LOCUS       NP_001094445            3167 aa            linear   ROD 20-SEP-2024
DEFINITION  intermembrane lipid transfer protein VPS13A [Rattus norvegicus].
ACCESSION   NP_001094445 XP_001077797 XP_219672
VERSION     NP_001094445.2
DBSOURCE    REFSEQ: accession NM_001100975.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 3167)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 3167)
  AUTHORS   Munoz-Braceras,S., Tornero-Ecija,A.R., Vincent,O. and Escalante,R.
  TITLE     VPS13A is closely associated with mitochondria and is required for
            efficient lysosomal degradation
  JOURNAL   Dis Model Mech 12 (2) (2019)
   PUBMED   30709847
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 3167)
  AUTHORS   Yeshaw,W.M., van der Zwaag,M., Pinto,F., Lahaye,L.L., Faber,A.I.,
            Gomez-Sanchez,R., Dolga,A.M., Poland,C., Monaco,A.P., van
            IJzendoorn,S.C., Grzeschik,N.A., Velayos-Baeza,A. and Sibon,O.C.
  TITLE     Human VPS13A is associated with multiple organelles and influences
            mitochondrial morphology and lipid droplet motility
  JOURNAL   Elife 8, e43561 (2019)
   PUBMED   30741634
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 3167)
  AUTHORS   Nagata,O., Nakamura,M., Sakimoto,H., Urata,Y., Sasaki,N.,
            Shiokawa,N. and Sano,A.
  TITLE     Mouse model of chorea-acanthocytosis exhibits male infertility
            caused by impaired sperm motility as a result of ultrastructural
            morphological abnormalities in the mitochondrial sheath in the
            sperm midpiece
  JOURNAL   Biochem Biophys Res Commun 503 (2), 915-920 (2018)
   PUBMED   29928881
REFERENCE   5  (residues 1 to 3167)
  AUTHORS   Munoz-Braceras,S., Calvo,R. and Escalante,R.
  TITLE     TipC and the chorea-acanthocytosis protein VPS13A regulate
            autophagy in Dictyostelium and human HeLa cells
  JOURNAL   Autophagy 11 (6), 918-927 (2015)
   PUBMED   25996471
REFERENCE   6  (residues 1 to 3167)
  AUTHORS   Hayashi,T., Kishida,M., Nishizawa,Y., Iijima,M., Koriyama,C.,
            Nakamura,M., Sano,A. and Kishida,S.
  TITLE     Subcellular localization and putative role of VPS13A/chorein in
            dopaminergic neuronal cells
  JOURNAL   Biochem Biophys Res Commun 419 (3), 511-516 (2012)
   PUBMED   22366033
REFERENCE   7  (residues 1 to 3167)
  AUTHORS   Tomemori,Y., Ichiba,M., Kusumoto,A., Mizuno,E., Sato,D., Muroya,S.,
            Nakamura,M., Kawaguchi,H., Yoshida,H., Ueno,S., Nakao,K.,
            Nakamura,K., Aiba,A., Katsuki,M. and Sano,A.
  TITLE     A gene-targeted mouse model for chorea-acanthocytosis
  JOURNAL   J Neurochem 92 (4), 759-766 (2005)
   PUBMED   15686477
REFERENCE   8  (residues 1 to 3167)
  AUTHORS   Rampoldi,L., Dobson-Stone,C., Rubio,J.P., Danek,A., Chalmers,R.M.,
            Wood,N.W., Verellen,C., Ferrer,X., Malandrini,A., Fabrizi,G.M.,
            Brown,R., Vance,J., Pericak-Vance,M., Rudolf,G., Carre,S.,
            Alonso,E., Manfredi,M., Nemeth,A.H. and Monaco,A.P.
  TITLE     A conserved sorting-associated protein is mutant in
            chorea-acanthocytosis
  JOURNAL   Nat Genet 28 (2), 119-120 (2001)
   PUBMED   11381253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 1, 2009 this sequence version replaced NP_001094445.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.4842.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..3167
                     /product="intermembrane lipid transfer protein VPS13A"
                     /note="chorein; vacuolar protein sorting-associated
                     protein 13A; vacuolar protein sorting 13A"
                     /calculated_mol_wt=359928
     Region          4..>2005
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          2202..>2349
                     /region_name="SHR-BD"
                     /note="SHR-binding domain of vacuolar-sorting associated
                     protein 13; pfam06650"
                     /db_xref="CDD:461974"
     Region          <2627..3091
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          2759..2936
                     /region_name="VPS13_C"
                     /note="Vacuolar-sorting-associated 13 protein C-terminal;
                     pfam16909"
                     /db_xref="CDD:465310"
     CDS             1..3167
                     /gene="Vps13a"
                     /gene_synonym="RGD1311340"
                     /coded_by="NM_001100975.2:152..9655"
                     /db_xref="GeneID:309243"
                     /db_xref="RGD:1311340"
ORIGIN      
        1 mvfesvvvdv lnrflgdyvv nldqsqlslg iwkgavvlkn lvikenalhe ldvpfkvkvg
       61 rigslqlkip wknlytqpve avleeiylli vpssriqydp ikeekqlmea kqqelkriee
      121 akqkvvdqen preekqdtfa eklvtqiikn lqvqissihv ryedditnre kplsfgislq
      181 nlslqttdqy wipclhddte klvrklirld nlfaywnvns emfylndydd alealkngiv
      241 neniipegyd fvfrpisana klqmnrrsdf dfsdpkinld ielhtivief nkpqyfslme
      301 llesidmmtq nlpyrkfkps vplhlhaeew wayaihgile vnvcpslrmw swehiknhry
      361 kmkqyrefyk kkltnkkpsp eilmsleele ktldvfniti arqqaevevk kagykiykeg
      421 lkdpednagw fswmwswses nanqqqdvkp gilaemltpe ekallyeaig ysetavdptl
      481 pktfealkff vhlksmsivl renrqkpell nvvveglsts ivqrpgaqal kfetkidsfh
      541 itglpddfkk phllsslddm slfritfein pldetvsqrc tieaeplemi ydartvnsiv
      601 effrppkdvr laqlttatlt kleefrekta tgllyiietq kvldlrinvk asyvivpqyg
      661 nfsptsnlll ldlghlkvts krrsglpdvk psgasledim hraydsfdiq lssiqllysr
      721 vgdnwkeark lnvstqhili pmhvnielsk amvfmdikmp kfkifgklpl vslrisdkkl
      781 qgimellesi pkpepvtdvs aparsfqiqa stmpvshisq kliplleqsa teddseeeff
      841 dapcspleey pqvscrvest rrkklqkkdg smnfiqlsmr fevaevliqf yhlvgdcelp
      901 vlemgvlglg teveirkfdl kgnaflkelw lkcpgyldeh kkpvylittl dntmedlltl
      961 efmrveknap nlnstynnvl qlikvnfssl dihlhteall ntmnylnnil pelgetsasv
     1021 saaepedkgd iikklalklp tnediitlql laelsclrif iqdqkqnise ikiegldsem
     1081 imkplvtein aklrniivld sdkmavykka vyitgkevfs fkmisymdat agyaytdmsv
     1141 vdarvyltvg cievvfvtkf lysilafinn fqavknalae atvqaagmaa dgvkelarks
     1201 srfaldvnik apvvlipqsp vsrnvfvadf glitiknifv tvtetqsnip pvidlitikl
     1261 skmrlyrsqf mnntyqevld lllplnlevi vernlswewy kevpcfnika qlkpmefils
     1321 qedlttvfqt lygniwygrd vpapssvnkg peimttevts tsyhsgatmv tsavvevhpq
     1381 aspanttlnv sfqtdhlimt lyspgpdqas ftdvrdpsle laefklenii sdlkvytdds
     1441 mvfsfslknc ilddkrphvm katprmiglt vgfdkkdmvd vkyrqirdvf vtdvvvqemy
     1501 vcasveflmt varvffdaym tstaletsvq twttreapvq elrkwemnil iknpeivfva
     1561 dmtrndapal vittqceicc kgepesntvt aaikdfqvra cpflpvkrkg rvttvlqpcd
     1621 lfyqatqfgt dpqtidisvk sltlkvspvi intiitvtsa lyttketvpe estsnvahlw
     1681 dkkdtknlkm wfleesnete kvvptdevmp ggetlnlnid sifivleagi ghrtvpmlla
     1741 kssflgeskn wrtlinlhcq lelevhyfne mfgvweplle pleidqsddf rpwnlgikmk
     1801 kkakeaives dseeenykvp eyktaisffs rdqlnitlsk cglvmlsnlv eafteaatgs
     1861 savflrdlap fmilnslglt vsvspsdsfh vlnvplaksy elkneeslsm dyvrtkdndh
     1921 fnamtslssk lffilltpan hsvadkiplt kvgrrlytvr hresgversi icqidtvegs
     1981 kkvtirspvq iknhfsipis vfegdtllgi aspenefnip lasyrsslsl kpededyqlc
     2041 egidfeeiik hdgqllkkkc rsispskksf vinivpekdn laslsaysed gwdlpyvmhl
     2101 wppilirnll pykiayyleg ientvctlse ghssqiynve mdqaklhlkl ldylnhdwks
     2161 efqidpnqqd infinftclt emeksdldia ihmtyntgqt vvafhspywm vnktnrmlqy
     2221 kadgihrkhp pnykkpvlfs fqpnhffnnn kvqlmvtdse lsdqfsidtv gshgaikckg
     2281 lkmeyqvgvt idlssfnitr ivtfipfymi knksryhisv teegsdkwls ldleqcipfw
     2341 penasdilli qversegppk riyfnkqdsc illrldnelg gviaevnlae hstvitfsdy
     2401 hegaatflli nhtksdpvqy nqsslseied slppgkavyy twadpvgsrk lkwscgqsyg
     2461 evthkddmmt pisvgkktiy lvsffeglqr iilftedprv fkvtyeseka elaelevvla
     2521 lqdvgislvn nytkqevayi gitssdvvwe tkpkkksrwk pmsvkhtekl ekefreytes
     2581 spledkvvel dnsipvlltp sgndmkilep hviavrrnyl palkveynts ahqssfriqi
     2641 yriqiqnqih gaifpfvfyp ikpprsvtmd sapkpftdvs ivmrsaghsq isrikyfkvl
     2701 iqemdlrldl gfvyaladlv pktevtekte veyfhrdvea feqefevvss vdqsqvnlfe
     2761 yfhispiklh lsvslssgrd eakdteqhgg lipvhslnll lksigatltd vqdvvfklaf
     2821 fqlnyqfhtt selqsevirh yskqaikqmy vlilgldvlg npfglirefs egveaffyep
     2881 yqgaiqgpee fvegmalglk alvggavggl agaaskitsa makgvaamtm dedyqqkrre
     2941 amnkqpaglr egitrggkgl vsgfvsgitg ivtkpikgaq kegaagffkg vgkglvgava
     3001 rptggiidma sstfqgikra tetseveslr pprffnedgv irpyrlrdgt gnqmlqvmen
     3061 grfakykyft hvmvnktdmf mitrcgvlfv tkgtfgqltc ewqytfdeft kepfivhgrr
     3121 lrieakervk svfhakefgk iinfktpeda rwiltkleea repsprl
//
