LOCUS       NM_022286               2483 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus VPS33B, late endosome and lysosome associated
            (Vps33b), mRNA.
ACCESSION   NM_022286
VERSION     NM_022286.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Banushi,B., Forneris,F., Straatman-Iwanowska,A., Strange,A.,
            Lyne,A.M., Rogerson,C., Burden,J.J., Heywood,W.E., Hanley,J.,
            Doykov,I., Straatman,K.R., Smith,H., Bem,D., Kriston-Vizi,J.,
            Ariceta,G., Risteli,M., Wang,C., Ardill,R.E., Zaniew,M.,
            Latka-Grot,J., Waddington,S.N., Howe,S.J., Ferraro,F., Gjinovci,A.,
            Lawrence,S., Marsh,M., Girolami,M., Bozec,L., Mills,K. and
            Gissen,P.
  TITLE     Regulation of post-Golgi LH3 trafficking is essential for collagen
            homeostasis
  JOURNAL   Nat Commun 7, 12111 (2016)
   PUBMED   27435297
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Bem,D., Smith,H., Banushi,B., Burden,J.J., White,I.J., Hanley,J.,
            Jeremiah,N., Rieux-Laucat,F., Bettels,R., Ariceta,G., Mumford,A.D.,
            Thomas,S.G., Watson,S.P. and Gissen,P.
  TITLE     VPS33B regulates protein sorting into and maturation of
            alpha-granule progenitor organelles in mouse megakaryocytes
  JOURNAL   Blood 126 (2), 133-143 (2015)
   PUBMED   25947942
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Wartosch,L., Gunesdogan,U., Graham,S.C. and Luzio,J.P.
  TITLE     Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome
            Fusion with Endosomes and Autophagosomes
  JOURNAL   Traffic 16 (7), 727-742 (2015)
   PUBMED   25783203
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   Tornieri,K., Zlatic,S.A., Mullin,A.P., Werner,E., Harrison,R.,
            L'hernault,S.W. and Faundez,V.
  TITLE     Vps33b pathogenic mutations preferentially affect
            VIPAS39/SPE-39-positive endosomes
  JOURNAL   Hum Mol Genet 22 (25), 5215-5228 (2013)
   PUBMED   23918659
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   Zlatic,S.A., Tornieri,K., L'Hernault,S.W. and Faundez,V.
  TITLE     Clathrin-dependent mechanisms modulate the subcellular distribution
            of class C Vps/HOPS tether subunits in polarized and nonpolarized
            cells
  JOURNAL   Mol Biol Cell 22 (10), 1699-1715 (2011)
   PUBMED   21411634
REFERENCE   6  (bases 1 to 2483)
  AUTHORS   Takamori,S., Holt,M., Stenius,K., Lemke,E.A., Gronborg,M.,
            Riedel,D., Urlaub,H., Schenck,S., Brugger,B., Ringler,P.,
            Muller,S.A., Rammner,B., Grater,F., Hub,J.S., De Groot,B.L.,
            Mieskes,G., Moriyama,Y., Klingauf,J., Grubmuller,H., Heuser,J.,
            Wieland,F. and Jahn,R.
  TITLE     Molecular anatomy of a trafficking organelle
  JOURNAL   Cell 127 (4), 831-846 (2006)
   PUBMED   17110340
REFERENCE   7  (bases 1 to 2483)
  AUTHORS   Lo,B., Li,L., Gissen,P., Christensen,H., McKiernan,P.J., Ye,C.,
            Abdelhaleem,M., Hayes,J.A., Williams,M.D., Chitayat,D. and
            Kahr,W.H.
  TITLE     Requirement of VPS33B, a member of the Sec1/Munc18 protein family,
            in megakaryocyte and platelet alpha-granule biogenesis
  JOURNAL   Blood 106 (13), 4159-4166 (2005)
   PUBMED   16123220
REFERENCE   8  (bases 1 to 2483)
  AUTHORS   Gissen,P., Johnson,C.A., Gentle,D., Hurst,L.D., Doherty,A.J.,
            O'Kane,C.J., Kelly,D.A. and Maher,E.R.
  TITLE     Comparative evolutionary analysis of VPS33 homologues: genetic and
            functional insights
  JOURNAL   Hum Mol Genet 14 (10), 1261-1270 (2005)
   PUBMED   15790593
REFERENCE   9  (bases 1 to 2483)
  AUTHORS   Gissen,P., Johnson,C.A., Morgan,N.V., Stapelbroek,J.M., Forshew,T.,
            Cooper,W.N., McKiernan,P.J., Klomp,L.W., Morris,A.A., Wraith,J.E.,
            McClean,P., Lynch,S.A., Thompson,R.J., Lo,B., Quarrell,O.W., Di
            Rocco,M., Trembath,R.C., Mandel,H., Wali,S., Karet,F.E.,
            Knisely,A.S., Houwen,R.H., Kelly,D.A. and Maher,E.R.
  TITLE     Mutations in VPS33B, encoding a regulator of SNARE-dependent
            membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis
            (ARC) syndrome
  JOURNAL   Nat Genet 36 (4), 400-404 (2004)
   PUBMED   15052268
REFERENCE   10 (bases 1 to 2483)
  AUTHORS   Pevsner,J., Hsu,S.C., Hyde,P.S. and Scheller,R.H.
  TITLE     Mammalian homologues of yeast vacuolar protein sorting (vps) genes
            implicated in Golgi-to-lysosome trafficking
  JOURNAL   Gene 183 (1-2), 7-14 (1996)
   PUBMED   8996080
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081707.1.
            
            On Sep 16, 2004 this sequence version replaced NM_022286.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081707.1, U35245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..2483
                     /gene="Vps33b"
                     /note="VPS33B, late endosome and lysosome associated"
                     /db_xref="GeneID:64060"
                     /db_xref="RGD:620644"
     exon            1..407
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2165
                     /gene="Vps33b"
                     /note="r-vps33b; vacuolar protein sorting 33B; vacuolar
                     protein sorting homolog r-vps33b; vacuolar protein sorting
                     33 homolog B"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 33B"
                     /protein_id="NP_071622.1"
                     /db_xref="GeneID:64060"
                     /db_xref="RGD:620644"
                     /translation="MAFPHRLDAPELPDFSMLKRLARDQLIYLLEQLPGKKDLFIEAD
                     LMSPLDRIANVSILKQHEVDKLYKVENKLTLSSNEQLCFLVRPRIKTMRYIANLVNAD
                     KLAGRVRKYKIILSPQKFYACEMVLEEEGVYGDVSCDEWAFSLLPLDVDLLSMELPEF
                     FRDYFLEGDQRWINTVAQALHLLSTLYGPFPNCYGIGRCTKMSYDLWRKLEEEEDSET
                     KGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLVDDTFRIKCGSVDFGPEVTSSDKSLK
                     VLLNAEDKVFSEIRNEHFSNVFGFLSQKARNLQAQYDRRRGMDIKQMKNFVSQELKGL
                     KQEHRLLSLHIGACESIMKKKTKQDFQELIKTEHALLEGFNIRESTSYIEEHIDRQVS
                     PIESLRLMCLLSITENGLIPKDYRSLKTQYLQSYGPEHLLTFSNLRRAGLLTEQASGD
                     TLTAVENKVSKLVTDKAAGKITDAFSSLAKRSNFRAISKKLNLIPRVDGEYDLKVPRD
                     MAYVFSGAYVPLSCRIIEQVLDRRSWQGLDEVVRLLNCSDFAFTDMAKEDKASSESLR
                     LILVVFLGGCTFSEISALRFLGREKGYRFIFLTTAVTNSARLMEAMSEVKS"
     exon            408..488
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            489..550
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            551..600
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            601..668
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            669..714
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            715..809
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            810..914
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1011
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1089
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1163
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1250
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1341
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1416
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1481
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1536
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1583
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1716
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1790
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1892
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1968
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2085
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2460
                     /gene="Vps33b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggttctc ccggcacgct gccgagtgtg cggatgttat agggaatcct gctgacaggc
       61 tgagtggacc caggtaggac cagtgactgt aggtcgccaa ggagagtcac tcgacgctgt
      121 ggccgtctgt gcagtaggtg gtcattcatc cgtctagtgc ggcagacgag cgagggcccc
      181 tcgggggtcc tggaacccag agcccaggca agcgggatac cagcctgcgg tgtcacctag
      241 ggctgtcgcc ggccttttca gaacaggggc catcctgctg ctctcacacg gtggctcagg
      301 tgacctctcc catggctttc ccccatcgac tggacgcccc tgagcttccc gacttctcta
      361 tgctcaagag gctggctcgg gaccagctca tctatctgct agaacagctt cctgggaaaa
      421 aggatttgtt cattgaggca gatctcatga gccctttgga tcgaattgct aacgtctcta
      481 tcctgaagca acatgaagta gacaagctgt acaaggtgga aaacaaactt actctcagct
      541 ccaatgaaca attgtgcttc ttggtcagac ctcgaatcaa gactatgcgc tacattgcca
      601 atcttgtcaa tgctgacaaa ctggctggcc gagttagaaa atacaaaatc atcttaagtc
      661 ctcagaagtt ttatgcatgt gagatggtgc ttgaggaaga gggagtctat ggagatgtga
      721 gctgtgatga atgggccttt tctctgctgc ctcttgatgt ggatctgctg agcatggaac
      781 tgccagaatt tttcagggat tacttcctgg aaggggatca gcgttggatc aacacggtgg
      841 ctcaggcctt gcaccttctc agtactctct atgggccctt ccctaactgc tatggcattg
      901 gcagatgcac gaagatgtca tatgacctgt ggaggaaact ggaggaggaa gaggacagtg
      961 aaacgaaagg tcggagacca gagattggac acatctttct cttggacaga gatgtggact
     1021 ttgtgacagc actttgctcc caagtggttt atgagggctt ggtagatgac accttccgaa
     1081 tcaagtgtgg aagtgtcgac tttggcccag aagtcacatc ctctgacaag agcctgaagg
     1141 tgctgctcaa cgctgaggac aaggtgttca gtgagatccg caatgagcac ttctccaatg
     1201 tctttggctt cttgagccag aaagcccgga acttgcaggc tcaatatgac cgccggagag
     1261 gtatggacat aaagcagatg aagaacttcg tgtcccaaga gctcaaggga ctgaaacagg
     1321 agcaccgcct tctgagtctc catattggag cttgtgaatc aatcatgaag aagaaaacca
     1381 agcaggactt ccaggagcta atcaagaccg agcatgcact gctggagggc ttcaacattc
     1441 gagagagcac tagctacatt gaagaacaca tagaccggca ggtgtcgccc atagaaagcc
     1501 tacgcctcat gtgccttttg tccatcactg agaatggttt gattcccaag gattatcggt
     1561 ccctgaaaac acagtatctg cagagctacg gccccgagca cctgctaacc ttctccaacc
     1621 ttcggagagc cgggcttcta acagagcagg cttcggggga caccctcact gcagtagaga
     1681 ataaagtgag caagctggtg actgacaagg ccgcaggaaa aatcactgat gccttcagtt
     1741 ctctggccaa gaggagcaat tttcgtgcca tcagcaaaaa gctgaatttg atcccacgtg
     1801 tagatgggga gtatgacctg aaagtgcccc gggacatggc ttacgtcttc agtggcgcct
     1861 acgtgcctct gagctgccga atcattgagc aggtgctgga ccggcggagt tggcagggcc
     1921 tagatgaagt ggtccggctg ctaaactgca gtgactttgc attcacagac atggctaagg
     1981 aagacaaggc ttccagtgag tcactccgcc tcatcttggt ggtgttcttg gggggctgca
     2041 cgttctcaga gatatcagcc ctgcgcttcc tgggtagaga gaaagggtac agatttattt
     2101 ttctgacaac tgctgttaca aacagtgctc gcctcatgga agccatgagt gaggtgaaat
     2161 cctgatgctt tcctggccag tgcggaagta attcctgatt gtggacccca gtgagaagct
     2221 ggtgtttcac atctaccttc taagactccc ccaacacaca catcctacct cccagctata
     2281 ctcttcagaa ctgggaactt cagaactaat tttcgggaga gaattcatat cctgtccccc
     2341 aggatactcc tcttgcttat aaagtgtata tagttcatgc tgctaaggta tgaggggaga
     2401 ggtattcctt gctaaatccc gtttaaatat tgtaaataaa gcctctcttc tcaaatgcaa
     2461 aaaaaaaaaa aaaaaaaaaa aaa
//
