LOCUS       NM_001025623            2421 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus vanin 1 (Vnn1), mRNA.
ACCESSION   NM_001025623 XM_215293
VERSION     NM_001025623.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Hosohata K, Jin D and Takai S.
  TITLE     In Vivo and In Vitro Evaluation of Urinary Biomarkers in
            Ischemia/Reperfusion-Induced Kidney Injury
  JOURNAL   Int J Mol Sci 22 (21), 11448 (2021)
   PUBMED   34768879
  REMARK    GeneRIF: In Vivo and In Vitro Evaluation of Urinary Biomarkers in
            Ischemia/Reperfusion-Induced Kidney Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Sahni S, Krisp C, Molloy MP, Nahm C, Maloney S, Gillson J, Gill AJ,
            Samra J and Mittal A.
  TITLE     PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer
            progression
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (11), 129682 (2020)
   PUBMED   32663515
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Hosohata K, Jin D, Takai S and Iwanaga K.
  TITLE     Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal
            Tubular Injury in Dahl-Salt Sensitive Rats
  JOURNAL   Int J Mol Sci 20 (18), 4481 (2019)
   PUBMED   31514290
  REMARK    GeneRIF: urinary vanin-1 is a potentially sensitive biomarker for
            ameliorating renal tubular damage in salt-sensitive hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Hosohata K, Jin D, Takai S and Iwanaga K.
  TITLE     Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model
            of Hydronephrosis
  JOURNAL   Int J Mol Sci 19 (10), 3186 (2018)
   PUBMED   30332759
  REMARK    GeneRIF: Urinary vanin-1 may serve as a candidate biomarker of
            renal tubular injury due to hydronephrosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   Wedel J, Jansen PA, Botman PN, Rutjes FP, Schalkwijk J and
            Hillebrands JL.
  TITLE     Pharmacological Inhibition of Vanin Activity Attenuates Transplant
            Vasculopathy in Rat Aortic Allografts
  JOURNAL   Transplantation 100 (8), 1656-1666 (2016)
   PUBMED   27014792
  REMARK    GeneRIF: Pharmacological inhibition of vanin activity attenuates
            development of transplant vasculopathy. This was accompanied by
            reduced macrophage infiltration and increased
            glutathione-synthesizing capacity.
REFERENCE   6  (bases 1 to 2421)
  AUTHORS   Fugmann T, Borgia B, Revesz C, Godo M, Forsblom C, Hamar P,
            Holthofer H, Neri D and Roesli C.
  TITLE     Proteomic identification of vanin-1 as a marker of kidney damage in
            a rat model of type 1 diabetic nephropathy
  JOURNAL   Kidney Int 80 (3), 272-281 (2011)
   PUBMED   21544065
  REMARK    GeneRIF: Proteomic-based study identifies vanin-1 as a marker of
            kidney damage in a rat model of type 1 diabetic nephropathy.
REFERENCE   7  (bases 1 to 2421)
  AUTHORS   Berruyer C, Martin FM, Castellano R, Macone A, Malergue F,
            Garrido-Urbani S, Millet V, Imbert J, Dupre S, Pitari G, Naquet P
            and Galland F.
  TITLE     Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to
            oxidative stress
  JOURNAL   Mol Cell Biol 24 (16), 7214-7224 (2004)
   PUBMED   15282320
REFERENCE   8  (bases 1 to 2421)
  AUTHORS   Martin F, Penet MF, Malergue F, Lepidi H, Dessein A, Galland F, de
            Reggi M, Naquet P and Gharib B.
  TITLE     Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced
            intestinal inflammation associated with higher glutathione stores
  JOURNAL   J Clin Invest 113 (4), 591-597 (2004)
   PUBMED   14966568
REFERENCE   9  (bases 1 to 2421)
  AUTHORS   Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C,
            Granjeaud S, Mattei MG, Mungall AJ, Naquet P and Galland F.
  TITLE     Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and
            encode isoforms of pantetheinase ectoenzymes
  JOURNAL   Immunogenetics 53 (4), 296-306 (2001)
   PUBMED   11491533
REFERENCE   10 (bases 1 to 2421)
  AUTHORS   Aurrand-Lions M, Galland F, Bazin H, Zakharyev VM, Imhof BA and
            Naquet P.
  TITLE     Vanin-1, a novel GPI-linked perivascular molecule involved in
            thymus homing
  JOURNAL   Immunity 5 (5), 391-405 (1996)
   PUBMED   8934567
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098934.1.
            
            On Jul 22, 2005 this sequence version replaced XM_215293.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098934.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..2421
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /note="vanin 1"
                     /db_xref="GeneID:29142"
                     /db_xref="RGD:1310075"
     exon            1..346
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1669
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /EC_number="3.5.1.92"
                     /note="pantetheinase"
                     /codon_start=1
                     /product="pantetheinase precursor"
                     /protein_id="NP_001020794.1"
                     /db_xref="GeneID:29142"
                     /db_xref="RGD:1310075"
                     /translation="MSLSRWLAWAAAFSVFCVLKVSSLDTFLAAVYEHAVILPKVTLL
                     PVSHSEALALMNQNLDLLEGAILSAAKQGAHIIVTPEDGIYGVQFTRDTIYPYLEDIP
                     DPQVNWIPCDNPERFGSTPVQERLSCLAKNNSIYVVANMGDKKPCNTSDSHCPPDGRF
                     QYNTDVVFDSRGKLVARYHKQNLFMGEEQFNAPPEPEVVTFDTPFGKFGIFTCFDILF
                     HDPAVTLVTEFQVDTILFPTAWMDVLPHLAAIEFHSAWAIGMGVNFLAANLHIPLRRM
                     TGSGIYAPDSPRAFHYDRKTQEGKLLLAQLDSHPSHSPVNWTSYASSVEAPPTEKEEF
                     RSFVFFDEFTFVELKGITGNYTVCQNDLCCHLSYQMSEKRADEVYALGAFDGLHTVEG
                     QYHLQICILLKCKTTNLRTCGSSVDTASTRFEMFSLSGTFGTRYVFPEVLLSEVKLAP
                     GEFQVLSDGRLVSLKPTSGPVLTVGLFGRLYEKDWASNASSDLIAHSLIIMLILAPII
                     HYLC"
     exon            347..477
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            478..670
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            671..962
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1321
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1492
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..2352
                     /gene="Vnn1"
                     /gene_synonym="Tiff66"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttaaaattaa ccttttaaat ttattttgaa gacaccaagg tctgggcacc acgtgattcg
       61 tgcttttttt tttttttacc ataaaagtag gaagctacgt tttggttttc cgcagtcttt
      121 ggacttcagc atgagcctgt ctcggtggct ggcgtgggct gcagcgtttt ccgtcttctg
      181 tgtcttaaaa gtcagctctc tggacacttt cctcgcagct gtttacgagc atgctgtgat
      241 cctgcctaaa gtcaccctgt tacctgtgtc tcacagtgag gcactggcat taatgaacca
      301 gaatctggac cttctggaag gagcgatctt atcagcagct aagcagggtg cgcacattat
      361 tgtgactcca gaagatggta tatacggtgt gcagttcacc agggatacca tctacccata
      421 cctggaggat atcccagacc ctcaagtaaa ctggataccc tgtgataatc cggaaagatt
      481 tggctctacc ccggtgcagg agagactcag ctgcttggcc aagaacaact caatctatgt
      541 cgtggcgaac atgggagaca agaagccatg caacaccagc gactctcact gtccacctga
      601 cggccgattc caatacaaca ctgatgtggt gtttgattcc cggggtaaat tggttgccag
      661 ataccataag caaaaccttt tcatgggaga agagcaattc aatgcccccc cggagcctga
      721 ggtcgtgact tttgacaccc cctttggaaa gtttggcatc ttcacctgtt tcgatattct
      781 cttccatgat cctgctgtca ccctagtgac agagttccag gtggacacca tactgttccc
      841 aactgcctgg atggacgtgc ttcctcattt ggcagccatt gaattccact cagcttgggc
      901 tataggcatg ggagtcaatt tcctagcagc taatctacat attcccttga ggagaatgac
      961 aggaagtggt atctatgcac ccgattctcc acgggccttt cattatgaca ggaagacaca
     1021 ggaaggaaag ctcctccttg cacagctgga ctctcacccg agtcactccc cagtgaactg
     1081 gacttcctat gccagcagtg tagaagcacc cccaactgaa aaggaggaat ttcggagttt
     1141 tgttttcttt gatgagttta cctttgtgga gctcaaaggg atcacaggaa attacactgt
     1201 ttgccagaac gacctctgct gtcatctaag ctaccagatg tctgagaagc gagctgatga
     1261 agtttatgct cttggggctt ttgacgggtt gcacaccgtg gaagggcagt atcacctgca
     1321 gatttgcatt ctgctaaagt gtaaaactac caatttacgc acctgtggta gttcagtgga
     1381 cacagcttct accaggtttg aaatgttctc cctcagtggc acttttggaa cgcggtatgt
     1441 cttccctgag gtgttgctga gtgaagtcaa gcttgctcct ggggagtttc aggtgttgag
     1501 tgacgggcgc ctggttagcc tgaagccaac gtctggacct gtgttaacag tcggtctctt
     1561 tgggaggttg tatgagaagg actgggcatc aaatgcttcc tcagacctca tagcacactc
     1621 actgataata atgctgatcc tagctcctat tatacattac ttgtgttaat agaatttcta
     1681 cattttctgt tttatttaga acatttaaaa ttggtaggtg cagaaaaaaa agtatctgtt
     1741 tgccaacagt ggactctggg gtaaacaaat aaagtgcctc ctctttagag gagcatgcgt
     1801 cccagataca cttcaggaaa attaataaaa ctttgagcat tggtctatct tagaactgag
     1861 atgttgggcc aaatgaaggt cacatatatt tgattcagtt aaaaggcact tcaaaatatc
     1921 ataatatata tttataagac atttgaatct attatacatc ttactcggtt atggttaaaa
     1981 ttttcagtaa gtttgttcat ttgggctatt aagtatatta tctcaataaa tacatttcca
     2041 ttctcttaag aggcaaatcc tgtagcttta gttcttcagt tcaagtccca gttcccacaa
     2101 cctcagaacg tgactgtctt ggtgtcttgg gaaataaata cctaagtgac atccttagca
     2161 tgggctttaa tctgatatga ctgctatcct cagaagaaat caggacaaag gtgagaatca
     2221 agtgaagacc atgtgaacac agagaaagat ggccgtctac aacaaggaaa ggggcctcag
     2281 gagaaagcaa cctgctaaca tgttgaactt ccaggccccc agaatattga ggcaataaat
     2341 ttctctttta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa a
//
