LOCUS       NM_001012194            1908 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus VRK serine/threonine kinase 1 (Vrk1), mRNA.
ACCESSION   NM_001012194 XM_343106
VERSION     NM_001012194.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Quiel,A., Jurgen,B., Greinacher,A., Lassen,S., Worl,R., Witt,S. and
            Schweder,T.
  TITLE     Sensitive detection of idiotypic platelet-reactive alloantibodies
            by an electrical protein chip
  JOURNAL   Biosens Bioelectron 36 (1), 207-211 (2012)
   PUBMED   22572157
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Kim,W., Chakraborty,G., Kim,S., Shin,J., Park,C.H., Jeong,M.W.,
            Bharatham,N., Yoon,H.S. and Kim,K.T.
  TITLE     Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase
            VRK1 during interphase
  JOURNAL   J Biol Chem 287 (8), 5278-5289 (2012)
   PUBMED   22194607
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Shin,J., Chakraborty,G., Bharatham,N., Kang,C., Tochio,N.,
            Koshiba,S., Kigawa,T., Kim,W., Kim,K.T. and Yoon,H.S.
  TITLE     NMR solution structure of human vaccinia-related kinase 1 (VRK1)
            reveals the C-terminal tail essential for its structural stability
            and autocatalytic activity
  JOURNAL   J Biol Chem 286 (25), 22131-22138 (2011)
   PUBMED   21543316
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Lopez-Sanchez,I., Sanz-Garcia,M. and Lazo,P.A.
  TITLE     Plk3 interacts with and specifically phosphorylates VRK1 in Ser342,
            a downstream target in a pathway that induces Golgi fragmentation
  JOURNAL   Mol Cell Biol 29 (5), 1189-1201 (2009)
   PUBMED   19103756
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Kang,T.H., Park,D.Y., Choi,Y.H., Kim,K.J., Yoon,H.S. and Kim,K.T.
  TITLE     Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in
            mammalian cells
  JOURNAL   Mol Cell Biol 27 (24), 8533-8546 (2007)
   PUBMED   17938195
  REMARK    GeneRIF: These findings collectively support a role of VRK1 as a
            novel mitotic histone H3 kinase in mammals.
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Nichols,R.J. and Traktman,P.
  TITLE     Characterization of three paralogous members of the Mammalian
            vaccinia related kinase family
  JOURNAL   J Biol Chem 279 (9), 7934-7946 (2004)
   PUBMED   14645249
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079130.1.
            
            [WARNING] On Oct 18, 2024 this sequence was replaced by
            NM_001012194.2.
            
            On Feb 11, 2005 this sequence version replaced XM_343106.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1908
                     /gene="Vrk1"
                     /note="VRK serine/threonine kinase 1"
                     /db_xref="GeneID:362779"
                     /db_xref="RGD:1306069"
     exon            1..290
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..455
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1540
                     /gene="Vrk1"
                     /EC_number="2.7.11.1"
                     /note="vaccinia related kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase VRK1"
                     /protein_id="NP_001012194.1"
                     /db_xref="GeneID:362779"
                     /db_xref="RGD:1306069"
                     /translation="MPRVKAAQAGRQGPAKRRLAEQFAAGEIITDMSKKEWKLGLPIG
                     QGGFGCIYLADTNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIHT
                     HKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLR
                     ILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPDGVHKEYKEDPK
                     RCHDGTLEFTSIDAHNGVAPSRRGDLEILGYCMIQWLSGCLPWEDNLKDPNYVRQSKI
                     RYRDNVAALMEKCFPERNKPGEIAKYMETVKLLDYTEKPLYQNLRDILLQGLKAIGSK
                     DDGKLDFSAVENGSVNTKPASKKRKKGAVEEESSVCAVEESPVCAVEESPVCAVEDME
                     CADTQAQEAIQTRSRTRKKAQQ"
     exon            456..511
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..581
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..669
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..778
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..871
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1004
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1125
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1184
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1363
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1508
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1878
                     /gene="Vrk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgtactac gctgtgggac ggcgagttgg ccgctctggg tagggagccc tgaggtggcg
       61 gcgggacggt gggtacagcg acgcatcaga gaggcgcctg ctcatccggg tgtcaggcgg
      121 cgcggctgct gggtcgggtc agcccgggaa ccctcgcctc tctgcccgct cgcggagctg
      181 ccggaagccc ggttctagaa ggccgcccga agcctggaca gggccaggtg gcggacaccg
      241 ggacaggaat ctggaccggc cgagcttgcc tcttccttag cagcggtgag tgaaaatgcc
      301 tcgtgtaaaa gcagctcagg ctggaagaca gggacctgca aagaggcgcc tcgcagagca
      361 gtttgccgct ggagagatca taaccgacat gtctaaaaag gaatggaaac taggcttgcc
      421 tattggccaa ggaggctttg gctgcatcta tctggcggac acaaattctt ccaaaccggt
      481 cggcagtgat gcgccctgtg ttgtgaaagt ggaacccagt gacaatggac ctcttttcac
      541 tgaattaaag ttctaccaga gggctgctaa accagagcaa attcagaaat ggattcatac
      601 acataaattg aagtatcttg gtgttcctaa gtattgggga tctggtctac atgataaaaa
      661 tggaaaaagt tacaggttta tgataatgga ccgctttggg agtgaccttc agaaaatata
      721 tgaagcaaat gccaaaaggt tttctcggaa aactgtcttg cagctaagct taagaattct
      781 ggatatcctg gagtacatcc acgagcacga gtatgtgcat ggggacatca aggcctccaa
      841 cctccttctg agttacaaga accctgacca ggtgtatttg gttgactatg gacttgctta
      901 tcggtactgc ccagatggag ttcataaaga gtacaaggaa gatcccaaaa ggtgccacga
      961 cggcacactg gagttcacca gcatcgatgc tcacaatggc gtggccccat ctcgacgtgg
     1021 tgatttggaa atacttggtt actgcatgat ccagtggctc agcggctgtc ttccttggga
     1081 ggataacttg aaagacccca actacgtcag acagtccaaa attagataca gagacaatgt
     1141 cgcagctttg atggagaaat gctttcctga gaggaataag ccaggtgaga tcgctaagta
     1201 catggagact gtgaaactac tggactacac tgaaaagccg ctttaccaaa acctacgtga
     1261 catccttctg caaggactaa aagctatagg aagtaaggat gacggcaaac tggattttag
     1321 tgctgtggag aacggaagtg tgaacacaaa accagcttca aagaagcgga agaaaggcgc
     1381 tgtggaagaa gaaagctcag tgtgcgctgt ggaagaaagc ccagtgtgcg ctgtggaaga
     1441 aagcccagtg tgcgccgtgg aagacatgga gtgcgcagac acacaggcgc aagaggccat
     1501 acagactcgt tcacgaacca gaaagaaagc ccagcaataa ctgagatgcc agaaaccgtc
     1561 ttctctgcct gttcatttga ctgtttcctc cttttctatt ttatgtttta ttttcatgtg
     1621 agtcttgtgg ggtgtgagta ataattgaat gactactttt ttgaaaagca aactttatta
     1681 aaatgagtat tttgtgtact ttattgaagg attatttata aagtctcaaa tctttagtcg
     1741 tcacaaccca cgtgctttgg gacttgggag cgtgtgctgg ctctggccgc tctgcacttc
     1801 ccaggttggg cagagctctc tacaggctcc ttgcttttac ggaatgaaga acttaaaata
     1861 aaggtctctt ttgctttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
