LOCUS       NM_001108138            3184 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus VPS11 core subunit of CORVET and HOPS complexes
            (Vps11), mRNA.
ACCESSION   NM_001108138 XM_001061508 XM_006242937 XM_236189
VERSION     NM_001108138.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3184)
  AUTHORS   Wartosch,L., Gunesdogan,U., Graham,S.C. and Luzio,J.P.
  TITLE     Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome
            Fusion with Endosomes and Autophagosomes
  JOURNAL   Traffic 16 (7), 727-742 (2015)
   PUBMED   25783203
REFERENCE   2  (bases 1 to 3184)
  AUTHORS   Perini,E.D., Schaefer,R., Stoter,M., Kalaidzidis,Y. and Zerial,M.
  TITLE     Mammalian CORVET is required for fusion and conversion of distinct
            early endosome subpopulations
  JOURNAL   Traffic 15 (12), 1366-1389 (2014)
   PUBMED   25266290
REFERENCE   3  (bases 1 to 3184)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   4  (bases 1 to 3184)
  AUTHORS   Graham,S.C., Wartosch,L., Gray,S.R., Scourfield,E.J., Deane,J.E.,
            Luzio,J.P. and Owen,D.J.
  TITLE     Structural basis of Vps33A recruitment to the human HOPS complex by
            Vps16
  JOURNAL   Proc Natl Acad Sci U S A 110 (33), 13345-13350 (2013)
   PUBMED   23901104
REFERENCE   5  (bases 1 to 3184)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   6  (bases 1 to 3184)
  AUTHORS   Zhu,G.D., Salazar,G., Zlatic,S.A., Fiza,B., Doucette,M.M.,
            Heilman,C.J., Levey,A.I., Faundez,V. and L'hernault,S.W.
  TITLE     SPE-39 family proteins interact with the HOPS complex and function
            in lysosomal delivery
  JOURNAL   Mol Biol Cell 20 (4), 1223-1240 (2009)
   PUBMED   19109425
REFERENCE   7  (bases 1 to 3184)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   8  (bases 1 to 3184)
  AUTHORS   Kim,B.Y., Sahara,Y., Yamamoto,A., Kominami,E., Kohsaka,S. and
            Akazawa,C.
  TITLE     The interaction of mammalian Class C Vps with nSec-1/Munc18-a and
            syntaxin 1A regulates pre-synaptic release
  JOURNAL   Biochem Biophys Res Commun 350 (3), 691-697 (2006)
   PUBMED   17027648
REFERENCE   9  (bases 1 to 3184)
  AUTHORS   Richardson,S.C., Winistorfer,S.C., Poupon,V., Luzio,J.P. and
            Piper,R.C.
  TITLE     Mammalian late vacuole protein sorting orthologues participate in
            early endosomal fusion and interact with the cytoskeleton
  JOURNAL   Mol Biol Cell 15 (3), 1197-1210 (2004)
   PUBMED   14668490
REFERENCE   10 (bases 1 to 3184)
  AUTHORS   Kim,B.Y., Kramer,H., Yamamoto,A., Kominami,E., Kohsaka,S. and
            Akazawa,C.
  TITLE     Molecular characterization of mammalian homologues of class C Vps
            proteins that interact with syntaxin-7
  JOURNAL   J Biol Chem 276 (31), 29393-29402 (2001)
   PUBMED   11382755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Jul 23, 2021 this sequence version replaced
            XM_006242937.4, NM_001108138.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168871.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760389,
                                           SAMN12840105 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000008.1  53595156-53595377   c
            223-371             JAXUCZ010000008.1  53593168-53593316   c
            372-507             JAXUCZ010000008.1  53592943-53593078   c
            508-671             JAXUCZ010000008.1  53592302-53592465   c
            672-919             JAXUCZ010000008.1  53591435-53591682   c
            920-1121            JAXUCZ010000008.1  53589627-53589828   c
            1122-1273           JAXUCZ010000008.1  53589118-53589269   c
            1274-1460           JAXUCZ010000008.1  53588351-53588537   c
            1461-1607           JAXUCZ010000008.1  53587812-53587958   c
            1608-1796           JAXUCZ010000008.1  53587507-53587695   c
            1797-1958           JAXUCZ010000008.1  53587241-53587402   c
            1959-2098           JAXUCZ010000008.1  53586614-53586753   c
            2099-2301           JAXUCZ010000008.1  53586326-53586528   c
            2302-2473           JAXUCZ010000008.1  53586066-53586237   c
            2474-2696           JAXUCZ010000008.1  53581834-53582056   c
            2697-3184           JAXUCZ010000008.1  53580939-53581426   c
FEATURES             Location/Qualifiers
     source          1..3184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3184
                     /gene="Vps11"
                     /note="VPS11 core subunit of CORVET and HOPS complexes"
                     /db_xref="GeneID:315600"
                     /db_xref="RGD:1308038"
     exon            1..222
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2861
                     /gene="Vps11"
                     /note="vacuolar protein sorting 11 homolog; VPS11
                     CORVET/HOPS core subunit"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 11
                     homolog"
                     /protein_id="NP_001101608.2"
                     /db_xref="GeneID:315600"
                     /db_xref="RGD:1308038"
                     /translation="MAAYLQWRRFVFFEKELVKEPLGNDGATPGAAPTSGPTASKFLC
                     LPPGITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNILASV
                     GEDEEGINPLVKIWNLEKRDGGNPLCTRILPAIPGTEPTVVSCLTVHENLNFMAIGFT
                     DGSVTLNKGDITRDRHSKTQILHKGSYPVTGLAFRQAGKTTHLFVVTTENVQSYIVSG
                     KDYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIA
                     HWFRGYLVIVSRDRKVSPKSEFTSRDSQNSDKQILNIYDLCNKFIAYSAVFEDVVDVL
                     AEWGSLYVLTRDGRVHALQEKDTQTKLEMLFKKNLFEMAINLAKSQHLDSDGLAQIFM
                     QYGDHLYSKGNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLAN
                     ADHTTLLLNCYTKLKDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYYSHALYLAEN
                     HAHHEWYLKIQLEDIKNYQEALRYIGKLPFEQAESNMKRYGKILMHHIPEQTTQLLKG
                     LCTDYRPSLEGRGDREFPSCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYD
                     TLLELRLQNWAHEKDPQAKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYL
                     YEQGKLFQQIMHYHMQHEQYRQVIAVCERHGEQEPSLWEQALSYFARKEEDCKEYVAA
                     VLRHIENKSLMPPLLVVQTLAHNSTATLSIIRDYLVQKLQKQSQQIAQDELRVRRYRE
                     ETTRIRQEIQELKASPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDAD
                     CPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGVFNKLTLLT
                     DPPTARLTPSLEAGLQRDLLMHSRRGT"
     exon            223..371
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            372..507
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            508..671
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            672..919
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1121
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1273
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1460
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1607
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1796
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1958
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2098
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2301
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2473
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2696
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..3184
                     /gene="Vps11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgatcttgct tccggaggcg tgggccctcg tcaagatggc ggcctacctg cagtggcggc
       61 gattcgtttt cttcgagaag gagttggtga aggaaccgct gggtaatgat ggggccactc
      121 ccggggccgc accgacctcg ggacccactg cttccaagtt cctttgcctc cctcctggca
      181 ttactgtctg cgactcaggc cgcgggagcc tggtctttgg agatatggaa ggccagatct
      241 ggttcttgcc acgttctcta cagcttacag ggttccaggc ctacaagcta cgggtgacac
      301 acttgtatca gctgaagcag cacaatattc tggcatcagt tggtgaggat gaagagggca
      361 ttaaccccct ggtaaagatc tggaacctgg agaagagaga tggtggcaat ccactctgca
      421 ctcggatcct ccctgccatc ccagggacag agccaactgt cgtgtcttgt ttgaccgtcc
      481 atgagaatct caacttcatg gccattggct tcacggatgg cagtgtcact ctgaacaagg
      541 gagatattac ccgggacagg cacagcaaga cccagatttt gcacaagggc agctatcctg
      601 ttactggact ggcttttcgc caggcaggaa agaccactca cttgtttgtc gtgacaactg
      661 aaaatgttca gtcctacata gtttcaggaa aggactaccc tcgcgtggag ttggacaccc
      721 atggttgtgg cctgcgctgt tcggccctca gcgacccttc tcaggacctg cagttcattg
      781 tcgctggaga tgagtgtgtc tacctttacc agccggatga acgcgggccc tgctttgcct
      841 ttgagggcca taagctcatc gcccactggt ttagaggcta ccttgtcatt gtctcccgtg
      901 accggaaggt ttctcccaag tcggagttta ccagcaggga ctcacagaac tctgacaagc
      961 aaattctcaa catctatgac ctgtgcaaca agttcatagc ctacagcgct gtttttgagg
     1021 atgtagtgga tgtgctcgct gagtggggct ccctgtacgt gctgaccagg gatgggcggg
     1081 tccacgcatt gcaggagaag gacacacaga ccaaactgga gatgctgttt aagaagaatc
     1141 tctttgagat ggcaattaac ctggctaaga gtcagcatct ggacagtgat gggctagctc
     1201 aaatcttcat gcagtatgga gaccatctct acagcaaagg caaccatgat ggggctgttc
     1261 agcagtatat ccgaaccatt gggaagttgg agccgtccta tgtgatccgt aaatttctag
     1321 atgcccaacg catccacaac ctgactgcct acctacaaac tctgcatcgg caatctctgg
     1381 ctaatgccga tcacaccacc ctgctcctga actgctatac caagctcaag gacagctcga
     1441 agctggagga attcatcaag acgaagagcg agagtgaagt ccactttgat gtggagacag
     1501 ccatcaaggt cctccggcag gctggctact actcccatgc cctttatctg gctgagaacc
     1561 acgcacatca tgagtggtac ttaaagatcc agctagagga cattaagaac tatcaggaag
     1621 cccttcggta tatcggcaag ctgccttttg agcaggcaga gagtaacatg aaacgctatg
     1681 gcaagatcct catgcaccac ataccagagc agacaaccca gttgctgaaa ggcctctgta
     1741 ctgactatcg gcccagtctg gaaggccgag gcgatcggga gtttccaagc tgccgggcca
     1801 actccgagga gttcatcccc atctttgcaa acaacccaag agagctgaaa gccttcctgg
     1861 agcacatgag cgaagtgcag ccagactcac cccagggcat ctatgacacg ctcctggagc
     1921 tacggctgca gaactgggcc catgagaagg atccacaggc caaggagaaa cttcatgcag
     1981 aggccatctc cctgctgaag agtggccgat tctgtgatgt gtttgacaag gcattggtcc
     2041 tgtgccagat gcatgacttc caggatgggg tcctttacct ctatgagcag gggaagctgt
     2101 tccagcagat catgcattac cacatgcagc acgagcagta tcggcaggtg attgctgtgt
     2161 gtgaacgcca tggggagcag gagccctccc tgtgggagca ggccctcagc tacttcgccc
     2221 gcaaggagga agactgcaag gagtatgtgg cagccgtgct tagacacatc gagaacaaga
     2281 gcctgatgcc acctctcctg gtggtacaga cgctggcaca caactccaca gctactctgt
     2341 ccatcatccg agattacctg gtccaaaaac tgcagaaaca gagccagcag attgcacagg
     2401 atgagcttcg ggtgcggcgg tacagagagg agaccactcg catccgccag gaaatccaag
     2461 agctcaaggc gagtccaaag attttccaga agaccaagtg cagcatctgt aacagtgcct
     2521 tggagctgcc ttcagtccac ttcctgtgtg gccactcctt ccaccaacac tgctttgaga
     2581 gctactcaga aagtgatgct gactgcccca cctgcctccc tgagaatcgg aaggtgatgg
     2641 atatgatccg ggcccaggaa cagaaacgag atctccatga tcaattccag catcagctca
     2701 agtgctcgaa tgacagcttc tccgtgattg cggactactt tggccgaggg gttttcaaca
     2761 agctgactct gctgaccgat ccccctacag ccagactgac ccccagcctg gaggctgggc
     2821 tacagcggga cctgctgatg cactccagga ggggaacgta attaagcagc ccctgggaaa
     2881 gcctgcaacc ctgggctcta aacaaggatg ggcctgaggg acatccggta gcagacatga
     2941 ccacagttcc agacctcgac actcaagaag gggatctgct tttcctgcct ccctttgcca
     3001 gcctgctatc cctcctgctg accagcaata tagattattc cacaccagtg aggagggcac
     3061 ctcggcaacc tctctgtgga caatagctgc tttatcctct gttcaagggc accaggctgt
     3121 gcttgggtcc ttgctcccag agcctataaa taaaagagta taataataac atgagggttg
     3181 aaaa
//
