LOCUS       NM_001007740            1292 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus VPS26 retromer complex component A (Vps26a),
            mRNA.
ACCESSION   NM_001007740 XM_342140
VERSION     NM_001007740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   McNally,K.E., Faulkner,R., Steinberg,F., Gallon,M., Ghai,R.,
            Pim,D., Langton,P., Pearson,N., Danson,C.M., Nagele,H.,
            Morris,L.L., Singla,A., Overlee,B.L., Heesom,K.J., Sessions,R.,
            Banks,L., Collins,B.M., Berger,I., Billadeau,D.D., Burstein,E. and
            Cullen,P.J.
  TITLE     Retriever is a multiprotein complex for retromer-independent
            endosomal cargo recycling
  JOURNAL   Nat Cell Biol 19 (10), 1214-1225 (2017)
   PUBMED   28892079
REFERENCE   2  (bases 1 to 1292)
  AUTHORS   Peng,D., Wang,J., Zhang,R., Jiang,F., Tam,C.H.T., Jiang,G.,
            Wang,T., Chen,M., Yan,J., Wang,S., Yan,D., He,Z., Ma,R.C.W.,
            Bao,Y., Hu,C. and Jia,W.
  TITLE     CDKAL1 rs7756992 is associated with diabetic retinopathy in a
            Chinese population with type 2 diabetes
  JOURNAL   Sci Rep 7 (1), 8812 (2017)
   PUBMED   28821857
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1292)
  AUTHORS   Eze,I.C., Imboden,M., Kumar,A., von Eckardstein,A., Stolz,D.,
            Gerbase,M.W., Kunzli,N., Pons,M., Kronenberg,F., Schindler,C. and
            Probst-Hensch,N.
  TITLE     Air pollution and diabetes association: Modification by type 2
            diabetes genetic risk score
  JOURNAL   Environ Int 94, 263-271 (2016)
   PUBMED   27281273
REFERENCE   4  (bases 1 to 1292)
  AUTHORS   Follett,J., Bugarcic,A., Yang,Z., Ariotti,N., Norwood,S.J.,
            Collins,B.M., Parton,R.G. and Teasdale,R.D.
  TITLE     Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal
            Association of Retromer and Induces alpha-Synuclein Aggregation
  JOURNAL   J Biol Chem 291 (35), 18283-18298 (2016)
   PUBMED   27385586
REFERENCE   5  (bases 1 to 1292)
  AUTHORS   Lin,T.B., Lai,C.Y., Hsieh,M.C., Wang,H.H., Cheng,J.K., Chau,Y.P.,
            Chen,G.D. and Peng,H.Y.
  TITLE     VPS26A-SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn
            Neurons Mediates Neuropathic Pain in Rats
  JOURNAL   J Neurosci 35 (44), 14943-14955 (2015)
   PUBMED   26538661
  REMARK    GeneRIF: VPS26A-SNX27 interaction plays a role in the development
            of neuropathic pain.
REFERENCE   6  (bases 1 to 1292)
  AUTHORS   Gorbea,C., Pratt,G., Ustrell,V., Bell,R., Sahasrabudhe,S.,
            Hughes,R.E. and Rechsteiner,M.
  TITLE     A protein interaction network for Ecm29 links the 26 S proteasome
            to molecular motors and endosomal components
  JOURNAL   J Biol Chem 285 (41), 31616-31633 (2010)
   PUBMED   20682791
REFERENCE   7  (bases 1 to 1292)
  AUTHORS   Collins,B.M., Skinner,C.F., Watson,P.J., Seaman,M.N. and Owen,D.J.
  TITLE     Vps29 has a phosphoesterase fold that acts as a protein interaction
            scaffold for retromer assembly
  JOURNAL   Nat Struct Mol Biol 12 (7), 594-602 (2005)
   PUBMED   15965486
REFERENCE   8  (bases 1 to 1292)
  AUTHORS   Arighi,C.N., Hartnell,L.M., Aguilar,R.C., Haft,C.R. and
            Bonifacino,J.S.
  TITLE     Role of the mammalian retromer in sorting of the cation-independent
            mannose 6-phosphate receptor
  JOURNAL   J Cell Biol 165 (1), 123-133 (2004)
   PUBMED   15078903
REFERENCE   9  (bases 1 to 1292)
  AUTHORS   Seaman,M.N.
  TITLE     Cargo-selective endosomal sorting for retrieval to the Golgi
            requires retromer
  JOURNAL   J Cell Biol 165 (1), 111-122 (2004)
   PUBMED   15078902
REFERENCE   10 (bases 1 to 1292)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079150.1.
            
            On Nov 29, 2004 this sequence version replaced XM_342140.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079150.1, FQ211877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1292
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /note="VPS26 retromer complex component A"
                     /db_xref="GeneID:361846"
                     /db_xref="RGD:1359254"
     exon            1..84
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1065
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /note="vesicle protein sorting 26A; vacuole protein
                     sorting 26; H beta 58; vacuolar protein sorting 26 homolog
                     A; VPS26 retromer complex comonent A"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 26A"
                     /protein_id="NP_001007741.1"
                     /db_xref="GeneID:361846"
                     /db_xref="RGD:1359254"
                     /translation="MSFLGGFFGPICEIDVALSDGETRKMAEMKTEDGKVEKHYLFYD
                     GESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELT
                     QSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPEV
                     NNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITG
                     IGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNL
                     VLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM"
     exon            85..234
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            235..310
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            311..467
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            468..632
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            633..739
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            740..808
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            809..951
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1262
                     /gene="Vps26a"
                     /gene_synonym="Vps26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcgggg cgcaggcacc caggctgtga gttctcctaa gggaaagccg agtggagtgg
       61 ggggacccgg cggcggtgac aatgagtttt cttggaggct tttttggtcc catctgtgag
      121 atcgatgttg cccttagtga tggggagacc aggaaaatgg cagaaatgaa aacggaagat
      181 ggcaaagtag aaaaacacta tctcttctat gatggggaat ctgtctcagg aaaggtaaac
      241 ctagccttta agcagcctgg aaagaggcta gagcatcaag gaattagaat tgaatttgta
      301 ggtcaaattg agcttttcaa tgacaagagt aatactcatg aatttgtaaa cctagtgaag
      361 gaactagcct tgcctggaga gctgactcag agcagaagct atgactttga attcatgcaa
      421 gttgaaaagc catatgagtc atacatcggt gccaatgtcc gcctgaggta tttccttaag
      481 gtgaccattg tgagaagact gacagactta gtgaaagagt acgatcttat tgttcaccag
      541 ctcgccacct acccagaggt caacaactcc attaaaatgg aggtgggaat tgaagactgt
      601 ctgcacatag agtttgagta caataagtcc aagtatcatt taaaggatgt aattgttgga
      661 aaaatttact tcttattagt aagaataaaa atacaacaca tggagttaca gctgatcaag
      721 aaagagatca caggaattgg acccagcacc acaacagaga cagaaacaat cgctaagtat
      781 gaaataatgg atggggcgcc agtaaaagga gaatctattc cgataagatt gttcttagca
      841 gggtatgacc caacccccac aatgagagat gtgaacaaga agttttcagt aaggtacttt
      901 ttgaacctcg tgcttgttga tgaggaggac agaaggtact tcaagcagca ggagattatc
      961 ctgtggagaa aagcacctga gaaactgaga aaacagagga cgaactttca ccagcgattt
     1021 gaatctccag aatcgcaggc gtctgcagaa cagcctgaga tgtaagcaag cgggacagag
     1081 caacaagtgc aagaaccagg ccgagagggg agcccagctg gttaaagatg gccgcagcat
     1141 ggggacgtcc caactccagc tccatgtctg ctagtcttcc ttatcccaga gtgctgcgtt
     1201 tattttacag tgtgattaaa gggtctttgt gtatatacat cttaaaaagt gcttcttgga
     1261 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
