LOCUS       NM_001025716            2848 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus vacuolar protein sorting 4 homolog B (Vps4b),
            mRNA.
ACCESSION   NM_001025716 XM_341107
VERSION     NM_001025716.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2848)
  AUTHORS   Cui,G., Wang,Y., Yu,S., Yang,L., Li,B., Wang,W., Zhou,P., Wu,J.,
            Lu,T. and Chen,D.
  TITLE     The expression changes of vacuolar protein sorting 4B (VPS4B)
            following middle cerebral artery occlusion (MCAO) in adult rats
            brain hippocampus
  JOURNAL   Cell Mol Neurobiol 34 (1), 83-94 (2014)
   PUBMED   24077878
  REMARK    GeneRIF: The up-regulation of VPS4B played an important role in the
            pathophysiology after middle cerebral artery occlusion.
REFERENCE   2  (bases 1 to 2848)
  AUTHORS   Colombo M, Moita C, van Niel G, Kowal J, Vigneron J, Benaroch P,
            Manel N, Moita LF, Thery C and Raposo G.
  TITLE     Analysis of ESCRT functions in exosome biogenesis, composition and
            secretion highlights the heterogeneity of extracellular vesicles
  JOURNAL   J Cell Sci 126 (Pt 24), 5553-5565 (2013)
   PUBMED   24105262
REFERENCE   3  (bases 1 to 2848)
  AUTHORS   Sandrin V and Sundquist WI.
  TITLE     ESCRT requirements for EIAV budding
  JOURNAL   Retrovirology 10, 104 (2013)
   PUBMED   24107264
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2848)
  AUTHORS   Baietti MF, Zhang Z, Mortier E, Melchior A, Degeest G, Geeraerts A,
            Ivarsson Y, Depoortere F, Coomans C, Vermeiren E, Zimmermann P and
            David G.
  TITLE     Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
  JOURNAL   Nat Cell Biol 14 (7), 677-685 (2012)
   PUBMED   22660413
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2848)
  AUTHORS   Dores MR, Chen B, Lin H, Soh UJ, Paing MM, Montagne WA, Meerloo T
            and Trejo J.
  TITLE     ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates
            ubiquitin-independent ESCRT-III/MVB sorting
  JOURNAL   J Cell Biol 197 (3), 407-419 (2012)
   PUBMED   22547407
REFERENCE   6  (bases 1 to 2848)
  AUTHORS   Hislop JN, Marley A and Von Zastrow M.
  TITLE     Role of mammalian vacuolar protein-sorting proteins in endocytic
            trafficking of a non-ubiquitinated G protein-coupled receptor to
            lysosomes
  JOURNAL   J Biol Chem 279 (21), 22522-22531 (2004)
   PUBMED   15024011
REFERENCE   7  (bases 1 to 2848)
  AUTHORS   von Schwedler UK, Stuchell M, Muller B, Ward DM, Chung HY, Morita
            E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Krausslich HG,
            Kaplan J, Morham SG and Sundquist WI.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
REFERENCE   8  (bases 1 to 2848)
  AUTHORS   Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S,
            Abts HF and Kohrer K.
  TITLE     Mammalian cells express two VPS4 proteins both of which are
            involved in intracellular protein trafficking
  JOURNAL   J Mol Biol 312 (3), 469-480 (2001)
   PUBMED   11563910
REFERENCE   9  (bases 1 to 2848)
  AUTHORS   Bishop N and Woodman P.
  TITLE     ATPase-defective mammalian VPS4 localizes to aberrant endosomes and
            impairs cholesterol trafficking
  JOURNAL   Mol Biol Cell 11 (1), 227-239 (2000)
   PUBMED   10637304
REFERENCE   10 (bases 1 to 2848)
  AUTHORS   Perier F, Coulter KL, Liang H, Radeke CM, Gaber RF and Vandenberg
            CA.
  TITLE     Identification of a novel mammalian member of the
            NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in
            yeast
  JOURNAL   FEBS Lett 351 (2), 286-290 (1994)
   PUBMED   8082782
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099128.1.
            
            On Jul 22, 2005 this sequence version replaced XM_341107.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099128.1, SRR8487230.81763.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2848
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p11"
     gene            1..2848
                     /gene="Vps4b"
                     /note="vacuolar protein sorting 4 homolog B"
                     /db_xref="GeneID:360834"
                     /db_xref="RGD:1305969"
     exon            1..215
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1523
                     /gene="Vps4b"
                     /EC_number="3.6.4.6"
                     /note="vacuolar protein sorting 4b"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 4B"
                     /protein_id="NP_001020887.1"
                     /db_xref="GeneID:360834"
                     /db_xref="RGD:1305969"
                     /translation="MASTNTNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHV
                     VKYEAQGDKAKQSIRAKCTEYLDRAEKLKEYLKKKEKKPQKPMKEEQSGPVDEKGNDS
                     DGEAESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLF
                     TGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKN
                     LFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLG
                     ATNIPWVLDSAIRRRFEKRIYIPLPEAHARAAMFRLHLGSTQNSLTEADFQELGRKTD
                     GYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNCIVNDLLTPCSPGDPGAI
                     EMTWMDVPGDKLLEPVVSMWDMLRSLSSTKPTVNEQDLLKLKKFTEDFGQEG"
     exon            216..327
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            328..484
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            485..552
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            553..672
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            673..829
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            830..978
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1060
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1280
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1421
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..2822
                     /gene="Vps4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaagtttt gtgaggaggg tctggtggct gctggagttc ctggtagatt tactgctcta
       61 gagctgggac tgccgctggg ggtctcagag ccgccagcct ccggagcgtt gcggctgtga
      121 cccgggcgcg actcgacggc gctgctgcgg gccggcctcg tctgtagggg accctttgga
      181 tctccaccat ggcgtccacg aacaccaacc tccagaaagc aatagatctt gcaagcaaag
      241 cagcccagga agacaaagct gggaactatg aggaagctct ccaactctac cagcatgctg
      301 ttcagtattt tctccatgtt gttaaatatg aagcacaagg tgataaagcc aagcaaagca
      361 tcagggccaa gtgtacagaa tatcttgata gagcagaaaa actaaaggaa tatctgaaga
      421 aaaaagagaa gaagccacag aagcccatga aagaggaaca gtcaggtcca gtcgatgaga
      481 aggggaatga cagtgatggg gaagcagaat ctgatgatcc tgaaaaaaag aaactgcaga
      541 atcaacttca aggtgccatt gttatagagc gaccgaatgt gaagtggagt gatgttgctg
      601 gtctggaagg agccaaagaa gctcttaaag aggctgtcat tctgcctatt aagtttcctc
      661 atctgtttac agggaagagg acaccttgga gaggaatcct attatttggg ccaccaggaa
      721 caggaaaatc ctatttagcc aaagctgttg cgacagaagc aaacaactca acgtttttct
      781 caatatcttc ctccgacctg gtgtctaagt ggctggggga gagtgaaaaa ctggttaaga
      841 acttattcca gctcgccaga gagaacaagc cttccatcat cttcatcgat gagattgact
      901 ctctgtgcgg ttccagaagt gagaatgaga gcgaggctgc acggagaatt aagactgagt
      961 tcctggttca gatgcaagga gttggtgtgg acaatgatgg cattttggtt ctgggagcta
     1021 caaatatccc ctgggtgctg gactctgcaa ttaggcgaag atttgagaaa cgtatttata
     1081 ttcctttgcc tgaagcccac gctcgggcag ccatgtttag actgcacttg ggcagcactc
     1141 agaacagcct cacagaagca gacttccaag agcttgggag gaagacagat ggctattcag
     1201 gagcagatat aagcatcatc gtacgggatg cacttatgca gcctgtgaga aaagttcagt
     1261 cggctactca cttcaaaaag gttcgtgggc cctcaagggc tgatcctaac tgcattgtaa
     1321 atgacctgct gacaccctgc tctccgggag atccaggggc tattgaaatg acgtggatgg
     1381 atgtccctgg agataaactc ttggagccag ttgtttccat gtgggatatg ctgcggtccc
     1441 tatccagcac aaagcccaca gtcaatgagc aggacttgtt gaaactgaag aagtttacag
     1501 aagattttgg ccaggaaggc taacacagag acagcaagaa catgtttatg ctgcatttcc
     1561 tctcttttgt aggtattttg cctttctcgg atggcattca gattatttcc agcaaaactc
     1621 atttacccag ggaaacatac acgtcatttg gtgtccctta agtctctgtt gtccttttcc
     1681 tatactacct gttaagttct ccaattcaca aacattgtta aattgtaagg aggggagccg
     1741 gggcatgtgg aacagcagag tggggacagc gaggagcctc accctgcttc atggacagca
     1801 gctaggattc tcatgagcac tcactcaaag agcaaggcct ttctttttcc ttttttaaaa
     1861 atgaaattga gacagggcta aagctaatga tatataaatg tcttgaaaaa atctttaagc
     1921 attttaccaa tgtaaagtta ctgctttatt aaaaattaag aatggtagaa tctttactct
     1981 cagggatggg cagcaaaacg tagagcactg tgaagaattt gggtctgtgg cacaggcagt
     2041 gctcgtgttg agtttgcagt gggttgattt ctcctgcgta gattaaaatg attcctctaa
     2101 agcgggcttt tataactcca tgactccttc cactgtgcac ttgagacttt ctgaatcagt
     2161 catcatcttt gccttgtcta cgtcagtgtc ttttgtagcc aagattgacc aagagaggtg
     2221 gcaaagaagt atacagtttt tgagaattgt cctgaaatac tgtaatggga acctttaata
     2281 tgaaaatggc ttccttttga ctttgggatg tttcctgtgg atgatgtggg tatgtgtgta
     2341 catatatata catacttttt taaatatagg ctaacaagag tcatgtcttt cacttttaag
     2401 ttcagggagc agtttgttct aaccacacag acattctcag tgtggtattt catggagctt
     2461 tagagacaaa ctggtatctc attatgtaat gaaatataaa cataccatca tgttatttta
     2521 atgtcttcaa atacatgatc tgaggggggt gtgtcacaca cttgtgtacc aactcttagt
     2581 tgtgccttga acatttgcat tgactacctg caaacaatta ctaggttaac tagaattgct
     2641 atgcagttct atcttgcaag tgctacacag taactgcagt ttaaagtata tttgcacatt
     2701 ttacatgcta tgctatatga ttgcctttgg gttttctgta cagattattt ttgttgatat
     2761 tcaatgaaaa ttgtaggcgg gaaatatatt gttcctatgt gaagtaaatt gctataacct
     2821 gcaaaaaaaa aaaaaaaaaa aaaaaaaa
//
