LOCUS       NM_001105718            3196 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus VPS35 retromer complex component (Vps35), mRNA.
ACCESSION   NM_001105718 XM_001068608 XM_214646
VERSION     NM_001105718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3196)
  AUTHORS   Shin,H.A., Park,M., Lee,H.J., Duong,V.A., Kim,H.M., Hwang,D.Y.,
            Lee,H. and Lew,H.
  TITLE     Unveiling Neuroprotection and Regeneration Mechanisms in Optic
            Nerve Injury: Insight from Neural Progenitor Cell Therapy with
            Focus on Vps35 and Syntaxin12
  JOURNAL   Cells 12 (19), 2412 (2023)
   PUBMED   37830626
  REMARK    GeneRIF: Unveiling Neuroprotection and Regeneration Mechanisms in
            Optic Nerve Injury: Insight from Neural Progenitor Cell Therapy
            with Focus on Vps35 and Syntaxin12.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3196)
  AUTHORS   Chen,X., Tsika,E., Levine,N. and Moore,D.J.
  TITLE     VPS35 and alpha-Synuclein fail to interact to modulate
            neurodegeneration in rodent models of Parkinson's disease
  JOURNAL   Mol Neurodegener 18 (1), 51 (2023)
   PUBMED   37542299
  REMARK    GeneRIF: VPS35 and alpha-Synuclein fail to interact to modulate
            neurodegeneration in rodent models of Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3196)
  AUTHORS   Vazquez-Sanchez,S., Bobeldijk,S., Dekker,M.P., van Keimpema,L. and
            van Weering,J.R.T.
  TITLE     VPS35 depletion does not impair presynaptic structure and function
  JOURNAL   Sci Rep 8 (1), 2996 (2018)
   PUBMED   29445238
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3196)
  AUTHORS   Tora,D., Gomez,A.M., Michaud,J.F., Yam,P.T., Charron,F. and
            Scheiffele,P.
  TITLE     Cellular Functions of the Autism Risk Factor PTCHD1 in Mice
  JOURNAL   J Neurosci 37 (49), 11993-12005 (2017)
   PUBMED   29118110
REFERENCE   5  (bases 1 to 3196)
  AUTHORS   McNally,K.E., Faulkner,R., Steinberg,F., Gallon,M., Ghai,R.,
            Pim,D., Langton,P., Pearson,N., Danson,C.M., Nagele,H.,
            Morris,L.L., Singla,A., Overlee,B.L., Heesom,K.J., Sessions,R.,
            Banks,L., Collins,B.M., Berger,I., Billadeau,D.D., Burstein,E. and
            Cullen,P.J.
  TITLE     Retriever is a multiprotein complex for retromer-independent
            endosomal cargo recycling
  JOURNAL   Nat Cell Biol 19 (10), 1214-1225 (2017)
   PUBMED   28892079
REFERENCE   6  (bases 1 to 3196)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   7  (bases 1 to 3196)
  AUTHORS   Verges,M., Luton,F., Gruber,C., Tiemann,F., Reinders,L.G.,
            Huang,L., Burlingame,A.L., Haft,C.R. and Mostov,K.E.
  TITLE     The mammalian retromer regulates transcytosis of the polymeric
            immunoglobulin receptor
  JOURNAL   Nat Cell Biol 6 (8), 763-769 (2004)
   PUBMED   15247922
REFERENCE   8  (bases 1 to 3196)
  AUTHORS   Arighi,C.N., Hartnell,L.M., Aguilar,R.C., Haft,C.R. and
            Bonifacino,J.S.
  TITLE     Role of the mammalian retromer in sorting of the cation-independent
            mannose 6-phosphate receptor
  JOURNAL   J Cell Biol 165 (1), 123-133 (2004)
   PUBMED   15078903
REFERENCE   9  (bases 1 to 3196)
  AUTHORS   Zhang,P., Yu,L., Gao,J., Fu,Q., Dai,F., Zhao,Y., Zheng,L. and
            Zhao,S.
  TITLE     Cloning and characterization of human VPS35 and mouse Vps35 and
            mapping of VPS35 to human chromosome 16q13-q21
  JOURNAL   Genomics 70 (2), 253-257 (2000)
   PUBMED   11112353
REFERENCE   10 (bases 1 to 3196)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1, CB583538.1, CB732662.1, CV120410.1, CK596387.1,
            EV778075.1, CV106736.1, DV725274.1 and BP475974.1.
            
            On Sep 20, 2008 this sequence version replaced NM_001105718.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.968305.1,
                                           SRR26643429.55382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                JAXUCZ010000019.1  37938989-37939012
            25-615              CB583538.1         1-591
            616-1028            CB732662.1         59-471
            1029-1693           CV120410.1         8-672
            1694-1984           CK596387.1         259-549
            1985-2282           EV778075.1         305-602
            2283-2717           CV106736.1         309-743
            2718-3054           DV725274.1         521-857
            3055-3196           BP475974.1         1-142               c
FEATURES             Location/Qualifiers
     source          1..3196
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..3196
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /note="VPS35 retromer complex component"
                     /db_xref="GeneID:25479"
                     /db_xref="RGD:1589784"
     exon            1..63
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2451
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /note="Maternal embryonic message 3; vacuolar protein
                     sorting 35 homolog"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 35"
                     /protein_id="NP_001099188.2"
                     /db_xref="GeneID:25479"
                     /db_xref="RGD:1589784"
                     /translation="MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALK
                     HASNMLGELRTSMLSPKSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAG
                     NIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNI
                     LPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRI
                     LVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHL
                     QTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPGIPAEIKLFDIFSQQVAT
                     VIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLEHIATSS
                     AVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTE
                     IVSQDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFADEQSLVGRFIHLLRSEDPDQQYL
                     ILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSQMDDKWEKKCQKIFSFAHQ
                     TISALIKAELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDELSDSKAQ
                     LAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRN
                     TDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTI
                     QVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRSRRESPESEGPIYEGLIL"
     exon            64..162
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            163..259
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            260..383
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            384..566
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..780
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            781..864
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            865..974
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1071
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1220
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1428
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1584
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1707
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1887
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2127
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2271
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..3192
                     /gene="Vps35"
                     /gene_synonym="Mem3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgacggcg ggcggctccg gcggagtagg cgctgctgct tgtgggtccc cggagtcgcc
       61 atgcctacaa cacagcaatc accccaggat gagcaagaaa aactcttgga tgaagccatc
      121 caggctgtga aagttcaatc attccagatg aaaagatgcc tggacaaaaa caagctgatg
      181 gacgctctga aacatgcctc gaatatgctt ggagaactcc ggacttctat gttatcacca
      241 aagagttact atgaacttta tatggctatt tctgatgagc tgcactactt ggaggtctat
      301 ttgactgatg aatttgctaa aggaagaaag gtggcagatc tctatgaact tgtacagtat
      361 gctggaaaca ttattccaag gctttatctc ttgatcacag ttggagttgt gtatgtcaag
      421 tcatttcctc agtccaggaa agatattctg aaagatttgg tagaaatgtg ccgtggcgtg
      481 cagcatccac taaggggttt gtttcttcga aattatcttc ttcagtgtac taggaacatt
      541 ttacctgatg aaggagagcc aacagatgaa gaaacaactg gtgatatcag tgattccatg
      601 gattttgtac tactcaactt tgcagaaatg aataagctct gggtgcggat gcagcatcaa
      661 ggacatagtc gagatagaga aaaaagagaa cgagagagac aagaactgag aattttagtg
      721 ggaactaatt tggtgcgcct tagtcagttg gaaggtgtaa atgtggaacg ttacaaacag
      781 attgttttaa caggcatttt ggagcaagtt gtgaattgta gagatgcttt ggctcaagag
      841 tatctcatgg agtgcatcat tcaggttttt cctgatgaat tccatctcca gactttgaat
      901 ccttttctta gagcttgtgc tgagttacac caaaatgtaa atgtgaaaaa cataatcatt
      961 gctttaattg acagattagc tttatttgct catcgtgaag atggacctgg aattccagct
     1021 gagattaaac tttttgacat attttcacaa caggtggcta cagtgataca gtccagacaa
     1081 gacatgccat cagaggacgt tgtatcttta caagtctctc tcattaatct tgctatgaaa
     1141 tgttaccctg atcgtgtgga ctatgttgat aaagttctag aaacaacagt ggagatattc
     1201 aataaactta accttgaaca tattgctacc agtagtgcag tttcaaagga gcttaccaga
     1261 cttttgaaga ttccagttga tacttacaac aatatcttaa cagtcttaaa gttaaagcat
     1321 ttccacccac tttttgagta ctttgactac gagtccagaa agagcatgag ctgttatgtg
     1381 cttagtaatg ttctggatta taacacagaa atcgtctctc aggaccaggt agattccata
     1441 atgaatttgg tgtccacgtt gattcaggat cagccagacc agcctgtaga agaccctgac
     1501 ccagaagact ttgctgatga acagagcctt gttggccgat ttattcacct tctgcgttct
     1561 gaagaccctg atcagcagta tttgattttg aatacagcac gaaaacattt tggggctggt
     1621 ggaaatcagc ggattcgctt cacactgcca cctttggtat ttgcagctta tcagttggct
     1681 tttcggtaca aagagaattc tcaaatggat gacaaatggg aaaagaaatg ccagaagatt
     1741 ttttcatttg cccatcagac tatcagtgct ttgattaaag ccgagctggc tgagttacca
     1801 ctgagacttt ttcttcaagg agcattagct gctggggaga ttggcttcga aaatcatgaa
     1861 acagtagcat atgaatttat gtcccaggcg ttttctctat atgaggatga actcagtgac
     1921 tccaaagcac agctggctgc tatcactttg atcattggta cttttgagag gatgaaatgc
     1981 ttcagtgaag agaatcatga gcccttgaga actcagtgtg cacttgctgc atcaaaactt
     2041 ctgaaaaaac cggaccaagg ccgagctgtg agcacatgtg cacatctctt ttggtctggc
     2101 cgaaacacag acaaaaatgg ggaagagctt catggaggta aaagggtcat ggagtgccta
     2161 aagaaggcac taaaaatagc aaatcagtgc atggacccct ctctacaagt tcagctcttt
     2221 atagagattc tgaacaggta catctatttc tatgaaaaag aaaatgatgc ggtaacaatt
     2281 caggtcttga accaacttat tcaaaaaatt cgagaagatc tcccaaacct tgagtccagt
     2341 gaagaaacag agcaaattaa caagcatttt cacaacacgt tggagcactt gcgctcaaga
     2401 cgggaatcac cagagtctga ggggccaatc tatgaaggtc tcatccttta aaagaagaca
     2461 gctcagcata ctcctttcta cacatcagaa agggcttaac taggtctccc ttccatagat
     2521 tgtgcctttc agaaatgctg aggtaggttt cccattcctt acctgtgatg tgtttaccca
     2581 gcacctccag acaccttcag gaccttaact cactgcataa ttgtttaagt ctgtctgatc
     2641 atcccaagta gcatgactga tctgcttttt aaacttctgt gatccgtgaa acctgaaagc
     2701 aaaactcact tattctggct actaatggag ctctcctttc ttatttttat tttgatgcat
     2761 tgttgattgt gtattttcta aattaatgga gaatactaac ccaaacatac ttgtttcttt
     2821 gttctctggt cctatctgag attactttag aggacaggag tactgtgtgt gaaattcagc
     2881 ttgggcttgc cctgaatgca agatagagcc tatgtgtaat atattcccta caactagaat
     2941 atattaatgc atgtcgaaga attttaaagc accacggtca gaagcagaag ctatattttg
     3001 catatttgga ctcagctatc cattaagaac tatgccatca tctggataca tcaaaataat
     3061 ttgattctat aaaatagaaa ttttgtgact taatataatt tatgtataac ctccactatt
     3121 gtaaatttat gtgaaatgca tcataactac aactttttca tcagtgaaat aataaagttg
     3181 ctgttaacaa ttaaaa
//
