LOCUS       NM_001396993            2665 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus VPS37C subunit of ESCRT-I (Vps37c), transcript
            variant 2, mRNA.
ACCESSION   NM_001396993 XM_003749059
VERSION     NM_001396993.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2665)
  AUTHORS   Okumura M, Katsuyama AM, Shibata H and Maki M.
  TITLE     VPS37 isoforms differentially modulate the ternary complex
            formation of ALIX, ALG-2, and ESCRT-I
  JOURNAL   Biosci Biotechnol Biochem 77 (8), 1715-1721 (2013)
   PUBMED   23924735
REFERENCE   2  (bases 1 to 2665)
  AUTHORS   Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD,
            Bycroft M, Perisic O, Ye Y, McDonald B, Scheel H, Hofmann K, Neil
            SJ, Martin-Serrano J and Williams RL.
  TITLE     The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA
            domain
  JOURNAL   Structure 20 (3), 414-428 (2012)
   PUBMED   22405001
REFERENCE   3  (bases 1 to 2665)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 2665)
  AUTHORS   Morita E, Sandrin V, Alam SL, Eckert DM, Gygi SP and Sundquist WI.
  TITLE     Identification of human MVB12 proteins as ESCRT-I subunits that
            function in HIV budding
  JOURNAL   Cell Host Microbe 2 (1), 41-53 (2007)
   PUBMED   18005716
REFERENCE   5  (bases 1 to 2665)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000046.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001396993.2.
            
            On Oct 29, 2021 this sequence version replaced XM_003749059.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487227.156069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               JACYVU010000046.1  1163568-1163780
            214-312             JACYVU010000046.1  1181483-1181581
            313-484             JACYVU010000046.1  1184981-1185152
            485-567             JACYVU010000046.1  1185845-1185927
            568-2665            JACYVU010000046.1  1187030-1189127
FEATURES             Location/Qualifiers
     source          1..2665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2665
                     /gene="Vps37c"
                     /gene_synonym="RGD1309258"
                     /note="VPS37C subunit of ESCRT-I"
                     /db_xref="GeneID:108348178"
                     /db_xref="RGD:11384366"
     exon            1..213
                     /gene="Vps37c"
                     /gene_synonym="RGD1309258"
                     /inference="alignment:Splign:2.1.0"
     exon            214..312
                     /gene="Vps37c"
                     /gene_synonym="RGD1309258"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1281
                     /gene="Vps37c"
                     /gene_synonym="RGD1309258"
                     /note="isoform 1 is encoded by transcript variant 2;
                     vacuolar protein sorting-associated protein 37C; vacuolar
                     protein sorting 37C; VPS37C, ESCRT-I subunit; vacuolar
                     protein sorting 37 homolog C"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 37C
                     isoform 1"
                     /protein_id="NP_001383922.1"
                     /db_xref="GeneID:108348178"
                     /db_xref="RGD:11384366"
                     /translation="MEGLKDKTLQELEEMQNDPEAIARLALESPEVQDLQLEREMALA
                     TNRSLAEQNLEFQGPLEISRSNLSDKYQELRKLVERCQEQKAKLEKFSSALQPGTLLD
                     LLQIEGMKIEEESEAMAEKFLEGEVPLETFLESFSSMRTLLHLRRVRVEKLQDVVRRP
                     RALPELAGDAPPKRPPPPRPAPQAAPPETEEQTPQPSVVTPYPLPYSPSPGLPVGPTA
                     QGALQPAPFPVVTQPSSYGGPLGPSYPSPQPGPRAMVGYSWSPQRSGPPRPGYPVAPT
                     STSGPGYPLVGGQTPGPGYPQQSPYFPSGSKPPYPTQPQLPGFPGQPPPPVPPQPPYP
                     SGVTPPYGFHPPGSAWPRY"
     exon            313..484
                     /gene="Vps37c"
                     /gene_synonym="RGD1309258"
                     /inference="alignment:Splign:2.1.0"
     exon            485..567
                     /gene="Vps37c"
                     /gene_synonym="RGD1309258"
                     /inference="alignment:Splign:2.1.0"
     exon            568..2665
                     /gene="Vps37c"
                     /gene_synonym="RGD1309258"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccttccgc gggtgttgct cctgaagcca cccgcgtatg agtgccggta tcgtggccat
       61 cccgaggccc acaaagcagg acgccgggag cgcggcggag gggcactgcg gctcgctccc
      121 ggctggacgc gggaggaagt cacatccggt aggggcgggc tcgtggattc cggaagtgca
      181 ggcagcggct gattgcccgt ggcggcggct ccggagaaga tggaggggct gaaagacaag
      241 accctgcagg agctggagga aatgcagaat gacccagaag ccattgcccg gctggccttg
      301 gaatcgcctg aggttcagga cctgcagtta gaacgggaga tggctctggc caccaaccgg
      361 agcctggcag agcagaacct ggagttccaa ggtcccctgg aaatcagccg ctctaacctc
      421 tcagacaaat accaggagct gcggaagctt gtggagcggt gccaggagca gaaagccaag
      481 ctggagaaat tttcctcagc actgcagcct gggaccttgt tggaccttct acagattgaa
      541 ggcatgaaga tcgaggagga gtctgaggcc atggctgaga agttcctgga aggtgaggtg
      601 cccttggaga cattcttaga gtccttttct tccatgagga cactgctgca cctgcgtcga
      661 gttcgtgtag agaagctcca ggacgtggtg aggcggcctc gagctctgcc agagctggct
      721 ggagatgccc ctccaaagcg cccaccaccc ccacgcccgg cgccccaggc agcaccccct
      781 gagactgaag aacagactcc gcagccctct gtagtgactc cctacccttt gccctacagc
      841 ccatccccag gcttgcctgt gggccccaca gcccagggag ccctgcagcc agcccccttc
      901 cctgtggtga cccagccttc ctcctatggg gggcccctgg gtccttctta cccatcacct
      961 cagccaggac ccagggccat ggtgggttac tcttggtctc cacagaggag tggcccgccc
     1021 cggcctggct atcctgtggc tccgactagc acctctggtc caggataccc cttagtgggg
     1081 ggccaaactc ctggtcctgg ttatcctcaa cagtcccctt acttcccatc aggaagcaaa
     1141 cctccctacc caacacagcc tcagctccct ggcttcccag gacagccccc gccgccagtg
     1201 ccccctcaac ctccataccc ttctggggta acacccccct atggctttca ccctccagga
     1261 tctgcctggc ctaggtatta gtctggtcca tgtccatctt cttccttcta caccacagcc
     1321 tttggcctcc atttgctgag atttgaggtt aacactggac ctggaggtga catgctctga
     1381 aatgtttgga cacacaggag ccttgagcct atagttggaa gcacataggc ctcctgaaag
     1441 gccctgaaca gtacagcatg aatccttctg ggagctcctt ctgccaggga ccagctcagc
     1501 acatcctgag tggcctggtg ggggggagcc cagggctctc tggtgtctgt gtgaacgggt
     1561 gtgttcatgt ctttgcacag ctacctgcgc ttgatccctg acagctgaac caatgtagaa
     1621 tgatcttgat ggcagggtgg ccctgggtct cagaccctgc tcatccgggc tgtcccttgg
     1681 aacttggcat gtttgatgtg gaatcacatg ccaagtgagg tcagagctct gactgtccat
     1741 ttaaggacag tctgtcttat ttaccacagt tgggtcctag gaaaaacggg gacttcgtgc
     1801 cctgagagcc ttattttagt tgctgtgcca atgtcaggca agtgtattct atgtgctgac
     1861 aaggaccaca gcagcagtgg tatcgtgaga gagttgggat gccgagggag acccaggcct
     1921 caaactgtat ggttagatgt cctggggtca ccctggagcc cttggctgga gtgggggacc
     1981 agggttacct cccagccatt ttccactcct gggcccctcc acttctggct ggctttttct
     2041 gaggttcacc cacccctcca ctcctttagt gccttgactc ttatttgcta gctgcccctt
     2101 taccttgtgt atttccttcc ttctcccagt gtccctgcag aacagacacc agacctaccc
     2161 tttcagaaca tccccatggt gcttcccaga catcatcact acactggggc tgctttctct
     2221 acactctgtt tccagactaa agggtaggac tgtgagcgca gccccagccc tggatggggc
     2281 cgaagcctgc ttagtaatga aagtgactac accatatact gaaggggttg cagcagatga
     2341 tgcatctgta tggctggtcc agatgtgaac caggtctcag ggtggaccct ggagctgcta
     2401 cgggttagga aactgtatgt gccttgaaac atcccctgcc tgggtaccca gcctctggtg
     2461 ggaccaaggt gctggggtca aggaggaacc ccatcttctg gtgccactcc gcccacagac
     2521 caggggtgca gtaccaactc ggcttgcttc tcctaagtta tttataacgt ggaatcacta
     2581 atggagtctg tggtagactg ctgctgaact ggataatgac tgcccgtctg tttgtgcaat
     2641 tgccataata aacgtcgatg agttc
//
