LOCUS       NP_001382518            4390 aa            linear   ROD 22-SEP-2024
DEFINITION  intermembrane lipid transfer protein VPS13D [Rattus norvegicus].
ACCESSION   NP_001382518 XP_006239411 XP_038966063
VERSION     NP_001382518.1
DBSOURCE    REFSEQ: accession NM_001395589.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 4390)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 4390)
  AUTHORS   Seong,E., Insolera,R., Dulovic,M., Kamsteeg,E.J., Trinh,J.,
            Bruggemann,N., Sandford,E., Li,S., Ozel,A.B., Li,J.Z., Jewett,T.,
            Kievit,A.J.A., Munchau,A., Shakkottai,V., Klein,C., Collins,C.A.,
            Lohmann,K., van de Warrenburg,B.P. and Burmeister,M.
  TITLE     Mutations in VPS13D lead to a new recessive ataxia with spasticity
            and mitochondrial defects
  JOURNAL   Ann Neurol 83 (6), 1075-1088 (2018)
   PUBMED   29604224
REFERENCE   3  (residues 1 to 4390)
  AUTHORS   Anding,A.L., Wang,C., Chang,T.K., Sliter,D.A., Powers,C.M.,
            Hofmann,K., Youle,R.J. and Baehrecke,E.H.
  TITLE     Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the
            Regulation of Mitochondrial Size and Clearance
  JOURNAL   Curr Biol 28 (2), 287-295 (2018)
   PUBMED   29307555
REFERENCE   4  (residues 1 to 4390)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Jul 20, 2021 this sequence version replaced
            XP_038966063.1, XP_006239411.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4390
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..4390
                     /product="intermembrane lipid transfer protein VPS13D"
                     /note="vacuolar protein sorting-associated protein 13D;
                     vacuolar protein sorting 13D"
                     /calculated_mol_wt=490580
     Region          1..>1271
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          138..349
                     /region_name="VPS13"
                     /note="Vacuolar sorting-associated protein 13, N-terminal;
                     pfam16908"
                     /db_xref="CDD:465309"
     Region          <2467..>3103
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          2643..2678
                     /region_name="UBA_VP13D"
                     /note="UBA domain found in vacuolar protein
                     sorting-associated protein 13D (VP13D) and similar
                     proteins; cd14306"
                     /db_xref="CDD:270491"
     Region          3277..3560
                     /region_name="SHR-BD"
                     /note="SHR-binding domain of vacuolar-sorting associated
                     protein 13; pfam06650"
                     /db_xref="CDD:461974"
     Region          3615..3775
                     /region_name="beta-trefoil_Ricin_VPS13D"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in vacuolar protein sorting-associated protein 13D
                     (VPS13D) and similar proteins; cd23453"
                     /db_xref="CDD:467331"
     Site            order(3627..3630,3636,3638,3641,3646..3647)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467331"
     Site            order(3684..3687,3700,3702,3705,3711..3712)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467331"
     Site            order(3731..3734,3746,3748,3751,3767..3768)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467331"
     Region          <3838..4300
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     CDS             1..4390
                     /gene="Vps13d"
                     /coded_by="NM_001395589.2:209..13381"
                     /db_xref="GeneID:313825"
                     /db_xref="RGD:1308403"
ORIGIN      
        1 mleglvawvl ntylgkyvnn lntdqlsval lkgavelenl plkkdalkel elpfevkagl
       61 igkvtlqipf yrphvdpwvi sisglhviga pekiqdfnde kekllererk kvllqaleer
      121 wkserrqqkg esywysvtas vvtrivenie lkiqdvhlrf edgltnpshp fafgiciknv
      181 smqnaanepv qklmrkkrld vaefsiywdv nctllgdlpq aelqeamars mesrshhyil
      241 epvcasallk rncskeplrs rhspriecdi qletiplkls qlqyrqimaf lkelerkerq
      301 vkfrkwkpkv avskncreww yfalnanlye ireqrkcctw dfllhrarda vfytdryfnk
      361 lkggvlsadd keemcrieee qsfeelkilr elvhdrfykq eelaeslrep qfdspgaspg
      421 dpdgsggsgm lqylqswfpg wggwygqqsp egkvaeglta eshehwmped ilgteeffdp
      481 tadascmnty tkrdhvfakl nvqlqrgtvt llhqergaah anesafmqle fsdvkllaes
      541 lprrnsslll vrlgglflrd lategtmfpl lvfpnpqkev grvsqsfglq tasedrsdqy
      601 saadpdnpvf emlyernpvh shferrlhvs trplniiynp qaikkvadff ykgkvhtsgf
      661 gyqselelrv aeaarrqynk lkmqtkaeir qtldrllvgd fieeskrwtv rldisapqvi
      721 fpddftfknp vlvvvdlgrm lltntqedsr rksgddsase enqfsddeyk tplatppstp
      781 ppetnssnge ktppfsgvef seeqlqahlm stqmyerysl tfmdlqvmvg rvrdnwkrvq
      841 didvgpthvv ekfnvhlqle rrliytsdpk ypgavlsgnl pdlkihined kisalkncfa
      901 llttpetkps dtqfrekifp qegprgslqd svmnltqsiv mleqhtrevl vesqlllaef
      961 kvncmqlgve ssgryisvlk vfgtnahfvk rpydaevslt vhglllvdtm qtygadfdll
     1021 mashknlsfd iptgslrdsr aqspvsgpnv afqtdvatln dqsattsvsl ekiltkeqes
     1081 likleyqfvs secpsmnlds tlqvislqvn nldiilnpet iveligflqk sfpkekddvs
     1141 pqplmtdler simeqgtvqs tyeqntevav eihrlnllll rtvgmsdger hgrkiatasi
     1201 ggtkvnvsmg ssfdmngslg clqlmdltqe nvknqyvvsi gnsigyeniv sdigyfesvf
     1261 vrmedaslte alsftfaeks kqecflnlkm aslhynhsak flkeltlsmd eleenfrsml
     1321 ksaatkvttv latktaeyse mvslfetpkk trdpfvleen eiygfglpsp rsdtvkliln
     1381 iniespvvsi prrpgspell vghlgqifiq nfvagddesr sdrlqveikd iklyslnctq
     1441 lagrdgagpe vsrafcppsg sasvssqeea hftrhdffes lhrgqafhil nnttiqfkle
     1501 kipieretel tfslspdelg tssimkiegk fvnpvqvvla khvyeqvlqt mdnlvysedl
     1561 nkfaasapps pcpnsplppl sscgeptaek kenglfshss fssasqksls vkeskaftqi
     1621 qanfciselq vqlsgdltlg aqglvslkfq dfevefskdh pqtlsiqial rsllmedlle
     1681 knpdskyksl mvsrgapkps slaqkeylsq scpsvscvey pamprslpsh meeapnvfql
     1741 yqrpistcrk kqkevqdksy pqtpppspsv depkvlvgks kfddslvhin iflvdkkhpe
     1801 fsssygrinr sidvdfncld vlitlqtwvv ildffgigst adnhamkvpp egplqnvkae
     1861 atasmqselq epvnskldlk vhslslvlsk atselakanv sklvahmemi egdlalqgsi
     1921 gslslsdltp hgdlyrerft tsgeealifq tfkygqpdpl lqrehdirvs lqmasvqyvh
     1981 tqrfqaevva fiqhftqlqd vlgrqraave gqtvrdqaqr csrilldiea gapvllipes
     2041 srsnnlivan lgklkvknkf lfagfpgtfs lqdkesvpsa sptdtmkhsm kkmpstedpk
     2101 gpqvqglfmm ppagmglgsl ksdfvpsasi kqrgqqavpp isqssssped hvclldcivv
     2161 dlqdmdifaa erhpregska sesssgdlif psyfvrqtgg slltepcrlk lqvernldke
     2221 ishtvadisv hgslssvhcs ldlckyklir gllennlgep iedfmrpydl qdprihtvls
     2281 gevytcmcfl idmvnvslel kdpkgkegtg slarfdfkkc kllyesfsnq tksinlvshs
     2341 mmafdtrysg qkpshgmtnv fncifqpsks ssatqgsiqi elhfrstkds scftvvlnnl
     2401 rvflifdwll lvhdflhtps dvkkqnvtpa ryrnassesa vvpktvksgv vtkrsslpvs
     2461 nerhlevkvn vtgtefvvve dvscfdtnai ilkgttvlty kprfvdrpfs gslfgievfs
     2521 crlgneqdta lsivdpvqiq velvgnssyq nssglmdafn sedfppilei qlqaldirls
     2581 yndvqlflai aksipeqasa aapdsaalea dsvssnlpga srigedvreg srhtldpvle
     2641 lqlarlqelg fsmddcrkal lvcqgqlkka aswlfknaep lkslslvsss rdnqgamsap
     2701 risgvevkae svcicfiddc mdcdvplael tfsrlnflqh irtnpegyah ftlsgdyynr
     2761 alsgwepfie pwpcsvswqq qaasrlhppr lkleakakrr ldinitsvli dqyvstkesw
     2821 ladyckedke tesaktedwm gssvdppcfg qslplvylrt rstasltnle hqiyaraevk
     2881 tpkrrqpfvp falrnhtgct lwfatltttp traalshsgs pgvvpegnga flddthnvse
     2941 wrevltgeei pfefeargkl rhrhthdlri hqlqvrvngw eqvspvsvdk vgtffryaap
     3001 dknsssstig spssrtniih pqvyfsslpp vrvvfavtme gsarkvitvr salivknrle
     3061 tpmelrldsp sapdkpvvlp aimpgdsfav plhltswrlq arpkglgvff ckapihwtnv
     3121 vktaevsssk rechsmdtek srffrfcvai kkenypdymp snifsdsakq ifrqpghtiy
     3181 llptvvicnl lpceldfyvk gmpingtlkp gkeaalptad tsqnielgvs lenfplckel
     3241 lippgtqnym vrmrlydisr rqlnltiria craegslkif isapywlink tglplifrqd
     3301 naktdaagqf eehelarsls pllfcyadke qpnlctmrig rgihpegmpg wcqgfsldgg
     3361 sgvralkviq qgnrpgliyn igidvkkgrg ryidtcmvif aprylldnks shklafaqre
     3421 fargqgtanp sgyistlpgs svvfhwprnd ydqllcvrlm dvpnciwsgg fevnknnsfh
     3481 inmrdtlgkc fflrveitlr gatyrisfsd tdqlpppfri dnfskvpivf tqhgvaeprl
     3541 rtevkpmmsl hyawdeptlp pfitltvkga gsseincnmn dfqnnrqlyy enfiyiaaty
     3601 tfsglqegkg rpvashkait caelvldvsp ktqrvilkkk epgkrsqlwr mtgtgmlahe
     3661 gsavphnpnk psatrsiegs aildiaglaa vtdnryeplm lrkpdrrrst tqtwcfhegk
     3721 ltcglhglvv qakgglsglf dgaevvlgpd ssvellgsvp peqqfanqkm rpgsgmlsvr
     3781 vipdgptral qitdfcqrks erssyeveel pvteqelqkl rnpdthqele vlvrleggig
     3841 vslinkvpee lvfasltgin ihytqlatsh mlelsiqdvq vdnqligttq pfmlyvtpls
     3901 nenevietgp avqvnavkfp sksaltniyk hlmvtaqkft vqieeklllk llsffgydqa
     3961 esevekyden ihektaeqgg tptryyfenl kisipqikls vftsnklpld lkalkstlgf
     4021 plirfedavi nldpftrvhp yetkefiind ilkhfqeell sqaarilgsv dflgnpmgll
     4081 ndvsegvtgl ikygnvggli rnvthgvsns aakfagtlsd glgktmdnrh qsereyiryh
     4141 aatsgehlva gihglahgii ggltsvitst vegvkteggv sgfisglgkg lvgtvtkpva
     4201 galdfaseta qavrdtatls gprtqaqrvr kprcctgpqg llprysesqa egqeqlfklt
     4261 dniqdeffia venidsycvl isskavyflk sgdyidreai flevkyddly hclvskdhgk
     4321 vyvqvtkkaa nsssgvsipg pshqkpmvhv ksevlavkls qeinyaksly yeqqlmlrls
     4381 edqeqlelds
//
