LOCUS       NM_001401405            1625 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus VRK serine/threonine kinase 2 (Vrk2), mRNA.
ACCESSION   NM_001401405 XM_008770432
VERSION     NM_001401405.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Cheng,L.C., Baboo,S., Lindsay,C., Brusman,L.,
            Martinez-Bartolome,S., Tapia,O., Zhang,X., Yates,J.R. 3rd and
            Gerace,L.
  TITLE     Identification of new transmembrane proteins concentrated at the
            nuclear envelope using organellar proteomics of mesenchymal cells
  JOURNAL   Nucleus 10 (1), 126-143 (2019)
   PUBMED   31142202
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Quiel,A., Jurgen,B., Greinacher,A., Lassen,S., Worl,R., Witt,S. and
            Schweder,T.
  TITLE     Sensitive detection of idiotypic platelet-reactive alloantibodies
            by an electrical protein chip
  JOURNAL   Biosens Bioelectron 36 (1), 207-211 (2012)
   PUBMED   22572157
REFERENCE   3  (bases 1 to 1625)
  AUTHORS   Fernandez,I.F., Blanco,S., Lozano,J. and Lazo,P.A.
  TITLE     VRK2 inhibits mitogen-activated protein kinase signaling and
            inversely correlates with ErbB2 in human breast cancer
  JOURNAL   Mol Cell Biol 30 (19), 4687-4697 (2010)
   PUBMED   20679487
REFERENCE   4  (bases 1 to 1625)
  AUTHORS   Blanco,S., Sanz-Garcia,M., Santos,C.R. and Lazo,P.A.
  TITLE     Modulation of interleukin-1 transcriptional response by the
            interaction between VRK2 and the JIP1 scaffold protein
  JOURNAL   PLoS One 3 (2), e1660 (2008)
   PUBMED   18286207
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1625)
  AUTHORS   Blanco,S., Santos,C. and Lazo,P.A.
  TITLE     Vaccinia-related kinase 2 modulates the stress response to hypoxia
            mediated by TAK1
  JOURNAL   Mol Cell Biol 27 (20), 7273-7283 (2007)
   PUBMED   17709393
REFERENCE   6  (bases 1 to 1625)
  AUTHORS   Blanco,S., Klimcakova,L., Vega,F.M. and Lazo,P.A.
  TITLE     The subcellular localization of vaccinia-related kinase-2 (VRK2)
            isoforms determines their different effect on p53 stability in
            tumour cell lines
  JOURNAL   FEBS J 273 (11), 2487-2504 (2006)
   PUBMED   16704422
REFERENCE   7  (bases 1 to 1625)
  AUTHORS   Nichols,R.J., Wiebe,M.S. and Traktman,P.
  TITLE     The vaccinia-related kinases phosphorylate the N' terminus of BAF,
            regulating its interaction with DNA and its retention in the
            nucleus
  JOURNAL   Mol Biol Cell 17 (5), 2451-2464 (2006)
   PUBMED   16495336
REFERENCE   8  (bases 1 to 1625)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 11, 2022 this sequence version replaced XM_008770432.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.35709.1,
                                           SRR26360190.336944.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000014.1  104635487-104635549 c
            64-204              JAXUCZ010000014.1  104632001-104632141 c
            205-254             JAXUCZ010000014.1  104583335-104583384 c
            255-324             JAXUCZ010000014.1  104582587-104582656 c
            325-412             JAXUCZ010000014.1  104581139-104581226 c
            413-518             JAXUCZ010000014.1  104567130-104567235 c
            519-611             JAXUCZ010000014.1  104565828-104565920 c
            612-744             JAXUCZ010000014.1  104542215-104542347 c
            745-865             JAXUCZ010000014.1  104532889-104533009 c
            866-924             JAXUCZ010000014.1  104530035-104530093 c
            925-1091            JAXUCZ010000014.1  104526313-104526479 c
            1092-1238           JAXUCZ010000014.1  104519794-104519940 c
            1239-1625           JAXUCZ010000014.1  104514815-104515201 c
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1625
                     /gene="Vrk2"
                     /note="VRK serine/threonine kinase 2"
                     /db_xref="GeneID:360991"
                     /db_xref="RGD:1311585"
     exon            1..63
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            64..204
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1580
                     /gene="Vrk2"
                     /EC_number="2.7.11.1"
                     /note="vaccinia related kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase VRK2"
                     /protein_id="NP_001388334.1"
                     /db_xref="GeneID:360991"
                     /db_xref="RGD:1311585"
                     /translation="MAPRRKEKYKLPVPLPEGKILDDMEGNQWALGKMIGSGGFGLIY
                     LAFPTNKPEKDARHVIKVEYQENGPLFSELKFYQRAAKRECIQKWVKQRKLDYLGVPV
                     FYGFGLTDFKGRSYRFMVMERLGIDLQKLLNQNGAFKKLTVLQLGIRMLDVLEYIHEN
                     EYVHGDIKAANLLLGYANPDRVYLADYGLSYRYCPNGNHKQYHEDPRKGHNGTLEFTS
                     LDAHKGVAPSRRSDVEILGYCMLRWLCGKLPWETNLENPVAVQTAKTKLLDELPESVL
                     KWTTSGSSCRELAEFFMYVHNLAYDAKPDYQKLKKILNPDGVPLGPLDFSTKAQGVNM
                     QTPIHRKVDSPKAIKKPANEFPTKYTRKVCGETRATWREEQEERRPAVLLSDLATPEN
                     SRTRKVREYSDTFSEMLSFRQTQSYPRFQGSHCKPYLDCTRRDPIRKPRPLPQYGSKP
                     TGNLGVTDLESSPRFWPAVLQLTLSEEAKADVYYYGLTIFCLLTLVCLALCFL"
     exon            205..254
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..324
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..412
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..518
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..611
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..744
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..865
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..924
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1091
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1238
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1625
                     /gene="Vrk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctgcgag gcctcggccc cgcctggccg tggagaccgg cgctgcgggg actcagacgg
       61 cagatgccat ggcaccgaga agaaaagaga aatacaagct tccggttcca cttccagaag
      121 gcaaaattct ggatgatatg gaaggaaacc agtgggcact gggcaagatg attggctccg
      181 gagggtttgg gctgatatac ttagctttcc ccacaaataa accagagaaa gatgcaagac
      241 atgtcataaa agtggaatat caggaaaatg gcccattatt ttcagagctt aaattttatc
      301 agagagctgc aaaaagagaa tgtatccaaa agtgggtaaa acagaggaaa cttgattatt
      361 taggagttcc tgtattttat ggatttggtc tgactgattt caaaggaaga agctacagat
      421 tcatggtaat ggaaagactg gggatcgatt tacagaagct cttgaaccag aacggtgctt
      481 ttaaaaaatt aactgtcctg caacttggaa tcaggatgct cgatgtactg gaatatatac
      541 atgaaaatga atatgttcat ggcgatataa aagcagcaaa tctactgctg ggttacgcaa
      601 atccagaccg ggtttatctt gcagactacg gactttccta cagatattgt cccaacggga
      661 accacaaaca gtatcacgaa gatccccgaa agggccataa cgggacacta gaatttacaa
      721 gtttggatgc acacaaagga gtcgcccctt ccaggaggag cgatgttgag atccttggtt
      781 actgcatgct gcgctggctc tgcggaaagc tgccttggga aacaaaccta gagaaccccg
      841 tggctgtcca gaccgctaaa accaaactgc tggatgaact cccggagtct gtgcttaagt
      901 ggactacgtc tggaagcagt tgccgtgaac ttgccgagtt cttcatgtat gttcataatt
      961 tagcttacga tgccaagcca gactatcaga agctcaagaa aattctgaat ccagatggag
     1021 tacctttagg gccactggac ttttccacca aagcacaggg cgtcaatatg cagactccaa
     1081 tccaccgaaa agttgattca ccaaaggcta taaagaaacc agccaatgaa ttcccaacta
     1141 agtacacaag gaaagtctgt ggagagacaa gagcaacatg gagagaggag caggaagagc
     1201 gccggcctgc agtgctgctg agcgacttgg caacaccaga aaactccaga acaaggaaag
     1261 tacgtgagta ttctgatact ttcagtgaaa tgctgagttt ccgacagaca cagagctatc
     1321 cacgtttcca aggctcacac tgtaagccct atctggactg caccaggaga gatcccatca
     1381 ggaagccgag acccctgccc cagtatggat ccaagcccac gggcaatctg ggtgtcaccg
     1441 acttggaaag ctctccaaga ttctggcctg cagttcttca gctgactctg agtgaagagg
     1501 caaaggcaga tgtgtactac tatggactca ctatattctg cctgctcaca ttagtatgtc
     1561 ttgctttgtg ttttctctga agtcactgaa taaactggct tttgcttttg tttttaatct
     1621 ttaaa
//
