LOCUS       NM_145678               2105 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus vacuolar protein sorting 4 homolog A (Vps4a),
            mRNA.
ACCESSION   NM_145678
VERSION     NM_145678.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2105)
  AUTHORS   Ren,J., Yuan,D., Xie,L., Tao,X., Duan,C., Bao,Y., He,Y., Ge,J. and
            Lu,H.
  TITLE     Up-regulation of Vps4A promotes neuronal apoptosis after
            intracerebral hemorrhage in adult rats
  JOURNAL   Metab Brain Dis 32 (2), 565-575 (2017)
   PUBMED   28064406
  REMARK    GeneRIF: Vps4A was involved in promoting neuronal apoptosis via
            inhibiting Akt phosphorylation after intracerebral hemorrhage
REFERENCE   2  (bases 1 to 2105)
  AUTHORS   Thoresen,S.B., Campsteijn,C., Vietri,M., Schink,K.O., Liestol,K.,
            Andersen,J.S., Raiborg,C. and Stenmark,H.
  TITLE     ANCHR mediates Aurora-B-dependent abscission checkpoint control
            through retention of VPS4
  JOURNAL   Nat Cell Biol 16 (6), 550-560 (2014)
   PUBMED   24814515
REFERENCE   3  (bases 1 to 2105)
  AUTHORS   Cashikar,A.G., Shim,S., Roth,R., Maldazys,M.R., Heuser,J.E. and
            Hanson,P.I.
  TITLE     Structure of cellular ESCRT-III spirals and their relationship to
            HIV budding
  JOURNAL   Elife 3, e02184 (2014)
   PUBMED   24878737
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2105)
  AUTHORS   Sandrin,V. and Sundquist,W.I.
  TITLE     ESCRT requirements for EIAV budding
  JOURNAL   Retrovirology 10, 104 (2013)
   PUBMED   24107264
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2105)
  AUTHORS   Baietti,M.F., Zhang,Z., Mortier,E., Melchior,A., Degeest,G.,
            Geeraerts,A., Ivarsson,Y., Depoortere,F., Coomans,C., Vermeiren,E.,
            Zimmermann,P. and David,G.
  TITLE     Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
  JOURNAL   Nat Cell Biol 14 (7), 677-685 (2012)
   PUBMED   22660413
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2105)
  AUTHORS   Tanaka,H., Fujita,H., Katoh,H., Mori,K. and Negishi,M.
  TITLE     Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a
            novel Rho family GTPase, Rnd2
  JOURNAL   Biochem J 365 (Pt 2), 349-353 (2002)
   PUBMED   11931639
REFERENCE   7  (bases 1 to 2105)
  AUTHORS   Garrus,J.E., von Schwedler,U.K., Pornillos,O.W., Morham,S.G.,
            Zavitz,K.H., Wang,H.E., Wettstein,D.A., Stray,K.M., Cote,M.,
            Rich,R.L., Myszka,D.G. and Sundquist,W.I.
  TITLE     Tsg101 and the vacuolar protein sorting pathway are essential for
            HIV-1 budding
  JOURNAL   Cell 107 (1), 55-65 (2001)
   PUBMED   11595185
REFERENCE   8  (bases 1 to 2105)
  AUTHORS   Scheuring,S., Rohricht,R.A., Schoning-Burkhardt,B., Beyer,A.,
            Muller,S., Abts,H.F. and Kohrer,K.
  TITLE     Mammalian cells express two VPS4 proteins both of which are
            involved in intracellular protein trafficking
  JOURNAL   J Mol Biol 312 (3), 469-480 (2001)
   PUBMED   11563910
REFERENCE   9  (bases 1 to 2105)
  AUTHORS   Howard,T.L., Stauffer,D.R., Degnin,C.R. and Hollenberg,S.M.
  TITLE     CHMP1 functions as a member of a newly defined family of vesicle
            trafficking proteins
  JOURNAL   J Cell Sci 114 (Pt 13), 2395-2404 (2001)
   PUBMED   11559748
REFERENCE   10 (bases 1 to 2105)
  AUTHORS   Bishop,N. and Woodman,P.
  TITLE     ATPase-defective mammalian VPS4 localizes to aberrant endosomes and
            impairs cholesterol trafficking
  JOURNAL   Mol Biol Cell 11 (1), 227-239 (2000)
   PUBMED   10637304
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 13, 2022 this sequence version replaced NM_145678.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213218.1, FQ219248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000019.1  51844793-51844983
            192-303             JAXUCZ010000019.1  51849882-51849993
            304-451             JAXUCZ010000019.1  51850088-51850235
            452-513             JAXUCZ010000019.1  51851577-51851638
            514-633             JAXUCZ010000019.1  51851740-51851859
            634-790             JAXUCZ010000019.1  51853454-51853610
            791-939             JAXUCZ010000019.1  51854560-51854708
            940-1021            JAXUCZ010000019.1  51855008-51855089
            1022-1241           JAXUCZ010000019.1  51855615-51855834
            1242-1382           JAXUCZ010000019.1  51857196-51857336
            1383-2105           JAXUCZ010000019.1  51857917-51858639
FEATURES             Location/Qualifiers
     source          1..2105
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2105
                     /gene="Vps4a"
                     /note="vacuolar protein sorting 4 homolog A"
                     /db_xref="GeneID:246772"
                     /db_xref="RGD:628810"
     exon            1..191
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1484
                     /gene="Vps4a"
                     /EC_number="3.6.4.6"
                     /note="vacuolar protein sorting 4a; vacuolar protein
                     sorting protein 4a"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 4A"
                     /protein_id="NP_663711.1"
                     /db_xref="GeneID:246772"
                     /db_xref="RGD:628810"
                     /translation="MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIK
                     YEAHSDKAKESIRAKCMQYLDRAEKLKDYLRNKEKHGKKPVKENQSEGKGSDSDSEGD
                     NPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPW
                     RGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQ
                     HKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWV
                     LDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADI
                     SIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAIEMTWMDV
                     PGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES"
     exon            192..303
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            304..451
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            452..513
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            514..633
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            634..790
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            791..939
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1021
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1241
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1382
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..2105
                     /gene="Vps4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctcctcg ttcaccgtcg gactcggctc cgactgctag tggcagccct gcccgcgccg
       61 agagtcgacc tgccaggctc ctgagcagcg gacctaccac ctcggctcct ccgggccgga
      121 ccgaggccgc aagcagcacc gcggggtgtg gggcggaccc aggatatgaa atgacaacgt
      181 caaccctcca gaaagccatc gatctggtga caaaagccac agaagaggac aaagccaaga
      241 actacgagga ggcacttcgg ctctaccagc atgctgtgga gtatttcctc cacgccatca
      301 aatatgaagc ccacagtgac aaagccaagg agagcattcg agcaaagtgc atgcagtacc
      361 tagacagagc ggagaagctg aaggattatt taagaaacaa agagaaacat ggcaaaaagc
      421 cagtcaaaga gaatcagagt gaaggcaagg gtagtgacag tgacagcgaa ggggataatc
      481 cagagaaaaa gaaattacaa gaacagttga tgggtgctgt tgtgatggag aagcccaaca
      541 ttcggtggaa tgatgtagct ggactggagg gagctaaaga agctctcaaa gaagctgtga
      601 ttttgccgat aaaatttcca cacttattca caggcaaacg tactccttgg cgaggcatac
      661 tgctctttgg gcccccaggc acaggcaagt cctacctggc caaagccgtg gcaacagaag
      721 ccaacaactc taccttcttc tctgtgtcct cctcggatct gatgtctaag tggttggggg
      781 aaagcgagaa gctagtcaaa aacctgtttg agttggccag acagcacaag ccttccatca
      841 tcttcattga tgaggtggat tccctctgcg ggtcacggaa tgaaaatgag agcgaggcag
      901 cccgaaggat caaaacagag ttcttggtcc aaatgcaggg agtggggaat aataatgatg
      961 ggactcttgt tcttggtgcc acaaacatcc cctgggtgtt ggattcagcc atcaggagga
     1021 ggtttgaaaa gcgaatttat atcccattgc cagaggaagc ggcccgtgcc cagatgtttc
     1081 ggttacacct gggaagcaca cctcacaacc tcacagatgc taacatccat gagctggccc
     1141 gcaagacaga aggctactca ggagcagata tcagcattat cgtgcgggac tctctcatgc
     1201 agccagtcag aaaagtacag tcagcaacac acttcaagaa ggtttgtggt ccttctcgaa
     1261 ccaaccctag tgttatgatt gatgatcttc tgaccccatg ttctccagga gatccagggg
     1321 ctatagagat gacttggatg gatgtccctg gtgataaact cttagagcct gtggtttgca
     1381 tgtcggacat gctccggtct ctggccacta cccggcccac agtgaatgca gatgacctcc
     1441 tgaaagtaaa gaaattctct gaggactttg gacaggagag ttaaagcttc atgttgataa
     1501 tgaaattgag agtctgactg gagcaaattc atgggacttc ccacaccagt ggccaggcag
     1561 ggcctgaagt cgtgaagtca atagtattcc ctctactgcc tggctgccga cctagtagga
     1621 tgaaggaggg gcctcggcag ctgcagagat gcttcaccat gtaggacacg tgacactggc
     1681 tctgcacact tcactactgg atgctcacac tctgccctga tctgtttttg tctaactttt
     1741 gttcccctaa attaatgctg ctttgatttc tgtcttgttt ataaataaag aggaaaatca
     1801 tctggaaagt gttaaggagt gggagccacc aggcccctgc tctcactcct ttcctcttaa
     1861 ctttggctac ttgtgagctg actgtggtaa agtaggaaaa gccatcccac cctcctaagc
     1921 ttgcatctgg agcttcaggt cctccttgca ggagctgatg gcttctgtga gcacaatgcc
     1981 gtttctatca ggagagacgg cagacaggca ggtctttatc gctgccttca ctgagaactg
     2041 agaactgagc ccagcctctg ctggtcctgt cctggagatg tctaataaac cctttccctt
     2101 cttga
//
