaatccagag attctgatgt gcagcttgaa gtagaacatg
     1501 aagtagtgtg actcggggcc ttgtttgaag tcatagctcc tcaaagaatc ccttgaatgt
     1561 atattcttgc cactccctta agacttacaa atcagcactg gtgttgggga acctgagtgg
     1621 tgccccgtga tgtgaaactc ctctctatcc ctcagccctg cagttgtgaa tggaggtgag
     1681 tggaggctcc ataggacctt cctgtgatgt cataataaac tgttttaatc aaaa
//
