LOCUS       NP_001012186             875 aa            linear   ROD 31-MAR-2024
DEFINITION  vam6/Vps39-like protein [Rattus norvegicus].
ACCESSION   NP_001012186 XP_342501
VERSION     NP_001012186.2
DBSOURCE    REFSEQ: accession NM_001012186.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 875)
  AUTHORS   Wartosch,L., Gunesdogan,U., Graham,S.C. and Luzio,J.P.
  TITLE     Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome
            Fusion with Endosomes and Autophagosomes
  JOURNAL   Traffic 16 (7), 727-742 (2015)
   PUBMED   25783203
REFERENCE   2  (residues 1 to 875)
  AUTHORS   Perini,E.D., Schaefer,R., Stoter,M., Kalaidzidis,Y. and Zerial,M.
  TITLE     Mammalian CORVET is required for fusion and conversion of distinct
            early endosome subpopulations
  JOURNAL   Traffic 15 (12), 1366-1389 (2014)
   PUBMED   25266290
REFERENCE   3  (residues 1 to 875)
  AUTHORS   Jiang,P., Nishimura,T., Sakamaki,Y., Itakura,E., Hatta,T.,
            Natsume,T. and Mizushima,N.
  TITLE     The HOPS complex mediates autophagosome-lysosome fusion through
            interaction with syntaxin 17
  JOURNAL   Mol Biol Cell 25 (8), 1327-1337 (2014)
   PUBMED   24554770
REFERENCE   4  (residues 1 to 875)
  AUTHORS   Graham,S.C., Wartosch,L., Gray,S.R., Scourfield,E.J., Deane,J.E.,
            Luzio,J.P. and Owen,D.J.
  TITLE     Structural basis of Vps33A recruitment to the human HOPS complex by
            Vps16
  JOURNAL   Proc Natl Acad Sci U S A 110 (33), 13345-13350 (2013)
   PUBMED   23901104
REFERENCE   5  (residues 1 to 875)
  AUTHORS   Pols,M.S., ten Brink,C., Gosavi,P., Oorschot,V. and Klumperman,J.
  TITLE     The HOPS proteins hVps41 and hVps39 are required for homotypic and
            heterotypic late endosome fusion
  JOURNAL   Traffic 14 (2), 219-232 (2013)
   PUBMED   23167963
REFERENCE   6  (residues 1 to 875)
  AUTHORS   Zlatic,S.A., Tornieri,K., L'Hernault,S.W. and Faundez,V.
  TITLE     Clathrin-dependent mechanisms modulate the subcellular distribution
            of class C Vps/HOPS tether subunits in polarized and nonpolarized
            cells
  JOURNAL   Mol Biol Cell 22 (10), 1699-1715 (2011)
   PUBMED   21411634
REFERENCE   7  (residues 1 to 875)
  AUTHORS   Zhu,G.D., Salazar,G., Zlatic,S.A., Fiza,B., Doucette,M.M.,
            Heilman,C.J., Levey,A.I., Faundez,V. and L'hernault,S.W.
  TITLE     SPE-39 family proteins interact with the HOPS complex and function
            in lysosomal delivery
  JOURNAL   Mol Biol Cell 20 (4), 1223-1240 (2009)
   PUBMED   19109425
REFERENCE   8  (residues 1 to 875)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   9  (residues 1 to 875)
  AUTHORS   Richardson,S.C., Winistorfer,S.C., Poupon,V., Luzio,J.P. and
            Piper,R.C.
  TITLE     Mammalian late vacuole protein sorting orthologues participate in
            early endosomal fusion and interact with the cytoskeleton
  JOURNAL   Mol Biol Cell 15 (3), 1197-1210 (2004)
   PUBMED   14668490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Sep 11, 2008 this sequence version replaced NP_001012186.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.10478.1,
                                           SRR26643429.12965.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     Protein         1..875
                     /product="vam6/Vps39-like protein"
                     /note="Vam6; vacuolar protein sorting 39 homolog; VPS39
                     HOPS complex subunit"
                     /calculated_mol_wt=100477
     Region          24..279
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     Region          449..551
                     /region_name="Vps39_1"
                     /note="Vacuolar sorting protein 39 domain 1; pfam10366"
                     /db_xref="CDD:371008"
     Region          588..735
                     /region_name="Clathrin"
                     /note="Region in Clathrin and VPS; pfam00637"
                     /db_xref="CDD:459884"
     Region          761..869
                     /region_name="Vps39_2"
                     /note="Vacuolar sorting protein 39 domain 2; pfam10367"
                     /db_xref="CDD:402126"
     CDS             1..875
                     /gene="Vps39"
                     /coded_by="NM_001012186.2:149..2776"
                     /db_xref="GeneID:362199"
                     /db_xref="RGD:1304858"
ORIGIN      
        1 mhdafepvpi leklplqidc laaweewllv gtkqghllly rirkdvgcnr fevtleksnk
       61 nfskkiqqih vvsqfkilvs llenniyvhd lltfqqittv skakgaslft cdlqhtetge
      121 evlrmcvavr kklqlyfwkd refhelqgdf svpdvpksma wcensicvgf krdyylirvd
      181 akgsikelfp tgkqleplva pladgkvavg qddltvvlne egictqkcal nwtdipvame
      241 hqppyivavl pryveirtle prllvqsiel qrprfitsgg sniiyvasnh fvwrlipvpm
      301 atqiqqllqd kqfelalqla emkddsdsek qqqihhiknl yafnlfcqkr fdesmqvfak
      361 lgtdpthvmg lypdllptdy rkqlqypnpl ptlsgaelek ahlalidylt qkrsqlvkkl
      421 ndsdhqssts plmegtptik skqkllqiid ttllkcylht nvalvapllr lennhchiee
      481 sehvlkkahk yseliilyek kglhekalqv lvdqskkans plkghertvq ylqhlgtenl
      541 hlifsysiwv lrdfpedglk iftedlpeve slprdrvlnf lienfkalai pylehiihvw
      601 eetgtrfhnc liqlycekvq nlmkdyllsl ptgkspvpag eeagelgesr qklltfleis
      661 ssydpgrlic dfpfdgllee ralllgrmgk heqalfiyvh vlkdtkmake ychkhydqnk
      721 egnkdvylsl lrmylsppsi hclgpiklel lepqanlqaa lqvlelhysk ldttkainll
      781 pantqindir iflekvleen aqkkrfnqvl knllhaeflr vqeerilhqq vkciiteekv
      841 cmvckkkign safarypngv vvhyfcskev nsadt
//
